The Hippopotamus Defence is just what a club player needs. It’s a straightforward and clear-cut chess opening that avoids the ever growing body of mainline theory. It’s universal: Black can use the Hippo against virtually all of White’s choices (1.e4, 1.d4, 1.c4, 1.f4, the Colle, London, Trompowsky, Réti and others). It’s not very well known and will surprise many opponents. On top of all that, the Hippo is seriously underestimated: with its characteristic double fianchetto it may look quiet, but inside there lurks a very dangerous animal. FIDE Master Alessio de Santis is one of the world’s greatest experts on the Hippo and has written a practical, well-structured and accessible manual. His book can be studied on three levels: after a first flash of 3 to 4 hours you will be familiar with the Hippo’s basic moves and key variations, its strategic themes and recurring manoeuvres. In the second and third stage De Santis leads you through the most important concrete lines and introduces the Semi-Hippopotamus to counter some specific White ideas. You can use the Hippo as a surprise weapon or as your main repertoire. The extensive explanations and clear conclusions make this book an easy-to-navigate manual for all club players. If you like to confront your opponents with some unexpected counter-attacks, then you need not look any further.
Why the microbiome--our rich inner ecosystem of microorganisms--may hold the keys to human health. We are at the dawn of a new scientific revolution. Our understanding of how to treat and prevent diseases has been transformed by knowledge of the microbiome—the rich ecosystem of microorganisms in and on every human. These microbial hitchhikers may hold the keys to human health. In Gut Feelings, Alessio Fasano and Susie Flaherty show why we must go beyond the older, myopic view of microorganisms as our enemies to a broader understanding of the microbiome as a parallel civilization that we need to understand, respect, and engage with for the benefit of our own health. Recent advances in understanding the microbiome and its role in human health dovetail with the development of personalized or “precision” medicine to create treatments and prevention programs targeted to the molecular imprint of an individual. Fasano and Flaherty explore the microbiome's part in such diseases as gut inflammatory disorders, obesity, neurological conditions, and cancer, and they explain new research in prebiotics, probiotics, synbiotics, and psychobiotics. They also discuss the microbiome and immune function, including a possible role in COVID-19 treatment. By simultaneously expanding our perspective to encompass large datasets and multiple factors in human health, and narrowing our focus to identify the individual communities in the human microbiome, we will enlarge—and perhaps reinvent—our understanding of how to combat disease and maintain health.
The Hippopotamus Defence is just what a club player needs. It’s a straightforward and clear-cut chess opening that avoids the ever growing body of mainline theory. It’s universal: Black can use the Hippo against virtually all of White’s choices (1.e4, 1.d4, 1.c4, 1.f4, the Colle, London, Trompowsky, Réti and others). It’s not very well known and will surprise many opponents. On top of all that, the Hippo is seriously underestimated: with its characteristic double fianchetto it may look quiet, but inside there lurks a very dangerous animal. FIDE Master Alessio de Santis is one of the world’s greatest experts on the Hippo and has written a practical, well-structured and accessible manual. His book can be studied on three levels: after a first flash of 3 to 4 hours you will be familiar with the Hippo’s basic moves and key variations, its strategic themes and recurring manoeuvres. In the second and third stage De Santis leads you through the most important concrete lines and introduces the Semi-Hippopotamus to counter some specific White ideas. You can use the Hippo as a surprise weapon or as your main repertoire. The extensive explanations and clear conclusions make this book an easy-to-navigate manual for all club players. If you like to confront your opponents with some unexpected counter-attacks, then you need not look any further.
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