Stephen Hawking says that the 21st century will be the century of complexity and indeed now systems biology or medicine means dealing with complexity. Both the genome and physiome have emerged in studying complex physiological systems. Computational and mathematical modeling has been regarded as an efficient tool to boost the understanding about living systems in normal or pathophysiological states. Covering applied methodology, basic case studies and complex applications, this volume provides researchers with an overview of modeling and computational studies of physiology (i.e. quantitative physiology), which is becoming an increasingly important branch of systems biology. This book aims to build multi-scale models to investigate functions in living systems and explain how biomolecules, cells, organs, organ systems and organisms carry out the chemical or physical functions. Some of the models addressed are related to gene expression, calcium signalling, neural activity, blood dynamics and bone mechanics. Combining theory and practice, with extensive use of MATLAB, this book is designed to establish a paradigm for quantitative physiology by integrating biology, mathematics, physics and informatics etc. To benefit from this book, the readers are expected to have a background in general physiology and mathematics
The importance and actuality of nanotechnology is unabated and will be for years to come. A main challenge is to understand the various properties of certain nanostructures, and how to generate structures with specific properties for use in actual applications in Electrical Engineering and Medicine. One of the most important structures are nanowires, in particular superconducting ones. They are highly promising for future electronics, transporting current without resistance and at scales of a few nanometers. To fabricate wires to certain defined standards however, is a major challenge, and so is the investigation and understanding of these properties in the first place. A promising approach is to use carbon nanotubes as well as DNA structures as templates. Many fundamental theoretical questions are still unanswered, e.g. related to the role of quantum fluctuations. This work is tackling them and provides a detailed analysis of the transport properties of such ultrathin wires. It presents an account of theoretical models, charge transport experiments, and also conveys the latest experimental findings regarding fabrication, measurements, and theoretical analysis. In particular, it is the only available resource for the approach of using DNA and carbon nanotubes for nanowire fabrication. It is intended for graduate students and young researchers interested in nanoscale superconductivity. The readers are assumed to have knowledge of the basics of quantum mechanics and superconductivity.
‘Fortresses must carry out the same tasks as the fortresses of old....They must allow themselves to be surrounded and thus tie down as many enemy forces as possible.’ So Hitler directed in March 1944 and, in so doing, sealed the fate of Ternopol', Kovel', Poznan and Breslau, cities in the Ukraine and Poland that were in the path of the Red Army’s advance towards Nazi Germany. German forces, under orders to resist at all costs, adopted all-round defence and struggled to hold out while waiting for relief – which never came. In this gripping and original book, Alexey Isaev describes, in vivid detail, what happened next –intense and ruthless fighting, horrendous casualties among soldiers and civilians, the fabric of these historic cities torn apart. His account is based on pioneering archival research which offers us an unrivalled insight into the tactics on both sides, the experience of the close-quarter fighting in the streets and houses, and the dreadful aftermath. At the same time he shows why these cities were chosen and how the wider war passed them by as the Wehrmacht retreated and the battlefront moved westward. Each of these cities suffered a similar fate to Stalingrad but their story has never been told before in such graphic and circumstantial detail.
Stephen Hawking says that the 21st century will be the century of complexity and indeed now systems biology or medicine means dealing with complexity. Both the genome and physiome have emerged in studying complex physiological systems. Computational and mathematical modeling has been regarded as an efficient tool to boost the understanding about living systems in normal or pathophysiological states. Covering applied methodology, basic case studies and complex applications, this volume provides researchers with an overview of modeling and computational studies of physiology (i.e. quantitative physiology), which is becoming an increasingly important branch of systems biology. This book aims to build multi-scale models to investigate functions in living systems and explain how biomolecules, cells, organs, organ systems and organisms carry out the chemical or physical functions. Some of the models addressed are related to gene expression, calcium signalling, neural activity, blood dynamics and bone mechanics. Combining theory and practice, with extensive use of MATLAB, this book is designed to establish a paradigm for quantitative physiology by integrating biology, mathematics, physics and informatics etc. To benefit from this book, the readers are expected to have a background in general physiology and mathematics
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