Progressive multiple sclerosis places a huge burden on individuals, carers and society and treatment options are currently limited. However, there have been significant recent advances in understanding progressive disease and this book draws the field together into a single, accessible, clinically focused text. Progressive Multiple Sclerosis sets out the basic science, pathology, epidemiology and treatment possibilities in progressive multiple sclerosis. The biological processes underlying disease progression are elucidated as are specific pathophysiological mechanisms. The basic science of axonal degeneration and the clinical understanding of progressive multiple sclerosis are discussed in the context of emerging and future therapies for disease progression as are trials which might be conducted for progressive multiple sclerosis. An overview of biomarkers for the disease is included and existing symptomatic therapies for progressive multiple sclerosis are covered in detail. Each chapter addresses specific aspects of progressive multiple sclerosis providing an extensive review of the current literature and a discussion of the likely mechanisms of tissue injury relevant to the disease. Progressive Multiple Sclerosis is ideal for both general neurologists and those with a specialist interest in multiple sclerosis. It will also be of interest to neurologists in training and other medical professionals treating this common disease. Dr Alastair Wilkins is Senior Lecturer in Neurology, University of Bristol, and Consultant Neurologist at Frenchay Hospital, Bristol, UK. He researches axonal injury in multiple sclerosis and related disorders.
Part of the Oxford Neurology Library series, this practical pocketbook will summarise the latest understanding of what might cause the disease, the methods of diagnosis and assessment, and current management techniques.
This first full study of the subject discusses how 17C Catholic missionaries tried to force the Copts (Egyptian members of the Church of Alexandria) into union with the Church of Rome, and the slow accumulation of knowledge of Coptic beliefs, undertaken by Catholics and Protestants. Includes a survey of the study of the Coptic language in the West.
This book celebrates the quatercentenary of the birth of Thomas Willis on 27 January 1621. As a physician in Oxford, Willis's work in the 1650s provides an example of rural medical practice in early modern England. As a member of the Oxford Philosophical Club that met from the 1640s, he was central to the move from classical scholasticism to accounts of anatomy and physiology based on observation and experiment. As Sedleian professor of natural philosophy in Oxford, the surviving records of his lectures from the 1660s provide an example of pedagogy in medicine at that time. And, after moving to London in 1667, Willis continued to interact with a community of scientists and physicians who transformed ideas on respiration, muscular movement and the nervous system. Despite a busy clinical practice, Willis found time to write extensively on anatomy and physiology, clinical medicine and therapeutics. These contributions are recognized as wise, original and influential. Between 1659 and 1675, Willis published fourteen treatises. These appeared in six published works, one in two parts, written in Latin. Four of the titles contain engraved plates depicting the brain, muscle, lungs and stomach. The illustrators were Christopher Wren, Richard Lower, Edmund King and possibly Willis himself. Soon after his death, the treatises were published as collected works, also in Latin. Starting in 1679, his writings were translated into English and published as Dr Willis's practice of physic, eventually completed in 1684. The eighteen chapters of this bio-bibliography are in four sections: chapter 1 is biographical; chapters 2 - 4 describe aspects of the history of the book and illustration relevant to Willis's printed works; chapters 5 - 14 provide bibliographical details of Willis's treatises contained in 102 copies printed in Latin, English, Dutch and French between 1659 and 1721; and chapters 15 - 18 summarise the content of Willis's works and their contribution to medical science.
Mehrdimensionale Chromatographie im analytischen Labor: Dieses Buch bespricht erstmals alle gängigen Verfahren sowie Anwendungen auf verschiedensten Gebieten, von der Pharmazie, Biologie und Chemie bis hin zur Umwelttechnik und erdölverarbeitender Industrie. Die Autoren sind selbst aktiv in der einschlägigen Forschung tätig.
Although deconstruction has become a popular catchword, as an intellectual movement it has never entirely caught on within the university. For some in the academy, deconstruction, and Jacques Derrida in particular, are responsible for the demise of accountability in the study of literature. Countering these facile dismissals of Derrida and deconstruction, Herman Rapaport explores the incoherence that has plagued critical theory since the 1960s and the resulting legitimacy crisis in the humanities. Against the backdrop of a rich, informed discussion of Derrida's writings -- and how they have been misconstrued by critics and admirers alike -- The Theory Mess investigates the vicissitudes of Anglo-American criticism over the past thirty years and proposes some possibilities for reform.
This title in the PROCEDURES IN COSMETIC DERMATOLOGY SERIES presents up-to-the-minute, practical guidance on botulinum toxin injection techniques shaping today's practice. Succinctly written and lavishly illustrated, it focuses on procedural how-to's and offers step-by-step advice on proper techniques, pitfalls, and tricks of the trade—so you can refine and hone your skills...and expand your surgical repertoire. You'll find current, to-the-point guidance on the cosmetic use of the toxin — edited by pioneers in the field, Drs. Jean and Alastair Carruthers. Implement the newest procedures into your practice immediately and confidently—with the outstanding guidance you'll find in this volume of the PROCEDURES IN COSMETIC DERMATOLOGY SERIES. Covers the hottest topics—including botox aesthetics, facial treatments, neck treatment, adjunctive treatment, pain relief, and facial asymmetry—all in one concise, accessible volume. Features a wealth of color illustrations and photographs that depict cases as they present in practice. Discusses common pitfalls and emphasizes how to optimize outcomes, enabling readers to improve their technique. Highlights emerging topics in the field, with guidance on the newest developments in cosmetic surgery. Includes a comprehensive, instructional DVD containing video clips of techniques and procedures as well as the experts' hints and tips. Use of fillers in combination with Botox to better sculpt the lower face Coverage of new fillers like Juvederm, Evolence, Radiesse and Perlane to keep you on the cutting edge New and expanded coverage of periocular treatment Highest quality video footage of procedures on the bonus DVD
The broad valley of the Bradano river and its tributary, the Basentello, separates the Apennine mountains in Lucania from the limestone plateau of the Murge in Apulia in southeast Italy. This book aims to explain how the pattern of settlement and land use changed in the valley over the whole period from the Neolithic to the late medieval.
Comprehensive text highlighting current clinical research in the area of multiple sclerosis. Includes expanded coverage of genetics, neurobiology, pathophysiology, and historical background.
This book gives an inside view of journalists at work in the Midlands, Yorkshire, South-East England and Central Scotland - with relevance also to other areas. It examines news priorities, decision-making, sources and the differences between newspapers, television news and radio.
Can an outrageously immoral man or a scandalous woman teach morality or lead people to virtue? Does personal fallibility devalue one's words and deeds? Is it possible to separate the private from the public, to segregate individual failing from official function? Chaucer addressed these perennial issues through two problematic authority figures, the Pardoner and the Wife of Bath. The Pardoner dares to assume official roles to which he has no legal claim and for which he is quite unsuited. We are faced with the shocking consequences of the belief, standard for the time, that immorality is not necessarily a bar to effective ministry. Even more subversively, the Wife of Bath, who represents one of the most despised stereotypes in medieval literature, the sexually rapacious widow, dispenses wisdom of the highest order. This innovative book places these "fallible authors" within the full intellectual context that gave them meaning. Alastair Minnis magisterially examines the impact of Aristotelian thought on preaching theory, the controversial practice of granting indulgences, religious and medical categorizations of deviant bodies, theological attempts to rationalize sex within marriage, Wycliffite doctrine that made authority dependent on individual grace and raised the specter of Donatism, and heretical speculation concerning the possibility of female teachers. Chaucer's Pardoner and Wife of Bath are revealed as interconnected aspects of a single radical experiment wherein the relationship between objective authority and subjective fallibility is confronted as never before.
Why do authors use pseudonyms and pen-names, or ingeniously hide names in their work with acrostics and anagrams? How has the range of permissible given names changed and how is this reflected in literature? Why do some characters remain mysteriously nameless? In this rich and learned book, Alastair Fowler explores the use of names in literature of all periods - primarily English but also Latin, Greek, French, and Italian - casting an unusual and rewarding light on the work of literature itself. He traces the history of names through Homer, Spenser, Shakespeare, Milton, Thackeray, Dickens, Joyce, and Nabokov, showing how names often turn out to be the thematic focus. Fowler shows that the associations of names, at first limited, become increasingly salient and sophisticated as literature itself develops.
Alastair Hudson's Equity and Trusts is an ideal textbook for undergraduate courses on the law of trusts and equitable remedies. It provides a clear, current and comprehensive account of the subject through which the author's enthusiasm and expertise shine through, helping to bring to life an area of the law which students often find challenging. Fully updated and revised, this Seventh Edition contains an analysis of Jones v Kernott and trusts of homes; a new treatment of dishonest assistance and unconscionable receipt; a full treatment of the law on super-injunctions; coverage of all of the trusts law cases precipitated by the collapse of Lehman Brothers; a reflection on women and equity, and the politics of trusts law; a new treatment of the Hastings-Bass princip≤ and analysis of over 200 new cases and the Perpetuities and Accumulations Act 2009. Equity and Trusts remains the most comprehensive and up-to-date coverage of the law of Equity and Trusts, while still a lively and thoughtful account of the issues raised by it. This book has been cited as being authoritative in the courts of numerous countries. The seventh edition is supported by a companion website which includes: * over 50 short podcast lectures by the author discussing and clarifying key topics from within the book, which cover an entire course; * a set of brief video documentaries filmed on location which provide context and bring to life selected key topics; * a brief introductory video presentation from the author introducing the viewer to the subject of Equity and Trusts and to the book in particular.
Football manager Charlie Gordon is struggling with one defeat after another at the club he loves. Only a decent Cup run is keeping him in work, but tensions are running close to the surface ahead of the next round: Chelsea away. Footballers fall into two categories: artists or assassins. Soon Charlie is going to find out which players can deliver - and just how much pressure they can all stand. Meanwhile, as the country prepares for a general election, one of the most dangerous political assassinations in the IRA's history is being planned in London. An active service unit await the critical signal to proceed... Both sides will converge on the capital for a result that will shake everyone's lives, with consequences far beyond football.
Drawing on a range of contexts and data sources, from urban multilingualism to studies of animal communication, Posthumanist Applied Linguistics offers us alternative ways of thinking about the human predicament, with major implications for research, education and politics. Exploring the advent of the Anthropocene, new forms of materialism, distributed language, assemblages, and the boundaries between humans, other animals and objects, eight incisive chapters by one of the world's foremost applied linguistics open up profound questions to do with language and the world. This critical posthumanist applied linguistic perspective is essential reading for all researchers and students in the fields of Applied Linguistics and Sociolinguistics.
Critical Care MCQs is the perfect companion for anyone sitting exams in intensive care, as a training resource or just wanting to improve their knowledge in this constantly developing area of medical practice. Written by critical care doctors with experience of UK and European examination formats, this book leads the reader through 450 true/false questions with referenced explanations, covering core syllabus topics and key influential papers to date. A detailed list of further resources and recommendations relevant to critical care revision is also provided to enable readers to further their knowledge and understanding. It is hoped that this book will prove invaluable for preparation and success in upcoming intensive care exams for both candidates and trainers. This book would be useful for not only candidates sitting the UK Final Fellowship of Intensive Care Medicine (FFICM) and European Diploma of Intensive Care (EDIC) exams, but also the Indian Diploma in Critical Care Medicine (IDCCM), the Diploma of the Irish Board of Intensive Care Medicine (DIBICM), the Australia and New Zealand Fellowship of the College of Intensive Care Medicine (CICM), American Board and any other country-related intensive care exams.
Written and edited by an international team of renowned authorities, MacSween's Pathology of the Liver, 8th Edition, remains the field’s definitive reference on liver pathology. This must-have text is ideal for surgical pathologists in practice and in training who examine liver specimens on a day-to-day basis. It provides invaluable assistance in recognizing the huge variety of appearances of the liver that result from infections, tumors, and tumor-like lesions, as well as organ damage caused by drugs and toxins. With expert, comprehensive coverage of all malignant and benign hepatobiliary disorders, MacSween’s is a convenient, one-stop resource for use in the reporting room as well as in personal study. Shares the knowledge and experience of a “who’s who list of experts in the field of hepatobiliary pathology, led by editors Alastair D. Burt, Linda D. Ferrell, and Stefan G. Hübscher. Features more than 1,000 high-quality, full color illustrations, providing a complete visual guide to each tumor or tumor-like lesion. Discusses advances in molecular diagnostic testing, its capabilities, and its limitations, including targeted/personalized medicine. Incorporates the latest TNM staging and WHO classification systems, as well as new diagnostic biomarkers and their utility in differential diagnosis, newly described variants, and new histologic entities. Includes relevant data from ancillary techniques (immunohistochemistry, cytogenetics, and molecular genetics), giving you the necessary tools required to master the latest breakthroughs in diagnostic technology. Provides you with all of the necessary diagnostic tools to make a complete and accurate pathologic report, including clinicopathologic background throughout. Directs you to the most recent and authoritative sources for further reading with a comprehensive reference list that highlights key articles and up-to-date citations.
Arabs and Arabists contains nineteen selected articles by Alastair Hamilton on the Western acquisition of knowledge of the Arab and Ottoman world in the early modern period. The first essays are on Arabs who visited Europe and gave instruction to Western Arabists, and on Europeans who either visited the Arab (or the Ottoman) world in search of manuscripts and information or who, like Franciscus Raphelengius, Isaac Casaubon and Adriaen Reland, studied it at a distance and remained in the West. These are followed by a section on the actual study of the Arabic language in Europe, and above all the creation of the first Arabic-Latin dictionaries, and another on the European study of Islam and Western translations of the Qur’an.
Innovating Professional Services provides a practical and detailed guide for change agents and leaders in professional service firms who are seeking to transform their firm’s performance through innovation. Focusing on the professional services sector, the book highlights process innovation - the re-engineering of services and internal support processes to reduce cost and increase value to clients. Detailed techniques such as the use of lean, process mapping, waste identification, service experience mapping and value profiling are explained, drawing on the author's extensive experience in working with leading law, business service and consulting firms to create measurable improvements. With case studies to illuminate the challenges of driving major improvement through innovation, this book is valuable reading for leaders and change agents in law firms, accountants, consultants, architects, financial services and engineering services.
This is the second edition of Principles of Equity and Trusts , the concise new textbook from Alastair Hudson – the author of the definitive classic, Equity and Trusts. Through clear and careful analysis, the author explains what the law is, its foundational principles, and its social and economic effect. By beginning with the core principles on which this field is based, even the most complex academic debates concerning express, resulting and constructive trusts, the family home, charities law and other equitable doctrines become comprehensible and interesting. This book offers a fresh, lively and often humorous account of Equity and Trusts. Through easy-to-follow worked examples and analysis of the case law, Alastair helps you to answer problem questions and to prepare coursework. The author shows how the law affects real people in real situations. Each chapter begins with a clear and concise introduction to the core principles. It contains numbered headings for ease of navigation and advice on studying this subject. Students also have access to Professor Hudson’s ever-popular supporting website, which has had hundreds of thousands of hits over the years. It has over 50 brief podcasts on key issues which have been specially re-recorded to coincide with the publication of this book. That website also contains detailed lectures, a variety of videos explaining the law and guidance on tackling assessments. Characterised by the passion and enthusiasm for his subject matter that make Alastair Hudson’s classic textbook so popular, Principles of Equity and Trusts is sure to be a winner with both academics and students alike.
This new edition considers all of the academic commentary governing the area of equity and trusts - in particular the emerging law of restitution and the raft of new case law over the 1990s. It is suitable both as a sholarly reference and as a resource for students.
This issue will cover the following: Examination of the Varus Ankle, Foot and Tibia, Anatomy of the Varus Ankle and Foot, Imaging of the Varus Ankle and Foot, Pathology of the Varus Ankle and Foot, Varus Ankle After Tibia Fracture Varus Ankle and Hindfoot Deformity After Talar Fracture, Varus Ankle and Ankle Instability, Varus Ankle and Osteochondral Lesions of the Talus, Planning the Correction of the Varus Ankle in Conjunction with Ankle Replacement. Single or Staged Approach, Varus Ankle – Management with a Frame, Varus Hindfoot and Neurological Disorders, Varus Deformity After Calcaneus Fracture, Varus Ankle – Adopting Your Ankle Fusion Technique
As literary scholars have long insisted, an interdisciplinary approach is vital if modern readers are to make sense of works of medieval literature. In particular, rather than reading the works of medieval authors as addressing us across the centuries about some timeless or ahistorical 'human condition', critics from a wide range of theoretical approaches have in recent years shown how the work of poets such as Chaucer constituted engagements with the power relations and social inequalities of their time. Yet, perhaps surprisingly, medieval historians have played little part in this 'historical turn' in the study of medieval literature. The aim of this volume is to allow historians who are experts in the fields of economic, social, political, religious, and intellectual history the chance to interpret one of the most famous works of Middle English literature, Geoffrey Chaucer's 'General Prologue' to the Canterbury Tales, in its contemporary context. Rather than resorting to traditional historical attempts to see Chaucer's descriptions of the Canterbury pilgrims as immediate reflections of historical reality or as portraits of real life people whom Chaucer knew, the contributors to this volume have sought to show what interpretive frameworks were available to Chaucer in order to make sense of reality and how he adapted his literary and ideological inheritance so as to engage with the controversies and conflicts of his own day. Beginning with a survey of recent debates about the social meaning of Chaucer's work, the volume then discusses each of the Canterbury pilgrims in turn. Historians on Chaucer should be of interest to all scholars and students of medieval culture whether they are specialists in literature or history.
Davidson’s Essentials presents the content of the prestigious Davidson’s Principles & Practice of Medicine textbook in an accessible and portable format, to facilitate quick revision of information. Following the structure and style of the textbook, it allows the reader to study the key information in a format that complements the core text. This distinctive approach will be an invaluable companion book for those studying and working in a clinical environment. A distillation of the core information required for studying clinical medicine. Presents the key information in a format more appropriate for practical clinical work. Compiled with the assistance of junior doctors with a clear understanding of what a medical student really needs to know. Includes additional chapters of new content to aid clinical practice - a practically-focussed chapter on therapeutics; a useful guide to interpreting major clinical investigations; and an exam-oriented guide to the OSCE.
This comprehensive study examines British shipbuilding and industrial relations from 1870 to 1950, addressing economic, social and political history to provide an holistic approach to industry, trade-unionism and the early history of the Labour Party. Examining the impact of new machinery, of independent rank-and-file movements and of craft and trade unions, The Tide of Democracy provides an authoritative account of industrial action in shipyards in the period and their effect on the birth and development of the Labour Party. This volume is clearly presented, elegantly written and suffused with a distinctly human touch which brings the technical material to life. Unique in the combined attention it gives to Scottish and English history, and drawing upon an impressive range of primary sources, this volume will be indispensable for specialist researchers, undergraduates and postgraduate students.
The Oxford Specialist Handbook of Urological Surgery returns fully updated for a second edition to guide the reader step-by-step through all types of urological operations. Including both background information on key urological problems and alternative surgical options, this Handbook is designed to guide the trainee through all aspects of urological surgery, from gaining clear and accurate consent to examining risks and complications of procedures. With each chapter written by subspecialty experts, this Handbook is packed with tips and tricks that offer practical and theatre-based advice gleaned over years of theatre experience to aid the reader. It also includes helpful pointers on aspects of surgery including patient positioning, indications and contraindications, types of incisions, and choice of ideal instrument, alongside aftercare and follow-up for the patient. Fully updated in accordance with new European guidelines and NICE clinical guidance, with extra topics on technological developments including robotic assisted surgery and a brand new chapter on female urology and incontinence, the Oxford Specialist Handbook of Urological Surgery is an essential resource for all urological trainees and junior doctors.
In twentieth-century England, many working-class people were victims of values and circumstances not of their own making. They were people to whom things were done to, not for. Billy and Tommy Jones and their mother, Mary, were such people. The boys were born out of wedlock at a time when such a thing was regarded as a disgrace -the sins of the father being visited on the sons. Neither boy knows they have a brother – it is to be a dark family secret between the Catholic church and Mary, the boy’s mother. The trajectory of the boy’s lives takes them to different parts of the world where they suffer the consequences of circumstances beyond their control which they must confront and resolve. Billy is injured in WW2, falls in love with his nurse, and is left struggling with shellshock after being discharged from the army. Eventually, through the kindness and compassion of strangers, he regains his health and, in a surprising turn of events, learns the truth about his birth. Tommy is a victim of the British Home Child program and is sent to Canada when he is thirteen to work on a five-year indenture labor contract on a dairy farm in Quebec. When his contract ends, he travels to Jersey, a Channel Island, just before the Germans invade and occupy the island. To avoid capture and deportation to Germany, Tommy becomes resourceful in surprising ways. The Soldier and the Orphan is a fast-paced, emotionally packed novel with strong characters and surprising twists. It will elicit unexpected tears of joy and sadness as the story touches on colonialist attitudes, discrimination, love, and tragedy. And for readers wanting an extra taste of mystery and suspense. The Soldier and the Orphan brews up a good share of deceits and secrets, and even murder as the novel threads to a powerful, heart-warming conclusion. The Soldier and the Orphan will appeal to readers of all ages and backgrounds but will be of special interest to those who have traced their Canadian ancestry back to a British Home Child. Readers who enjoyed the Orphan Train and The Guernsey Literary and Potato Peel Pie Society will enjoy the unique plots and settings of this novel.
Since its first publication more than 35 years ago, MacSween’s Pathology of the Liver, by Drs. Alastair D. Burt, Linda D. Ferrell, and Stefan G. Hübscher, has established itself as the definitive reference on liver pathology. The 7th Edition continues the tradition of excellence with more than 1,000 high-quality illustrations, coverage of the new and emerging diagnostic applications and techniques that pathologists must be familiar with, an up-to-date review of drug-induced injury, and much more. A must-have for every surgical pathologist, MacSween’s remains the most authoritative and comprehensive book in its field. Provides comprehensive, state-of-the-art coverage of all malignant and benign hepatobiliary disorders from an international "who’s who" in the field. Helps you quickly recognize the wide variety of liver appearances that result from infections, tumors, and tumor-like lesions, as well as organ damage caused by drugs and toxins. Features 1,000+ full-color illustrations that provide a complete visual guide to each tumor or tumor-like lesion and assist in the recognition and diagnosis of any tissue sample you’re likely to encounter. Incorporates relevant data from ancillary techniques (immunohistochemistry, cytogenetics, and molecular genetics), giving you the tools required to master the latest breakthroughs in diagnostic technology. Includes an updated chapter on mechanisms of liver disease, including coverage of regression and remodeling of disease and new information on next generation sequencing; an up-to-date review of drug-induced injury, including the effects of herbal and alternative medicines. Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.
This book looks at language in unexpected places. Drawing on a diversity of materials and contexts, including farewell addresses to British workers in colonial India, letters written from parents to their children at home, a Cornish anthem sung in South Australia, a country fair in rural Australia, and a cricket match played in the middle of the 19th century in south India, this book explores many current concerns around language, mobility and place, including native speakers, generic forms, and language maintenance. Using a series of narrative accounts – from a journey to southern India to eating cheese in China, from playing soccer in Germany to observing a student teacher in Sydney – this book asks how it is that language, people and cultures turn up unexpectedly and how our lines of expectation are formed.
Lots of twists and turns that keep you guessing right up to the end' 5***** reader review 'Tis the season for dead bodies . . . Nobody remembers the young men entering the abandoned London flat a few weeks ago. Nobody cares if they left. Until the unbearable smell of decay. DCI Antonia Hawkins is called in to view the dead men; three, lying neat in a row. There's no damage to the bodies, no obvious cause of death. Is this a suicide pact? Or is that just how it's meant to look? If there is a link between the three very different men then Hawkins needs to find it, and fast. Because unless she does, more are going to die . . . ____________ 'Couldn't put it down' 5***** reader review 'First class thriller . . . it gripped me from the start. Plenty of twists and turns' 5***** reader review 'Everything that I want in a really good thriller' 5***** reader review 'A gripping finale' 5***** reader review
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