This book covers the fundamentals of protein inactivation during bioseparation and the effect on protein processing. Bioseparation of Proteins is unique because it provides a background of the bioseparation processes, and it is the first book available to emphasize the influence of the different bioseparation processes on protein inactivation.Bioseparation of Proteins covers the extent, mechanisms of, and control of protein inactivation during these processes along with the subsequent and essential validation of these processes. The book focuses on the avoidance of protein (biologicalproduct) inactivation at each step in a bioprocess. It compares protein inactivation exhibited during the different bioseparation processes by different workers and provides a valuable framework for workers in different areas interested in bioseparations.Topics include separation and detection methods; estimates of protein inactivation and an analysis of this problem for different separation processes; strategies for avoiding inactivation; the molecular basis of surface activity and protein adsorption,process monitoring, and product validation techniques; and the economics of various bioseparation processes and quality control procedures.Key Features* Protein inactivation and other aspects of biological stability are critical to an effective bioseparation process; This book is a detailed and critical review of the available literature in an area that is essential to the effectiveness, validation, and economics of bioseparation processes for drugs and other biological products; Conveniently assembled under one cover, the survey of the literature and resulting perspective will greatly assist engineers and chemists in designingand improving their own processes; Key features of the text include:* detailed data on biological stability under various bioseparation conditions* extensive case studies from the literature on separation processes, validation, and economics* simplified analysis of protein refolding and inactivation mechanisms* consideration of adsorption theories and the effect of heterogeneity* coverage of both classical and novel bioseparation techniques, including chromatographic procedures
This book focuses on the meaning of statistical inference and estimation. Statistical inference is concerned with the problems of estimation of population parameters and testing hypotheses. Primarily aimed at undergraduate and postgraduate students of statistics, the book is also useful to professionals and researchers in statistical, medical, social and other disciplines. It discusses current methodological techniques used in statistics and related interdisciplinary areas. Every concept is supported with relevant research examples to help readers to find the most suitable application. Statistical tools have been presented by using real-life examples, removing the “fear factor” usually associated with this complex subject. The book will help readers to discover diverse perspectives of statistical theory followed by relevant worked-out examples. Keeping in mind the needs of readers, as well as constantly changing scenarios, the material is presented in an easy-to-understand form.
RITUAL ART OF INDIA shows the splendor and diversity of an art form that has enriched every stage of human life in India--and reveals the inward-seeking quality of relationship with the divine that exemplifies Indian ritual art. A stunning guide with over 100 color photos and 34 b&w photos.
Biomarkers and Biosensors offers thorough coverage of biomarker/biosensor interaction, current research trends, and future developments in applications of drug discovery. This book is useful to researchers in this field as well as clinicians interested in new developments in early detection and diagnosis of disease or the mode of operation of biomarkers. Biomarkers and Biosensors also emphasizes kinetics, and clearly delineates how this influences the biomarker market. - Offers thorough coverage of the kinetics of biomarker interaction with the biosensor surface - Provides evidence-based approach to evaluate effectiveness - Provides pharmaceutical chemists the possibilities and methodology in assessing the effectiveness of new drugs - Provides the information needed for the selection of the best biomarker for a specific application
Recent advances in technology and instrumentation, mean that robot-assisted surgery has become increasingly established as an alternative to traditional open surgeries. This book is a practical guide to robotic surgery, beginning with an overview of the techniques and anaesthesia, highlighting the vital role played by anaesthetists in early patient recovery. The following sections cover all major surgical subspecialties including, general surgery, thoracic and vascular, gynaecological, urogynaecological, and paediatric and adult urology. The text is highly illustrated with clinical images and tables, and is further enhanced by an interactive DVD ROM demonstrating robotic surgical procedures including sleeve gastrectomy, rectopexy, hysterectomy, hernia repair, and much more. Key points Practical guide to robotic surgery covering all major subspecialties Provides overview of techniques and anaesthesia Highly illustrated with clinical images and tables Includes interactive DVD ROM demonstrating robotic surgical procedures
Education is a vital part of growing up. Everyone goes through the education system to help carve a path towards their future self and what career they want to focus on as they get older. However, what most people become confused on is the difference between “general education” and “special education.” General education is the education provided to students who physically attend school. Now, special education is the education provided by the school plus extra programs and services to help aid and guide the students through the general education. Special Education is defined as, “the means through which children who have disabilities receive an education specifically designed to help them reach their learning potential” (Friend, ).ICT in education is becoming increasigly important and has potential advantages to disabled learners if the technolgies are appropriately designed, including for accessibility and usability, and used. This paper presents the first sets of recommendations for learning technologies for disabled people aimed at disabled learners, teachers, developers and educational institutions respectively. They were developed as part of the work of the Enable Network for ICT Learning for Disabled People and involved input from both experts and end-users. The concise format facilitates production in a variety of formats and languages for accessibility and wide distribution. The paper discusses the recommendations and their relationship to existing guidelines. The results indicated that these students felt ready to use the technology resources in their studies. However, they did not receive support by the teachers and they noticed differences in approach, depending on the stage of the educational course and the type of disability. This book has been written for the education of Divyang people on ICT and communication, which includes the use of ICT in their education, what is the use of ICT, what is the importance of ICT, how can it contribute, how can we help Divyang people to become self-dpendent, authors are publishing articles on various aspects in it, which will not only help in bringing fundamental changes in the education of Divyangs, but also in their lives, so that not only India, but the interest towards ICT will come from it, how can we simplify and improve our education, various people have given their views.
Completely revised and updated, this third edition of Pharmaceutical Dosage Forms and Drug Delivery elucidates the basic principles of pharmaceutics, biopharmaceutics, dosage form design, and drug delivery – including emerging new biotechnology-based treatment modalities. The authors integrate aspects of physical pharmacy, chemistry, biology, and biopharmaceutics into drug delivery. This book highlights the increased attention that the recent spectacular advances in gene therapy and nanotechnology have brought to dosage form design and drug delivery. With the expiration of older patents and generic competition, the biopharmaceutical industry is evolving faster than ever. Apart from revising and updating existing chapters on the basic principles, this edition highlights the emerging emphasis on drug discovery, antibodies and antibody-drug conjugates as therapeutic moieties, individualized medicine including patient stratification strategies, targeted drug delivery, and the increasing role of modeling and simulation. Although there are numerous books on pharmaceutics and dosage forms, most cover different areas of the discipline and do not provide an integrated approach. The integrated approach of this book not only provides a singular perspective of the overall field, but also supplies a unified source of information for students, instructors and professionals, saving their time and money.
Knowledge Management is the process by which an organization identifies, creates, manages and delivers information to enhance workforce performance.KM is a discipline that promotes an integrated approach to identifying, capturing, evaluating, retrieving, and sharing all of an enterprise's information assets. These assets may include databases, documents, policies, procedures, and previously un-captured expertise and experience in individual workers. All these issues are covered in thirty three s in the book broadly divided into the following five sections. Fundamentals of Knowledge Management, Latest Tools and Techniques for Knowledge Management, Databases, Data mining, Knowledge Discovery in Biotechnology and Bioinformatics, Data mining and Knowledge Discovery in Agriculture and Allied Fields, Indigenous Knowledge Protection and IPR Issues The book contains original research and case studies by academic and research contributors on strategies, tools, techniques and technologies for Knowledge Management. The focus of this book is on the identification of innovative KM strategies and the application of theoretical concepts to real-world situations. This first serves as a complete introduction to the concepts and principles of KM, starting with basics of data, information, knowledge and wisdom. Clarified differences among Explicit, Implicit and Tacit Knowledge. The book also covers traditional KM approaches as well as emerging topics such as cloud computing, Semantic Web, Rough Computing, Fuzzy logic, Artificial intelligence, Machine learning, social networks, Tools and Techniques for Geo Spatial Data Knowledge Discovery. The focus of the book is on how KM impacts organizations and individuals and steps that should be taken to maximize benefits, including directions for how to select, develop, and evaluate KM systems.
Biosensors are portable and convenient devices that permit the rapid and reliable analysis of substances. They are increasingly used in healthcare, drug design, environmental monitoring and the detection of biological, chemical, and toxic agents. Fractal Binding and Dissociation Kinetics for Different Biosensor Applications focuses on two areas of expanding biosensor development that include (a) the detection of biological and chemical pathogens in the atmosphere, and (b) biomedical applications, especially in healthcare. The author provides numerous examples of practical uses, particularly biomedical applications and the detection of biological or chemical pathogens. This book also contains valuable information dedicated to the economics of biosensors. After reading this book, the reader will gain invaluable insight into how biosensors work and how they may be used more effectively.* No other book provides a detailed kinetic analysis of the binding and dissociation reactions occurring on the biosensor surfaces* Packed with examples of practical uses of biosensors* Includes chapters dedicated to the economics of biosensors
A Fractal Analysis of Chemical Kinetics with Applications to Biological and Biosensor Interfaces analyzes the kinetics of binding and dissociation of different analytes by different biosensor techniques, demonstrating, and then comparing each other. Emphasis is on newer instrumentation techniques, such as surface plasmon resonance imaging (SPRi), and classical techniques, such as surface plasmon resonance (SPR), and finally, DNA biosensors and nanobiosensors. In addition, the closing chapter includes discussion of biosensor economics. - Presents and compares different biosensor techniques - Evaluates the kinetics of binding and dissociation of different analytes on biosensor surfaces - Explores the major applications of biosensors in the field
In an age when cross-border business transactions are increasingly effected without the transference of physical products, revenue concerns of states have led to a multitude of tax disputes based on the concept of ‘nexus’. This important and timely book is the most authoritative to date to discuss one of the major tax topics of our time – the question of how taxing rights on income generated from cross-border activities in the digital age should be allocated among jurisdictions. Demonstrating in prodigious depth that it is the economic nexus of the tax entity or activity with the state, and not the physical nexus, which meets the jurisdictional requirement, the author – a leading authority on this area who is a Senior Commissioner of Income Tax and a Member of the Dispute Resolution Panel of the Government of India – addresses such dimensions of the subject as the following: whether a strict territorial nexus as a normative principle is ingrained in source rule jurisprudence; detailed scrutiny of such classical doctrines as benefit theory, neutrality theory, and internation equity; comparative critique of the Organisation for Economic Co-operation and Development (OECD) and United Nation (UN) model tax treaties; whether international law and customary principles mandate a strict territorial link with the source state for the assumption of tax jurisdiction; whether the economic nexus-based tax jurisdiction and absence of a physical presence breach the constitutional doctrine of extraterritoriality or due process; and whether retrospective tax legislation breaches the principle of constitutional fairness. The book offers a politically informed analysis of the nexus principle and balances the dynamics of physical presence and economic nexus standards, based on an in-depth survey of the historical evolution of judicial pronouncements and international practices in this regard. Dr Singh’s book exposes an urgently needed missing link in the international source rule literature and takes a giant step towards solving the thorny question of appropriate tax apportionment. It sheds brilliant light on the policies states may adopt when signing new tax treaties, so that unintended results may be foreseen and avoided. Tax practitioners, taxation authorities, and academic researchers in the field of international tax law and policy will greatly appreciate the book’s forthright enhancement of the ability to defend challenges based on the nexus doctrine.
This book provides a thorough introduction to the essential topics in modern materials science. It brings together the spectrum of materials science topics, spanning inorganic and organic materials, nanomaterials, biomaterials, and alloys within a single cohesive and comprehensive resource. Synthesis and processing techniques, structural and crystallographic configurations, properties, classifications, process mechanisms, applications, and related numerical problems are discussed in each chapter. End-of-chapter summaries and problems are included to deepen and reinforce the reader's comprehension. Provides a cohesive and comprehensive reference on a wide range of materials and processes in modern materials science; Presents material in an engaging manner to encourage innovative practices and perspectives; Includes chapter summaries and problems at the end of every chapter for reinforcement of concepts.
This will help us customize your experience to showcase the most relevant content to your age group
Please select from below
Login
Not registered?
Sign up
Already registered?
Success – Your message will goes here
We'd love to hear from you!
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.