Probiotics: A Clinical Guide is one of the first books on the market to present current and evidence-based recommendations for primary care providers and gastroenterologists on the use of probiotics as a way to treat specific diseases and disorders. Why you will want Probiotics: A Clinical Guide: Unique focus on the clinical use of probiotics in a wide variety of diseases Comprehensive review of the science behind probiotics and probiotic products In-depth review of current literature for specific diseases or disorders Recommendations of the use of probiotics is supported by evidence-based clinical trials Each chapter includes a table that outlines the exact probiotic organisms and dosages that are the most efficacious A glance at what is inside Probiotics: A Clinical Guide: Basic Physiology Intestinal microecology; stimulating the immune response, nutrients to nourish the organism, role in fermentation and metabolism, and much more... Use in Clinical Medicine Probiotics in children, adult infectious diarrhea, surgical infections, allergic disease, ulcerative colitis, crohn’s disease, liver disease, and more... Probiotics: A Clinical Guide by Dr. Martin Floch & Dr. Adam Kim is a ground-breaking book that will serve as a valuable reference and clinical guide for gastroenterologists, internists, family practitioners, nurse practitioners, and physician assistants.
This book introduces readers to Web content credibility evaluation and evaluation support. It highlights empirical research and establishes a solid foundation for future research by presenting methods of supporting credibility evaluation of online content, together with publicly available datasets for reproducible experimentation, such as the Web Content Credibility Corpus. The book is divided into six chapters. After a general introduction in Chapter 1, including a brief survey of credibility evaluation in the social sciences, Chapter 2 presents definitions of credibility and related concepts of truth and trust. Next, Chapter 3 details methods, algorithms and user interfaces for systems supporting Web content credibility evaluation. In turn, Chapter 4 takes a closer look at the credibility of social media, exemplified in sections on Twitter, Q&A systems, and Wikipedia, as well as fake news detection. In closing, Chapter 5 presents mathematical and simulation models of credibility evaluation, before a final round-up of the book is provided in Chapter 6. Overall, the book reviews and synthesizes the current state of the art in Web content credibility evaluation support and fake news detection. It provides researchers in academia and industry with both an incentive and a basis for future research and development of Web content credibility evaluation support services.
Drugs and the Neuroscience of Behavior presents an introduction to the rapidly advancing field of psychopharmacology by examining how drug actions in the brain affect psychological processes. Author Adam Prus provides historical background to give readers an appreciation for the development of drug treatments and neuroscience over time, covering major topics in psychopharmacology including new drugs and recent trends in drug use. Empirically supported pedagogical features offer students the opportunity to reflect on what they read to ensure understanding before progressing to new content. The Third Edition includes a new chapter on depressants and discussions of major topics such as the opioid epidemic, the risks associated with vaping, and MDMA-assisted psychotherapy for PTSD. Included with this title: The password-protected Instructor Resource Site (formally known as SAGE Edge) offers access to all text-specific resources, including a test bank and editable, chapter-specific PowerPoint® slides.
The recognition and reconciliation of ‘opposites’ lies at the heart of our most personal and global problems and is arguably one of the most neglected developmental tasks of Western education. Such problems are ‘wicked’ in the sense that they involve real-life decisions that have to be made in rapidly changing contexts involving irreducible tensions and paradoxes. By exploring our human tendency to bifurcate the universe, Education for Wicked Problems & the Reconciliation of Opposites proposes a way to recognise and (re)solve some of our most wicked problems. Applying an original theory of bi-relational development to wicked problems, Adam proposes that our everyday ways of knowing and being can be powerfully located and understood in terms of the creation, emergence, opposition, convergence, collapse and trans-position of dyadic constituents such as nature/culture, conservative/liberal and spirit/matter. He uses this approach to frame key debates in and across domains of knowledge and to offer new perspectives on three of the most profound and related problems of the twenty-first century: globalisation, sustainability and secularisation. This book is a comprehensive study of dyads and dyadic relationships and provides a multidisciplinary and original approach to human development in the face of wicked problems. It will be of great interest to students and academics in education and psychosocial development as well as professionals across a range of fields looking for new ways to recognise and (re)solve the wicked problems that characterise their professions.
This compelling book examines the price-based revolution in investing, showing how research over recent decades has reinvented technical analysis. The authors discuss the major groups of price-based strategies, considering their theoretical motivation, individual and combined implementation, and back-tested results when applied to investment across country stock markets. Containing a comprehensive sample of performance data, taken from 24 major developed markets around the world and ranging over the last 25 years, the authors construct practical portfolios and display their performance—ensuring the book is not only academically rigorous, but practically applicable too. This is a highly useful volume that will be of relevance to researchers and students working in the field of price-based investing, as well as individual investors, fund pickers, market analysts, fund managers, pension fund consultants, hedge fund portfolio managers, endowment chief investment officers, futures traders, and family office investors.
This book provides a detailed, self-contained description of automatic indexing of crystal diffraction patterns, considering both ab initio indexing and indexing of patterns originating from known structures. Introductory chapters equip the reader with the necessary basic knowledge of geometric crystallography, as well as kinematic and dynamic theories of crystal diffraction. Subsequent chapters delve and describe ab initio indexing of single crystal diffraction patterns and indexing of patterns for orientation determination. The book also reviews methods of indexing powder diffraction and electron spot-type patterns, as well the subject of multigrain indexing. Later chapters are devoted to diffraction by helical structures and quasicrystals, as well as some aspects of lattice parameter refinement and strain determination. The book is intended equally for materials scientists curious about ‘nuts and bolts’ of diffraction pattern indexing and orientation mapping systems, as well as interdisciplinary researchers from physics, chemistry, and biology involved in crystallographic computing. It provides a rigorous, yet accessible, treatment of the subject matter for graduate students interested in understanding the functioning of diffraction pattern indexing engines.
Optimization is ubiquitous in power system engineering. Drawing on powerful, modern tools from convex optimization, this rigorous exposition introduces essential techniques for formulating linear, second-order cone, and semidefinite programming approximations to the canonical optimal power flow problem, which lies at the heart of many different power system optimizations. Convex models in each optimization class are then developed in parallel for a variety of practical applications like unit commitment, generation and transmission planning, and nodal pricing. Presenting classical approximations and modern convex relaxations side-by-side, and a selection of problems and worked examples, this is an invaluable resource for students and researchers from industry and academia in power systems, optimization, and control.
Why are poor countries poor and rich countries rich? How are wealth and poverty related to changes in health, life expectancy, education, population growth and politics? This non-technical introduction to development studies explores the dynamics of socio-economic development and stagnation in developing countries. Thoroughly updated and revised, this second edition includes new material on the effects of the 2008 financial crisis, the emergence of the BRICS economies, the role of institutions in development and the accelerated growth of economies in Africa and Asia. Taking a comparative approach, Szirmai places contemporary debates within their broader contexts and combines insights and theories from economics, economic history, political science, anthropology and sociology. Each chapter includes comparative statistics and time series for thirty-one developing countries. Assuming no prior knowledge of economics, this book is well-suited for students in interdisciplinary development studies and development economics, for policy-makers and for practitioners pursuing careers in developing countries. Visit www.dynamicsofdevelopment.com for additional resources.
Beyond the skin as protective barrier, surgeons and dermatologists explore the science of skin as they work with it every day on patients and clients with aging skin, facial scars, deformities, skin cancer, sun damage, vascular lesions, and traumatic injuries. This compilation of topics in Facial Plastic Surgery Clinics provides a primer on the basic science of skin, wound healing, exploration of genes, stem cells, and molecular science, along with direct clinical information related to surgery and medicine applicable in skin disorders, cosmetic procedures, and reconstructive procedures. Guest Editors David Hom and Adam Ingraffea lead a group of facial plastic surgeons and dermatologists who present an Overview of a specific skin problem, Therapeutic options, Clinical outcomes, Complications and sequela, along with a review of the most current literature to date on the subject of skin as is clinically and surgically relevant for dermatologists, facial plastic surgeons, plastic surgeons, and general practitioners.
Heart disease is currently the leading cause of maternal mortality in developed countries and is expected to increase further due to advanced maternal age and conditions such as type 2 diabetes. Maternal Cardiac Care: A Guide to Managing Pregnant Women with Heart Disease is an up-to-date, multidisciplinary resource for physicians and advanced practice nurses caring for pregnant patients with a variety of preexisting and emerging cardiac issues. - Offers comprehensive information on caring for women with heart disease, in an easy-to-follow, quick-access format. - Shares knowledge from a multidisciplinary group of experts who are well versed in the team approach needed to treat this high-risk patient population. - Includes extensive references for readers who want to delve more deeply into specific subjects. - Ideal for obstetricians, internists, cardiologists, critical care specialists, and advanced practice nurses involved in caring for pregnant patients, as well as institutions and departments that need detailed guidance on establishing a maternal cardiac care program.
In the past decade, fintech has shaken up the financial sector in Latin America providing innovations in lending, payments, insurance, and regulation and compliance. This paper examines this development by focusing on both fintech services and regulation. Exploring fintech’s macro-critical impact using country- and bank-level data, we find that booming financial technologies in Latin America have helped boost competition in the banking sector and inclusion. Additionally, we demonstrate that fintech firms in Latin America experienced robust growth even during the pandemic supported by external funding. Finally, we discuss how regulators are addressing the risks associated with financial technologies and how they are leveraging fintech tools in their supervisory activities.
This book investigates a biologically inspired method of robot arm control, developed with the objective of synthesising human-like motion dynamically, using nonlinear, robust and adaptive control techniques in practical robot systems. The control method caters to a rising interest in humanoid robots and the need for appropriate control schemes to match these systems. Unlike the classic kinematic schemes used in industrial manipulators, the dynamic approaches proposed here promote human-like motion with better exploitation of the robot’s physical structure. This also benefits human-robot interaction. The control schemes proposed in this book are inspired by a wealth of human-motion literature that indicates the drivers of motion to be dynamic, model-based and optimal. Such considerations lend themselves nicely to achievement via nonlinear control techniques without the necessity for extensive and complex biological models. The operational-space method of robot control forms the basis of many of the techniques investigated in this book. The method includes attractive features such as the decoupling of motion into task and posture components. Various developments are made in each of these elements. Simple cost functions inspired by biomechanical “effort” and “discomfort” generate realistic posture motion. Sliding-mode techniques overcome robustness shortcomings for practical implementation. Arm compliance is achieved via a method of model-free adaptive control that also deals with actuator saturation via anti-windup compensation. A neural-network-centered learning-by-observation scheme generates new task motions, based on motion-capture data recorded from human volunteers. In other parts of the book, motion capture is used to test theories of human movement. All developed controllers are applied to the reaching motion of a humanoid robot arm and are demonstrated to be practically realisable. This book is designed to be of interest to those wishing to achieve dynamics-based human-like robot-arm motion in academic research, advanced study or certain industrial environments. The book provides motivations, extensive reviews, research results and detailed explanations. It is not only suited to practising control engineers, but also applicable for general roboticists who wish to develop control systems expertise in this area.
Physicians help people heal, but how well do they take care of their own physical and mental well-being? How does a physician’s personal history, medical training, and medical culture predispose and perpetuate potential health issues, relationship challenges, financial strain, abuse, or burnout in physicians? Does the prevalent mindset of pushing beyond our needs and losing ourselves in the physician identity perpetuate burnout or sustainability? How do emotions such as fear, obligation, guilt, and shame affect medical training, medical practice, physician lives, and their relationships? Saving Lives without Destroying Yours is a self-help book for physicians to set boundaries to improve their mental health and wellbeing, break intergenerational medical training traps, protect themselves, engage more in their life roles, and design a life and medical practice where physicians can thrive, not just survive. This book empowers physicians to know themselves – their needs, wants, abilities, and limitations - while being understanding and non-judgmental towards others’ needs when setting boundaries. Takeaway pearls include building self-awareness, setting boundaries, communicating assertively, identifying patterns of abuse, building healthy relationships, and managing interpersonal conflict using dialectical behavioural therapy principles and emotional intelligence. Dr. Mammoliti and Mr. Ly combine their experience in psychiatry, psychotherapy, coaching, and occupational therapy to encourage a comprehensive self-reflection journey and guide physicians in boundary setting. Discover how to say No appropriately and say Yes to a more meaningful and healthy life.
This issue consists of 17 case studies, each involving a difficult decision that has to be made in the catheterization laboratory. Reading about the cases and seeing the ECGs will help cardiac electrophysiologists sharpen their clinical skills. The cases are also useful reading for those studying for board certification.
In the distal regions of the human lung, one of the most challenging problems facing a large multicellular organism is solved--ensuring an adequate supply of oxygen for aerobic tissue metabolism while removing associated waste products. Conduits for both air and blood converge at the alveolar level to match ventilation with perfusion and thus assure the free diffusion of oxygen and carbon dioxide. Despite their thin walls and their intimate relationship to the pulmonary capillary bed, the alveolus must present a barrier function robust enough to resist alveolar flooding from the hydrostatic pressures generated by the weight of the lungs and the volume of blood in the pulmonary circuit. The strategic position of the alveolar region and its vast associated capillary network ensure its importance in the synthesis and degradation of a wide range of molecules. Finally, the alveoli have evolved important immune functions vital to protecting the host from a variety of inhaled pollutants and microorganisms. Understanding alveolar structure and function is essential not only to appreciate the elegance of the human lung in its pristine state but also to understand the perturbations that underlay many lung diseases.
The sixth edition of this comprehensive yet concise Rosen & Barkin’s 5 Minute Emergency Medicine Consult pulls together up-to-date and evidence-based practice guidelines for easy use in a busy emergency department. In just two brief, bullet-friendly, clutter-free pages, you can quickly decipher the information you need to confirm your diagnosis, order tests, manage treatment and more!
This book is an absolute game-changer' - Dr Xand Van Tulleken 'Everyone concerned about their fertility should read this book' - Dr Raj Mathur, Chair of the British Fertility Society The book you can trust to help you achieve a healthy pregnancy. Whether you are trying for a baby now or preparing for a family in future, The Fertility Book is the no-nonsense guide you need to help you to optimize your chances of a healthy pregnancy. World-renowned fertility consultant Adam Balen and reproductive biologist Grace Dugdale dispel the myths in this comprehensive guide to reproductive health, explaining in easy-to-understand terms the genetic and lifestyle factors at play. They take an honest look at the evidence for both conventional and alternative approaches, equipping you with powerful tools to improve your chances of a natural conception and an understanding of how to create the best environment for a healthy pregnancy. If you do decide to seek help through assisted conception, this book will be with you every step of the way, explaining what treatments are available and how to approach them, so that you can come to an informed decision about what is right for you. Professor Adam Balen and Grace Dugdale have decades of experience helping couples on their journey to conception and beyond. Now in this, their first book for a general readership, they explain everything you need to know to understand your own fertility.
Nicolson crafts a geography of the ancient world and a brilliant exploration of our connections to the past. What is the nature of things? What is justice? How can I be myself? How should we treat each other? Before the Greeks, the idea of the world was dominated by god-kings and their priests. Twenty-five hundred years ago, in a succession of small eastern Mediterranean harbor cities, a few heroic men and women decided to cast off mental subservience and apply their own thinking minds to the conundrums of life. These great innovators shaped the beginnings of western philosophy. Through the questioning voyager Odysseus, Homer explored how we might navigate our way through the world. Heraclitus, in Ephesus, was the first to consider the interrelatedness of things. Xenophanes of Colophon was the first champion of civility. On the Aegean island of Lesbos, the early lyric poets Sappho and Alcaeus asked themselves, “How can I be true to myself?” On Samos, Pythagoras imagined an everlasting soul and took his ideas to Italy, where they flowered again in surprising and radical forms. The award-winning writer Adam Nicolson travels with us through this transforming world and asks what light these ancient thinkers can throw on our deepest preconceptions. Enhanced with maps, photographs, and artwork, How to Be is an expedition into early ideas. Nicolson takes us to the dawn of investigative thought and makes the fundamental questions of the ancient philosophers new again. What are the principles of the physical world? How can we be good in it? And why do we continue to ask these questions? It is an enthralling, exhilarating journey.
Used by generations of physicians who encounter patients with dermatological diseases, Lever’s Dermatopathology: Histopathology of the Skin comprehensively covers skin disease in which histopathology plays an important role in diagnosis. The updated 12th Edition, edited by Drs. David E. Elder, Rosalie Elenitsas, George F. Murphy, Misha Rosenbach, Adam I. Rubin, John T. Seykora, and Xiaowei Xu, maintains the proven, clinicopathologic classification of cutaneous disease while incorporating a “primer” on pattern-algorithm diagnosis. It features larger images throughout, as well as thoroughly revised content with new diseases and new information on pathophysiology and molecular pathogenesis—all in an easy-to-navigate, highly readable format.
A How-to Guide for Implementing Algorithms and Protocols Addressing real-world implementation issues, Understanding and Applying Cryptography and Data Security emphasizes cryptographic algorithm and protocol implementation in hardware, software, and embedded systems. Derived from the author’s teaching notes and research publications, the text is designed for electrical engineering and computer science courses. Provides the Foundation for Constructing Cryptographic Protocols The first several chapters present various types of symmetric-key cryptographic algorithms. These chapters examine basic substitution ciphers, cryptanalysis, the Data Encryption Standard (DES), and the Advanced Encryption Standard (AES). Subsequent chapters on public-key cryptographic algorithms cover the underlying mathematics behind the computation of inverses, the use of fast exponentiation techniques, tradeoffs between public- and symmetric-key algorithms, and the minimum key lengths necessary to maintain acceptable levels of security. The final chapters present the components needed for the creation of cryptographic protocols and investigate different security services and their impact on the construction of cryptographic protocols. Offers Implementation Comparisons By examining tradeoffs between code size, hardware logic resource requirements, memory usage, speed and throughput, power consumption, and more, this textbook provides students with a feel for what they may encounter in actual job situations. A solutions manual is available to qualified instructors with course adoptions.
This book pioneers the field of gain-cell embedded DRAM (GC-eDRAM) design for low-power VLSI systems-on-chip (SoCs). Novel GC-eDRAMs are specifically designed and optimized for a range of low-power VLSI SoCs, ranging from ultra-low power to power-aware high-performance applications. After a detailed review of prior-art GC-eDRAMs, an analytical retention time distribution model is introduced and validated by silicon measurements, which is key for low-power GC-eDRAM design. The book then investigates supply voltage scaling and near-threshold voltage (NTV) operation of a conventional gain cell (GC), before presenting novel GC circuit and assist techniques for NTV operation, including a 3-transistor full transmission-gate write port, reverse body biasing (RBB), and a replica technique for optimum refresh timing. Next, conventional GC bitcells are evaluated under aggressive technology and voltage scaling (down to the subthreshold domain), before novel bitcells for aggressively scaled CMOS nodes and soft-error tolerance as presented, including a 4-transistor GC with partial internal feedback and a 4-transistor GC with built-in redundancy.
This issue of Physical Medicine and Rehabilitation Clinics of North America is devoted to "Difficult to Treat Pain Syndromes," and is edited by Adam L. Schreiber, DO of the Jefferson Medical College of Thomas Jefferson University. Articles in this issue will include: Carpal Tunnel Syndrome Diagnosis; Non-surgical Treatment of Carpal Tunnel Syndrome; Parsonage Turner Syndrome Diagnosis and Treatment; Trochanteric Pain Syndrome Diagnosis and Treatment; Complex Regional Pain Syndrome Diagnosis and Treatment; Discogenic Spine Pain Syndrome Diagnosis and Treatment; Failed Back Surgery Syndrome Diagnosis and Treatment; Myofascial Pain Syndrome Diagnosis and Treatments; Opioid Syndrome Diagnosis and Treatment; Spinal Cord Pain Syndrome Diagnosis and Treatment; Cerebral Vascular Accident Hemishoulder Pain Syndrome Diagnosis and Treatment; and Cancer Pain Syndromes.
Process Intensification: Engineering for Efficiency, Sustainability and Flexibility is the first book to provide a practical working guide to understanding process intensification (PI) and developing successful PI solutions and applications in chemical process, civil, environmental, energy, pharmaceutical, biological, and biochemical systems. Process intensification is a chemical and process design approach that leads to substantially smaller, cleaner, safer, and more energy efficient process technology. It improves process flexibility, product quality, speed to market and inherent safety, with a reduced environmental footprint. This book represents a valuable resource for engineers working with leading-edge process technologies, and those involved research and development of chemical, process, environmental, pharmaceutical, and bioscience systems. - No other reference covers both the technology and application of PI, addressing fundamentals, industry applications, and including a development and implementation guide - Covers hot and high growth topics, including emission prevention, sustainable design, and pinch analysis - World-class authors: Colin Ramshaw pioneered PI at ICI and is widely credited as the father of the technology
Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function. Antibacterial Agents is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated “lab-to-clinic” approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects (including links to current guidelines, significant drug interactions, cautions and contraindications), prodrugs and future improvements. Agents covered include: agents targeting DNA - quinolone, rifamycin, and nitroimidazole antibacterial agents agents targeting metabolic processes - sulfonamide antibacterial agents and trimethoprim agents targeting protein synthesis - aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones agents targeting cell wall synthesis - β-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin Antibacterial Agents will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.
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