This issue of Endocrinology Clinics brings the reader up to date on the latest information about hormones and cancer of the breast and prostate. The first section focuses on the breast, and topics covered include the following. The role of sex steroids and their receptors in normal breast development; estrogen carcinogenesis in breast cancer; hormonal mechanisms underlying the relationship between obesity and breast cancer; postmenopausal hormone replacement therapy and the risk of breast cancer; aromatase inhibitors, anti-estrogen and SERMS in the treatment of breast cancer; and androgens in breast cancer in men and women. The second section is devoted to the prostate, and topics covered include the following. Overview of prostate anatomy, histology, and pathology; the critical role of sex steroids in normal prostate development; estrogens and androgens in prostate cancer development and the rationale for hormonal chemopreventive therapies; weighing the clinical evidence regarding the timing and extent of androgen ablative therapy for prostate cancer treatment; new hormonal therapies for castration-resistant prostate cancer; and the management of the side effects of castration therapy.
Current scientific evidence suggests that free radicals— unstable by-products produced by normal human metabolic processes—damage the body, resulting in chronic health disorders and degenerative changes associated with aging. Nutritional products on the market today promise antioxidants can reduce—possibly even reverse—damage caused by these free radicals. If true, that would mean less chronic disease and premature aging, at the very least. But are antioxidants indeed the new Fountain of Youth? Media reports extol antioxidants as the solution to disease and aging, and some studies do seem to back up those reports. Yet the studies that have been completed are far from conclusive, and taking antioxidant supplements can be dangerous. This book explores current thinking, analyzes studies, and answers the questions: What are antioxidants? What do they do? Is there any real benefit to taking them as supplements? Are there real dangers for me? Media report preliminary and conflicting scientific studies on antioxidants, notwithstanding the fact that the final analysis about their effectiveness and safety is incomplete. The result is increasing sales of dietary supplements and so-called functional foods or nutraceuticals that are not regulated, nor proven, and a possible public safety crisis from hypersupplementation. Milbury and Richer bring us up to date, sharing nuances and emerging news regarding antioxidants—and their dangers. Understanding the Antioxidant Controversy is an educated consumers' and health professionals' guide to this controversial topic.
Futures and Options are concerned with the valuation of derivatives and their application to hedging and speculating investments. This book contains 22 chapters and is divided into five parts. Part I contains an overview including a general introduction as well as an introduction to futures, options, swaps, and valuation theories. Part II: Forwards and Futures discusses futures valuation, the futures market, hedging strategies, and various types of futures. Part III: Option Theories and Applications includes both the basic and advanced valuation of options and option strategies in addition to index and currency options. Part IV: Advanced Analyses of Options takes a look at higher level strategies used to quantitatively approach the analysis of options. Part V: Special Topics of Options and Futures covers the applications of more obscure and alternative methods in derivatives as well as the derivation of the Black-Scholes Option Pricing Model.This book applies an active interdisciplinary approach to presenting the material; in other words, three projects involving the use of real-world financial data on derivative, in addition to homework assignments, are made available for students in this book.
How do fashion designers design? How does design function within the industry? How can design practices open up sustainable pathways for fashion's future? Designing Fashion's Future responds to these questions to offer a fresh understanding of design practices within the sprawling, shifting fashion system. Fashion design is typically viewed as the rarefied practice of elite professionals, or else as a single stage within the apparel value chain. Alice Payne shows how design needn't be reduced to a set of decisions by a designer or design team, but can instead be examined as a process, object, or agent that shapes fashion's material and symbolic worlds. Designing Fashion's Future draws on more than 50 interviews with industry professionals based in Australia, Asia, North America, Europe, and the United Kingdom. These diverse perspectives from multinational retailers, independent and experimental contexts ground the discussion in contemporary industry practices.
Advances in Quantitative Analysis of Finance and Accounting (New Series) is an annual publication designed to disseminate developments in the quantitative analysis of finance and accounting. The publication is a forum for statistical and quantitative analyses of issues in finance and accounting as well as applications of quantitative methods to problems in financial management, financial accounting, and business management. The objective is to promote interaction between academic research in finance and accounting and applied research in the financial community and the accounting profession.
A compelling firsthand investigation of how social media and big data have amplified the close relationship between privacy and inequality Online privacy is under constant attack by social media and big data technologies. But we cannot rely on individual actions to remedy this--it is a matter of social justice. Alice E. Marwick offers a new way of understanding how privacy is jeopardized, particularly for marginalized and disadvantaged communities--including immigrants, the poor, people of color, LGBTQ+ populations, and victims of online harassment. Marwick shows that there are few resources or regulations for preventing personal information from spreading on the internet. Through a new theory of "networked privacy," she reveals how current legal and technological frameworks are woefully inadequate in addressing issues of privacy--often by design. Drawing from interviews and focus groups encompassing a diverse group of Americans, Marwick shows that even heavy social media users care deeply about privacy and engage in extensive "privacy work" to protect it. But people are up against the violation machine of the modern internet. Safeguarding privacy must happen at the collective level.
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