This book is about “Angiogenesis”. A process in which new vasculature is formed from pre-existing capillaries. Angiogenesis process is associated with the proliferation and growth of both physiologically normal and neoplastic tissues, through the formation of vascular supply, essential for delivering growth requirements such as oxygen and nutrients. The book describes more than 100 genes and their key regulatory functions in the context of normal healthy condition, disease and malignancy, cancer proliferation and progression. New insights into the role of angiogenesis and the therapeutic inhibition of its regulators are investigated, due to the great potential for exploitation in the development of a novel treatment for cancer. New scientists, junior researchers and biomedical science students will find this book an invaluable introductory reference to their insight about angiogenesis and angiogenic role of more than 100 angiogenes and their role in healthy, disease and malignant conditions.
This book presents the so-called Shuffled Shepherd Optimization Algorithm (SSOA), a recently developed meta-heuristic algorithm by authors. There is always limitations on the resources to be used in the construction. Some of the resources used in the buildings are also detrimental to the environment. For example, the cement utilized in making concrete emits carbon dioxide, which contributes to the global warming. Hence, the engineers should employ resources efficiently and avoid the waste. In the traditional optimal design methods, the number of trials and errors used by the designer is limited, so there is no guarantee that the optimal design can be found for structures. Hence, the deigning method should be changed, and the computational algorithms should be employed in the optimum design problems. The gradient-based method and meta-heuristic algorithms are the two different types of methods used to find the optimal solution. The gradient-based methods require gradient information. Also, these can easily be trapped in the local optima in the nonlinear and complex problems. Therefore, to overcome these issues, meta-heuristic algorithms are developed. These algorithms are simple and can get out of the local optimum by easy means. However, a single meta-heuristic algorithm cannot find the optimum results in all types of optimization problems. Thus, civil engineers develop different meta-heuristic algorithms for their optimization problems. Different applications of the SSOA are provided. The simplified and enhanced versions of the SSOA are also developed and efficiently applied to various optimization problems in structures. Another special feature of this book consists of the use of graph theoretical force method as analysis tool, in place of traditional displacement approach. This has reduced the computational time to a great extent, especially for those structures having smaller DSI compared to the DKI. New framework is also developed for reliability-based design of frame structures. The algorithms are clearly stated such that they can simply be implemented and utilized in practice and research.
Chronic fatigue syndrome (CFS) is a condition that causes persistent and debilitating tiredness. The condition has no obvious cause but persists for more than six months, and patients tend to avoid activity due to constant fatigue. A wide variety of causes are thought to contribute to the condition, while the relatively low disease prevalence and lack of diagnostic criteria has made it difficult to identify and diagnose CFS. Here, Naheed Ali presents an overview of CFS, its causes, symptoms and outcomes, and the treatment options available to sufferers. He also includes information about lifestyle changes, preventative measures, and emotional and mental approaches to having the disorder. Readers will find here a ready resource for understanding CFS and the various ways of approaching it, and living well in spite of it.
This book presents efficient metaheuristic algorithms for optimal design of structures. Many of these algorithms are developed by the author and his graduate students, consisting of Particle Swarm Optimization, Charged System Search, Magnetic Charged System Search, Field of Forces Optimization, Democratic Particle Swarm Optimization, Dolphin Echolocation Optimization, Colliding Bodies Optimization, Ray Optimization. These are presented together with algorithms which are developed by other authors and have been successfully applied to various optimization problems. These consist of Partical Swarm Optimization, Big Band Big Crunch algorithm, Cuckoo Search Optimization, Imperialist Competitive Algorithm and Chaos Embedded Metaheuristic Algorithm. Finally a multi-objective Optimization is presented to Solve large scale structural problems based on the Charged System Search algorithm, In the second edition seven new chapters are added consisting of Enhance colliding bodies optimization, Global sensitivity analysis, Tug of War Optimization, Water evaporation optimization, Vibrating System Optimization and Cyclical Parthenogenesis Optimization algorithm. In the third edition, five new chapters are included consisting of the recently developed algorithms. These are Shuffled Shepherd Optimization Algorithm, Set Theoretical Shuffled Shepherd Optimization Algorithm, Set Theoretical Teaching-Learning-Based Optimization Algorithm, Thermal Exchange Metaheuristic Optimization Algorithm, and Water Strider Optimization Algorithm and Its Enhancement. The concepts and algorithm presented in this book are not only applicable to optimization of skeletal structure, finite element models, but can equally be utilized for optimal design of other systems such as hydraulic and electrical networks.
This book is about “Angiogenesis”. A process in which new vasculature is formed from pre-existing capillaries. Angiogenesis process is associated with the proliferation and growth of both physiologically normal and neoplastic tissues, through the formation of vascular supply, essential for delivering growth requirements such as oxygen and nutrients. The book describes more than 100 genes and their key regulatory functions in the context of normal healthy condition, disease and malignancy, cancer proliferation and progression. New insights into the role of angiogenesis and the therapeutic inhibition of its regulators are investigated, due to the great potential for exploitation in the development of a novel treatment for cancer. New scientists, junior researchers and biomedical science students will find this book an invaluable introductory reference to their insight about angiogenesis and angiogenic role of more than 100 angiogenes and their role in healthy, disease and malignant conditions.
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