Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function. Antibacterial Agents is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated “lab-to-clinic” approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects (including links to current guidelines, significant drug interactions, cautions and contraindications), prodrugs and future improvements. Agents covered include: agents targeting DNA - quinolone, rifamycin, and nitroimidazole antibacterial agents agents targeting metabolic processes - sulfonamide antibacterial agents and trimethoprim agents targeting protein synthesis - aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones agents targeting cell wall synthesis - β-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin Antibacterial Agents will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.
From New York Times bestselling author Alan Moore-one of the most influential writers in the history of comics-"a wonderful collection, brilliant and often moving" (Neil Gaiman) which takes us to the fantastical underside of reality. In his first-ever short story collection, which spans forty years of work, Alan Moore presents a series of wildly different and equally unforgettable characters who discover--and in some cases even make and unmake--the various uncharted parts of existence. In "A Hypothetical Lizard," two concubines in a brothel of fantastical specialists fall in love with tragic ramifications. In "Not Even Legend," a paranormal study group is infiltrated by one of the otherworldly beings they seek to investigate. In "Illuminations," a nostalgic older man decides to visit a seaside resort from his youth and finds the past all too close at hand. And in the monumental novella "What We Can Know About Thunderman," which charts the surreal and Kafkaesque history of the comics industry's major players over the last seventy-five years, Moore reveals the dark, beating heart of the superhero business. From ghosts and otherworldly creatures to theoretical Boltzmann brains fashioning the universe at the big bang, Illuminations is exactly that--a series of bright, startling tales from a contemporary legend that reveal the full power of imagination and magic.
Following the treaty of Utrecht, Portugal, successful diplomatically where she had failed militarily, embarked on a lengthy period of balancing the interests of Britain, France and Spain against her own political and economic needs. This study, drawing extensively on state papers and other collections, follows the course of Anglo-Portuguese relations through the years of John V, the age of Pombal and the 1762 war with Spain, to the years of the French revolution and the flight of the court to Brazil under the threat of Napoleon's army.
From New York Times bestselling author Alan Moore-one of the most influential writers in the history of comics-"a wonderful collection, brilliant and often moving" (Neil Gaiman) which takes us to the fantastical underside of reality. In his first-ever short story collection, which spans forty years of work, Alan Moore presents a series of wildly different and equally unforgettable characters who discover--and in some cases even make and unmake--the various uncharted parts of existence. In "A Hypothetical Lizard," two concubines in a brothel of fantastical specialists fall in love with tragic ramifications. In "Not Even Legend," a paranormal study group is infiltrated by one of the otherworldly beings they seek to investigate. In "Illuminations," a nostalgic older man decides to visit a seaside resort from his youth and finds the past all too close at hand. And in the monumental novella "What We Can Know About Thunderman," which charts the surreal and Kafkaesque history of the comics industry's major players over the last seventy-five years, Moore reveals the dark, beating heart of the superhero business. From ghosts and otherworldly creatures to theoretical Boltzmann brains fashioning the universe at the big bang, Illuminations is exactly that--a series of bright, startling tales from a contemporary legend that reveal the full power of imagination and magic.
Looking at the building of country houses as a whole, this book investigates why owners embarked on extensive building programmes, often following a grand tour. It explores the cost of building and the cost of furnishing and decoration.
Unbeknownst to many fans, Oscar-winning actor Alan Arkin, whose movie career was revitalized with his 2006 role in the indie hit Little Miss Sunshine, also had a brief career as a science-fiction writer in the 1950s. "People Soup" is a charming and somewhat unsettling tale of two boys who inadvertently concoct a magical potion. The story is the inspiration for a short film with the same name that Arkin directed in 1969, starring his sons Matthew and Adam.
A wonderful collection, brilliant and often moving ... Both mind-expanding and cosmic while utterly rooted in our urban reality'NEIL GAIMAN'One of the great fiction minds of his generation' ROLLING STONEIn his first-ever short story collection, which spans forty years of work and features many never-before-published pieces, international bestselling author and legendary creator of From Hell, The League of Extraordinary Gentlemen and other modern classics, Alan Moore, presents nine stories full of wonder and strangeness, each taking us deeper into the fantastical underside of reality.In A Hypothetical Lizard, two concubines in a brothel for fantastical specialists fall in love, with tragic ramifications. In Not Even Legend, a paranormal study group is infiltrated by one of the otherworldly beings they seek to investigate. In Illuminations, a nostalgic older man decides to visit a seaside resort from his youth and finds the past all too close at hand. And in the monumental novella What We Can Know About Thunderman, which charts the surreal and Kafkaesque history of the comics industry over the last seventy-five years through several sometimes-naive and sometimes-maniacal people rising and falling on its career ladders, Moore reveals the dark, beating heart of the superhero business.From ghosts and otherworldly creatures to theoretical Boltzmann brains fashioning the universe at the big bang, Illuminations is exactly that - a series of bright, startling tales from a contemporary legend that reveal the full power of imagination and magic.'One of the most significant fiction writers in English ... Moore's influence can be felt everywhere--in our literature, on our screens, in our politics'GUARDIANIlluminations became a Sunday Times Top 5 Bestseller on 15th October 2022
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