The Hells Angels. The Bandidos. Asian triads. Russian mobsters and corrupt cops. Even the KKK. Just part of a day's work for Alex Caine, an undercover agent who has seen it all. Alex Caine started life as a working-class boy who always thought he'd end up in a blue-collar job. But after a tour in Vietnam and a stretch in prison on marijuana-possession charges, he fell into the cloak-and-dagger world of a contracted agent or "kite": infiltrating criminal groups that cops across North America and around the globe were unable to penetrate themselves. Thanks to his quick-wittedness and his tough but unthreatening demeanor, Caine could fit into whatever unsavory situation he found himself. Over twenty-five years, his assignments ran the gamut from bad-ass bikers to triad toughs. When a job was over, he'd slip away to a new part of the continent or world, where he would assume a new identity and then go back to work on another group of bad guys. Told with page-turning immediacy, Befriend and Betray gives a candid look behind the scenes at some familiar police operations and blows the lid off others that law enforcement would much prefer to keep hidden. And it offers an unvarnished account of the toll such a life takes, one that often left Caine to wonder who he really was, behind those decades of assumed identities. Or whether justice was ever truly served.
Once again, Alex Caine risks it all. In his latest book, Alex Caine rubs shoulders with the members of a Hong Kong triad who are deeply involved in the drug trade and a group of Ottawa skinheads that plans to detonate a bomb in the heart of the nation’s capital. Caine is blindsided when he learns that his girlfriend Shannon has been doing the same undercover work as him. When her cover is blown by members of the Russian mafia, Shannon is murdered by the mysterious Henry, who ends up in Caine’s crosshairs. The author also delves into the abuses committed on Canada’s Native communities, as shown by recent police scandals in Saskatoon. With the same intensity, he shines a light on the harassment of female officers in the RCMP. As he writes the closing chapters of his book, Caine gets a call from his former employers, who appoint him to a team of organized crime experts. Just a few days before the murderous attacks at Charlie Hebdo, Alex and his colleagues are called upon to prevent terrorist cells from activating on Canadian soil. The seasoned group of law enforcement veterans is given a list of eighteen suspects who must be neutralized at all costs. Befriend and Betray II gives readers an insider’s view of an elusive figure who knows how to walk the thin line between the good guys and the bad guys—between the missions he must carry out and the characters he must become.
The compelling story of the rise and rule of one of the world's most feared outlaw motorcycle gangs - in the bestselling tradition of Dead Man Running and The Brotherhoods.
From the #1 national bestselling author of Befriend and Betray, an intimate exposé of a criminal empire and the massacre that nearly started a global biker war. Having once infiltrated the Bandidos for three years in a landmark police operation, Alex Caine is uniquely positioned to reveal the untold story of the Hells Angels’ fiercest rivals. Grounded in the crucible of the little understood Shedden massacre of 2006 and one unlikely prospect’s descent into the biker lifestyle, The Fat Mexican exposes the violent criminal history of the Bandidos motorcycle club, the Hells Angels’ fiercest competition: their violent beginnings, the terror their aggressive expansion caused rivals and innocents alike, and the internal politics and rivalries that drive them to this day.
The Outlaws Motorcycle Club's story is told here for the first time in paperback, by the #1 national bestselling criminal underworld author and former infiltrator Alex Caine. They are the original biker gang, and their 60 years of war with the Hells Angels is the stuff of legend. Right down to their signature logo (a skull known as "Charlie"), the McCook Outlaws Motorcycle Club, formed in 1935, defined the look and sensibility of the twentieth-century biker. In the 1950s, a rising gang of toughs in California threatened to steal their thunder. But, recognizing an opportunity for expansion, the Outlaws reached out. The nascent Hells Angels sent them home to Chicago, beaten, humiliated and forever bent on the Angels' destruction. 60 years and thousands of maimed and murdered later, the Hells Angels are a dominant criminal empire. The Outlaws, loosely allied with the #2 club in the biker universe, the Bandidos, sit at #3, though they rule in places like the UK, the Great Lakes, Florida and the US Midwest. The Outlaws continue to define the vicious biker character like few of their peers. Working undercover, Alex Caine witnessed a Bandidos-mediated truce between the Outlaws and Angels in the 1980s. But like every deal between bikers it soured, and a storm of unimaginable violence is brewing. The Outlaws are expanding and determined to unseat the Angels once and for all.
Explains how to perform and analyze the results of the latest physicochemical methods With this book as their guide, readers have access to all the current information needed to thoroughly investigate and accurately determine a compound's pharmaceutical properties and their effects on drug absorption. The book emphasizes oral absorption, explaining all the physicochemical methods used today to analyze drug candidates. Moreover, the author provides expert guidance to help readers analyze the results of their studies in order to select the most promising drug candidates. This Second Edition has been thoroughly updated and revised, incorporating all the latest research findings, methods, and resources, including: Descriptions and applications of new PAMPA models, drawing on more than thirty papers published by the author's research group Two new chapters examining permeability and Caco-2/MDCK and permeability and the blood-brain barrier Expanded information and methods to support pKa determination New examples explaining the treatment of practically insoluble test compounds Additional case studies demonstrating the use of the latest physicochemical techniques New, revised, and expanded database tables throughout the book Well over 200 drawings help readers better understand difficult concepts and provide a visual guide to complex procedures. In addition, over 800 references serve as a gateway to the primary literature in the field, facilitating further research into all the topics covered in the book. This Second Edition is recommended as a reference for researchers in pharmaceutical R&D as well as in agrochemical, environmental, and other related areas of research. It is also recommended as a supplemental text for graduate courses in pharmaceutics.
From Batman Unauthorized: Vigilantes, Jokers, and Heroes in Gotham City: Alex Bledsoe imagines Alfred's reaction to Bruce Wayne's confusion over the onset of puberty.
Together for the first time in one box set, four thrilling stories featuring profiler Maggie O’Dell, only from New York Times bestselling author Alex Kava. AT THE STROKE OF MADNESS With only an old man afflicted with Alzheimer’s as a material witness, FBI Special Agent Maggie O’Dell is fast on the trail of a diabolical serial killer who targets people with physical disabilities, removing each victim’s imperfections to keep as a twisted trophy. A NECESSARY EVIL When a monsignor is found knifed to death in an airport restroom, FBI special agent Maggie O’Dell is called in to profile the ritualistic murder, the latest in a series of killings. Maggie soon discovers a disturbing Internet game that’s popular among victims of abuse by Catholic priests, and wonders if the group has turned cyberspace justice into reality. EXPOSED Maggie knows dangerous minds, but she must tackle a new opponent from within a biosafety isolation ward—someone targeted Quantico with a deadly virus, and Maggie might have been contaminated. She just fears her last case might end with the most intelligent killer she’s ever faced escalating from murder…to epidemic. BLACK FRIDAY On the busiest shopping day of the year, a group of idealistic college students believe they’re about to carry out an elaborate media stunt at the largest mall in America. What they don’t realize is that instead of electronic jamming devices, their backpacks contain explosives, and they’re about to become unwitting suicide bombers. Agent O’Dell has to work quickly to figure out who is behind the terrorist plot.
This is a book about the comics genre and language, how these were used to create Batman, and how that character's longevity is largely due to the medium's unique formal qualities. It argues that Batman's core appeal is his mythic nature which allows him to transcend changes in reader tastes, the vicissitudes of the comics industry, and the changing media landscape. While including some historical elements, it is mostly a study of how the formal aspects of comics are able to evoke uniquely mythic qualities that have made Batman such a long-lived cultural phenomenon and how efforts to adapt these qualities into other media, particularly live-action feature films, have succeeded or failed based on the strategies employed. The book sheds light both on comics as a medium and art form with its own language, syntax and codes and on the process of adaptation--a growing area of study, given Hollywood's continuing interest in working with comic book superheroes.
*BASED ON ACCOUNTS FEATURED IN THE #1 NETFLIX DOCUMENTARY FILM RUNNING WITH THE DEVIL* A 2023 Next Generation Indie Book Award Finalist for Best True Crime John McAfee: internet pioneer, presidential candidate, and probable madman. After parting ways with the eponymous McAfee Antivirus software company in 1994, McAfee embarked on innumerable business, political, and criminal enterprises. From investing in cybersecurity and cryptocurrency, to accusations of murdering his neighbor in Belize, to making two unsuccessful bids for President of the United States—the latter attempt done in exile following a federal indictment—this larger-than-life man nurtured a rakish public profile while evading law enforcement for his involvement with drugs, weapons, and murder. For six months, Alex Cody Foster—hired as McAfee’s ghostwriter—traveled with McAfee across America and Europe, occasionally going on the run to evade purported killers and kidnappers. Foster tells the incomparable tale of how the two of them met, where their adventures had taken them, and what precipitated McAfee’s death.
The Superstate is everywhere, and it's authority is absolute. Yoga Town is a city divided. While they wait to leave the earth, the 1% can bend reality to their will, they live in a consequence free world where anything goes. Meanwhile, the masses are pacified by a drugged out, government mandated digital dreamscape while they wait to perish on this dying planet. But there is still hope, for angels roam the earth. With their help, maybe some rebellious spirits can start to make a change. Experience 15 surreal and disturbing tales of rebellious fembots, celebrity turkey shoots, violent astral projection and an all-new take on the TV dinner.
Dear Sergeant Fuller, You won’t know me for another two years, but I am your daughter…. So begins a letter sent decades into the past, from a daughter searching for answers to a soldier serving in war-torn Vietnam, in this true story of service and sacrifice, love and redemption, and the power of forgiveness. A box with Love Letters from Vietnam etched on the lid waits buried in a closet, holding scrawled thoughts written on Air Force stationery from a passionate yet deeply flawed soldier stationed outside Da Nang to his young wife in east Texas. Years pass before a fateful, deadly winter night leads the soldier’s daughter, Jennifer, to open the box, read the letters, and answer her father back in time. She tucks her letters into a package with no address, because she no longer knows where to send them. Until she is sitting in a theater in Austin, Texas, at a performance by singer-songwriter Alex Woodard and hears him talk about writing songs inspired by letters. Her remarkable correspondence with her father takes Woodard on his first steps into the dichotomy between dark and light, as he imagines himself as Sergeant Fuller in Vietnam and begins to write songs sung from Fuller’s heart. Woodard’s quest to learn more about the man and the war he fights both in Vietnam and back at home evolves into an extraordinary journey, propelled by an album included with the book that features Woodard as Sergeant Fuller and his friend Molly Jenson as Jennifer. Their voices carry the songs inspired by these beautiful, raw, revealing love letters not only sent from Vietnam, but as the story unfolds, beyond.
Oxford Assess and Progress: Clinical Medicine returns for a second edition with new questions, new illustrations, and updated cross-references to the ninth edition of the Oxford Handbook of Clinical Medicine. This essential revision resource is packed with over 600 SBAs and EMQs that cover all the core aspects of clinical medicine to help you ace your Finals. Each question is accompanied by extensive feedback which explains not only the rationale behind the correct answer, but also why other options are incorrect. Cross-references to the Oxford Handbook of Clinical Medicine and other definitive sources such as NICE and Resuscitation Council guidelines point you in the right direction for further study. To help you revise efficiently, each question is ranked by difficulty, allowing you to track your progression and test the limits of your knowledge. Books in the Oxford Assess and Progress series are written and edited by practicing clinicians and experts in medical education who review each question is reviewed to ensure that the content is of the best standard and reflective of real medical Finals. Progress to exam success with the second edition of Oxford Assess and Progress: Clinical Medicine.
A no-holds-barred exposé on the financial transactions of the world's favourite sport The transfer fees clubs pay to sign top players now top €4 billion a year but much of the money has been flowing out of the game. A small group of wealthy investors including Russian oligarchs, English racehorse owners and a former billionaire gold miner have seized the opportunity to enter this booming market. Some have moved in on the territory of banks and lent money to clubs in exchange for a share in fees generated by Cristiano Ronaldo, Neymar and dozens more of today's stars. Others have acquired obscure teams to get a piece of the pie. Even as the global financial crisis sent fortunes tumbling this select group found a profitable place to park their money. The size of the transfer market has continued to rise –- it increased seven-fold in value the last two decades, more than the FTSE share index. Between them, these wealthy investors have amassed hundreds of millions of euros in profits. At the same time, they have managed to stay out of the spotlight the world’s most popular sport brings. Football’s Secret Trade follows the money along a trail very few know about, from nondescript offices in the U.K. and ramshackle stadiums of South American clubs you have probably never heard of to offshore bank accounts in the Caribbean. Warning – you won’t see a major transfer deal in the same light again.
Through the lenses of Shotokan Karate and biomedicine, sensei and biomedical scientist Alex W. Tong shows readers how body, mind, and spirit can be developed through martial arts practice. Through the practice of martial arts, a person can realize their full potential--not only in body, but in mind and spirit. The Science and Philosophy of Martial Arts shows readers how. Author, sensei, and biomedical scientist Alex W. Tong delves into the physical, mental, and spiritual components of martial arts and integrates contemporary sports psychology, kinesiology, and neuroscience into a nuanced and illuminating understanding of what martial arts practice can be. Structured into three sections, Tong discusses: The Mind: The dao of martial arts, mental tranquility, contemporary neuroscience, and warming up the brain The Body: Posture and stance, breathing in martial arts, and the physics of mastery and effort The Spirit: Soul, spirit, and moving zen; nature and manifestations of the spirit Each section includes observations on martial arts origins, physiology, and tangible results on martial arts training. Blending traditional and contemporary approaches, knowledge, and research, The Science and Philosophy of Martial Arts builds a vision of practice that elevates physical performance, awareness, decisiveness, and strength of spirit.
Cal is a hitman on the run from his powerful old boss. He has found sanctuary among the invisible poor in the barrio outside of Mexico City. He lives in and fixes up an old, dilapidated Catholic church, which is how he earned his nickname among the locals as "El Padre." The Father. The Priest. After a young Mexican woman he befriends is trafficked to a crime organization in Los Angeles headed by his old boss, Cal must come out of hiding to rescue her and, at the same time, face his dark past.
“Chicago is a tale of two cities,” headlines declare. This narrative has been gaining steam alongside reports of growing economic divisions and diverging outlooks on the future of the city. Yet to keen observers of the Second City, this is nothing new. Those who truly know Chicago know that for decades—even centuries—the city has been defined by duality, possibly since the Great Fire scorched a visible line between the rubble and the saved. For writers like Alex Kotlowitz, the contradictions are what make Chicago. And it is these contradictions that form the heart of Never a City So Real. The book is a tour of the people of Chicago, those who have been Kotlowitz’s guide into this city’s – and by inference, this country’s – heart. Chicago, after all, is America’s city. Kotlowitz introduces us to the owner of a West Side soul food restaurant who believes in second chances, a steelworker turned history teacher, the “Diego Rivera of the projects,” and the lawyers and defendants who populate Chicago’s Criminal Courts Building. These empathic, intimate stories chronicle the city’s soul, its lifeblood. This new edition features a new afterword from the author, which examines the state of the city today as seen from the double-paned windows of a pawnshop. Ultimately, Never a City So Real is a love letter to Chicago, a place that Kotlowitz describes as “a place that can tie me up in knots but a place that has been my muse, my friend, my joy.”
The Political Economy of Imperial Relations offers a much needed historical and theoretical intervention into the relationship between Britain and Malaya after the Second World War. It challenges existing accounts and details a strong continuity in this relationship from 1945 until 1960.
As each generation confronts aging and responds to its challenges, the literary community—ranging from Philip Roth to Jonathan Franzen—has provided nuanced and thoughtful depictions that transcend stereotypes of old men as feeble and broken individuals. Under the sage guidance of these authors—many facing old age themselves—older male characters have become increasingly prevalent in literary fiction. In Aging Masculinity in the American Novel, Alex Hobbs turns the spotlight on matters related to later life by examining a broad range of works. Hobbs looks at novels not only by literary lions of the Baby Boom generation, but authors on the cusp of old age who anticipate its consequences. In addition to works by Jonathan Franzen, Paul Auster, and Ethan Canin, the author considers the perspectives of female writers, such as Marilynne Robinson, Anne Tyler, and Jane Smiley, who have created complex older male characters. Hobbs argues that previous studies regarding male aging in popular culture have been reductive, and she suggests that male and female experiences and interpretations of aging are individualistic and unique. With a bold argument for how readers should contemplate masculinity in literary fiction, this book helps us better understand the full range of issues that older men face—from legacy and loss to health issues and grace. The author’s illuminating and persuasive perspectives will ignite a new way of thinking about this subject and its central place in the national conversation. Looking at how older men’s lives are documented in American fiction, Aging Masculinity in the American Novel will be of interest to scholars and students of popular culture, gender studies, aging studies, and literature.
Iraq War veteran Bronwyn Hyatt must reconnect with the Tufa, her people, and their ancient song if she is ever going to stop the death stalking her family.
“Food is the chief of all things, the universal medicine. . . . Food transmutes directly into body, mind, and spirit . . . creates our day-to-day health and happiness.” —from The Macrobiotic Path to Total Health Even in medical schools, alternative medicine is blossoming. Two thirds of them now offer courses in complementary healing practices, including nutrition. At the heart of this revolution is macrobiotics, a simple, elegant, and delicious way of eating whose health benefits are being confirmed at an impressive rate by researchers around the world. Macrobiotics is based on the laws of yin and yang—the complementary energies that flow throughout the universe and quicken every cell of our bodies and every morsel of the food we eat. Michio Kushi and Alex Jack, distinguished educators of the macrobiotic way, believe that almost every human ailment from the common cold to cancer can be helped, and often cured, by balancing the flow of energy (the ki) inside us. The most effective way to do this is to eat the right foods, according to our individual day-to-day needs. Now in this marvelous guide, they give us the basics of macrobiotic eating and living, and explain how to use this powerful source of healing to become healthier and happier, to prevent or relieve more than two hundred ailments, conditions, or disorders—both physical and psychological. This encyclopedic compendium of macrobiotic fundamentals, remedies, menus, and recipes takes into account the newest thinking and evolving practices within the macrobiotic community. The authors integrate all the information into a remarkable A to Z guide to macrobiotic healing—from AIDS, allergies, and arthritis, to cancer, diabetes, and heart disease. They also clearly explain what we need to know to start eating a true macrobiotic diet that will provide us with a complete balance of energy and nutrients. Living as we all do in environmental and climactic circumstances that are largely outside our personal control, it is vital that we follow a healthy lifestyle, including a flexible diet that we can adjust to meet our own individual needs. The Macrobiotic Path to Total Health gives us precisely the tools and the understanding we need to achieve this goal. Use it to build a strong, active body and a cheerful, resourceful mind.
London born author Alex Hyde-White’s English father named him Punch, hoping it would be lucky, and he started his life as a precocious son of a rather famous actor. In In the Volume, actor Hyde-White shares his story from Hollywood’s front lines, which spans more than four decades of the most transformational period in film and television history. This memoir chronicles Hyde-White’s early life growing up in England; moving to Palm Springs in the 1960’s; graduating from high school at sixteen; getting started in Hollywood; working as a cab driver, bartender, waiter, and ski shop clerk while looking for acting gigs; playing his first part in a movie as the photographer in The Toy; and more, acting in some huge box office hits. In the Volume reveals Hyde-White’s journey, at times majestic, magical, wondrous, and fulfilling. These intimate tales of triumph and failure offer both caution and inspiration.
Astronomy was a popular and important part of Victorian sciences, and British astronomers carried telescopes to remote areas in India, North America, and Caribbean and Pacific islands to watch solar eclipses. This book tells the full story of these expeditions: the long periods of planning and financing, and the day-to-day work of getting to field sites, setting up camp, and preparing, observing, and recording eclipses.
NATIONAL BESTSELLER • A moving and powerful account by an acclaimed journalist that "informs the heart. [This] meticulous portrait of two boys in a Chicago housing project shows how much heroism is required to survive, let alone escape" (The New York Times). "Alex Kotlowitz joins the ranks of the important few writers on the subiect of urban poverty."—Chicago Tribune The story of two remarkable boys struggling to survive in Chicago's Henry Horner Homes, a public housing complex disfigured by crime and neglect.
The headteacher’s office of a south London primary school is always busy. But today is results day and the phone won’t stop ringing. Jo, the headteacher of St. Barnabas, knows that the arrival of the school’s SATs results puts her job on the line. With the future of the school and its pupils at stake, Jo struggles to maintain order as her staff and superiors demand answers. Can she protect her students and herself? A sharp, wry and timely drama. Set against the backdrop of an education system in turmoil, Alex MacKeith’s debut play asks what it means to be a primary school teacher in contemporary Britain.
The question of our time: can we reclaim our lives in an age that feels busier and more distracting by the day? We've all found ourselves checking email at the dinner table, holding our breath while waiting for Outlook to load, or sitting hunched in front of a screen for an hour longer than we intended. Mobile devices and the web have invaded our lives, and this is a big idea book that addresses one of the biggest questions of our age: can we stay connected without diminishing our intelligence, attention spans, and ability to really live? Can we have it all? Alex Soojung-Kim Pang, a renowned Stanford technology guru, says yes. The Distraction Addiction is packed with fascinating studies, compelling research, and crucial takeaways. Whether it's breathing while Facebook refreshes, or finding creative ways to take a few hours away from the digital crush, this book is about the ways to tune in without tuning out.
FORBES #1 CAREER BOOK TO READ IN 2018 The larger-than-life journey of an 18-year-old college freshman who set out from his dorm room to track down Bill Gates, Lady Gaga, and dozens more of the world’s most successful people to uncover how they broke through and launched their careers. The Third Door takes readers on an unprecedented adventure—from hacking Warren Buffett’s shareholders meeting to chasing Larry King through a grocery store to celebrating in a nightclub with Lady Gaga—as Alex Banayan travels from icon to icon, decoding their success. After remarkable one-on-one interviews with Bill Gates, Maya Angelou, Steve Wozniak, Jane Goodall, Larry King, Jessica Alba, Pitbull, Tim Ferriss, Quincy Jones, and many more, Alex discovered the one key they have in common: they all took the Third Door. Life, business, success… it’s just like a nightclub. There are always three ways in. There’s the First Door: the main entrance, where ninety-nine percent of people wait in line, hoping to get in. The Second Door: the VIP entrance, where the billionaires and celebrities slip through. But what no one tells you is that there is always, always… the Third Door. It’s the entrance where you have to jump out of line, run down the alley, bang on the door a hundred times, climb over the dumpster, crack open the window, sneak through the kitchen—there’s always a way in. Whether it’s how Bill Gates sold his first piece of software or how Steven Spielberg became the youngest studio director in Hollywood history, they all took the Third Door.
Get caught up in this terrifying psychological thriller, book 6 in Alex Kava’s acclaimed Maggie O’Dell series. Veteran FBI profiler Maggie O’Dell and Assistant Director Cunningham believed the threat targeted Quantico. It targeted them. A deadly virus—virtually undetectable until it causes death from a million internal cuts. The victims appear random, but Maggie wonders if vengeance isn’t the guiding hand. An aficionado of contemporary killers, using bits and pieces from their crimes—the Beltway Sniper’s phrases, the Unabomber’s clues, the Anthrax Killer’s delivery. Maggie knows dangerous minds, but she must tackle this new opponent from within a biosafety isolation ward—while waiting to see if death is already multiplying inside her body. She just fears her last case might end with the most intelligent killer she’s ever faced escalating from murder…to epidemic. Originally published in 2008
Raised in poverty as an illegitimate child, Jack London dropped out of school to support his mother, working in mind-deadening jobs that would foster a lifelong interest in socialism. Brilliant and self-taught, he haunted California's waterside bars, brawling with drunken sailors and learning about love from prostitutes. His lust for adventure took him from the beaches of Hawaii to the gold fields of Alaska, where he experienced firsthand the struggles for survival he would later immortalize in classics like White Fang and The Call of the Wild. A hard-drinking womanizer with children to support, Jack London was no stranger to passion when he met and married Charmian Kittredge, the love of his life. Despite his adventurous past, London had never before met a woman like Charmian; she adored fornication and boxing, and willingly risked life and limb to sail and explore. She typed his manuscripts while he churned out novels, serving as his inspiration and his critic. Lover, fighter, and onetime hobo, Jack London lived large and died before he was forty. This is a rare biography, from bestselling historian Alex Kershaw, that proves the truth can be more fascinating--and a far greater adventure--than a fiction.
In pharmaceutical research, solubility plays a key part in the assessment of pharmacokinetic risks. Poor drug absorption, reduced efficacy, excessive metabolism, and adverse reactions are frequently related to issues of drug solubility. During early discovery research at pharmaceutical companies, many thousands of molecules are considered. Most are rejected due to perceived unfavorable properties. Here the author uses the Wiki-pS0TM database, which forms the backbone of this unique handbook. Also discussed is the emerging class of therapeutically promising research molecules called PROTACs (proteolysis-targeting chimeras), showing a propensity for ‘undruggable’ targets. FEATURES • A comprehensive and unique listing of measured aqueous intrinsic solubility focusing on drug-like and drug-relevant molecules. • The database can be used to predict the solubility of research pharmaceutical molecules. • Includes downloadable files of the database (.csv format). • The mining of the database can result in a better design of solubility assay protocols, leading to better quality of measurements. • Artificial intelligence and Bayesian statistics will likely be key to this subject area in the future. Alex Avdeef has been an American Association of Pharmaceutical Scientists (AAPS) Fellow since 2014, a former visiting senior research fellow at King’s College London, and is the author of Absorption and Drug Development (2nd ed., Wiley, 2012). In 2021, the book was translated into Chinese, by translators affiliated with the China Food and Drug Administration. For nearly 50 years, he has been teaching, researching, and developing methods, instruments, and analysis software for the measurement of ionization constants, solubility, dissolution, and permeability of drugs. His accomplishments in the development of instrumentation include several well-known instruments that are or recently have been manufactured by leading companies in the instrument market, including Thermo Fisher Scientific, Sirius Analytical, and Pion Inc. He has over 200 technical publications in primary scientific journals and book chapters. He has written several comprehensive technical guides and is a co-inventor on six patents. He cofounded Sirius Analytical (UK) in 1989, pION Inc. (USA) in 1996, and founded in–ADME Research (New York City) in 2011. His other positions were at Orion Research, Syracuse University, UC Berkeley, and Caltech.
From the author of national bestsellers The Bedford Boys and The Longest Winter comes "a rousing tale of little-known heroes" (Booklist). The Few tells the dramatic and unforgettable story of eight young Americans who joined Britain's Royal Air Force, defying their country's neutrality laws and risking their U.S. citizenship to fight side-by-side with England's finest pilots in the summer of 1940-over a year before America entered the war. Flying the lethal and elegant Spitfire, they became "knights of the air" and with minimal training but plenty of guts, they dueled the skilled and fearsome pilots of Germany's Luftwaffe. By October 1940, they had helped England win the greatest air battle in the history of aviation. Winston Churchill once said of all those who fought in the Battle of Britain, "Never in the field of human conflict was so much owed by so many to so few." These daring Americans were the few among the "few." Now, with the narrative drive and human drama that made The Bedford Boys and The Longest Winter national bestsellers, Alex Kershaw tells their story for the first time.
Part 2.1: Cerebral Ischemia; Vascular Tumors of the Head and Neck; Traumatic Arteriovenous Fistulae; Aneurysms. Part 2.2: Cerebral Arteriovenous Shunts; Spinal Arteriovenous Shunts; Spinal Vascular Tumors; Technical Aspects of Endovascular Neurosurger
In “a brilliant antidote to all the…false narratives about pot” (American Thinker), an award-winning author and former New York Times reporter reveals the link between teenage marijuana use and mental illness, and a hidden epidemic of violence caused by the drug—facts the media have ignored as the United States rushes to legalize cannabis. Recreational marijuana is now legal in nine states. Advocates argue cannabis can help everyone from veterans to cancer sufferers. But legalization has been built on myths—that marijuana arrests fill prisons; that most doctors want to use cannabis as medicine; that it can somehow stem the opiate epidemic; that it is beneficial for mental health. In this meticulously reported book, Alex Berenson, a former New York Times reporter, explodes those myths, explaining that almost no one is in prison for marijuana; a tiny fraction of doctors write most authorizations for medical marijuana, mostly for people who have already used; and marijuana use is linked to opiate and cocaine use. Most of all, THC—the chemical in marijuana responsible for the drug’s high—can cause psychotic episodes. “Alex Berenson has a reporter’s tenacity, a novelist’s imagination, and an outsider’s knack for asking intemperate questions” (Malcolm Gladwell, The New Yorker), as he ranges from the London institute that is home to the scientists who helped prove the cannabis-psychosis link to the Colorado prison where a man now serves a thirty-year sentence after eating a THC-laced candy bar and killing his wife. He sticks to the facts, and they are devastating. With the US already gripped by one drug epidemic, Tell Your Children is a “well-written treatise” (Publishers Weekly) that “takes a sledgehammer to the promised benefits of marijuana legalization, and cannabis enthusiasts are not going to like it one bit” (Mother Jones).
Alex Sheremet presents one of the most thorough and considered critiques on Woody Allen’s complete body of cinema work as well as the critical debates that surround it … but his text is only part of the full story.
Alex Sheremet presents one of the most thorough and considered critiques on Woody Allen’s complete body of cinema work as well as the critical debates that surround it … but his text is only part of the full story.
Woody Allen: Reel to Real is the first DigiDialogue from Take2Publishing … a product and a process where the author inspires a discourse between and amongst himself and his audience … Everyone has an opinion of Woody Allen, whether those opinions come from a learned perspective, or from the tabloids … and Sheremet's excitingly exhaustive analysis is the perfect fodder to generate and further this unique form of dialogue The genesis of this DigiDialogue is the Woody Allen:Reel to Real website, established some months ago to have Sheremet and his 'readers' further explore, expand and explain the theses he presents. On that site one can find a combination of faithful summaries of the key chapters of this book and one key chapter in its entirety … all married to dedicated 'Comment Boxes' that serve to propagate the dialogue. This version of the book contains Sheremet’s complete and original text in its entirety plus the initial dialogue that ensued from the DigiDialogue web-site. The dialogue between Sheremet and noted writers and critics, including Jonathan Rosenbaum and Dan Schneider, highlight much of Sheremet's unique perspective on Woody Allen and Sheremet's view of the debates that accompany him. Updated versions of this book will be released in the future, containing the continuing dialogue … and will be made available to all official purchasers free of charge. (The details can be found in the Publisher's Note inside the book.) According to John Pruzanski, managing publisher of Take2 Publishing, "the advent and popular uptake of eBooks finally provides the platform to open up the publishing world to new forms and factors and DigiDialogues have been specifically formulated to perform the task of bringing the readers into the publishing process.
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