In this accessible history of science and medicine, Marcus exposes the complex story of the efforts made from 1875 through 1915 to first conquer and, failing that, to control cancer--a dual approach that remains in force to this day. He reveals the messiness of real-time scientific research, tracing the repeated lurches of promise, discoveries of hope, and the inevitable despair that always followed. Other barriers existed to the research, such as inconsistency in test standards and inter-laboratory competition and mistrust. Researchers approached cancer from such disparate specialties as clinical medicine, zoology, botany, chemistry, nutrition, bacteriology, pathology, and microbiology. Although they came from diverse fields, each steadfastly maintained that cancer operated in an analogous fashion to other bacteriological diseases.
The last 20 years has seen a rapid increase in infectious diseases, particularly those that are termed "emerging diseases" such as SARS, "neglected diseases" such as malaria and those that are deemed biothreats such as anthrax. It is well-recognized that the most effective modality for preventing infectious diseases is vaccination. This book provides researchers with a better understanding of what is currently known about these diseases, including whether there is a vaccine available or under development. It also informs readers of the key issues in development of a vaccine for each disease. - Provides a comprehensive treatise of the agents that are responsible for emerging and neglected diseases and those that can be used as biothreats - Includes the processes such as the vaccine development pathway, vaccine manufacturing and regulatory issues that are critical to the generation of these vaccines to the marketplace - Each chapter will include a map of the world showing where that particular disease is naturally found
Much like DNA provides the structure and design for life, The DNA of Leadership defines the behaviors that are essential to become an outstanding leader. This book is the result of working with thousands of executives, reviewing their behaviors, and identifying characteristics that are required for high levels of success, including: Setting a forceful vision; Identifying and hiring extraordinary talent; Delegating for leveraging of results; Communicating for impact; Having difficult conversations; Creating a compelling business model. This book is written is for leaders at every level in an organization, from the first-time manager to the chief executive officer and offers practical ways to change your behavior and provides an active roadmap toward becoming a truly outstanding leader.
With the 13th edition, Wintrobe’s Clinical Hematology once again bridges the gap between the clinical practice of hematology and the basic foundations of science. Broken down into eight parts, this book provides readers with a comprehensive overview of: Laboratory Hematology, The Normal Hematologic System, Transfusion Medicine, Disorders of Red Cells, Hemostasis and Coagulation; Benign Disorders of Leukocytes, The Spleen and/or Immunoglobulins; Hematologic Malignancies, and Transplantation. Within these sections, there is a heavy focus on the morphological exam of the peripheral blood smear, bone marrow, lymph nodes, and other tissues. With the knowledge about gene therapy and immunotherapy expanding, new, up-to-date information about the process and application of these therapies is included. Likewise, the editors have completely revised material on stem cell transplantation in regards to both malignant and benign disorders, graft versus host disease, and the importance of long-term follow-up of transplantation survivors.
Master the full range of colorectal procedures performed today with Atlas of Surgical Techniques for the Colon, Rectum, and Anus. In this volume in the Surgical Techniques Atlas Series, top authorities provide expert, step-by-step guidance on surgery of the large bowel, rectum, and anus - including both open and closed approaches for many procedures - to help you expand your repertoire and hone your clinical skills. Rely on definitive, expert guidance from the same respected authorities that made Campbell-Walsh Urology the most trusted clinical reference source in the field. Assess and deepen your understanding of key information with answers and rationales for more than 2,800 board-style multiple-choice study questions. Over 2,800 board-style multiple-choice questions provide a realistic simulation of the actual board experience. Deepen your grasp of critical concepts by studying supporting pathology and radiologic images and understanding their correlation to key points. Benefit from the consistency of all questions, answers, and rationales re-written by a single author. Measure your proficiency with interactive self-assessment questions online. Get the most from your board prep by pairing this review with its parent text, Campbell-Walsh Urology, for detailed explanations and an enhanced learning experience.
Since 1954, Campbell-Walsh Urology has been internationally recognized as the pre-eminent text in its field. Edited by Alan J. Wein, MD, PhD(hon), Louis R. Kavoussi, MD, Alan W. Partin, MD, PhD, Craig A. Peters, MD, FACS, FAAP, and the late Andrew C. Novick, MD, it provides you with everything you need to know at every stage of your career, covering the entire breadth and depth of urology - from anatomy and physiology through the latest diagnostic approaches and medical and surgical treatments. Be certain with expert, dependable, accurate answers for every stage of your career from the most comprehensive, definitive text in the field! Required reading for all urology residents, Campbell-Walsh Urology is the predominant reference used by The American Board of Urology for its board examination questions. Visually grasp and better understand critical information with the aid of algorithms, photographs, radiographs, and line drawings to illustrate essential concepts, nuances of clinical presentation and technique, and decision making. Stay on the cutting edge with online updates. Get trusted perspectives and insights from hundreds of well-respected global contributors, all of whom are at the top and the cutting edge of their respective fields. Stay current with the latest knowledge and practices. Brand-new chapters and comprehensive updates throughout include new information on perioperative care in adults and children, premature ejaculation, retroperitoneal tumors, nocturia, and more! Meticulously revised chapters cover the most recent advancements in robotic and laparoscopic bladder surgery, open surgery of the kidney, management of metastic and invasive bladder cancer, and many other hot topics!Reference information quickly thanks to a new, streamlined print format and easily searchable online access to supplemental figures, tables, additional references, and expanded discussions as well as procedural videos and more at www.expertconsult.com. The new edition of Campbell-Walsh Urology is the must have reference for practitioners and residents!
This book re-evaluates epidemiological and occupational health studies, experimental studies in animals and in vitro experiments relating to the toxicity of 27 metal and metalloid elements for which evidence of carcinogenicity has been presented. Human carcinogenic risk is substantiated in relation to arsenic, beryllium, thorium, chromium, radioactive elements, probably lead, and some nickel and cobalt compounds, and respirable silica particles, but the carcinogenicity of iron, aluminium, titanium, tungsten, antimony, bismuth, mercury, precious metals, and certain related compounds in humans is unresolved. The toxicity and carcinogenicity of each element is specific but correlates poorly with its position in the Periodic Table. Carcinogenicity differs according to the valency of the ion and its ability to interact with and penetrate membranes in target cells and to bind, denature or induce mutations by genotoxic or epigenetic mechanisms. This important text comprehensively examines each of the elements providing detailed information on the carcinogenicity and toxicity and detailing the most up-to-date research in this area. The book is an essential tool for toxicologists, medicinal and biochemists, and environmental scientists working in both industry and academia.
Outdoor Adventure Education: Foundations, Theories, Models, and Research steeps students in the theories, concepts, and developments of outdoor adventure education, preparing them for careers in this burgeoning field. This text is based on author Alan W. Ewert’s pioneering book Outdoor Adventure Pursuits: Foundations, Models, and Theories. Ewert and Sibthorp, both experienced practitioners, researchers, and educators, explore the outdoor adventure field today in relation to the changes that have occurred since Ewert’s first book. The authors present a comprehensive text on outdoor and adventure foundations, theories, and research that will provide the basis for the next generation of professionals.
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