With the 13th edition, Wintrobe’s Clinical Hematology once again bridges the gap between the clinical practice of hematology and the basic foundations of science. Broken down into eight parts, this book provides readers with a comprehensive overview of: Laboratory Hematology, The Normal Hematologic System, Transfusion Medicine, Disorders of Red Cells, Hemostasis and Coagulation; Benign Disorders of Leukocytes, The Spleen and/or Immunoglobulins; Hematologic Malignancies, and Transplantation. Within these sections, there is a heavy focus on the morphological exam of the peripheral blood smear, bone marrow, lymph nodes, and other tissues. With the knowledge about gene therapy and immunotherapy expanding, new, up-to-date information about the process and application of these therapies is included. Likewise, the editors have completely revised material on stem cell transplantation in regards to both malignant and benign disorders, graft versus host disease, and the importance of long-term follow-up of transplantation survivors.
This is a revised and updated edition of a text used in undergraduate courses on cancer biology. It covers everything from the molecular basis of cancer to clinical aspects of the subject, and has a lengthy bibliography designed to assist newcomers with the cancer literature. An introduction acquaints students with the biological principles of cancer and the human dimensions of the disease by considering genuine cases of cancer in fictionalized letters. Other chapters discuss cancer pathology, metastasis, carcinogenesis, genetics, oncogenes and tumor suppressors, epidemiology, and the biological basis of cancer treatment. Also included are an appendix with descriptions of common forms of cancer, a glossary of cancer-related terms and colour plates to illustrate the pathology of many of the types of cancer discussed in the text. Upper-division undergraduates with a background in freshman biology and chemistry, as well as beginning graduate students will find this a valuable text.
Galvani's Spark describes the gradual understanding of the nerve impulse. Proceeding from a chance observation on a frog leg, to studies on squid giant axons and bacteria, this book concludes with the increasing realization that ion channells are responsible for a variety of clinical disorders.
Pediatric body CT began in earnest in 1976 when for the first time a body CT machine was installed in a pediatric institution, the Hospital for Sick Children in Toronto. The first images were received with great enthusiasm. More recently, newer equipment with faster scan times and better resolution has enabled us to delineate disease processes with even greater accuracy. In the past 9 years we have performed more than 5000 body scans in children. With this experience our examination techniques have changed and the indications for CT in children have been modified. CT has come to occupy an important and specific place in the management of pediatric patients. The performance of body CT studies in children is not always easy. Excellent diagnostic studies can be obtained only with a special understanding of the problems of pediatric patients and pediatric pathology. The information contained herein is a review of our experience with pediatric body CT, how we use body CT in children, and its relationship to other modalities in this department.
This book develops the mathematical tools essential for students in the life sciences to describe interacting systems and predict their behavior. From predator-prey populations in an ecosystem, to hormone regulation within the body, the natural world abounds in dynamical systems that affect us profoundly. Complex feedback relations and counter-intuitive responses are common in nature; this book develops the quantitative skills needed to explore these interactions. Differential equations are the natural mathematical tool for quantifying change, and are the driving force throughout this book. The use of Euler’s method makes nonlinear examples tractable and accessible to a broad spectrum of early-stage undergraduates, thus providing a practical alternative to the procedural approach of a traditional Calculus curriculum. Tools are developed within numerous, relevant examples, with an emphasis on the construction, evaluation, and interpretation of mathematical models throughout. Encountering these concepts in context, students learn not only quantitative techniques, but how to bridge between biological and mathematical ways of thinking. Examples range broadly, exploring the dynamics of neurons and the immune system, through to population dynamics and the Google PageRank algorithm. Each scenario relies only on an interest in the natural world; no biological expertise is assumed of student or instructor. Building on a single prerequisite of Precalculus, the book suits a two-quarter sequence for first or second year undergraduates, and meets the mathematical requirements of medical school entry. The later material provides opportunities for more advanced students in both mathematics and life sciences to revisit theoretical knowledge in a rich, real-world framework. In all cases, the focus is clear: how does the math help us understand the science?
Handbook of Hematologic Malignancies provides a unique, practical, and concise guide focused on the must-know points of diagnosis, prognosis, therapeutic management, and cutting edge clinical trial opportunities for each hematologic malignancy. With an ever-increasing growth of evidence and a significant expansion of available treatment options for patients with hematologic disease, remaining current and up-to-date can be extremely challenging for practicing clinicians. This comprehensive subspecialty handbook is designed and organized for the busy hematologist, hematologic oncologist, hematopathologist, and trainee in mind. Every chapter is richly illustrated with color figures and flow diagrams, and contains helpful tables on differential diagnosis, prognostic scoring systems and therapeutic options. A concise case-based review for testing pathologic diagnosis and clinical knowledge for each chapter is included for digital download online and in the e-book. Written by experienced clinicians at the world-renowned Moffitt Cancer Center in Tampa, Florida, as well as contributions from leading academicians throughout the country, this handbook is an essential resource for anyone diagnosing, treating, or managing patients with hematologic malignancy. KEY FEATURES: Contains clear prognostic and diagnostic tools (e.g., tables/flow diagrams/pathology images) with emphasis on key differential diagnoses and diagnostic dilemmas Easy to use treatment recommendations with bullet point format and key references. Discusses the future of patient management based on practice changing clinical trials Includes access to digitally downloadable case-based clinical scenarios and questions with high resolution pathology images linked to each individual chapter
The Epstein-Barr virus (EBV) was discovered in 1964. At the time, the very idea of a virus underlying a cancer was revolutionary. Cancer is, after all, not catching. Even now, the idea of a virus causing cancer surprises many people. But Epstein-Barr, named after its discoverers, Sir Anthony Epstein and Dr Yvonne Barr, is fascinating for other reasons too. Almost everyone carries it, yet it is only under certain circumstances that it produces disease. It has been associated with different, apparently unrelated, diseases in different populations: Burkitt's Lymphoma, producing tumours in the jaw, in African children; a nasal tumour in China; glandular fever in Europe and the USA; and the majority of cases of Hodgkin's Disease everywhere. This book tells the story of the discovery of the virus, and the recognition of its connection with these various diseases - an account that spans the world and involves some remarkable characters and individual stories.
The new edition of this text helps you make the most of your study time by focusing on only the core basics of pathology needed for course work or exams...while avoiding extraneous details. Nearly 800 full-color, generously sized clear illustrations help bring the subject to life and aid in memorization. User-friendly features-including clinical correlation and differential diagnosis boxes-help make the material more relevant, while an increased emphasis on clinical medicine and a new self-assessment section prepare you for real-life practice. Your purchase of this book entitles you to access www.studentconsult.com at no extra charge. This innovative web site offers you an interactive center with a wealth of additional resources. Focuses on only the core pathology that you need to know so you can make the most of your time in the classroom, and of your study time in preparing for exams. Presents nearly 800 full-color, generously sized illustrations that help you visualize pathologic processes and enhance memorization. Includes a self-assessment section that helps to prepare you for real-life practice. Uses clinical correlation boxes to help you apply basic pathology principles to real-life medicine. Features advanced concept boxes that enable you to review separate summaries of higher-level information without taking away from your study of the basics. Provides differential diagnosis boxes that help you link symptoms and signs to diseases and back to basic pathology principles. Features access to Student Consult at www.studentconsult.com, where you'll find a virtual microscope feature that enables you to see the microscopic pathological images you are likely to view in the lab • USMLE-style questions • "Integration Links" to bonus content in other Student Consult titles • and much more. Offers Evolve website access for instructors where they will find more images and an additional 150 multiple-choice questions .
In T.E.B., Dr. Alan Graber examines the influence and legacy of Dr. Thomas Evans Brittingham II, a legendary physician and educator at Vanderbilt University. Brittingham embodied what it meant to be a doctor. He taught his trainees-by his example-how to care for sick people. This book demonstrates Brittingham as an exemplar of a medical era when a doctor's history and physical exam were the principal means of diagnosis. Brittingham's practice of doctoring still represents the essence of good patient care. "This is much more than a biography. T.E.B. was a master of bedside clinical medicine and left his legend to a generation of young doctors. If anyone was ever 'called' to the profession of medicine, it was T.E.B." -Clifton K. Meador, MD, Professor of Medicine, Emeritus, Vanderbilt University
Reflecting the past 20 years of intense research in radioimmunotherapy, this timely reference surveys an expansive breadth of topics on the evolving developments in radiation therapy. Placed in the context of advances in cancer treatment, chapters progress systematically from basic principles and properties of radionuclides to detailed summaries of
Treatment of community-acquired pneumonia and hospital-acquired pneumonia, when to hospitalize a patient, methods of identifying low-risk CAP patients, switch and step-down therapy, approach to nonresloving pneumonia, management of parapneumonic effusions, empyema, and chronic bronchitis are discussed. The various antimicrobial agents are reviewed in deatil with suggested treatment regimens.
Imperialism and Colonialism: Christopher Bayly, Richard Rathbone and Richard Drayton is a collection of interviews that are being published as a book for the first time. These interviews have been conducted by one of England’s leading social anthropologists and historians, Professor Alan Macfarlane. Filmed over a period of several years, the three conversations in this volume are part of the series Creative Lives and Works. These transcriptions form a part of a larger set of interviews that cut across various disciplines, from the social sciences and the sciences to the performing and visual arts. The current volume is on three foremost imperial and global historians. Colonialism is intrinsically linked to its imperial past. Christopher Bayly, Richard Rathbone and Richard Drayton, come alive through these conversations in this book. They offer a refreshing perspective to the actions of the colonizer and the colonized, often deriding the actions of the former. Bayly talks at great length about his Indian experience, Rathbone talks about the tempered indifference of the larger academic community towards African history and its oral tradition and Drayton engages his readers with anecdotes and interesting insights into Creole culture. The book will be of enormous value not just to those interested in the subject of History, Culture Studies, Ethnography and Comparative Studies and Literature but also to the uninitiated because of the lucidity which conversations bring to even otherwise opaque discussions.. Please note: This title is co-published with Social Science Press, New Delhi. Taylor & Francis does not sell or distribute the Hardback in India, Pakistan, Nepal, Bhutan, Bangladesh and Sri Lanka.
How did those responsible for creating Britain's nineteenth-century settler empire render colonization compatible with humanitarianism? Avoiding a cynical or celebratory response, this book takes seriously the humane disposition of colonial officials, examining the relationship between humanitarian governance and empire. The story of 'humane' colonial governance connects projects of emancipation, amelioration, conciliation, protection and development in sites ranging from British Honduras through Van Diemen's Land and New South Wales, New Zealand and Canada to India. It is seen in the lives of governors like George Arthur and George Grey, whose careers saw the violent and destructive colonization of indigenous peoples at the hands of British emigrants. The story challenges the exclusion of officials' humanitarian sensibilities from colonial history and places the settler colonies within the larger historical context of Western humanitarianism.
Both teacher and reader will find here a careful presentation of both text and illustrations. The writing is clear, the organization is logical, and the illustrations are appropriate... this book is indeed good value." (TINS) "...the author has met his objective of whetting the appetite of his readers and encouraging the further pursuit of the subject." (Journal of Anatomy) "Brown argues (correctly in this reviewer's opinion) that neuroscience is primarily an experimental endeavor and therefore is taught best by presenting udergraduate students with the methods as well as the data of "classical" neurophysiological experiments. To this end, Brown has done a good job of supporting basic ideas with actual experimental methodology and results." (Choice)
The recent advances in the techniques for imaging the pancreas without surgical inter vention have reduced the inaccessibility of the pancreas. However, although certain lesions of the pancreas can now be recognised and localised without an operation, the pathology of the pancreas remains to be more thoroughly investigated. Moreover, the almost unrelated exocrine and endocrine functions of the pancreas have led to the management of different pancreatic diseases by different groups of specialists, while the effects of primarily non-pancreatic diseases upon the pancreas have tended to escape recognition. Even in the autopsy room the pancreas is often inadequately examined, and autolysis may make microscopiC examination unrewarding. This book is an attempt by a general histopathologist to make available some of his experience of the various aspects of pancreatic disease that he has encountered during his working career. My interest in the pathology of the pancreas was aroused while working with Prof. Arnold Rice Rich of the Johns Hopkins Hospital, Baltimore. Rich himself, in his earlier work, had continued the tradition, begun in the same department of pathology by Opie, of carrying out morbid anatomical and experimental studies on pancreatic disease. Rich later became more involved in work on tuberculosis and on the collagen diseases but his interest in disease of the pancreas persisted and the work he allotted to me included an experimental study of chemically induced diabetes mellitus.
Completely revised and updated, this comprehensive reference provides the latest clinically relevant information on all aspects of women's health care. New contributors offer up-to-the-minute reports on late pregnancy complications, multiple pregnancy, third-trimester hemorrhage, and infertility.
Practical, up-to-date, and ready-to-apply coverage of more than 1,000 diseases and disorders CURRENT Diagnosis & Treatment Obstetrics & Gynecology, 11e is a concise, yet comprehensive textbook on the medical and surgical management of obstetrics and gynecology. It succinctly covers more than 1,000 diseases and disorders,the latest screening guidelines, and underlying pathophysiology when relevant. The eleventh edition is enriched by contributions from more than 85 world-renowned contributors Thoroughly reviews all of obstetrics and gynecology Focuses on the practical aspects of clinical diagnosis and patient management Covers pathophysiology when relevant to diagnosis and treatment Emphasizes disease prevention and evidence-based medicine Includes more than 500 anatomic drawings, image studies, and diagrams Completely updated to reflect the latest research and advances Consistent presentation includes Clinical Findings, Diagnosis, Treatment, and Complications and Prognosis Quick-access design facilitates use at the point of care Updated to include the latest screening and management guidelines
Practical, up-to-date, and ready-to-apply coverage of more than 1,000 diseases and disorders For more than 70 years, professors, students, and clinicians have trusted LANGE for high-quality, current, concise medical information in a convenient, affordable, portable format. Whether for coursework, clerkships, USMLE prep, specialty board review, or patient care, there's a LANGE book that guarantees success. CURRENT Diagnosis & Treatment Obstetrics & Gynecology, 11e is a concise, yet comprehensive textbook on the medical and surgical management of obstetrics and gynecology. It succinctly covers more than 1,000 diseases and disorders,the latest screening guidelines, and underlying pathophysiology when relevant. The eleventh edition is enriched by contributions from more than 85 world-renowned contributors Thoroughly reviews all of obstetrics and gynecology Focuses on the practical aspects of clinical diagnosis and patient management Covers pathophysiology when relevant to diagnosis and treatment Emphasizes disease prevention and evidence-based medicine Includes more than 500 anatomic drawings, image studies, and diagrams Completely updated to reflect the latest research and advances Consistent presentation includes Clinical Findings, Diagnosis, Treatment, and Complications and Prognosis Quick-access design facilitates use at the point of care Updated to include the latest screening and management guidelines
This instructional atlas addresses the issues of patient selection, and looks at how to choose the appropriate implant design. It also provides step-by-step instructions for the technique of implantation through detailed illustrations. Coverage includes diagnosis, determination of the treatment plan, surgical principles, surgical procedure, patient follow-up and care.
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