Take Control of Your Data and Use Python with ConfidenceRequiring no prior programming experience, Managing Your Biological Data with Python empowers biologists and other life scientists to work with biological data on their own using the Python language. The book teaches them not only how to program but also how to manage their data. It shows how
Avian influenza, or 'bird flu', is a contagious disease of animals caused by viruses that normally infect only birds and, less commonly, pigs. Avian influenza viruses are highly species-specific, but have, on rare occasions, crossed the species barrier to infect humans. In domestic poultry, infection with avian influenza viruses causes two main forms of disease, distinguished by low and high extremes of virulence. The so-called 'low pathogenic' form commonly causes only mild symptoms (ruffled feathers, a drop in egg production) and may easily go undetected. The highly pathogenic form is far more dramatic. It spreads very rapidly through poultry flocks, causes disease affecting multiple internal organs, and has a mortality that can approach 100%, often within 48 hours.
Allegra Taylor has journeyed throughout the world in a quest to understand how healing works. She chronicles her own gradual acquisition of healing skills as she explores a whole range methods and ideas. She discovers that the healer is essentially a catalyst, not a magician. That health is much more than mere absence of disease. That the power to heal is one face of the power to love. That anyone can do it.
In many parts of the world there is a gathering groundswell of women seeking to reclaim their own direct experience of spiritual vision. The Goddess has become one of the most potent images of our time. Women are personally and collectively recovering their voices. Ladder to the Moon is a journey of discovery - meetings with women, like the author herself, who are asking, "What happened to the feminine aspect of the Divine? Was it ever there? If it was, can we reclaim it and come in from the cold? How can a woman, discouraged by the misogyny of most religions, begin to find a meaningful path?" The book is warmly personal and anecdotal - an Everywoman's search.
This book explores a series of powerful artifacts associated with King Solomon via legendary or extracanonical textual sources. Tracing their cultural resonance throughout history, art historian Allegra Iafrate delivers exciting insights into these objects and interrogates the ways in which magic manifests itself at a material level. Each chapter focuses on a different Solomonic object: a ring used to control demons; a mysterious set of bottles that constrain evil forces; an endless knot or seal with similar properties; the shamir, known for its supernatural ability to cut through stone; and a flying carpet that can bring the sitter anywhere he desires. Taken together, these chapters constitute a study on the reception of the figure of Solomon, but they are also cultural biographies of these magical objects and their inherent aesthetic, morphological, and technical qualities. Thought-provoking and engaging, Iafrate’s study shows how ancient magic artifacts live on in our imagination, in items such as Sauron’s ring of power, Aladdin’s lamp, and the magic carpet. It will appeal to historians of art, religion, folklore, and literature.
Written by clinicians from the National Cancer Institute and other leading institutions, this comprehensive, clear, concise oncology handbook is designed specifically for quick bedside consultation. It covers all malignancies and offers busy clinicians practical guidelines on daily patient management, including commonly used treatment regimens and chemotherapy dosing and schedules. The user-friendly format features tables, charts, bullet points, and algorithms. The thoroughly updated Third Edition places an increased emphasis on practical clinical information, and includes new chemotherapeutic agents, dosages, and treatment regimens and the latest clinical trials data. New chapters focus on basic genomics for practicing oncologists and basic principles of radiation. The succinct yet detailed presentation is ideal for board review as well as clinical reference.
A gripping and beautifully written dystopian page-turner from New York Times bestselling author and National Book Award finalist ALLEGRA GOODMAN. In the eighteenth glorious year of Enclosure, long after The Flood, a young girl named Honor moves with her parents to Island 365 in the Tranquil Sea. Life on the tropical island is peaceful—there is no sadness and no visible violence in this world. Earth Mother and her Corporation have created New Weather. The sky is always blue and it almost never rains. Every family fits into its rightful, orderly, and predictable place… Except Honor’s. Her family does not follow the rules. They ignore curfew, sing songs, and do not pray to Earth Mother. Honor doesn’t fit in with the other children at the Old Colony School. Then she meets Helix, a boy with a big heart who slowly helps her uncover a terrible secret about the Island: Sooner or later, those who do not fit disappear, and they don’t ever come back. Honor knows her family could be next, and when the unthinkable happens, she must make the dangerous journey to the Other Side of the Island—before Earth Mother comes for her too…
A flood of data indicate the importance and the relevance in both respiratory and extrapulmonary disease of Chlamydia pneumoniae infection today. Antibody prevalence rates in Western countries reach 50% in the adult population and remain high in old age suggesting a high rate of reinfection. Chlamydia pneumoniae can cause upper respiratory tract infections, like pharyngitis and sinusitis as well as bronchitis and more than 10% of community-acquired pneumonia. Recent data suggest a possible association of Chlamydia pneumoniae infection with wheezing and adult-onset asthma. However, the most intriguing hypothesis pertains the possible association between Chlamydia pneumoniae infection and atherosclerosis.
In The Wandering Throne of Solomon: Objects and Tales of Kingship in the Medieval Mediterranean Allegra Iafrate analyzes the circulation of artifacts and literary traditions related to king Solomon, particularly among Christians, Jews and Muslims, from the 10th to the 13th century. The author shows how written sources and objects of striking visual impact interact and describes the efforts to match the literary echoes of past wonders with new mirabilia. Using the throne of Solomon as a case-study, she evokes a context where Jewish rabbis, Byzantine rulers, Muslim ambassadors, Christian sovereigns and bishops all seem to share a common imagery in art, technology and kingship.
Allegra tells the journey of a young European woman who refuses to succumb to bitterness and desperation. It takes us, from the inner land of Europe, where her wealthy but selfish parents put her for adoption, to the shore of Africa where she becomes a successful designer and carries on the message of her humanitarian grandfather and realizes her Dream.
Being a subject and being conscious of being one are different realities. According to Hegel, the difference is not only conceptual, but also influences people's experience of the world and of one another. This book aims to explain some basic aspects of Hegel's conception of subjectivity with particular regard to the difference he saw in ancient and modern ways of thinking about and acting as individuals, persons and moral subjects.
A hopeful, speculative short story collection about how humanity grapples in a world transformed by climate change. “Climate fiction does not owe readers hope, but through humor and humanity Hyde manages to present a harsh reality without descending into despair, offering a space for mourning and for reimagining life in a permanently changed world. Each of the 15 stories is swiftly paced and engaging, rich with detail, highlighting and celebrating nature as it borders on the unnatural.” —The New York Times Book Review A vast caravan of RVs roams the United States. A girl grows a unicorn horn, complicating her small-town friendships and big city ambitions. A young lady on a spaceship bonds with her AI warden while trying to avoid an arranged marriage. In Allegra Hyde’s universe nothing is as it seems, yet the challenges encountered in these pages mirror those we face in our modern age. Spanning the length of our very solar system, the fifteen stories in this collection explore a myriad of potential futures through the concept of “global weirding,” planetary and social disruptions due to climate change. In unexpected and genre-defying ways, this revelatory collection reminds us that our world is precious, and that protecting it has the potential to bring us all together.
Chlamydia pneumoniae is now recognized as an important human pathogen. Chlamydia pneumoniae is involved in 5%-15% of community acquired pneumonias, and recent data indicate its relevance in severe pneumonia and as a respiratory pathogen in immunocompromised subjects. A causal role for Chlamydia pneumoniae in the initiation, exacerbations and promotion of asthma has been suggested. Approximately 5% of chronic bronchitis exacerbations have been attributed to Chlamydia pneumoniae infections, and chronic infection may facilitate access of other pathogens to the lower respiratory tract. Another field of potential great social impact is the possible involvement of Chlamydia pneumoniae in the pathogenesis of atherosclerosis and related cardiovascular diseases. This book presents the current state-of-the-art knowledge on Chlamydia pneumoniae infection and highlights future lines of research.
The beautiful Napa Valley attracts ten milli on visitors per year. This book selects the best wineries in the area and provides substantial new information, includin g up-to-date prices, directions, and an improved regional ma p.
Take Control of Your Data and Use Python with Confidence Requiring no prior programming experience, Managing Your Biological Data with Python empowers biologists and other life scientists to work with biological data on their own using the Python language. The book teaches them not only how to program but also how to manage their data. It shows how to read data from files in different formats, analyze and manipulate the data, and write the results to a file or computer screen. The first part of the text introduces the Python language and teaches readers how to write their first programs. The second part presents the basic elements of the language, enabling readers to write small programs independently. The third part explains how to create bigger programs using techniques to write well-organized, efficient, and error-free code. The fourth part on data visualization shows how to plot data and draw a figure for an article or slide presentation. The fifth part covers the Biopython programming library for reading and writing several biological file formats, querying the NCBI online databases, and retrieving biological records from the web. The last part provides a cookbook of 20 specific programming "recipes," ranging from secondary structure prediction and multiple sequence alignment analyses to superimposing protein three-dimensional structures. Tailoring the programming topics to the everyday needs of biologists, the book helps them easily analyze data and ultimately make better discoveries. Every piece of code in the text is aimed at solving real biological problems.
Protein phosphorylation is one of the most abundant reversible post-translational modifications in eukaryotes. It is involved in virtually all cellular processes by regulating protein function, localization and stability and by mediating protein-protein interactions. Furthermore, aberrant protein phosphorylation is implicated in the onset and progression of human diseases such as cancer and neurodegenerative disorders. In the last years, tens of thousands of in vivo phosphorylation events have been identified by large-scale quantitative phospho-proteomics experiment suggesting that a large fraction of the proteome might be regulated by phosphorylation. This data explosion is increasingly enabling the development of computational approaches, often combined with experimental validation, aiming at prioritizing phosphosites and assessing their functional relevance. Some computational approaches also address the inference of specificity determinants of protein kinases/phosphatases and the identification of phosphoresidue recognition domains. In this context, several challenging issues are still open regarding phosphorylation, including a better understanding of the interplay between phosphorylation and allosteric regulation, agents and mechanisms disrupting or promoting abnormal phosphorylation in diseases, the identification and modulation of novel phosphorylation inhibitors, and so forth. Furthermore, the determinants of kinase and phosphatase recognition and binding specificity are still unknown in several cases, as well as the impact of disease mutations on phosphorylation-mediated signaling. The articles included in this Research Topic illustrate the very diverse aspects of phosphorylation, ranging from structural changes induced by phosphorylation to the peculiarities of phosphosite evolution. Some also provide a glimpse into the huge complexity of phosphorylation networks and pathways in health and disease, and underscore that a deeper knowledge of such processes is essential to identify disease biomarkers, on one hand, and design more effective therapeutic strategies, on the other.
Allegra likes learning to draw at the Alphabet Afterschool Center. When she sees that the children are using a lot of drawing paper, Allegra tells her friends what her mother told her aobut saving trees. Find out what she said in Allegra's apple tree"--P. [4] of Cover.
Silberstein focuses her poems on those mysteries that populate our day to day lives, among them those strange spaces between people described as ‘friendship,’ ‘love,’ and ‘desire,’ which resist true expression in words. Instead, she turns to nature and its healing powers: “Let us sing aubades to morning light, / to each new day, to each new start, to all / the wild birds that whisper hope in their flight./ Do not acquaint me with the dark of night.” Allegra Silberstein was born in the middle of a blizzard on a farm in Wisconsin. Her Norwegian ancestors by-passed the flat prairie land and settled in the coulees and hills of the non-glaciated area near the Mississippi River. Her love of poetry began as a child when her mother recited poems as she worked. Silberstein has lived in California since 1963 but her growing years on the farm in Wisconsin brought a deep appreciation for the out-of-doors world that stays with her and sustains her. She has over a hundred publications in journals such as Blue Unicorn, California Quarterly, Iodine Poetry Journal, Poetry Now, Rattlesnake Review and others. Her work is included in anthologies like The Sacramento Anthology: 100 Poems; Gatherings: A Woman’s Place; and Where Do I Walk. She has two chapbooks: Acceptance, published by Small Poetry Press and In The Folds, published by Rattlesnake Review. In March of 2010 she was selected as the first Poet Laureate for the city of Davis, California. A review of Through Sun-glinting Particles appeared in the May 2012 issue of the Midwest Book Review.
When Allegra Huston was four years old, her mother was killed in a car crash. Soon afterward, she was introduced to an intimidating man wreathed in cigar smoke -- the legendary film director John Huston -- with the words, "This is your father." So began an extraordinary odyssey: from the magical Huston estate in Ireland to the Long Island suburbs to a hidden paradise in Mexico -- and, at the side of her older sister, Anjelica, into the hilltop retreats of Jack Nicholson, Ryan O'Neal, and Marlon Brando. Allegra's is the penetrating gaze of an outsider never quite sure if she belongs in this rarefied world and of a motherless child trying to make sense of her famous, fragmented family. Then, at the age of twelve, Allegra's precarious sense of self was shattered when she was, once more, introduced to her father -- her real one this time, the British aristocrat and historian John Julius Norwich. At the heart of Love Child is Allegra's search through the unreliable certainties of memory for the widely adored mother she never knew -- the ghost who shadowed her childhood and left her in a web of awkward and unwelcome truths. With clear-eyed tenderness, Allegra tells of how she forged bonds with both her famous fathers, transforming her mother's difficult legacy into a hard-won blessing. Beautifully written and forensically honest, Love Child is a seductive insight into one of Hollywood's great dynasties and the story of how, in a family that defied convention, one woman found her balance on the shifting sands of conflicting loyalties.
A tender affair and the redemptive power of art are at the core of this compelling novel from National Book Award finalist Allegra Goodman, “a romantic realist who dazzles with wit [and] compassion” (The Wall Street Journal). Collin James is young, creative, and unhappy. A college dropout, he waits tables and spends his free time beautifying the streets of Cambridge, Massachusetts, with his medium of choice: chalk. Collin’s art captivates passersby with its vibrant colors and intricate lines—until the moment he wipes it all away. Nothing in Collin’s life is meant to last. Then he meets Nina. . . . The daughter of a tech mogul who is revolutionizing virtual reality, Nina Lazare is trying to give back as a high school teacher—but her students won’t listen to her. When Collin enters her world, he inspires her to think bigger. Nina wants to return the favor—even if it means losing him. Against this poignant backdrop, Allegra Goodman paints a tableau of students, neighbors, and colleagues: Diana, a teenage girl trying to make herself invisible; her twin brother, Aidan, who’s addicted to the games produced by Nina’s father; and Daphne, a viral-marketing trickster who unites them all, for better or worse. Wise, warm, and enchanting, The Chalk Artist is both a finely rendered portrait of modern love and a celebration of all the realms we inhabit: real and imagined, visual and virtual, seemingly independent yet hopelessly tangled. Praise for The Chalk Artist “The virtual world Goodman conjures is as feverishly vivid as it is mysterious and alluring. Not since I pushed my way through C. S. Lewis’s fusty mothballed wardrobe and stepped out into the frozen, pine-scented forests of Narnia can I remember being so effectively transported into a viscerally, sometimes terrifyingly plausible alternate universe. . . . This is a novel full of wit and spark. . . . Irresistible and arresting.”—The New York Times Book Review “Enjoyably sharp dialogue and convincing portraits of multiple mindsets and terrains . . . One can’t help but marvel at how Goodman has captured the atmosphere of this virtual fantasy land so effectively in words.”—NPR “Mesmerizing depictions of virtual-reality landscapes of ‘Neverwhen’ and ‘Underworld’ make the games’ dangerous power over one of Nina’s students very real.”—People “Goodman’s latest combines fantastical flourishes (an imagined video game called ‘Underworld’) and realistic Cambridge details . . . in a narrative about art and ambition.”—The Boston Globe “Allegra Goodman creates suspense where you might least expect to find it.”—The Atlantic
This book explores a series of powerful artifacts associated with King Solomon via legendary or extracanonical textual sources. Tracing their cultural resonance throughout history, art historian Allegra Iafrate delivers exciting insights into these objects and interrogates the ways in which magic manifests itself at a material level. Each chapter focuses on a different Solomonic object: a ring used to control demons; a mysterious set of bottles that constrain evil forces; an endless knot or seal with similar properties; the shamir, known for its supernatural ability to cut through stone; and a flying carpet that can bring the sitter anywhere he desires. Taken together, these chapters constitute a study on the reception of the figure of Solomon, but they are also cultural biographies of these magical objects and their inherent aesthetic, morphological, and technical qualities. Thought-provoking and engaging, Iafrate’s study shows how ancient magic artifacts live on in our imagination, in items such as Sauron’s ring of power, Aladdin’s lamp, and the magic carpet. It will appeal to historians of art, religion, folklore, and literature.
A hopeful, speculative short story collection about how humanity grapples in a world transformed by climate change. “Climate fiction does not owe readers hope, but through humor and humanity Hyde manages to present a harsh reality without descending into despair, offering a space for mourning and for reimagining life in a permanently changed world. Each of the 15 stories is swiftly paced and engaging, rich with detail, highlighting and celebrating nature as it borders on the unnatural.” —The New York Times Book Review A vast caravan of RVs roams the United States. A girl grows a unicorn horn, complicating her small-town friendships and big city ambitions. A young lady on a spaceship bonds with her AI warden while trying to avoid an arranged marriage. In Allegra Hyde’s universe nothing is as it seems, yet the challenges encountered in these pages mirror those we face in our modern age. Spanning the length of our very solar system, the fifteen stories in this collection explore a myriad of potential futures through the concept of “global weirding,” planetary and social disruptions due to climate change. In unexpected and genre-defying ways, this revelatory collection reminds us that our world is precious, and that protecting it has the potential to bring us all together.
The human potential for transmitting energies of a healing nature through therapeutic touch has been realized for centuries and everyone knows how loving touch can effect our sense of well-being. In "Healing Hands," Allegra Taylor explores this potential we all possess to develop and channel our healing energies for the benefit of ourselves and our friends and family. Many techniques--from crystals to visualization to aromatherapy--are detailed, along with practical guidelines to good health and wholeness.
Ballet dancers have the strongest, most beautiful, probably the most envied bodies in the world. How do they stay slender and willowy while maintaining the extraordinary energy it takes to perform night after night? Can a nondancer or an amateur attain a dancer's figure and a dancer's vitality? And keep it? Here, in The Dancers' Body Book, the legendary ballerina Allegra Kent discloses the health, weight-watching, and relaxation secrets of some of the world's greatest ballet dancers -- from Suzanne Farrell and Fernando Bujones to Darci Kistler and Madame Alexandra Danilova. Combining them with two well-balanced diets -- one to lose weight by and one to live by -- and an exercise regimen that can be tailored to the individual, she provides a fabulous fitness program for everyone who longs to be slimmer, healthier, and more energetic. Fourteen varied menus incorporate delicious recipes from the dancers themselves (such as Jacques D'Amboise's Wonderful Dinner Salad and Dierdre Carberry's Almond Meringue Kisses), along with calorie guides and advice on how to create additional menus using your own favorite dishes. Helpful discussions on sports and exercise systems -- ranging from jogging and swimming to the sophisticated "Pilates" workout -- are also included, and in a special chapter entitled "A Healthy Outlook," the dancers talk candidly on such issues as smoking, anorexia, vitamins, doctors, massage, junk foods, fad diets, and injuries. Dancers take meticulous care of all their equipment because training and performance depend on it. Of course, the most essential piece of equipment, the body, needs the most care of all, and that is what this book is about: how to take care of the world's greatest machine. Allegra Kent joined the New York City Ballet at the age of fifteen and was a principal dancer with the company for thirty years, during which time she created a number of starring roles in ballets by Balanchine and Robbins. The mother of two daughters and a son, she is also the author of Allegra Kent's Water Beauty Book.
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