This book seeks to explain two core paradoxes associated with the Association of Southeast Asian Nations (ASEAN): How have diverse states hung together and stabilized relations in the face of competing interests, divergent preferences, and arguably weak cooperation? How has a group of lesser, self-identified Southeast Asian powers gone beyond its original regional purview to shape the form and content of Asian Pacific and East Asian regionalisms? According to Alice Ba, the answers lie in ASEAN's founding arguments: arguments that were premised on an assumed regional disunity. She demonstrates how these arguments draw critical causal connections that make Southeast Asian regionalism a necessary response to problems, give rise to its defining informality and consensus-seeking process, and also constrain ASEAN's regionalism. Tracing debates about ASEAN's intra- and extra-regional relations over four decades, she argues for a process-driven view of cooperation, sheds light on intervening processes of argument and debate, and highlights interacting material, ideational, and social forces in the construction of regions and regionalisms.
Understand how drug discovery incorporates the building blocks of complex life with this accessible guide Enzymes are among the fundamental building blocks of life, the proteins that catalyze some of the most important metabolic and biochemical reactions that sustain the complex organism. Understanding the unique structures and mechanisms of individual enzymes is key to medical treatment and pharmaceutical intervention, making it an especially essential aspect of drug discovery. The topic can appear challenging, however, as it requires command of interdisciplinary research combining biology, chemistry, and mathematics. Laboratory Guide to Enzymology brings these disciplines together to offer a practical, accessible overview of the lab-based work of creating effective enzyme essays. Beginning with a guide to the fundamentals of enzyme theory, the book connects that theory to a range of modern methods of computation and experimentation. The result is a detailed but highly readable volume elucidating the cornerstone of drug discovery research. Laboratory Guide to Enzymology readers will also find: Specific examples of enzyme application in drug discovery Detailed discussion of topics including enzyme catalysis, chemical kinetics, steady-state assays, and many more Appendices including a range of vital supplementary material Laboratory Guide to Enzymology is ideal for all biomedical and pharmaceutical researchers working in enzymology and assay development, as well as advanced students in the biomedical or biochemical sciences looking to develop a working knowledge of this field of research.
In Neural Organization, Arbib, Érdi, and Szentágothai integrate structural, functional, and dynamical approaches to the interaction of brain models and neurobiologcal experiments. In Neural Organization, Arbib, Érdi, and Szentágothai integrate structural, functional, and dynamical approaches to the interaction of brain models and neurobiologcal experiments. Both structure-based "bottom-up" and function- based "top-down" models offer coherent concepts by which to evaluate the experimental data. The goal of this book is to point out the advantages of a multidisciplinary, multistrategied approach to the brain. Part I of Neural Organization provides a detailed introduction to each of the three areas of structure, function, and dynamics. Structure refers to the anatomical aspects of the brain and the relations between different brain regions. Function refers to skills and behaviors, which are explained by means of functional schemas and biologically based neural networks. Dynamics refers to the use of a mathematical framework to analyze the temporal change of neural activities and synaptic connectivities that underlie brain development and plasticity—in terms of both detailed single-cell models and large-scale network models. In part II, the authors show how their systematic approach can be used to analyze specific parts of the nervous system—the olfactory system, hippocampus, thalamus, cerebral cortex, cerebellum, and basal ganglia—as well as to integrate data from the study of brain regions, functional models, and the dynamics of neural networks. In conclusion, they offer a plan for the use of their methods in the development of cognitive neuroscience.
Designed to help pre-service and in-service teachers gain the knowledge they need to facilitate students' understanding, competency, and interest in mathematics, the revised and updated Second Edition of this popular text and resource bridges the gap between the mathematics learned in college and the mathematics taught in secondary schools. Highlighting multiple types of mathematical understanding to deepen insight into the secondary school mathematics curriculum, it addresses typical areas of difficulty and common student misconceptions so teachers can involve their students in learning mathematics in a way that is interesting, interconnected, understandable, and often surprising and entertaining. Six content strands are discussed—Numbers and Operations; Algebra; Geometry; Measurement; Data Analysis and Probability; and Proof, Functions, and Mathematical Modeling. The informal, clear style supports an interactive learner-centered approach through engaging pedagogical features: Launch Questions at the beginning of each section capture interest and involve readers in learning the mathematical concepts. Practice Problems provide opportunities to apply what has been learned and complete proofs. Questions from the Classroom bring the content to life by addressing the deep "why" conceptual questions that middle or secondary school students are curious about, and questions that require analysis and correction of typical student errors and misconceptions; focus on counter intuitive results; and contain activities and/or tasks suitable for use with students. Changes in the Second Edition New sections on Robotics, Calculators, Matrix Operations, Cryptography, and the Coefficient of Determination New problems, simpler proofs, and more illustrative examples Answers and hints for selected problems provided
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