This is the second of three volumes of Methods in Molecular Biology that deal with Physical Methods of Analysis. The first of these, Spectroscopic Methods and Analyses dealt with NMR spec troscopy, mass spectrometry, and metalloprotein techniques, and the third will cover X-ray crystallographic methods. As with the first volume. Microscopy, Optical Spectroscopy, and Macroscopic Techniques is intended to provide a basic understand ing for the biochemist or biologist who needs to collaborate with spe cialists in applying the techniques of modern physical chemistry to biological macromolecules. The methods treated in this book fall into four groups. Part One covers microscopy, which aims to visualize individual molecules or complexes of several molecules. Electron microscopy is the more familiar of these, while scanning tunneling microscopy is a new and rapidly developing tool. Methods for determining the shapes and sizes of molecules in solution are described in Part Two, which includes chapters on X-ray and neutron scattering, light scattering, and ult- centrifugation. Calorimetry, described in Part Three, provides the means to monitor processes involving thermodynamic changes, whether these are intramolecular, such as conformational transition, or the interactions between solutes or between a solute and its sol vent. Part Four is concerned with optical and infrared spectroscopy and describes applications ranging from the measurement of protein concentration by UV absorbance to the analysis of secondary struc ture using circular dichroism and Fourier-transform infrared spec troscopy.
Why do people commit crime? How effective and reliable is the investigative process? How do jurors decide whether a person is guilty or innocent? How effective is treatment in reducing the risk of reoffending? In this up-to-date edition of his highly informative textbook, Adrian Scott reveals just how much forensic psychology can tell us - not only about offenders and their crimes, but also about the different stages of the criminal justice system. Covering social, psychological, biological and cognitive theories of crime, as well as research and theory relating to the investigative process, the courtroom and the penal system, this book provides in-depth coverage of the major areas within forensic psychology. It is essential reading for curious students seeking an engaging and accessible introduction to this fascinating topic.
Parry Sound, at the mouth of the Seguin River on Georgian Bay, traces its history back to William Beatty Jr. and the purchase of timber rights. From the heyday of lumbering, through mining ventures, the period of Prohibition, the arrival of the railway and the impact of the Great Wars, the unfolding years are all accompanied by an intriguing mixture of colourful personalities, politics and scandal. The story of this growing community has a richness that few Ontario towns can match. Today Parry Sound embraces its entrepreneurial heritage, its hockey history, its commitment to the arts and its place as a popular tourist destination.
This book reviews the pathophysiology and physical manifestations of acromegaly and discusses the multiple treatment options now available for the management of the patient with acromegaly. The book contains an ample number of illustrations that help to emphasize points of particular interest, including radiological, histopathological, and physical
Bone Marrow Processing and Purging: A Practical Guide provides an up-to-date practical guide to the major ex vivo procedures associated with bone marrow transplantation. Previously, this information was communicated primarily by word of mouth; now experts in the field present detailed descriptions and evaluations of methods for marrow harvesting, evaluation (including tumor infiltration, flow cytometric analysis, and colony assays), comparative methods for automated nucleated cell separation and enumeration, tumor cell purging, T cell depletion, stem cell selection, gene transfer, and cytopreservation. Special sections address quality control and FDA regulations. The book provides a unique information source intended for clinicians, researchers, technical staff, transplant nurses, and medical students involved in this rapidly expanding area of medicine.
In The Nature of the Book, a tour de force of cultural history, Adrian Johns constructs an entirely original and vivid picture of print culture and its many arenas—commercial, intellectual, political, and individual. "A compelling exposition of how authors, printers, booksellers and readers competed for power over the printed page. . . . The richness of Mr. Johns's book lies in the splendid detail he has collected to describe the world of books in the first two centuries after the printing press arrived in England."—Alberto Manguel, Washington Times "[A] mammoth and stimulating account of the place of print in the history of knowledge. . . . Johns has written a tremendously learned primer."—D. Graham Burnett, New Republic "A detailed, engrossing, and genuinely eye-opening account of the formative stages of the print culture. . . . This is scholarship at its best."—Merle Rubin, Christian Science Monitor "The most lucid and persuasive account of the new kind of knowledge produced by print. . . . A work to rank alongside McLuhan."—John Sutherland, The Independent "Entertainingly written. . . . The most comprehensive account available . . . well documented and engaging."—Ian Maclean, Times Literary Supplement
This book is a clear and practical introductory guide to the practice of medical acupuncture. It describes the Western medical approach to the use of acupuncture as a therapy following orthodox diagnosis. The text covers issues of safety, different approaches to acupuncture, basic point information, clinical issues and the application of acupuncture in clinical conditions, especially in the treatment of pain. - A practical guide to the principles and clinical practice of medical acupuncture - A clear guide to the neurophysiological principles which underlie medical approaches to acupuncture - A basic explanation of the different styles of medical acupuncture treatment - Allows the reader to accrue the practical knowledge necessary before beginning to work with medical acupuncture.
This book presents a comprehensive review of nuclear cardiology principles and concepts necessary to pass the Nuclear Cardiology Technology Specialty Examination. The practice questions are similar in format and content to those found on the Nuclear Medicine Technology Certification Board (NMTCB) and American Registry of Radiological Technologists (ARRT) examinations, allowing test takers to maximize their chances of success. The book is organized by test sections of increasing difficulty, with over 600 multiple-choice questions covering all areas of nuclear cardiology, including radionuclides, instrumentation, radiation safety, patient care, and diagnostic and therapeutic procedures. Detailed answers and explanations to the practice questions follow. It also includes helpful test-taking tips. Supplementary appendices include commonly used abbreviations and symbols in nuclear medicine, glossary of cardiology terms, and useful websites. Nuclear Cardiology Study Guide is a valuable reference for nuclear medicine technologists, nuclear medicine physicians, and all other imaging professionals in need of a concise review of nuclear cardiology.
DESPITE being one of the best-known and admired rail companies in the country, by 1947 the GWR was at the lowest ebb of its entire history. Worn out by war, there had been no maintenance for six years and the government couldn’t supply the steel it needed for repair. The latter half of the 1940s presented a multitude of challenges to overcome, some due to the recent war and others individual to the GWR: the staff coped with rationing, a desperately cold winter and a blazing hot summer, and dealt with floods, collisions, broken rails and failing locomotives. The incredible strength of character and can-do attitude of GWR workers kept the railway running through it all. This history, taken from GWR papers and illustrated from them throughout, reveals the details of every day, as well as the problems and difficulties the staff faced. Above all, it shows how well they overcame theirproblems with only muscle power and a steam crane to help – and, of course, no health and safety regulations and arguments to slow them down.Adrian Vaughan’s unique history of this famous rail company shows just how special the GWR was right through to the end of its very last year.
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