This book is the first one written about the JAK/STAT pathway. The JAK (Janus Kinase) Protein tyrosine kinases are novel phosphotransferases absolutely required for cellular signalling downstream of non-catalytic cytokine receptors (amongst others). These molecules are components in pathways utilising the STAT (Signal Transducers and Activators of Transcription) transcription factors. The basic components of the JAK/STAT pathway are covered in detail, and the centre piece of the book is a guided tour of the pathway itself. An interesting addition to the book is the chapter on the use of Drosophila melanogaster as a genetic system to probe the pathway at the whole organism level. The book is targeted to researchers who have an interest in intracellular signalling.
A fascinating page-a-day collection profiling extraordinary women of all races, eras, and nationalities. Our past is full of influential women. Whether politicians, troublemakers, explorers, artists, and even the odd murderer, women have shaped society around the globe. But too often, these women have been unfairly confined to the margins of history. On This Day She: Putting Women Back into History One Day at a Time corrects this imbalance. A day-by-day collection of inspiring stories about incredible women who made history but seldom received the acknowledgement they deserved, this book introduces readers to women of all colors, eras, and nationalities. From Queen Elizabeth I to Beyoncé, Doria Shafik to Lillian Bilocca, this book gives voice both to female icons and to those whom the history books have overlooked. These women campaigned, cured, and adventured their way through life. They include musicians, painters, scientists, poets, and more. Spanning centuries, On This Day She is a record of human existence at its most authentic.
Despite a recent surge of critical interest in the Shakespeare Tercentenary, a great deal has been forgotten about this key moment in the history of the place of Shakespeare in national and global culture – much more than has been remembered. This book offers new archival discoveries about, and new interpretations of, the Tercentenary celebrations in Britain, Australia and New Zealand and reflects on the long legacy of those celebrations. This collection gathers together five scholars from Britain, Australia and New Zealand to reflect on the modes of commemoration of Shakespeare across the hemispheres in and after the Tercentenary year, 1916. It was at this moment of remembering in 1916 that 'global Shakespeare' first emerged in recognizable form. Each contributor performs their own 'antipodal' reading, assessing in parallel events across two hemispheres, geographically opposite but politically and culturally connected in the wake of empire.
Ailsa Henderson analyses each nation's linguistic, racial, cultural, economic, and political diversity within a historical and contemporary context. Challenging the assumption that nationalism in Scotland can be characterized as "civic" in contrast to an "ethnic" model in Quebec, Henderson adopts a more complex model of national identity that distinguishes between nationalistic rhetoric, which is invariably civic in form, and public understandings of belonging, which tend to rely on ethnic markers. In Hierarchies of Belonging she demonstrates that nationalist rhetoric and a sense of belonging affect how citizens feel about the state, the nation, and each other.
Current debates concerning the future of social security provision in advanced capitalist states have raised the issue of a citizen’s basic income (CBI) as a possible reform package: a proposal based on the principles of individuality, universality and unconditionality which would ensure a minimum income guaranteed for all members of society. Implementing a CBI, would consequently entail radical reform of existing patterns of welfare delivery and would bring into question the institutionalized relationship between work and welfare. Ailsa McKay’s book makes a unique and positive contribution to the CBI literature by examining the proposal from a feminist economics perspective. Gender concerns are central to any debate on the future of social security policy, in that state intervention in the field of income redistribution has differential impacts on men and women. By drawing attention to the potential a CBI has in promoting equal rights of freedom for men and women this book serves to open up the debate to incorporate a more realistic and inclusive vision of the nature of modern socio-economic relationships.
Political culture in Nunavut has long been characterized by different approaches to political life: traditional Inuit attitudes toward governance, federal aspirations for the political integration of Inuit, and territorial strategies for institutional development. Ailsa Henderson links these features to contemporary political attitudes and behaviour, concluding that a distinctive political culture is emerging in Nunavut. Drawing upon extensive fieldwork and quantitative analysis, this book provides the first systematic, empirical study of political life in Nunavut, offering comprehensive analysis of the evolving nature of aboriginal self-government in the Arctic and shedding crucial light on Inuit–non-Inuit relations.
This book tells the forgotten story of the Shakespeare Hut, a vast, mock-Tudor building for New Zealand Anzac soldiers visiting London on leave from the front lines. Constructed in Bloomsbury in 1916, the Hut was to be the only built memorial to mark Shakespeare's Tercentenary in the midst of war. With a purpose-built performance space, its tiny stage hosted the biggest theatrical stars of the age. The Hut is a vivid and unique case study in cultural memory and performance of Shakespeare. One extraordinary building brings together Shakespeare's place in First World War theatre, in emerging new post-colonial identities, the story of Shakespearean performance in the twentieth century and in the struggle for women's suffrage. Grant Ferguson transports you to the Hut and its lively, idiosyncratic world. From a feminist-led stage to a hub of Indian intellectual and political debate, from a Shakespeare memorial to an Anzac social club, this is the story of a building truly at a crossroads.
Make this book the last thing you use before you take the exam. · 500+ single best answer (SBA) practice questions are presented according to the Medical Oncology Specialty Certificate Exam blueprint · Answer sections provide detailed descriptions for revision and signposting to appropriate resources · Refers to both National Institute for Health and Care Excellence (NICE) and European Society of Medical Oncology (ESMO) latest guidance · A valuable learning tool for doctors planning to undertake the Medical Oncology SCE and a useful resource for doctors studying for the FRCR (Oncology) and ESMO exams · Produced in partnership with the Association of Cancer Physicians Written by senior trainees and consultants and verified by experienced medical oncology consultants in the style of the specialty certificate exam, this collection of 500 single best answers offers an ideal preparation for success in the Specialty Certificate Examination in Medical Oncology. CONTENTS: Acute oncology, Breast cancer, Carcinoma of unknown primary, Colorectal and anal cancer, Gynaecological cancers, Haematological cancers, Less common cancers, Lung and thoracic cancers, Professional skills, Sarcoma, Scientific basis of malignancy, Skin cancers, Supportive care therapies, Systemic anti-cancer therapies, Upper gastrointestinal and hepatobiliary cancers, Urological and germ cell cancers.
Market manipulation comes in many forms. For a wrong that some say started life with groups of men dressed in Bourbon uniforms spreading false information in cod French accents, the speed of change has accelerated dramatically in the modern era, via the Internet, novel forms of electronic communication, ultra-fast computer-generated trading, new types of financial instruments, and increased globalisation. This means that opportunities for carrying-out new forms of manipulation now exist on an exponential scale. Looks at the mechanisms, criminal and civil, to confront market manipulation, its enforcement regimes, legal and evidential rules and potential loopholes. Shows how every individual involved in market transactions can fall foul of the law if they do not ensure integrity in their dealings. The ‘tricks’ used by those seeking to benefit from this special category of fraud and the relationship of dedicated provisions to the general law is outlined, with key statutory provisions set out in an appendix. A valuable accompaniment to The Little Book of Insider Dealing (Waterside Press, 2018). An invaluable pocket guide and law primer. An essential guide for investors. With practical examples and decided cases. An up-to-date treatment of a fast-moving topic. Describes both criminal and regulatory regimes. Contents include Forms of Market Manipulation; Suspicion, Identification, Detection and Investigation; Obligations and Enforcement; Criminal Offences, Defences and Punishment; Regulatory Provisions and Penalties; Evidence; Acronyms; Select Bibliography; Key Statutory Provisions and Index.
A new edition of the esteemed nursing text exploring social, cultural and political issues affecting individual and community health What makes a healthy community? And how can nurses and midwives support community health and wellbeing? In Community Health and Wellness, 4th Edition: Primary health care in practice, authors Anne McMurray and Jill Clendon advance the discussion of health as a product of the interaction between people and their environment. Engagingly written and based on extensive research, this valuable nursing textbook is ideal for nursing students as well as those working in the field. Issues such a gender and cultural inclusiveness provide essential backdrops to evidence-based policy, research and the provision of equitable health care for all. The Miller Family case study This new edition of Community Health and Wellness features a common family case study running throughout the text. The Miller family crosses Australia and New Zealand; providing examples of primary health care issues in both countries. These include child health services, accessing care, adolescent health, contemporary family issues, ageing, cultural support and inclusive health care. • global insights with a focus on primary health care practice in Australia and New Zealand • promotion of community health care across the lifespan • a unique socio-ecological approach to community health • the Ottawa Charter, the Jakarta Declaration and the Bangkok Charter are included as contemporary health promotion guidelines for practice • extensive references providing current, specific source information Emphasis on health literacy, intervention and health promotion. An evolving case study runs through each chapter and links to reflective activities. Focus on learning outcomes to facilitate the integration of policy, research and practice. Exploration of Australian and New Zealand nursing and midwifery roles in primary health care practice. Strong pedagogy to increase engagement and emphasise key issues. Reflective exercises and Action Points encourage readers to consider the key issues, their implications and how to move forward Research studies exemplify the central theme of each chapter and promote evidence-based practice. Evolve eBook and resources
Ideal for those new to the genre or for anyone who wishes to improve their technique, Ailsa Cox’s guide will help readers achieve their full potential as a short story writer. The book encourages you to be inventive, to break writing habits and to try something new, by showing the diversity of the short story genre, from cyberpunk to social observation. Each chapter of the book: introduces key aspects of the craft of short story writing, including structure, dialogue, characterization, viewpoint, narrative voice and more shows how a wide variety of published writers have approached the short story genre, in order to deepen the insights you gain from your own work gets you writing, with a series of original, sometimes challenging but always rewarding exercises, which can be tackled alone or adapted for use in a group includes activities at the end of each chapter. Ailsa Cox draws on her experience as a writer to provide essential information on drafting and editing, as well as a rich Resources section, which lists print and online journals that accept the work of new writers. Whether you’re writing as part of a course, in a workshop group or at home alone, this book will equip and inspire you to write better short stories, and make you a more skilled, enthusiastic and motivated writer of short stories.
Safeguarding adults is a rapidly evolving area of professional practice and this timely new text book provides an authoritative guide that critically engages with the recent developments and encapsulates some of the emerging approaches to contemporary adult safeguarding practice. Written by a collection of authors with a wealth of academic and practice experience, and with a strong focus on multi-disciplinary working, the text covers key topics such as: - Safeguarding adults who lack capacity, or whose level of capacity is unknown or unclear - Common issues and tensions surrounding the various UK laws and policies that seek to safeguard adults with mental health problems - Safeguarding older adults, with a unique and insightful focus on the perspective of carers -Current limitations in practice, including the blurred nature of the boundaries between informal and legally mandated care, relating to the safeguarding of people with learning disabilities. Illustrated throughout by engaging case studies to help readers apply what they have learnt to everyday practice, this comprehensive guide to safeguarding adults is essential reading for students across a broad range of health and social care disciplines, as well as practitioners looking for an up-to-date source of reference.
What in terms of Alice Munro’s creative artistry and creative power allowed her to become the first and only short story writer, the first and only Canadian, and just the thirteenth woman in history to win the Nobel Prize in Literature? And exactly when during Munro’s career did her artistry and power advance to ensure that she would earn such world-wide renown? The answers lie in studying the boldly innovative yet greatly under-examined group of her four mid-career breakthrough books. Our volume therefore provides a carefully orchestrated analysis of Munro’s subtle yet potent handling of form, technique and style both within individual stories and across these special collections. Reading Alice Munro’s Breakthrough Books: A Suite in Four Voices not only addresses a significant vacancy in Munro criticism – and, by extension, in all short story criticism – but, equally importantly, offers an exciting new model for how criticism can be collectively written.
Cut the Crap and Feel AMAZING' by author, Ailsa Frank will help people get into the AMAZING zone and rise above negative thinking and dramas. The techniques described in this book will help you to make changes to cut the crap from each area of your life - work, money, debt, wealth, relationships, love, parenting, addictions, heartache, bereavement, health, stress and mundane, everyday irritations. "e;The way you live your life is based on a series of habits and established patterns. By replacing old habits with new ones, you can change your life for the better,"e; says Ailsa Frank. Ailsa, who is also an experienced hypnotherapist provides you with the knowledge and tools you need to take control of your life and ensure that it follows a more positive direction - the direction in which you want it to go. From the moment you start reading this book you will begin to change the way you think as the creative techniques will free your mind from negative rigid thoughts patterns. The book has been developed to ensure you gain an 'I can do it' attitude and then apply the tools to each area of your life. Included are inspiring case studies and anecdotes which will help you understand how you too can change your life for the better. Ten years ago when Ailsa started working in therapy she found few people would admit to being stressed but in recent years she finds most people openly talk about stress and how it impacts on their lives. "e;With the recent recession and people living more pressurised lives I know it's the right time for this book to give them a bit of support to get themselves back into the positive again"e; says Ailsa. She combines her techniques and extensive experience with clients mixed with common sense to teach you how to help yourself. This book is about letting go of the negative and getting into the AMAZING zone, learning to manage your life better and sorting through the things you need to change.
This step-by-step manual explains how to adapt CBT (Cognitive Behaviour Therapy) approaches to OCD (Obsessive Compulsive Disorder) for autistic children and adults. It outlines why there is the need to adapt treatment for the autistic population, and includes detailed guidance on each phase of the approach. It explains assessment of OCD in autism, the links between the two conditions and difficulties in identifying aspects of OCD in autistic people. The book offers advice on dealing with difficult issues and on the next steps after treatment is complete. Accompanying worksheets and handouts are available to download.
Community Health & Wellness: Primary health care in practice, 5th Edition represents contemporary thinking and research in community health and wellness from Australia, New Zealand and the global community. It challenges students and health professionals to become more aware of the primary health care (PHC) environments in which they work in order to gain an understanding of what is socially determining the health of the individuals, families and communities within their care. Provides a focus on primary health care practice in Australia and New Zealand Research and evidence-based practice throughout each chapter Group exercises that can be used in practice or tutorial groups Reflective questions to challenge the understanding of key principles and practice Additional resources for lecturers via Evolve. • Two new chapters: Chapter 3 Assessing the Community Chapter 6 Working in groups • The SDH Assessment Circle - a new model for community assessment • Stronger emphasis on working with migrant and refugee families • A new continuous case study – the Mason and Smith families; both fly-in fly-out (FIFO) families.
Addressing for the first time Shakespeare’s place in counter-cultural cinema, this book examines and theorizes counter-hegemonic, postmodern, and post-punk Shakespeare in late 20th and early 21st century film. Drawing on a diverse range of case studies, Grant Ferguson presents an interdisciplinary approach that offers new theories on the nature and application of Shakespearean appropriations in the light of postmodern modes of representation. The book considers the nature of the Shakespearean inter-text in subcultural political contexts concerning the politicized aesthetics of a Shakespearean ‘body in pieces,’ the carnivalesque, and notions of Shakespeare as counter-hegemonic weapon or source of empowerment. Representative films use Shakespeare (and his accompanying cultural capital) to challenge notions of capitalist globalization, dominant socio-cultural ideologies, and hegemonic modes of expression. In response to a post-modern culture saturated with logos and semiotic abbreviations, many such films play with the emblematic imagery and references of Shakespeare’s texts. These curious appropriations have much to reveal about the elusive nature of intertextuality in late postmodern culture and the battle for cultural ownership of Shakespeare. As there has yet to be a study that isolates and theorizes modes of Shakespearean production that specifically demonstrate resistance to the social, political, ideological, aesthetic, and cinematic norms of the Western world, this book expands the dialogue around such texts and interprets their patterns of appropriation, adaptation, and representation of Shakespeare.
This step-by-step manual explains how to adapt CBT (Cognitive Behaviour Therapy) approaches to OCD (Obsessive Compulsive Disorder) for autistic children and adults. It outlines why there is the need to adapt treatment for the autistic population, and includes detailed guidance on each phase of the approach. It explains assessment of OCD in autism, the links between the two conditions and difficulties in identifying aspects of OCD in autistic people. The book offers advice on dealing with difficult issues and on the next steps after treatment is complete. Accompanying worksheets and handouts are available to download.
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