The shocking, three-decade story of A. Q. Khan and Pakistan's nuclear program, and the complicity of the United States in the spread of nuclear weaponry. On December 15, 1975, A. Q. Khan-a young Pakistani scientist working in Holland-stole top-secret blueprints for a revolutionary new process to arm a nuclear bomb. His original intention, and that of his government, was purely patriotic-to provide Pakistan a counter to India's recently unveiled nuclear device. However, as Adrian Levy and Catherine Scott-Clark chillingly relate in their masterful investigation of Khan's career over the past thirty years, over time that limited ambition mushroomed into the world's largest clandestine network engaged in selling nuclear secrets-a mercenary and illicit program managed by the Pakistani military and made possible, in large part, by aid money from the United States, Saudi Arabia, and Libya, and by indiscriminate assistance from China. Based on hundreds of interviews in the United States, Pakistan, India, Israel, Europe, and Southeast Asia, Deception is a masterwork of reportage and dramatic storytelling by two of the world's most resourceful investigative journalists. Urgently important, it should stimulate debate and command a reexamination of our national priorities.
The new book in the Francis and Gordon Jones mysteries set in 1950’s NorfolkA witty spoof of the classic boy’s detective stories. Following on from The Voice of Doom (ISBN: 97817893285) There is something freshly appealing and charming about the Francis and Gordon Jones mysteries, compared by some to the works of E F Benson, with inevitable nods to Dorothy Sayers and Conan Doyle. The second in the series of their detective adventures, The Coming Day, has five new intriguing cases for the intrepid investigators to solve. A missing girl in a Cornish seaside town … the mysterious death of a man dressed as a woman in a fleapit cinema … the unravelling of an old murder trial… the arrival of a foreign doctor coinciding with communal disaster … the search for a missing photograph. With its host of regular characters in the little Norfolk village of Branlingham, including the Revd. Challis, Mrs Jones of Bramley apple pie and curious corset-making fame, the terrifyingly autocratic Lady Darting, the snooping postmistress Miss Simms and ravishingly handsome actor Rufus Wolfe, Wright has created what the Bookhound calls ‘a literary delight … Brilliantly funny, deliciously wicked and thoroughly enjoyable’. Inspired by Anthony Wilson’s famous 1950s radio characters Norman and Henry Bones, these are sunny stories with an irresistible mingling of comedy and, sometimes unexpectedly, deeper themes. In the current glut of crime writing, they are unlike anything else.
Sir Richard Fairey was one of the great aviation innovators of the twentieth century. His career as a plane maker stretched from the Edwardian period to the jet age - he lived long enough to see one of his aircraft be the first to break the 1000mph barrier; and at least one of his designs, the Swordfish, holds iconic status. A qualified engineer, party to the design, development, and construction of the Royal Navy's state-of-the-art sea planes, Sir Richard founded Fairey Aviation at the Admiralty's behest in 1915. His company survived post-war retrenchment to become one of Britain's largest aircraft manufacturers. The firm built a succession of front-line aircraft for the RAF and the Fleet Air Arm, including the iconic Swordfish. In addition, Fairey Aviation designed and built several cutting-edge experimental aircraft, including long-distance record-breakers between the wars and the stunningly beautiful Delta 2, which broke the world speed record on the eve of Sir Richard's death in 1956. Fairey also came to hold a privileged position in the British elite - courting politicians and policymakers. He became a figurehead of the British aviation industry and his successful running of the British Air Commission earned him a knighthood. A key player at a pivotal moment, Fairey's life tells us much about the exercise of power in early twentieth-century Britain and provides an insight into the nature of the British aviation manufacturing industry at its wartime peak and on the cusp of its twilight years.
Henry St John, First Viscount Bolingbroke (1678-1751) enjoyed varied political and literary careers. This five-volume edition draws together his letters. It includes a general introduction, headnotes, biographical index and a consolidated index. It is suitable for historians and literary scholars working in the eighteenth century.
An indispensable resource for electrical technicians and trainees, Electrical Science for Technicians walks readers through the subject in a logical order, providing a historical overview alongside modern electrical theory and practice. You will be guided through the subject in a topic by topic manner with each section building upon the one that came before it. By adding context to the principles of electrical science they become easier to both understand and remember, providing a background in the subject that will remain with you for life. Fully aligned to the 17th edition of the wiring regulations Topic-based approach ensures suitability for both technicians and students Clear objectives outlined at the start and revisited at the end of each chapter as a checklist allow readers to check their learning before moving on
Silver Ley, first published in 1931, is the second volume in Adrian Bell's classic rural trilogy (the other volumes being Corduroy and The Cherry Tree). In Silver Ley the author moves from being a farm apprentice to a farm owner.
Development Arrested is a major reinterpretation of the two-centuries-old conflict between African American workers and the planters of the Mississippi Delta. Ranging across disciplines as diverse as rural studies, musicology, development studies and anthropology, it provides a unique assessment of the impact of the plantation system on those who suffered its depredations at first hand.
Although climate change has become the dominant concern of the twenty-first century, global powers refuse to implement the changes necessary to reverse these trends. Instead, they have neoliberalized nature and climate change politics and discourse, and there are indications of a more virulent strain of capital accumulation on the horizon. Adrian Parr calls attention to the problematic socioeconomic conditions of neoliberal capitalism underpinning the worldÕs environmental challenges, and she argues that, until we grasp the implications of neoliberalismÕs interference in climate change talks and policy, humanity is on track to an irreversible crisis. Parr not only exposes the global failure to produce equitable political options for environmental regulation, but she also breaks down the dominant political paradigms hindering the discovery of viable alternatives. She highlights the neoliberalization of nature in the development of green technologies, land use, dietary habits, reproductive practices, consumption patterns, design strategies, and media. She dismisses the notion that the free market can solve debilitating environmental degradation and climate change as nothing more than a political ghost emptied of its collective aspirations. Decrying what she perceives as a failure of the human imagination and an impoverishment of political institutions, Parr ruminates on the nature of change and existence in the absence of a future. The sustainability movement, she contends, must engage more aggressively with the logic and cultural manifestations of consumer economics to take hold of a more transformative politics. If the economically powerful continue to monopolize the meaning of environmental change, she warns, new and more promising collective solutions will fail to take root.
This text critically reviews the literature on attention and emotion, and offers an integrative cognitive attentional model of the development and maintenance of emotional disorders. It highlights the similarities and differences between disorders and offers specific new treatment implications. The book contains numerous summary sections so that readers less familiar with the cognitive literature can follow the main issues without being overwhelmed. The central aims of this work are: to review critically models of attention and their application to attentional processes in emotional disorders; To develop an integrative theoretical framework and model for conceptualizing attentional processes associated with the aetiology and maintenance of emotional stress reactions; and to discuss the implications for clinical practice of attentional theories of emotional dysfunction.
Myriad forms of communication occur within the criminal justice system as judges and attorneys speak to juries, law enforcement officers interact with the public, and the news media presents stories of events in courtrooms. Hindrances abound, however. Law enforcement officers and justice system personnel often encounter challenges that affect their ability to communicate with others, ranging from language barriers, to conflicting accounts of witnessed events, to errors caused by malfunctioning technology. Examining the relevancy of the U.S. Constitution to modern communications, The Foundations of Communication in Criminal Justice Systems demonstrates how information is conveyed from multiple perspectives in a range of scenarios, enabling readers to see how these matters relate to and affect the criminal justice system. Topics covered include: How to use the communications process within the justice system from the crafting of messages through the solicitation of feedback Effective methods for persuading individuals and audiences Federal regulations in the workplace and workplace communications tactics How law enforcement and public safety entities use marketing and advertising to influence the general public How to use multimedia resources when communicating Using multiple communications styles to support effective leadership The book concludes with discussions on innovations in communication technology, natural language processing, cybernetics, and other emerging concepts. With an emphasis on logical reasoning in communication, the book explores the perspectives of numerous players in the justice system, from patrol officers to attorneys. Supplemented by examples of written communication templates that can be adapted within a law enforcement organization, it provides readers with solid theoretical and applied approaches to the subject matter.
To have any hope of succeeding as a manager, you need to get your people all in. Whether you manage the smallest of teams or a multi-continent organization, you are the owner of a work culture—congratulations—and few things will have a bigger impact on your performance than getting your people to buy into your ideas and your cause and to believe what they do matters. Bestselling authors of The Carrot Principle and The Orange Revolution, Adrian Gostick and Chester Elton return to answer the most overlooked leadership questions of our day: Why are some managers able to get their employees to commit wholeheartedly to their culture and give that extra push that leads to outstanding results? And how can managers at any level build and sustain a profitable, vibrant work-group culture of their own? These leading workplace experts teamed up with research giant Towers Watson to analyze an unprecedented 300,000-person study, and they made a groundbreaking finding: managers of the highest-performing work groups create a “culture of belief.” In these distinctive workplaces, people believe in their leaders and in the company’s vision, values, and goals. Employees are not only engaged but also enabled and energized (termed the three Es), which leads to astonishing results—average annual revenues three times higher than for organizations lacking such a positive culture. And this was true during a period that included this most recent recession. Based on their extensive consulting experience and in-depth interviews with leaders and employees at exceptional companies such as American Express, Cigna, Avis Budget, Pepsi Bottling, and Hard Rock, the authors present a simple seven-step road map for creating a culture of belief: define a burning platform; create a customer focus; develop agility; share everything; partner with your talent; root for each other; and establish clear accountability. Delving into specific how-tos for each step, they share eye-opening stories of exceptional leaders in action, vividly depicting just how these powerful methods can be implemented by any manager. All In draws on cutting-edge psychology and all of the creative genius that have made Gostick and Elton a must-read for leaders worldwide. This vital resource will empower managers everywhere to inspire a new level of commitment and performance.
Henry St John, First Viscount Bolingbroke (1678-1751) enjoyed varied political and literary careers. This five-volume edition draws together his letters. It includes a general introduction, headnotes, biographical index and a consolidated index. It is suitable for historians and literary scholars working in the eighteenth century.
The previously untold story of the hidden politics that went on behind the scenes during the handling of the Royal abdication crisis of 1936. The King Who Had to Go describes the harsh realities of how the machinery of government responds when even the King steps out of line. It reveals the pitiless and insidious battles in Westminster and Whitehall that settled the fate of the King and Mrs Simpson. Prime Minister Stanley Baldwin had to fight against ministers and civil servants who were determined to pressure the King into giving up Mrs Simpson and, when that failed, into abdicating. Dubious police reports on Mrs Simpson's sex life poisoned the government's view of her and were used to blacken her reputation. Threats to sabotage her divorce were deployed to edge the King towards abdication. Covert intelligence operations convinced the hardliners that the badly coordinated and hopeless attempts of the King's allies, particularly Winston Churchill, to keep him on the throne amounted to a sinister anti-constitutional conspiracy. The book also shows how the King doomed his chances of keeping the throne by wildly unrealistic goals and ill-thought -out schemes. As each side was overwhelmed by desperation and distrust, Baldwin somehow held the balance and steered the crisis to as smooth a conclusion as possible.
Modern perspectives of law enforcement are both complex and diverse. They integrate management and statistical analysis functions, public and business administration functions, and applications of psychology, natural science, physical fitness, and marksmanship. They also assimilate theories of education, organizational behavior, economics, law and
When the RAF rearmed to meet the growing threat from Nazi Germany's remorseless expansion in the late 1930s, it faced immense challenges. It had to manage a huge increase in size as well as mastering rapid advances in aviation technology. To protect Britain from attack, the RAF's commanders had to choose the right strategy and the right balance in its forces. The choices had to be made in peacetime with no guidance from combat experience. These visions then had to be translated into practical reality. A shifting cast of government ministers, civil servants and industrialists with their own financial, political and military agendas brought further dynamics into play. The RAF's readiness for war was crucial to Britain's ability to respond to Nazi aggression before war broke out and when it did, the RAF's rearmament was put to the acid test of battle. Adrian Phillips uses the penetrating grasp of how top level decisions are made that he honed in his inside accounts of the abdication crisis and appeasement, to dissect the process which shaped the RAF of 1940. He looks beyond the familiar legends of the Battle of Britain and explores in depth the successes and failures of a vital element in British preparations for war.
In diesem Buch werden wertvolle Informationen zur Chemie der Tragerreagenzien dargeboten, die bisher in der chemischen Literatur oder in entsprechenden Abstracts nur sehr schwer zu finden waren. Materialien und deren Praparation, sowie Analysemethoden und Fallstudien werden ausfuhrlich beschrieben. In der Entwicklung von Tragerreagenzien und deren potentieller Anwendung in der organischen Synthese gab es in jungster Zeit einen regelrechten Boom. Ein ganz entscheidender Vorteil von Tragerreagenzien ist ihre Umweltvertraglichkeit. Sie stellen somit eine interessante Alternative zu den konventionellen Reagenzien dar, die korrodierend, unwirtschaftlich und vor allem schwer zu entsorgen sind.
Integrating classical knowledge of chromosome organisation with recent molecular and functional findings, this book presents an up-to-date view of chromosome organisation and function for advanced undergraduate students studying genetics. The organisation and behaviour of chromosomes is central to genetics and the equal segregation of genes and chromosomes into daughter cells at cell division is vital. This text aims to provide a clear and straightforward explanation of these complex processes. Following a brief historical introduction, the text covers the topics of cell cycle dynamics and DNA replication; mitosis and meiosis; the organisation of DNA into chromatin; the arrangement of chromosomes in interphase; euchromatin and heterochromatin; nucleolus organisers; centromeres and telomeres; lampbrush and polytene chromosomes; chromosomes and evolution; chromosomes and disease, and artificial chromosomes. Topics are illustrated with examples from a wide variety of organisms, including fungi, plants, invertebrates and vertebrates. This book will be valuable resource for plant, animal and human geneticists and cell biologists. Originally a zoologist, Adrian Sumner has spent over 25 years studying human and other mammalian chromosomes with the Medical Research Council (UK). One of the pioneers of chromosome banding, he has used electron microscopy and immunofluorescence to study chromosome organisation and function, and latterly has studied factors involved in chromosome separation at mitosis. Adrian is an Associate Editor of the journal Chromosome Research, acts as a consultant biologist and is also Chair of the Committee of the International Chromosome Conferences. The most up-to-date overview of chromosomes in all their forms. Introduces cutting-edge topics such as artificial chromosomes and studies of telomere biology. Describes the methods used to study chromosomes. The perfect complement to Turner.
This title is directed primarily towards health care professionals outside of the United States. The new edition of this popular handbook gives an authoritative, informative and accessible account of key areas of child protection practice. Covering research, policy and practice it is relevant to all professionals working in child care. No other book on child protection offers such comprehensive coverage of policy and practice. It provides research findings in all areas of child abuse, latest policies and indications of good practice, plus specialist chapters for different professionals. Chapters have been contributed by known experts in the field, both distinguished academics and practitioners. By combining the latest factual information with sophisticated analysis, it is the ideal course text for child protection programmes as well as meeting the needs of more experienced practitioners, academics and trainers. Practical. Examines the issues grounded in reality, and therefore gives the reader confidence in practice, coupled with an understanding of the responsibilities of colleagues in other professions. Comprehensive. Covers a broad review of what constitutes child abuse and characteristics of the abused and the abusers; medical, social and legal management of the process of protection; the actions involved in intervention. and training and new directions for research and practice. Authoritative. Contributors are senior professionals known nationally and internationally for their specific expertise in this area. Research based. All books should be, but amongst the professionals most closely involved in child protection, the heavy workload often means there is little time to catch up on and assimilate up-to-date research fully. This book offers a through guide to what research and policy initiatives can give to the practice of the reader. new chapters addressing issues of culture and parenting.. each chapter contains key messages for practitioners. key websites have been listed. a website on Evolve with supplementary material.
Reveals how Darwin's study of fossils shaped his scientific thinking and led to his development of the theory of evolution. Darwin's Fossils is an accessible account of Darwin's pioneering work on fossils, his adventures in South America, and his relationship with the scientific establishment. While Darwin's research on Galápagos finches is celebrated, his work on fossils is less well known. Yet he was the first to collect the remains of giant extinct South American mammals; he worked out how coral reefs and atolls formed; he excavated and explained marine fossils high in the Andes; and he discovered a fossil forest that now bears his name. All of this research was fundamental in leading Darwin to develop his revolutionary theory of evolution. This richly illustrated book brings Darwin's fossils, many of which survive in museums and institutions around the world, together for the first time. Including new photography of many of the fossils--which in recent years have enjoyed a surge of scientific interest--as well as superb line drawings produced in the nineteenth century and newly commissioned artists' reconstructions of the extinct animals as they are understood today, Darwin's Fossils reveals how Darwin's discoveries played a crucial role in the development of his groundbreaking ideas.
There is a growing concern that many important ecosystems, such as coral reefs and tropical rain forests, might be at risk of sudden collapse as a result of human disturbance. At the same time, efforts to support the recovery of degraded ecosystems are increasing, through approaches such as ecological restoration and rewilding. Given the dependence of human livelihoods on the multiple benefits provided by ecosystems, there is an urgent need to understand the situations under which ecosystem collapse can occur, and how ecosystem recovery can best be supported. To help develop this understanding, this volume provides the first scientific account of the ecological mechanisms associated with the collapse of ecosystems and their subsequent recovery. After providing an overview of relevant theory, the text evaluates these ideas in the light of available empirical evidence, by profiling case studies drawn from both contemporary and prehistoric ecosystems. Implications for conservation policy and practice are then examined.
This book is the only account of what the bee, as an example of an insect, actually detects with its eyes. Bees detect some visual features such as edges and colours, but there is no sign that they reconstruct patterns or put together features to form objects. Bees detect motion but have no perception of what it is that moves, and certainly they do not recognize "things" by their shapes. Yet they clearly see well enough to fly and find food with a minute brain. Bee vision is therefore relevant to the construction of simple artificial visual systems, for example for mobile robots. The surprising conclusion is that bee vision is adapted to the recognition of places, not things. In this volume, Adrian Horridge also sets out the curious and contentious history of how bee vision came to be understood, with an account of a century of neglect of old experimental results, errors of interpretation, sharp disagreements, and failures of the scientific method. The design of the experiments and the methods of making inferences from observations are also critically examined, with the conclusion that scientists are often hesitant, imperfect and misleading, ignore the work of others, and fail to consider alternative explanations. The erratic path to understanding makes interesting reading for anyone with an analytical mind who thinks about the methods of science or the engineering of seeing machines.
A "Blues geography" of New Orleans that compels readers to return to the history of the Black freedom struggle there to reckon with its unfinished business. Reading contemporary policies of abandonment against the grain, Clyde Woods explores how Hurricane Katrina brought long-standing structures of domination into view.
Henry St John, First Viscount Bolingbroke (1678-1751) enjoyed varied political and literary careers. This five-volume edition draws together his letters. It includes a general introduction, headnotes, biographical index and a consolidated index. It is suitable for historians and literary scholars working in the eighteenth century.
This books offers a definitive text on the vital topic fundraising. It provides students of fundraising and nonprofit professionals access to the most relevant theories and includes concrete examples of modern fundraising practice. The book contains clear learning objectives, recommended readings, case studies, summary self-test questions, and exercises at the end of each chapter. The Principles and Practice of Fundraising comprehensively addresses all the major forms of fundraising and critical topics such as donor behavior and fundraising planning. Praise for fundraising principles and practice "Not only will fundraisers benefit from this comprehensive yet accessible text, but this should be required reading for all nonprofit practitioners and scholars. Reading this book will provide valuable insight on a vital subject and enhance the success of any fundraising effort." ?John B. Ford, president, Academy of Marketing Science and professor of marketing, Old Dominion University "This is not just a how-to-do-it book. Rather, it provides deep knowledge about the nonprofit sector, its role in society, and the values and psychology of giving that is essential to responsible and effective fundraising." ?Paul Brest, president, William and Flora Hewlett Foundation and author, Money Well Spent "Adrian Sargeant is the world's foremost fundraising scholar. This text will be invaluable to the beginner, but new research findings mean it should also be a must read for established practitioners." ?Steve Thomas, co-chair, Resource Alliance, and chairman, Stephen Thomas Ltd, Toronto "Designed and written to fill the void in current fundraising and development textbooks for both undergraduate and graduate students studying nonprofit management and leadership, Fundraising Principles and Practice surpasses my expectations for a comprehensive approach that will benefit American Humanics programs." ?SueAnn Strom, vice president, Academic Partnerships, American Humanics®, Inc. "Sargeant is the accessible academic and this is typical of his work. It is rigorously researched, clear, concise, well written, well presented and entirely appropriate. Any fundraiser who knows what Adrian knows will outperform the others. It's as simple as that." ?Ken Burnett, author, Relationship Fundraising and The Zen of Fundraising
Perpetually covered in ice and snow, the mountainous Antarctic Peninsula stretches southwardd towards the South Pole where it merges with the largest and coldest mass of ice anywhere on the planet. Yet far from being an otherworldly "Pole Apart," the region has the most contested political history of any part of the Antarctic Continent. Since the start of the twentieth century, Argentina, Britain, and Chile have made overlapping sovereignty claims, while the United States and Russia have reserved rights to the entire continent. The environment has been at the heart of these disputes over sovereignty, placing the Antarctic Peninsula at a fascinating intersection between diplomatic history and environmental history. In Frozen Empires, Adrian Howkins argues that there has been a fundamental continuity in the ways in which imperial powers have used the environment to support their political claims in the Antarctic Peninsula region. British officials argued that the production of useful scientific knowledge about the Antarctic helped to justify British ownership. Argentina and Chile made the case that the Antarctic Peninsula belonged to them as a result of geographical proximity, geological continuity, and a general sense of connection. Despite various challenges and claims, however, there has never been a genuine decolonization of the Antarctic Peninsula region. Instead, imperial assertions that respective entities were conducting science "for the good of humanity" were reformulated through the terms of the 1959 Antarctic Treaty, and Antarctica's "frozen empires" remain in place to this day. In arguing for imperial continuity in the region, Howkins counters the official historical narrative of Antarctica, which rests on a dichotomy between "bad" sovereignty claims and "good" scientific research. Frozen Empires instead suggests that science, politics, and the environment have been inextricably connected throughout the history of the Antarctic Peninsula region--and remain so--and shows how political prestige in the guise of conducting "science for the good of humanity" continues to influence international climate negotiations.
`An important contribution to the development of cognitive therapy that synthesizes the best of traditional cognitive therapy with important new developments emerging from a range of different areas. Combining practical accessibility with theoretical sophistication, this book will be invaluable reading for both beginning therapists and experienced clinicians' - Jeremy D. Safran, Ph.D., Professor and Director of Clinical Psychology, New School for Social Research, New York `Like a powerful river with many tributaries, this book somehow manages to weave influences from all kinds of diverse sources into an exciting, coherent whole. It is everything you'd want of a new CBT book for students and practitioners - fresh, practical, accessible' - James Bennett-Levy, Oxford Cognitive Therapy Centre Assessment and Case Formulation in Cognitive Behavioural Therapy is a comprehensive guide to key areas of professional knowledge and skill. The successful outcome of therapy depends on the therapist's ability to work collaboratively with clients to create rounded assessments and formulations as a solid basis for therapeutic work. Drawing directly on their own clinical work, the authors describe how assessment and formulation should evolve throughout the process. The case examples chosen include helping individuals with axis I and II problems such as psychosis, depression, borderline personality disorder and family case formulation. The authors also discuss the importance of the therapist taking into account their own beliefs and emotions in formulating each case and present suggested self-practice/self-reflection trajectories to support continuous professional development in this area. Alec Grant is Principal Lecturer and Course Leader MSc in Cognitive Psychotherapy at INAM, University of Brighton. Michael Townend is Reader in Cognitive Behavioural Psychotherapy and Programme Leader for the MSc in Cognitive Behavioural Psychotherapy and Postgraduate Certificate in Clinical Supervision, University of Derby. Jem Mills is Managing Director Aurora CBT Ltd and also Cognitive Psychotherapist in Private Practice. Adrian Cockx is Community Psychiatric Nurse and MSc in Cognitive Psychotherapy student at University of Brighton.
It is the most common complex birth defect. Spina bifida affects approximately one out of every 1,000 children born in the United States. In this comprehensive guide, Dr. Adrian Sandler offers a wealth of useful information on the medical, developmental, and psychological aspects of this condition. Accurate, accessible, and up-to-date, Living with Spina Bifida is written especially for families and professionals who care for children, adolescents, and adults with spina bifida. This edition contains a new preface by the author, addressing recent developments in research and treatment, as well as an updated list of spina bifida associations.
In The Nature of the Book, a tour de force of cultural history, Adrian Johns constructs an entirely original and vivid picture of print culture and its many arenas—commercial, intellectual, political, and individual. "A compelling exposition of how authors, printers, booksellers and readers competed for power over the printed page. . . . The richness of Mr. Johns's book lies in the splendid detail he has collected to describe the world of books in the first two centuries after the printing press arrived in England."—Alberto Manguel, Washington Times "[A] mammoth and stimulating account of the place of print in the history of knowledge. . . . Johns has written a tremendously learned primer."—D. Graham Burnett, New Republic "A detailed, engrossing, and genuinely eye-opening account of the formative stages of the print culture. . . . This is scholarship at its best."—Merle Rubin, Christian Science Monitor "The most lucid and persuasive account of the new kind of knowledge produced by print. . . . A work to rank alongside McLuhan."—John Sutherland, The Independent "Entertainingly written. . . . The most comprehensive account available . . . well documented and engaging."—Ian Maclean, Times Literary Supplement
Wolf's discovery demonstrating that a reporter gene is expressed in myocytes subsequent to injection of naked DNA, was exploited by immunologists and vaccinologists to develop a new generation of vaccines. This observation galvanized the research and in a short lapse of time, an oceanic volume of knowledge has been accumulated. The research carried out in a variety of animal models showed the efficacy of genetic immunization against viruses, bacteria, and some parasites by the ability to induce a strong priming effect resulting from long-lasting persistence of plasmid as episomes. Furthermore, it was demonstrated that newborn or infant immune unresponsiveness to classical vaccines can be corrected by genetic immunization. The applications of genetic immunization for prophylaxis of infections was extended to immunotherapy, namely, cancerous, auto immune, and allergic diseases. Immunologists have provided pertinent information on the cellular basis of the immune responses elicited by genetic immunization, and molecular biologists have established the molecular basis of intrinsic adjuvant properties of plasmids.
This highly acclaimed text, now available in paperback, provides a thorough account of key concepts and theoretical results, with particular emphasis on viewing statistical inference as a special case of decision theory. Information-theoretic concepts play a central role in the development of the theory, which provides, in particular, a detailed discussion of the problem of specification of so-called prior ignorance . The work is written from the authors s committed Bayesian perspective, but an overview of non-Bayesian theories is also provided, and each chapter contains a wide-ranging critical re-examination of controversial issues. The level of mathematics used is such that most material is accessible to readers with knowledge of advanced calculus. In particular, no knowledge of abstract measure theory is assumed, and the emphasis throughout is on statistical concepts rather than rigorous mathematics. The book will be an ideal source for all students and researchers in statistics, mathematics, decision analysis, economic and business studies, and all branches of science and engineering, who wish to further their understanding of Bayesian statistics
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