Akihiro Kano's Books

Geomicrobiological Properties and Processes of Travertine

With a Focus on Japanese Sites

By: Akihiro Kano,Tomoyo Okumura,Chizuru Takashima,Fumito Shiraishi

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Geomicrobiological Properties and Processes of Travertine

With a Focus on Japanese Sites

By: Akihiro Kano,Tomoyo Okumura,Chizuru Takashima,Fumito Shiraishi

This book presents basic knowledge and key objectives of research of geological, geochemical, and microbial properties and processes in travertines, carbonate deposits precipitated from calcareous hot springs. Much of the contents are based on the authors’ researches performed in Japan and Indonesia over the last decade. Travertine is one of the most active sedimentary systems, which have a potential impact on the Earth’s environment. It is also an accessible epitome of the Earth’s history, cultivating ancestral bacteria and representing a modern analog for ancient stromatolites. Readers can learn how integration of various scopes and methods unveils mysterious phenomena in travertine and can find clues for considering the early history of the Earth and life. This book includes a monographic chapter on Japanese onsens, or hot springs, which may help tourists to select the best places to enjoy the unique features of travertine.

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Page Count

181

Publisher

Springer

Published Date

ISBN 10

9811313377

ISBN 13

9789811313370

Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents

By: Akihiro Hirakawa,Hiroyuki Sato,Takashi Daimon,Shigeyuki Matsui

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Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents

By: Akihiro Hirakawa,Hiroyuki Sato,Takashi Daimon,Shigeyuki Matsui

This book deals with advanced methods for adaptive phase I dose-finding clinical trials for combination of two agents and molecularly targeted agents (MTAs) in oncology. It provides not only methodological aspects of the dose-finding methods, but also software implementations and practical considerations in applying these complex methods to real cancer clinical trials. Thus, the book aims to furnish researchers in biostatistics and statistical science with a good summary of recent developments of adaptive dose-finding methods as well as providing practitioners in biostatistics and clinical investigators with advanced materials for designing, conducting, monitoring, and analyzing adaptive dose-finding trials. The topics in the book are mainly related to cancer clinical trials, but many of those topics are potentially applicable or can be extended to trials for other diseases. The focus is mainly on model-based dose-finding methods for two kinds of phase I trials. One is clinical trials with combinations of two agents. Development of dose-finding methods for two-agent combination trials requires reasonable models that can adequately capture joint toxicity probabilities for two agents, taking into consideration possible interactions of the two agents on toxicity probability such as synergistic or antagonistic effects. Another is clinical trials for evaluating both efficacy and toxicity outcomes in single- and two-agent combination trials. These methods are often applied to the phase I trials including MTAs because the toxicity and efficacy for a MTA does not monotonically increase with dose, but the efficacy often increases initially with the dose and then plateaus. Successful software implementations for several dose-finding methods are introduced in the book, and their operating characteristics in practice are discussed. Recent advance of the adaptive dose-finding methods in drug developments are also provided.

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Page Count

100

Publisher

Springer

Published Date

ISBN 10

4431555730

ISBN 13

9784431555735

Geomicrobiological Properties and Processes of Travertine

With a Focus on Japanese Sites

By: Akihiro Kano,Tomoyo Okumura,Chizuru Takashima,Fumito Shiraishi

Write a review Read reviews Take a Quiz Solve Book Puzzle

Geomicrobiological Properties and Processes of Travertine

With a Focus on Japanese Sites

By: Akihiro Kano,Tomoyo Okumura,Chizuru Takashima,Fumito Shiraishi

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

181

Publisher

Springer

Published Date

ISBN 10

9811313377

ISBN 13

9789811313370

Book's by Akihiro Kano

Geomicrobiological Properties and Processes of Travertine

Geomicrobiological Properties and Processes of Travertine

Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents

Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents

Geomicrobiological Properties and Processes of Travertine

Geomicrobiological Properties and Processes of Travertine

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