There is no area in medicine that has affected biological psychiatry more pro 15 years in en foundly than the developments that have occurred in the last docrinology and more specifically in neuroendocrinology. In the 1960s, the regulation of endocrine function was considered to rest primarily in the feed back system between the pituitary and the secretions of various target organs. In R. H. Williams' Fourth Edition of the Textbook of Endocrinology published in 1968, the chapter on neuroendocrinology did refer to the median eminence gland with a relatively brief mention of various releasing factors that were the subject of ongoing studies. Only six years later, in the Fifth Edition published in 1974, Seymour Reichlin's chapter on neuroendocrinology listed nine specific hypothalamic releasing factors of which three had already been isolated and purified and thus were referred to as hormones. Most recently in the current Sixth Edition, published in 1981, the chapter on neuroendocrinology contains a detailed description of the physiology of the various hypothalamic releasing factors and hormones, but also significant emphasis is given to the various neurotransmitters that have been shown to regulate the synthesis and release of these important hypothalamic hormones. In addition, there appeared for the first time in this classic textbook a chapter on psychoendocrinology. One may wonder why there is so much interest not only in endocrinology but more recently in psychology and psychiatry about psychoneuroendocrine It has been known for some time function. Several reasons may be suggested.
A Russian war hero who defeated Napoleon and became a mythic military figure. Alexander Mikaberidze's latest book is the first modern English-language biography of Mikhail Golenischev-Kutuzov, the famed Russian Field Marshal and central character of Leo Tolstoy's epic War and Peace. One of the most important military minds of the period, he is credited with defeating Napoleon and saving Russia, though his fame is not limited to the Napoleonic wars. As it often happens with national heroes, Kutuzov gradually became larger than life, a messianic character who led Holy Russia against the evils of the Revolution and anarchy; the Soviet leaders later exploited his personality for even more grandiose schemes. The real Kutuzov was gradually replaced by a mythical character who appeared at a time of great danger to save Russia. The impact of this propaganda can be still seen in modern Russia: In 2000, the public opinion poll showed that majority of the Russians consider Kutuzov as the Person of the 19th Century, far ahead of famous writers Alexander Pushkin and Leo Tolstoy, composer Peter Tchaikovsky or scientist Dmitry Mendeleyev, while the 2017 public opinion poll placed Kutuzov in the top twenty of the most distinguished historical personalities in world history (slightly behind Napoleon). As much as Kutuzov is venerated in Russia, he remains an overlooked figure in the West, with Western historiography comprising of just a handful of titles in English, French or German, the vast majority of them translations of older Soviet works or derived from them. This book provides a new biography of the field marshal, examining his personal life and military/diplomatic accomplishments, and relying on a wide range of primary and secondary sources as well as Russian archival material. Mikaberidze offers a fresh look at the historical figure whose character remains elusive but whose accomplishments are irrefutable.
“A delightful and courageous tale and a romping good read. Voila!” —Mark Greenside, author of I’ll Never Be French (No Matter What I Do) William Alexander is more than a Francophile. He wants to be French. There’s one small obstacle though: he doesn’t speak la langue française. In Flirting with French, Alexander sets out to conquer the language he loves. But will it love him back? Alexander eats, breathes, and sleeps French (even conjugating in his dreams). He travels to France, where mistranslations send him bicycling off in all sorts of wrong directions, and he nearly drowns in an immersion class in Provence, where, faced with the riddle of masculine breasts, feminine beards, and a turkey cutlet of uncertain gender, he starts to wonder whether he should’ve taken up golf instead of French. While playing hooky from grammar lessons and memory techniques, Alexander reports on the riotous workings of the Académie française, the four-hundred-year-old institution charged with keeping the language pure; explores the science of human communication, learning why it’s harder for fifty-year-olds to learn a second language than it is for five-year-olds; and, frustrated with his progress, explores an IBM research lab, where he trades barbs with a futuristic hand-held translator. Does he succeed in becoming fluent? Readers will be as surprised as Alexander is to discover that, in a fascinating twist, studying French may have had a far greater impact on his life than actually learning to speak it ever would. “A blend of passion and neuroscience, this literary love affair offers surprise insights into the human brain and the benefits of learning a second language. Reading William Alexander’s book is akin to having an MRI of the soul.” —Laura Shaine Cunningham, author of Sleeping Arrangements “Alexander proves that learning a new language is an adventure of its own--with all the unexpected obstacles, surprising breakthroughs and moments of sublime pleasure traveling brings.” —Julie Barlow, author of Sixty Million Frenchmen Can’t Be Wrong
Learn the principles of quantum machine learning and how to apply them While focus is on financial use cases, all the methods and techniques are transferable to other fields Purchase of Print or Kindle includes a free eBook in PDF Key Features Discover how to solve optimisation problems on quantum computers that can provide a speedup edge over classical methods Use methods of analogue and digital quantum computing to build powerful generative models Create the latest algorithms that work on Noisy Intermediate-Scale Quantum (NISQ) computers Book Description With recent advances in quantum computing technology, we finally reached the era of Noisy Intermediate-Scale Quantum (NISQ) computing. NISQ-era quantum computers are powerful enough to test quantum computing algorithms and solve hard real-world problems faster than classical hardware. Speedup is so important in financial applications, ranging from analysing huge amounts of customer data to high frequency trading. This is where quantum computing can give you the edge. Quantum Machine Learning and Optimisation in Finance shows you how to create hybrid quantum-classical machine learning and optimisation models that can harness the power of NISQ hardware. This book will take you through the real-world productive applications of quantum computing. The book explores the main quantum computing algorithms implementable on existing NISQ devices and highlights a range of financial applications that can benefit from this new quantum computing paradigm. This book will help you be one of the first in the finance industry to use quantum machine learning models to solve classically hard real-world problems. We may have moved past the point of quantum computing supremacy, but our quest for establishing quantum computing advantage has just begun! What you will learn Train parameterised quantum circuits as generative models that excel on NISQ hardware Solve hard optimisation problems Apply quantum boosting to financial applications Learn how the variational quantum eigensolver and the quantum approximate optimisation algorithms work Analyse the latest algorithms from quantum kernels to quantum semidefinite programming Apply quantum neural networks to credit approvals Who this book is for This book is for Quants and developers, data scientists, researchers, and students in quantitative finance. Although the focus is on financial use cases, all the methods and techniques are transferable to other areas.
Get a quick, expert overview of current diagnosis and management of scaphoid fractures with this concise, practical resource by Drs. Geert Buijze and Jesse B. Jupiter. This easy-to-read reference presents a summary of today's best evidence-based approaches to diagnosis and management in this critical area. - Provides must-know information on scaphoid fractures, including how to apply evidence-based management, anatomy, diagnosis, acute fracture management, malunion treatment, and nonunion management. - Presents case scenarios followed by discussions of the importance of the problem, current opinion, evidence, and key recommendations. - Consolidates today's evidence-based information on scaphoid fractures into one convenient resource.
This book presents a concept for fostering resource efficient manufacturing. The protection of our environment demands a more responsible use of natural resources, and a higher degree of transparency along manufacturing value chains will be required in order to make significant advances in this context. Industrial decision makers must be provided with adequate methods and tools to simultaneously and systematically pursue technical, economic and environmental targets. Building on established and complementary methods, such as material and energy flow analysis (MEFA), value stream mapping (VSM), life cycle costing (LCC) and environmental life cycle assessment (LCA), this book introduces a concept that allows a holistic modeling and multi-dimensional performance assessment of manufacturing systems on different levels – from processes up to entire value chains and product life cycles. It also demonstrates the application of the concept using two case studies from the metal mechanic industry.
As of 17 December 2010, the Rome I Regulation (EU Regulation 593/2008) on the law applicable to contractual obligations is directly applicable in all EU Member States with the exception of Denmark. The Rome I Regulation replaces the Rome Convention of 1980 in the EU Member States and will apply to all contracts concluded as of 17 December 2010. However, and herein lies the utility and great importance of this work, the Rome Convention and the Rome I Regulation will be applied in parallel for a significant time to come (the author himself anticipates a ten-to-fifteen year period); in the latter case to contracts made after 17 December, 2010. This is why this commentary takes into account both sources of law, in their mutual interaction and broader context. The comprehensiveness of the Rome Convention / Rome I Regulation is clearly apparent, but one of the great achievements of the author is his amassing of over 1,800 judicial decisions, most of which are furnished with a detailed commentary; where these decisions apply national laws, the latter are cited both in the original and in translation. For a number of rulings, the commentary include not only a case summary of the facts and an analysis of the conclusions drawn by the court, but also takes them as models to hypothesize what conclusions would be reached if the Rome I Regulation were to be applied.
A no-holds-barred portrait of the Bush administration architect evaluates his role in influencing a wide range of issues, from the war in Iraq and Social Security to the environment and energy, in a profile that also documents the controversial judicial matters that contributed to his downfall.
This introductory calculus text was developed by the author through his teaching of an honors calculus course at Notre Dame. The book develops calculus, as well as the necessary trigonometry and analytic geometry, from witin the relevant historical context, and yet it is not a textbook in the history of mathematics as such. The notation is modern, and the material is selected to cover the basics of the subject. Special emphasis is placed on pedagogy throughout. Whhile emphasizing the broad applications of the subject, emphasis is placed on the mathematical content of the subject.
Presenting a broad panorama of society and culture in the German lands and Russia from the Enlightenment to the breakthrough of modernity, this microhistory of one extraordinary family explores how the lives of individual people are entangled with the great forces of their age.
With questions and assignments written by Alexander Strauch, this Study Guide is designed as a companion to the text, "Paul s Vision for the Deacons: Assisting the Elders with the Care of God's Church." Together, these resources make excellent training material for deacons and the elders who lead them.
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