Alejandro Villagra's Books

The Sweet Penance of Music

Musical Life in Colonial Santiago de Chile

By: Alejandro Vera

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The Sweet Penance of Music

Musical Life in Colonial Santiago de Chile

By: Alejandro Vera

A monumental study of musical practices in 18th century Santiago de Chile, and the only English-language monograph about Chilean colonial music, A Sweet Penance of Music offers a comprehensive view of musicians within the city and their links with other Latin American urban centers in the wider colonial system. Author Alejandro Vera, recent winner of the International Casa de las Américas Musicology Prize for the Spanish edition of his monograph, provides a fascinating account of the quotidian cultural and social significance of music in varying physical spheres - from cathedrals, convents, and monasteries, to private houses and public spaces. He brings to life a city long neglected in the shadow of other colonial centers of economic power, asserting the importance of duality in the period and its music - particularly centering one nun harpist's conception of music as "sweet penance." Drawing from historical documents and musical scores of the period, A Sweet Penance of Music breaks new ground, laying the foundation for a revisionist approach to the study of music in the colonial Americas.

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Page Count

432

Publisher

Oxford University Press

Published Date

ISBN 10

0190940239

ISBN 13

9780190940232

Cancer Immunotherapy

Chapter 22. Epigenetic Approaches: Emerging Role of Histone Deacetylase Inhibitors in Cancer Immunotherapy

By: Eva Sahakian,Karrune Woan,Alejandro Villagra,Eduardo M. Sotomayor

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Cancer Immunotherapy

Chapter 22. Epigenetic Approaches: Emerging Role of Histone Deacetylase Inhibitors in Cancer Immunotherapy

By: Eva Sahakian,Karrune Woan,Alejandro Villagra,Eduardo M. Sotomayor

Histone deacetylase inhibitors (HDI) have been largely known for their ability to induce cell cycle arrest and apoptosis of tumor cells, effects that have translated into clinically significant antitumor activity against certain malignancies. In addition, there is now increasing evidence that HDIs are also endowed with immunoregulatory properties. Interestingly, while some reports have highlighted the anti-inflammatory effects of these compounds, others have shown pro-inflammatory effects triggered by HDIs in in vitro and in vivo studies. Known targets for HDIs are histone deacetylases (HDACs), enzymes that are recruited to gene promoters where they regulate transcription through histone modifications. Some HDACs, however, can also deacetylate nonhistone proteins, indicating that the role of HDACs in cell biology goes beyond their initial described effects on histones and encompasses now more complex regulatory functions. This complexity, along with the fact that most of the HDI currently in use are pan-HDI (multiple HDAC targets), might explain the divergent immunoregulatory effects of these compounds. Given this conundrum, in this chapter we have summarized the current understanding of the expression/function of specific HDACs in immune cells, knowledge that is providing important insights into their role in immunobiology and also paving the way for the development of more selective and potentially less toxic epigenetic-based approaches to effectively harness antitumor immune responses.

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Elsevier Inc. Chapters

Published Date

ISBN 10

0128059184

ISBN 13

9780128059180

Fragmented Lives, Assembled Parts

Culture, Capitalism, and Conquest at the U.S.-Mexico Border

By: Alejandro Lugo

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Fragmented Lives, Assembled Parts

Culture, Capitalism, and Conquest at the U.S.-Mexico Border

By: Alejandro Lugo

Southwest Book Award, Border Regional Library Association, 2008 Association of Latina and Latino Anthropologists Book Award, 2009 Established in 1659 as Misión de Nuestra Señora de Guadalupe de los Mansos del Paso del Norte, Ciudad Juárez is the oldest colonial settlement on the U.S.-Mexico border-and one of the largest industrialized border cities in the world. Since the days of its founding, Juárez has been marked by different forms of conquest and the quest for wealth as an elaborate matrix of gender, class, and ethnic hierarchies struggled for dominance. Juxtaposing the early Spanish invasions of the region with the arrival of late-twentieth-century industrial "conquistadors," Fragmented Lives, Assembled Parts documents the consequences of imperial history through in-depth ethnographic studies of working-class factory life. By comparing the social and human consequences of recent globalism with the region's pioneer era, Alejandro Lugo demonstrates the ways in which class mobilization is itself constantly being "unmade" at both the international and personal levels for border workers. Both an inside account of maquiladora practices and a rich social history, this is an interdisciplinary survey of the legacies, tropes, economic systems, and gender-based inequalities reflected in a unique cultural landscape. Through a framework of theoretical conceptualizations applied to a range of facets—from multiracial "mestizo" populations to the notions of border "crossings" and "inspections," as well as the recent brutal killings of working-class women in Ciudad Juárez—Fragmented Lives, Assembled Parts provides a critical understanding of the effect of transnational corporations on contemporary Mexico, calling for official recognition of the desperate need for improved working and living conditions within this community.

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Page Count

340

Publisher

University of Texas Press

Published Date

ISBN 10

0292778252

ISBN 13

9780292778252

My Documents

Stories

By: Alejandro Zambra

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My Documents

Stories

By: Alejandro Zambra

The landmark first story collection from internationally acclaimed author Alejandro Zambra, now featuring five additional stories and an introduction by his longtime collaborator, Megan McDowell An early desktop computer becomes the third partner in a doomed relationship; an older brother figure whose father lives in exile imparts hilarious life lessons to his young protégé. A man attempts to quit smoking despite the fact that he’s very good at it; another masquerades as the family man he'll never be. Throughout, Pinochet’s dictatorship casts a long shadow, and men in relationships exhibit their profound capacity for both love and harm. In these unforgettable stories—which span religion, romance, technology, soccer, solitude, and more—Alejandro Zambra unfolds a radical literary reflection on life, relationships, and the tender and brutal dimensions of masculinity in Chile from the 1980s to the present. Intimate and playful, provocative and profound, and brilliantly rendered by National Book Award winning translator Megan McDowell, My Documents a testament to the necessity of literature even—and especially—in times of political and personal crisis.

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273

Publisher

Penguin

Published Date

ISBN 10

0143136526

ISBN 13

9780143136521

Cancer Immunotherapy

Chapter 22. Epigenetic Approaches: Emerging Role of Histone Deacetylase Inhibitors in Cancer Immunotherapy

By: Eva Sahakian,Karrune Woan,Alejandro Villagra,Eduardo M. Sotomayor

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Cancer Immunotherapy

Chapter 22. Epigenetic Approaches: Emerging Role of Histone Deacetylase Inhibitors in Cancer Immunotherapy

By: Eva Sahakian,Karrune Woan,Alejandro Villagra,Eduardo M. Sotomayor

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Elsevier Inc. Chapters

Published Date

ISBN 10

0128059184

ISBN 13

9780128059180

Book's by Alejandro Villagra

The Sweet Penance of Music

The Sweet Penance of Music

Cancer Immunotherapy

Cancer Immunotherapy

Fragmented Lives, Assembled Parts

Fragmented Lives, Assembled Parts

My Documents

My Documents

Cancer Immunotherapy

Cancer Immunotherapy

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