This book is about selectively toxic agents. That is to say, it is about those substances that affect certain cells without harming others, even when they are close neighbours. Toxicity need not be fatal. It can be made easily reversible, as is the case with general anaesthetics. Selective toxicity covers an immense field: most of the drugs used for treating illness in man and his economic animals, as well as all of the fungicides, insecticides, and weed killers that are used in agriculture. Essentially, this book is a discussion of the physical and chemical means which contribute to selectivity, and this is the basis of molecular pharmacology. _Selective Toxicity began as a course of lectures that Professor F. G. Young encouraged me to give in University College London, in 1948 and again in 1949. The first edition appeared in 1951, as a very small book because little was then known about the factors that provide selectivity. Since those early days, the subject has undergone tremendous development. At first, industry was un receptive to the word 'toxicity', however qualified! Yet the market was being supplied with biologically powerful substances of which several had the potential to cause harm. This aspect was brought to light by two events of the early 1960s. The first of these was the discovery that a sedative, thalidomide, administered to expectant mothers, after what was then considered to be adequate testing, had caused permanent deformities in about 10000 children.
This thoroughly revised second edition of Social and Behavioral Aspects of Pharmaceutical Care offers a comprehensive overview of the social-economic aspects of pharmaceutical care. This new edition provides both the pharmacy student and practitioner with established principles from the social and behavioral sciences, along with current findings and examples of cases and reports of applications of these principles. Theoretical models and practical examples are included to elaborate the pharmacist's role in identifying patients' non-compliant behavior and managing drug-related problems. This valuable text includes clinical, economic, and humanistic considerations that are essential to pharmacy students and practicing pharmacists. This essential text also features a special focus on public health and the involvement of caregivers in facilitating behavioral change. Social and Behavioral Aspects of Pharmaceutical Care, Second Edition will help readers consider how organizations and social systems impact patient experiences with medications, contributing to an improved system of pharmaceutical practice and care.
Drs. Paul L. Kaufman, Albert Alm, Leonard A Levin, Siv F. E. Nilsson, James Ver Hoeve, and Samuel Wu present the 11th Edition of the classic text Adler's Physiology of the Eye, updated to enhance your understanding of ocular function. This full-color, user-friendly edition captures the latest molecular, genetic, and biochemical discoveries and offers you unparalleled knowledge and insight into the physiology of the eye and its structures. A new organization by function, rather than anatomy, helps you make a stronger connection between physiological principles and clinical practice; and more than 1,000 great new full-color illustrations help clarify complex concepts. - Deepen your grasp of the physiological principles that underlie visual acuity, color vision, ocular circulation, the extraocular muscle, and much more. - Improve your understanding of physiology by referring to this totally updated volume--organized by function, rather than anatomy--and make a stronger connection between physiological principles and clinical practice. - Better visualize information with a new, revamped format that includes 1,000 illustrations presented in full-color to better clarify complex concepts and functions. - Access the most recent molecular, genetic, and biochemical discoveries affecting eye function, and gain fresh perspectives from a new, international editorial team. - Search the entire contents online and download all the illustrations at www.expertconsult.com.
Inside the 3rd edition of this esteemed masterwork, hundreds of the most distinguished authorities from around the world provide today's best answers to every question that arises in your practice. They deliver in-depth guidance on new diagnostic approaches, operative technique, and treatment option, as well as cogent explanations of every new scientific concept and its clinical importance. With its new streamlined, more user-friendly, full-color format, this 3rd edition makes reference much faster, easier, and more versatile. More than ever, it's the source you need to efficiently and confidently overcome any clinical challenge you may face. Comprehensive, authoritative, and richly illustrated coverage of every scientific and clinical principle in ophthalmology ensures that you will always be able to find the guidance you need to diagnose and manage your patients' ocular problems and meet today's standards of care. Updates include completely new sections on "Refractive Surgery" and "Ethics and Professionalism"... an updated and expanded "Geneitcs" section... an updated "Retina" section featuring OCT imaging and new drug therapies for macular degeneration... and many other important new developments that affect your patient care. A streamlined format and a new, more user-friendly full-color design - with many at-a-glance summary tables, algorithms, boxes, diagrams, and thousands of phenomenal color illustrations - allows you to locate the assistance you need more rapidly than ever.
Master the assistive strategies you need to make confident clinical decisions and help improve the quality of life for people with disabilities with this new essentials text. Based on the Human Activity Assistive Technology (HAAT) model developed by Dr. Cook, the book provides the most important coverage of the devices, services, and practices that comprise assistive technology and focuses on the relationship between the human user and the assisted activity within specific contexts. Case studies, illustrations of assistive devices, review questions, and well-developed learning objectives help you focus on the most important areas of assistive technology application. - UNIQUE! OTA focus provides you with the specific information occupational therapy assistants need to know to implement and utilize assistive technologies. - Comprehensive coverage includes all areas of assistive technologies. - The AT industry - A historical perspective on the industry - Relevant legislation - Issues of professional practice - Service delivery in assistive technologies - General purpose assistive technologies - Specific areas of application for assistive technologies - And more - Content derived from market leader gives you similar chapters and organization to the Principles text, but has more of a focus on the practical skills and knowledge needed for the implementation of AT.
Healthcare organizations are experiencing rapid and complex changes in delivery of care, and nurses and health care providers must possess the leadership skills to navigate such change. Quantum Leadership: Creating Sustainable Value in Health Care, Seventh Edition provides strategies for handling periods of transformation while creating a healing environment for both providers and patients. With clarity and depth of detail, it features theories about contemporary leadership within today's complex and diverse healthcare delivery system. It works from a model of complexity leadership, in which leadership is not limited to those with certain titles but an attribute that every healthcare worker can develop for success in fast-moving, information-overloaded organizations. With Quantum Leadership: Creating Sustainable Value in Health Care, Seventh Edition, nursing students will feel confident in their leadership skills to manage changes in delivery of care with optimal patient-centered care.
Principles of Airway Management, 4th Edition, reviews the essential aspects of airway management: anatomy, equipment, intubation, fiberoptic endoscopy, surgical approaches, intubating LMA (lightwand), pediatric airway, CPR, and mechanical ventilation. The book features well-balanced discussions of the complexities and difficult issues associated with airway management; excellent organization that ensures the material can be learned and applied to various situations; the latest equipment and techniques; summary boxes which highlight the most important points of each chapter; and more than 400 illustrations (many in color, for the first time), tables, and boxes.
This case studies book is a unique, practical, cutting-edge, and indispensable go-to resource for front-line practitioners and educators in medicine. Each case study (chapter) is framed by a set of introductory learning objectives, an evaluation section, thought-provoking discussion questions, and references to further readings. Furthermore, the book is conveniently organized along the continuum of medical care delivery, providing quick access to ad-hoc solutions in safety- and quality-compromised situations, illustrating how skillful communication can be the key to a more effective prevention, intervention, and response to “close calls” and adverse events. The case studies book is unique and innovative in its interdisciplinary integration of the contemporary literature in communication science with current “hot buttons” of patient safety. It manifests a valuable interdisciplinary collaboration by translating the basic tenets of human communication science for practitioners of medicine, providing a conceptual, evidence-based foundation for formulating communication-based practice guidelines to advance patient safety and quality of care. The case studies put communication theory into practice to facilitate experiential learning, granting insights into the breadth and diverse aspects of safe and high quality healthcare delivery. Thought-provoking discussion questions and references for further reading make this book a valuable reference for medical practitioners across the world.
Now in a fully updated 9th Edition, Kendig's Disorders of the Respiratory Tract in Children, by Drs. Robert Wilmott, Andrew Bush, Robin Deterding, and Felix Ratjen, continues to provide authoritative, evidence-based information to residents, fellows, and practitioners in this wide-ranging specialty. Bringing key knowledge from global experts together in one easy-to-understand volume, it covers everything from the latest basic science and its relevance to today's clinical issues, to improving patient outcomes for the common and rare respiratory problems found in newborns and children worldwide. - Uses succinct, straightforward text, numerous tables and figures, summaries at the end of each chapter, and more than 500 full-color images to convey key information in an easy-to-digest manner. - Contains new chapters reflecting expanding knowledge on the respiratory complications of Down syndrome and other genetic disorders, modern molecular therapies for cystic fibrosis and asthma, and pulmonary embolism and thromboembolic disease. - Includes access to a new video library with demonstrations of key procedures. - Features a new templated format with more descriptive headings and bulleted text for quick reference and navigation. - Covers today's key issues, including the genetic basis of respiratory disease, new and emerging respiratory infections, interstitial lung diseases in infants and young children, technology and diagnostic techniques for pulmonary function tests, emerging lung infections, and new therapies for cystic fibrosis and asthma. - Provides up-to-date instruction on important procedures, such as bronchoscopy and pulmonary function testing. - Highlights the knowledge and expertise of three new editors, as well as more than 100 world authorities in the fields of pediatrics, pulmonology, neurology, microbiology, cardiology, physiology, diagnostic imaging, critical care, otolaryngology, allergy, and surgery. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
This volume presents a line of original experimental studies on the bodily self, investigating where people locate themselves in their bodies and how accurate they are at localizing their body parts. So far, it was not well known whether people locate themselves in one or more specific regions of their bodies. On the other hand, some systematic distortions in indicating bodily locations were already documented. In the present studies, participants were therefore asked to indicate their self-locations, as well as the locations of several of their body parts, using a self-directed, first-person perspective pointing paradigm in various virtual reality (VR) setups (different head-mounted displays and a large-screen immersive display). Overall, participants were found to locate themselves mainly in the (upper) face and the (upper) torso. However, striking differences in self-localization were found when testing in different VR setups. Upon further investigation, these differences were found to be foremost due to inaccuracies in body part localization. When taking these inaccuracies into account, differences between setups—and also with self-localization outside of VR—largely disappear. Another striking finding was that providing participants—in between pointing phases—with information about their bodies in the form of a real-time animated self-avatar, did not make them more accurate at locating their own body parts. While manipulating their viewpoint to chest-height of their self-avatar did shift the afterwards indicated locations of their own body parts upwards, towards where they were seen on the avatar. Potential explanations for the various new findings, also from tasks outside of VR, are discussed. Taken together, this volume suggests a differential involvement of multi-sensory information processing in experienced self-location within the body and the ability to locate body parts. Self-localization seems to be less flexible, possibly because it is strongly grounded in the 'bodily senses', while body part localization appears more adaptable to the manipulation of sensory stimuli, at least in the visual modality.
A comprehensive analysis of the astonishing changes that elevated the Chicago public school system from one of the worst in the nation to one of the most improved. How a City Learned to Improve Its Schools tells the story of the extraordinary thirty-year school reform effort that changed the landscape of public education in Chicago. Acclaimed educational researcher Anthony S. Bryk joins five coauthors directly involved in Chicago’s education reform efforts, Sharon Greenberg, Albert Bertani, Penny Sebring, Steven E. Tozer, and Timothy Knowles, to illuminate the many factors that led to this transformation of the Chicago Public Schools. Beginning in 1987, Bryk and colleagues lay out the civic context for reform, outlining the systemic challenges such as segregation, institutional racism, and income and resource disparities that reformers grappled with as well as the social conflicts they faced. Next, they describe how fundamental changes occurred at every level of schooling: enhancing classroom instruction; organizing more engaged and effective local school communities; strengthening the preparation, recruitment, and support of teachers and school leaders; and sustaining an ambitious evidence-based campaign to keep the public informed on the progress of key reform initiatives and the challenges still ahead. The power of this capacity building is validated by unprecedented increases in benchmarks such as graduation rates and college matriculation. This riveting account introduces key actors within the schools, city government, and business community, and the partnerships they forged. It also reveals the surprising yet essential role of Chicago's innovative information infrastructure in aligning disparate initiatives. In making clear how elements such as advocacy, civic capacity, improvement research, and strong democracy contributed to large-scale progress in the system's 600-plus schools, the book highlights the greater lessons that the Chicago story offers for system improvement overall.
The Illustrated Handbook of Cardiac Surgery is adapted from the Second Edition of the color illustrated Manual of Cardiac Surgery (Springer-Verlag, 1995). The Illustrated Handbook of Cardiac Surgery communicates all the important informa tion, but eliminates the detailed explanation of judgment and technique that is relevant only to cardiac surgeons or other individuals intensely interested in these details. The chapters covering operations explain the basic concepts and fundamentals of the operations. A selection of the most important biblio graphic sources follows each chapter, but are not cited in the text. Individuals interested in more exhaustive coverage of information sources should consult the Second Edition of the Manual of Cardiac Surgery. The Illustrated Handbook of Cardiac Surgery should appeal to all individuals caring for cardiac surgical patients: cardiologists, anesthesiologists, radiolo gists, general surgery residents rotating on cardiac surgery, medical students, physician assistants, nurses, perfusionists, and all other members of the car diac surgery team. It should even appeal to laypeople who want to read about cardiac surgery in more depth than is available in lay publications. Our attempt has been to produce a book that is clearly written, clearly illustrated, and affordable. The techniques chosen are those developed over three decades of clinical practice and resident training at the Oregon Health Sciences University and St. Vincent Hospital, Portland, Oregon, and Sutter Memorial Hospital, Sacra mento, California. These techniques have served us well.
Originally published in 1980-1981 as a two-volume set, the Manual of Cardiac Surgery has been completely revised and now includes new full-color illustrations in a single convenient volume. This new edition maintains the high standards established in the first edition: insightful descriptions of various cardiac surgical procedures illuminated by clear, brilliant illustrations.
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