The focus of this chapter is on the development of miRNA diagnostics and the process for miRNA biomarker development. We discuss pancreatic cancer as a model for the application of miRNA-based tests in different clinical biopsy specimen types. Asuragen’s miRInform® Pancreas test illustrates the development of a laboratory developed test (LDT) that was validated in compliance with Clinical Laboratory Improvement Amendments (CLIA) and College of American Pathologists (CAP) regulations. We provide an overview of work on miRNA-based signatures which is focused on resolving clinical dilemmas in solid and cystic pancreatic lesions. We also review some of the promising miRNA candidates identified in biofluids from other cancer types. These studies highlight the emergence of miRNA-based diagnostic tools which have the potential to impact the clinical management of cancer by guiding early diagnosis, aiding in the assessment of patients’ prognosis, and enabling the identification of novel, more effective therapeutic targets.
Dreams of Gold Dreams of Power These drove men and women to seek their fortune in Sarawak. They came from Britain to carve a future on virgin soil from China - to escape grinding poverty. They fought and traded, lived and died in the struggle to fulfil their dreams. Some lost their lives to bloodthirsty headhunters, or in the disease-ridden swamps and trackless jungles of the interior; some survived to make their fortune. Chinese, British, Malays rubbed shoulders with fearsome Sea Dayaks, and nomads in the hunter-gatherer stage of evolution. The Steam Age met the Stone Age in this exotic, untouched land. Cultures clashed in a multiracial society. Charles Brooke, enigmatic White Rajah of Sarawak, was a man of vision, a man with a mission to tame the natives first, then to protect them from exploitation. His dream was to take them gently towards modern civilisation, to bring them the rewards of self-development. He was paternalistic but loving, a truly benevolent despot. Dreams of Adventure Dreams of Romance Stephen Young, a young graduate, arrives in Sarawak in 1898. Seduced by its virgin beauty steaming jungle, majestic mountains and noble savages he stays. Erotic intrigue, passion, violence and warfare surround him. His goal is to survive these with his head and his heart intact.
REVISED 7/30/2021 EDITION This book clearly defines prophecy and explains how specific biblical messages can be linked to the crises that are hitting our world — global warming, climate change, dead zones in the ocean, polar ice melting, earthquakes, hurricanes, ocean acidification, and many other calamities. Mr. Alex Domenech comes across as an expert in biblical studies, demonstrating an impeccable understanding of the history of the Bible, its composition, and the historical, cultural, and religious contexts in which the scriptures were composed. The author also demonstrates great mastery of other disciplines related to the study of the Bible. This isn’t a book to be read quickly. It’s a study that will transform the way we approach the sacred scriptures, and readers will enjoy the concise definitions the author offers of complex terms. The Domenech Bible Interpretations will appeal to readers who are interested in the truth about the sacred scriptures, and those who are curious about the relationship between the Bible and contemporary times (Reviewed By Romuald Dzemo for Readers’ Favorite, 2018).
Power, passion, politics. The sleepy state of Sarawak is stirred up as never before by the arrival of Gerald McBryan. An unscrupulous adventurer, he soon has the Rajah and Ranee eating out of his hand. The eminence grise of Rajah Vyner, he forces through decisions that have shaped what Sarawak is today. Twilight of the White Rajahs is set in the Sarawak of the interwar and immediate postwar period. Vyner, like Henry VII of England, has inherited a tightly run ship of state. But his own playboy nature, the antics of his wife and most important his failure to produce a male heir, threaten the dynasty into which he was born. Outside forces also increase the pressure on his regime. War clouds in the Pacific and the South China Sea. The desire for self-determination. The bullying of the British Colonial Office. The turbulent wave of anti-cession created by the Rajah Muda, Peter Brooke. A war of hot tempers, cunning and deviousness ensued; a war that everyone was determined to win at all costs. Twilight of the White Rajahs recounts in fascinating detail the lives of the chief actors during this period. Twilight of the White Rajahs continues the saga of Golden Dreams of Borneo as the tough pioneering spirit of the 19th century gives way to the more sophisticated politics of the 20th.
The focus of this chapter is on the development of miRNA diagnostics and the process for miRNA biomarker development. We discuss pancreatic cancer as a model for the application of miRNA-based tests in different clinical biopsy specimen types. Asuragen’s miRInform® Pancreas test illustrates the development of a laboratory developed test (LDT) that was validated in compliance with Clinical Laboratory Improvement Amendments (CLIA) and College of American Pathologists (CAP) regulations. We provide an overview of work on miRNA-based signatures which is focused on resolving clinical dilemmas in solid and cystic pancreatic lesions. We also review some of the promising miRNA candidates identified in biofluids from other cancer types. These studies highlight the emergence of miRNA-based diagnostic tools which have the potential to impact the clinical management of cancer by guiding early diagnosis, aiding in the assessment of patients’ prognosis, and enabling the identification of novel, more effective therapeutic targets.
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