This book emphasizes the importance of social, economic, and environmental considerations when planning and implementing projects. For rural development workers, it aims to fill the gap in existing literature on the gathering and storage of rainwater.
The Art and Science of Dermal Formulation Development is a comprehensive guide to the theory and practice of transdermal and topical formulation development, covering preclinical studies, evaluation, and regulatory approval. It enables the reader to understand the opportunities and challenges in developing products and how risks can be mitigated. Over the last 25 years, expertise in this area has declined whilst drug delivery systems for other administration routes have developed significantly. The advantages offered by transdermal and topical drug delivery remain compelling for sectors including the pharmaceutical industry, personal care, and cosmetics. This text addresses the dearth of expertise and discusses how skin can be a route of delivery and the processes in formulation development, but how such an application is very different to that used for oral, IV, and other administration routes. Key Features: Presents a practical guide for both industry and academia Focuses on and draws together the fundamental principles behind transdermal and topical drug delivery Illustrates the practicalities of formulation design using key case studies Gives an understanding of the skin as a route of delivery and how formulation development for such application differs from that for other administration routes
Books dealing with the mechanisms of enzymatic reactions were written a generation ago. They included volumes entitled Bioorganic Mechanisms, I and II by T.C. Bruice and S.J. Benkovic, published in 1965, the volume entitled Catalysis in Chemistry and Enzymology by W.P. Jencks in 1969, and the volume entitled Enzymatic Reaction Mechanisms by C.T. Walsh in 1979. The Walsh book was based on the course taught by W.P. Jencks and R.H. Abeles at Brandeis University in the 1960's and 1970's. By the late 1970's, much more could be included about the structures of enzymes and the kinetics and mechanisms of enzymatic reactions themselves, and less emphasis was placed on chemical models. Walshs book was widely used in courses on enzymatic mechanisms for many years. Much has happened in the field of mechanistic enzymology in the past 15 to 20 years. Walshs book is both out-of-date and out-of-focus in todays world of enzymatic mechanisms. There is no longer a single volume or a small collection of volumes to which students can be directed to obtain a clear understanding of the state of knowledge regarding the chemicals mechanisms by which enzymes catalyze biological reactions. There is no single volume to which medicinal chemists and biotechnologists can refer on the subject of enzymatic mechanisms. Practitioners in the field have recognized a need for a new book on enzymatic mechanisms for more than ten years, and several, including Walsh, have considered undertaking to modernize Walshs book. However, these good intentions have been abandoned for one reason or another. The great size of the knowledge base in mechanistic enzymology has been a deterrent. It seems too large a subject for a single author, and it is difficult for several authors to coordinate their work to mutual satisfaction. This text by Perry A. Frey and Adrian D. Hegeman accomplishes this feat, producing the long-awaited replacement for Walshs classic text.
From one of the most exciting voices in dark fantasy comes a sweeping story of a soldier on a brutal quest to preserve her kingdom’s future. She was their hope, their martyr, their brother.… Driwna Marghoster, a soldier for the powerful merchant guild known as the Post, is defending her trade caravan from a vicious bandit attack when she discovers a dead body hidden in one of her wagons. Born of the elusive Oskoro people, the body is a rare and priceless find, the center of a tragic tale, and the key to a larger mystery. As she investigates who the body was meant for, Driwna finds herself on a path paved by deceit and corruption…and it will lead her to an evil more powerful than she can possibly imagine. "Adrian Selby’s Brother Red proves to be a thrilling fantasy epic about love, loyalty, and the importance of protecting people in need....this novel is a true page turner in its entirety."—The Nerd Daily Also by Adrian Selby Snakewood The Winter Road
Bone Marrow Processing and Purging: A Practical Guide provides an up-to-date practical guide to the major ex vivo procedures associated with bone marrow transplantation. Previously, this information was communicated primarily by word of mouth; now experts in the field present detailed descriptions and evaluations of methods for marrow harvesting, evaluation (including tumor infiltration, flow cytometric analysis, and colony assays), comparative methods for automated nucleated cell separation and enumeration, tumor cell purging, T cell depletion, stem cell selection, gene transfer, and cytopreservation. Special sections address quality control and FDA regulations. The book provides a unique information source intended for clinicians, researchers, technical staff, transplant nurses, and medical students involved in this rapidly expanding area of medicine.
This book covers the design and development of glucocorticoid receptor modulators (GRM) from cortisol to antibody-drug conjugate payloads over the last 70 years. The author starts with an introduction to the background of glucocorticoid receptor modulators as potential therapeutic modalities. This is followed by seven chapters in which he collates and discusses the medicinal chemistry journey of GRMs, reviewing topics such as cortisol-based glucocorticoids, the different approaches that have been pursued to enable chronic dosing of GRM compounds by inactivation in plasma and the liver, the application of prodrugs to GRMs, selective GRMs, targeted delivery of GRMs using polymers and nanoparticles, and rational drug design approaches applied in the development of GRMs. Particular attention is given to the development of glucocorticoid receptor modulators as immunology antibody-drug conjugate payloads. In the book’s final chapter, the author critiques the medicinal chemistry progress made since the discovery of cortisone and the promise of the latest antibody-drug conjugates that release a GRM payload. In this book, readers will also find an overview of the X-ray structures of glucocorticoid receptor antagonists and a list of all the earlier reviews that cover part of the medicinal chemistry story of GRM collated by keywords organized in a table. With several examples of crystal structures and molecular modeling, this book illustrates the huge effort by multiple companies and research groups to develop glucocorticoid receptor modulators. Professionals and scholars alike will find it a handy tool, and appreciate the latest research findings that it presents.
This book explores the lives and achievements of two Irish sisters, Edith and Florence Stoney, who pioneered the use of new electromedical technologies, especially X-rays but also ultraviolet radiation and diathermy. In addition, the narrative follows several intertwined themes as experienced by the sisters during their lifetimes. Their upbringing, influenced by their liberal-minded scientist father, set the tone for both their lives. Irish independence fractured their family heritage. Their professional experiences, fulfilling for Florence as a qualified doctor but often frustrating for Edith as a Cambridge-educated scientist, mirrored those of other aspiring women during this period, when the suffragist movement expanded and women’s lobby groups were formed. World War I created an environment in which their unusual specialist knowledge was widely needed, and the sisters’ war experiences are carefully examined in the book. But ultimately this is the extraordinary story of two independent but closely bonded sisters and their abiding love and support for one another.
Football is all about opinions, and few people hold more opinions about more topics than talkSPORT's host of the Drive show, Adrian Durham. Whether it is the quality of Arsenal's 'Invincibles' or the supposed brilliance of manager Jose Mourinho, you can bet that Durham will have a view on the matter. Just because everyone else agrees that Pele is the greatest footballer who ever lived, doesn't mean that Durham will agree with that view - and he will supply a whole range of fascinating reasons as to why he is right. Packed with lively comment on so many of the questions that football fans love to argue about, this book is full of the one thing that all football supporters can relate to: passion. If you ever want to provoke a lively debate,Is He All That? is sure to provide you with plenty of material. It will make you question your assumptions about the game, make you think and make you laugh.
From an acclaimed social and architectural historian, the tumultuous, scandalous, glitzy, and glamorous history of English country houses and high society during the interwar period As WWI drew to a close, change reverberated through the halls of England's country homes. As the sun set slowly on the British Empire, the shadows lengthened on the lawns of a thousand stately homes. In The Long Weekend, historian Adrian Tinniswood introduces us to the tumultuous, scandalous and glamorous history of English country houses during the years between World Wars. As estate taxes and other challenges forced many of these venerable houses onto the market, new sectors of British and American society were seduced by the dream of owning a home in the English countryside. Drawing on thousands of memoirs, letters, and diaries, as well as the eye-witness testimonies of belted earls and bibulous butlers, Tinniswood brings the stately homes of England to life as never before, opening the door to a world by turns opulent and ordinary, noble and vicious, and forever wrapped in myth. We are drawn into the intrigues of legendary families such as the Astors, the Churchills and the Devonshires as they hosted hunting parties and balls that attracted the likes of Charlie Chaplin, T.E. Lawrence, and royals such as Edward VIII and Wallis Simpson. We waltz through aristocratic soiré, and watch as the upper crust struggle to fend off rising taxes and underbred outsiders, property speculators and poultry farmers. We gain insight into the guilt and the gingerbread, and see how the image of the country house was carefully protected by its occupants above and below stairs. Through the glitz of estate parties, the social tensions between old money and new, the hunting parties, illicit trysts, and grand feasts, Tinniswood offers a glimpse behind the veil of these great estates -- and reveals a reality much more riveting than the dream.
Many of us think of the ill-behaved celebrity and the tabloid splash as modern inventions, but the antics of footballers and soap stars are as nothing when set alongside the hell-raising of the 18th century celebs. The Gin Lane Gazette is stuffed with true stories of boozy MPs who settled their political differences with duels in Hyde Park; peers of the realm who sat the unburied corpses of their cherished mistresses at their dinner tables; entertainers who rode horses standing upright in the saddle, while wearing a mask of bees; and famous courtesans who ate 1,000-guinea banknotes stuffed into sandwiches, simply to make a point. Before it was dashed from their lips by the Victorian party-poopers, our Georgian forebears drank deep from the cup of life.
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