Suitable for medical students, this title includes a chapter on Surgery and Radiology. It contains teaching notes provided alongside each answer to help the reader understand the subject matter.
It didn’t take long for students around the world to realize that anatomy texts just don’t get any better than Gray’s Anatomy for Students. Only in its 2nd edition, this already popular, clinically focused reference has moved far ahead of the competition and is highly recommended by anyone who uses it. A team of authors with a wealth of diverse teaching and clinical experience has updated and revised this new edition to efficiently cover what you’re learning in contemporary anatomy classes. An improved format, updated clinical material, and remarkable artwork by renowned illustrators Richard Tibbitts and Paul Richardson make anatomy easier than ever for you to master. Unique coverage of surface anatomy, correlative diagnostic images, and clinical case studies demonstrate practical applications of anatomical concepts. And, an international advisory board, comprised of more than 100 instructors, ensures that the material is accurate, up to date, and easy to use. Uses more than 1,000 innovative original illustrations— by renowned illustrators Richard Tibbitts and Paul Richardson—to capture anatomical features with unrivalled clarity, and makes body structures easy to locate and remember from one illustration to another through consistent use of color. Includes over 300 clinical photographs, including radiological images depicting surface anatomy and common clinical applications of anatomic knowledge. Presents an organization by body region that parallels the approach used in most of today’s anatomy courses. Features conceptual overviews summarizing each body region's component parts, functions, and relationship to other bodily organs. Uses clinical cases to underscore the real-life relevance of the material. Features a rewritten abdomen section for greater clarity. Provides updates and revisions to clinical material to provide you with the absolute latest knowledge in the field. Includes expanded discussions of cranial nerves for added clinical relevancy. Uses a new internal design and presents an improved index for easier retrieval of information. Provides more information on the general aspects of anatomy via introduction chapter.
This manual gives information on the causative organisms, epidemiology and clinical features of all important childhood infections. It includes guidance on the clinical management of the infections and on steps to be taken to prevent future cases.
The 7 chapters in this book have been selected from the contents of the Oncological Imaging section in Grainger & Allison's Diagnostic Radiology 6e. These chapters provide a succinct up-to-date overview of current imaging techniques and their clinical applications in daily practice and it is hoped that with this concise format the user will quickly grasp the fundamentals they need to know. Throughout these chapters, the relative merits of different imaging investigations are described, variations are discussed and recent imaging advances are detailed. Please note that the following chapters represent a portion of the oncological imaging aspects in the comprehensive 6th edition of Grainger's & Allison's Diagnostic Radiology (for example, abdominal tumours are considered in section C "Abdominal Imaging")
Confidently diagnose challenging musculoskeletal lesions with expert guidance. Radiology and Pathology Correlation of Bone Tumors: A Quick Reference and Review is a practical, hands-on clinical reference that helps you evaluate all of the diagnostic clues at your disposal to accurately identify the most frequently encountered benign and malignant bone tumors. Co-written by a radiologist and a pathologist, it shows you how to correlate radiography, scintigraphy, CT, MRI, PET, and PET-CT with gross pathology, histopathology, immunohistochemistry, and genetics to achieve maximum diagnostic certainty. This compact, high-yield resource is an ideal tool for quick look-upsin everyday practice as well as board review.
Master the information you need to know for practice and prepare for certification or recertification with a succinct, comprehensive account of the entire spectrum of imaging modalities and their clinical applications. Throughout six outstanding editions, Grainger and Allison's Diagnostic Radiology has stood alone as the single comprehensive reference on general diagnostic radiology. Now in two succinct volumes, the 7th Edition of this landmark text continues to provide complete coverage of all currently available imaging techniques and their clinical applications – the essential information you need to succeed in examinations and understand current best practices in radiological diagnosis - Organizes content along an organ and systems basis, covering all diagnostic imaging techniques in an integrated, correlative fashion, with a focus on the topics that matter most to a trainee radiologist in the initial years of training. - Contains more than 4,000 high-quality illustrations that enhance and clarify the text. - Features an expanded section on cardiac imaging to reflect major developments in cardiac MRI, including 3D ultrasound, PET, and SPECT. - Integrates functional and molecular imaging throughout each section, and includes the latest image-guided biopsy and ablation techniques. - Provides an ideal resource for written, oral, and re-certifying board study as well as for a clinical practice refresher on topics that may have been forgotten.
Long recognized as the standard general reference in the field, this completely revised edition of Grainger and Allison?s Diagnostic Radiology provides all the information that a trainee needs to master to successfully take their professional certification examinations as well as providing the practicing radiologist with a refresher on topics that may have been forgotten. Organized along an organ and systems basis, this resource covers all diagnostic imaging modalities in an integrated, correlative fashion and focuses on those topics that really matter to a trainee radiologist in the initial years of training. "...the latest edition ... continues the fine tradition set by its predecessors.... help young radiologists to prepare for their examinations and continue to be a source of information to be dipped in and out of ... senior radiologists will also find the book useful ..." Reviewed by: RAD Magazine March 2015 "I am sure the current edition will be successful and help young radiologists to prepare for their examinations and continue to be a source of information to be dipped in and out of..." Reviewed by RAD Magazine, March 2015 Master the field and prepare for certification or recertification with a succinct, comprehensive account of the entire spectrum of imaging modalities and their clinical applications. Effectively apply the latest techniques and approaches with complete updates throughout including 4 new sections (Abdominal Imaging, The Spine, Oncological Imaging, and Interventional Radiology) and 28 brand new chapters. Gain the fresh perspective of two new editors—Jonathan Gillard and Cornelia Schaefer-Prokop -- eight new section editors -- Michael Maher, Andrew Grainger, Philip O’Connor, Rolf Jager, Vicky Goh, Catherine Owens, Anna Maria Belli, Michael Lee -- and 135 new contributors. Stay current with the latest developments in imaging techniques such as CT, MR, ultrasound, and coverage of hot topics such as: Image guided biopsy and ablation techniques and Functional and molecular imaging. Solve even your toughest diagnostic challenges with guidance from nearly 4,000 outstanding illustrations. Quickly grasp the fundamentals you need to know through a more concise, streamlined format. Access the full text online at Expert Consult.
Gathered together for the first time from a major publisher - a collection of short stories by Adam Roberts. Unique twisted visions from the edges and the centre of the SF genres. Stories that carry Adam Roberts' trademark elegance of style and restless enquiry of the genre he loves so much. Acclaimed stories, some that have appeared in magazines, some in anthologies, some appearing for the first time. Stories to make you think, to make you laugh, to make you wonder, to make you uneasy. Stories that ask questions, stories that sow mysteries. But always stories that entertain.
This atlas addresses controversies on imaging modalities for ENT. The relative merits of MRI and CT imaging for particular areas and specific pathologies are discussed. Using a large number of images in both modalities of normal anatomy and pathologies, this should be a useful aid to diagnosis for both radiologists and ENT specialists.
An Integrated Guide to Human Drug Metabolism: From Basic Chemical Transformations to Drug-Drug Interactions uses the chemistry of each of the metabolic transformations to underpin the discussion of drug interactions with foods, herbal medicines and other drugs. Each of the human metabolic processes will be covered, employing examples drawn from known metabolic transformations of drugs used clinically. The clinical relevance of metabolism is discussed, focusing on appropriate prescribing (age-related dosage adjustments, routes of administration, and personalized medicines). Appropriate for use in the classroom or for self-study, An Integrated Guide to Human Drug Metabolism is useful for students and researchers needing a reference for interdisciplinary research in drug interactions. Metabolism is at the center of personalized medicine, as it is a governing factor in the response of the patient to a drug. For example, does the patient express the genes, and so enzymes, which are responsible for the metabolism of a drug? Do they express the genes responsible for the bioactivation of a prodrug into its active form? Examples of clinically used agents for which metabolic phenotyping is essential will be used to highlight the increasing necessity for understanding the genetic profile of individual patients. This book includes questions and answers to gauge learning of each chapter, real-life case studies, and the basic science as a basis for the discussion of clinical aspects. - Covers each of the human metabolic processes, employing examples drawn from known metabolic transformations of drugs used clinically - Provides an integrated approach, linking together the science and practice strands of human drug metabolism - Contains questions and answers to assess learning of material and real-life case studies
This best-selling emergency department reference is now in its thoroughly updated Fourth Edition. The foremost authorities provide practical information on over 600 clinical problems in a fast-access two-page outline format that's perfect for on-the-spot consultation during care in the emergency department. Coverage of each disorder includes clinical presentation, pre-hospital, diagnosis, treatment, disposition, and ICD-9 coding. Icons enable practitioners to quickly spot the information they need. This edition provides up-to-date information on topics such as emerging infections, new protocols, and new treatments.
Featuring over 4,000 large-size illustrations and unique, effective pedagogy, the Fifth Edition of Dr. Greenspan's best-seller is the ideal teaching text on musculoskeletal imaging for radiologists and orthopedists at every level of training. Orthopedic Imaging: A Practical Approach covers all orthopedic problems and imaging modalities and offers indispensable guidance on selecting cost-effective imaging techniques. The Fifth Edition has a new full-color design, with colorized tables and schematics and full-color illustrations including PET-CT. All conventional tomography has been replaced by CT. Coverage of MRI—the scan of choice for more clinical situations than ever—has been greatly expanded, especially in areas related to arthritis. More three-dimensional CT scans have been added, particularly to areas covering trauma. Musculoskeletal ultrasound coverage has been increased. Practical Points to Remember appear at the end of each chapter to outline salient points. A companion website will offer the fully searchable text and images.
Step-Up to the Bedside, Second Edition is a comprehensive case-based review book for the USMLE Step 1 and Step 2 CS. It presents 100 clinical cases following the USMLE format and focuses on the basic science underlying each clinical scenario. The case-based presentation helps students assimilate and synthesize basic science information and provides excellent preparation for USMLE Step 1, USMLE Step 2 CS, and clinical clerkships. This edition contains thirty completely new cases, and all existing cases have been extensively updated. Each case now opens with learning objectives and ends with USMLE-style questions. Quick Hits bullets, mnemonics, figures, and tables help readers retain information. Fifty of the cases will be available online.
This title in the Rapid Diagnosis in Ophthalmology Series presents a wealth of full-color images - along with differential diagnoses - in side-by-side page layouts to assist you in identifying a full range of retinal disorders. A templated format expedites access to the guidance you need to diagnose the most common retinal conditions - from simple to complex - encountered in practice. Coverage of cutting-edge topics including lucentis therapy for wet ARMD, Avastin therapy for macular disease, and guidance on OCT imaging, help you keep your knowledge up to date. Hundreds of full-color images present conditions as they present in real life. Common diagnostic pitfalls discuss what to look out for when making a difficult diagnosis. A templated, color-coded layout and differential diagnosis boxes for each condition help you make quick, accurate clinical decisions. A focus on the most common conditions encountered in practice allows you to efficiently formulate treatment plans and referrals. SERIES EDITORS: Jay S. Duker, MD, Director, New England Eye Center, Vitreoretinal Diseases and Surgery Service; Director, Pediatric Retinal Referral Center, Uveitis & Immunology Service; Professor and Chair of Ophthalmology, Tufts University School of Medicine, Boston, MA and Marian S. Macsai, MD, Chief, Division of Ophthalmology, Evanston Northwestern Healthcare; Professor and Vice-Chair of the Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, MI
Provides a range of short clinical cases with questions and detailed structured answers to test students' problem-solving and decision-making skills in a structured and objective fashion.
Completely revised and including new additional material, this second edition of the bestselling Get Through MRCGP: Clinical Skills Assessment provides candidates with a definitive, one-stop revision resource for the CSA part of the MRCGP examination. Fully revised in accordance with the current MRCGP and MRCGP(INT) curriculum Mock examinations cover a spread of topics and skills outlined in the RCGP curriculum Comprehensive discussion of areas that stations test and detailing points needing to be covered to achieve the best results Brand new material including six new cases and task boxes to refocus the reader's attention on the different challenges of each station Completely rewritten introductory chapter Offers valuable advice on how to approach the exam, focus time in day-to-day GP surgeries and how to develop skills required to pass the CSA Written by an experienced author team that has extensive knowledge of both national and international primary care clinical skills assessment, Get Through MRCGP: Clinical Skills Assessment, Second Edition is essential reading for postgraduate candidates preparing for this challenging examination.
A comprehensive and critical review of recent literature regarding the relationships between physical illness and drugs of abuse, describing the association between each of the principal classes of illicit drugs (cocaine, marijuana, opioids, and common hallucinogens and stimulants) and the major categories of physical illness.
This volume presents both the radiologist's and the pathologist's approach to differential diagnosis of musculoskeletal tumors and tumor-like lesions and details the radiologic and histopathologic features helpful in confirming a diagnosis. The book is illustrated with over 1,200 radiographs, CT and MR images, full-color photomicrographs, and schematic drawings. Tables list important diagnostic features, and schematic drawings summarize both radiologic and pathologic differential diagnoses. This edition includes state-of-the-art information on PET, thin-section CT, 3-D CT, MRI, enzyme histochemistry, immunohistochemistry, flow cytometry, cytogenetics, and molecular cytogenetics. The new co-author, Gernot Jundt, was instrumental in revising the WHO classification of musculoskeletal lesions. Illustrations have been updated, and improved captions begin with the diagnosis.
This second edition of '320 Single Best Answer Questions for Final Year Medical Students' is an invaluable resource for medical students preparing for their final examinations. Additionally, the breadth of topics covered and detailed answers expands the versatility of this book to a larger audience including doctors preparing for postgraduate exams and other allied healthcare professionals who will be examined in general internal medicine.This improved edition contains updated and new questions that are in line with the most recent developments in clinical guidelines as well as being written in accordance with the recent changes to medical school examinations. The 320 questions are divided into 11 commonly tested areas of medicine, surgery and sub-specialities. They are designed to provide a comprehensive coverage of the medical school curriculum and to allow practice by speciality or random selection.The questions are written in the format of medical final examinations. The answers provide detailed explanations as to how the correct answer is reached, followed by a clear discussion of how the incorrect answers are ruled out and supplementary information about other important aspects of each question. The answers are designed to allow the reader to further enhance their clinical knowledge, understanding and single best answer technique, thus making this book an excellent aid for exam preparation.Related Link(s)
Oxford Case Histories in Lung Cancer contains a comprehensive selection of 40 clinical cases that reflects the multidisciplinary approach to the management of lung cancer. Written by authors specialising in respiratory medicine, oncology, pathology, radiology, palliative care, and thoracic surgery, the cases cover both incidents commonly faced in clinical practice, or those that pose particular challenges. Each case consists of a brief case history, followed by questions and answers to discuss common questions arising during the management of lung cancer. The answers are based on the best available evidence from the latest research, and should help optimise the diagnostic pathways available to patients. The text is also extensively illustrated with over 75 CT and MRI scans and X-ray images to help the reader develop interpretative skills. The book may also be used in multidisciplinary sessions to help make arguments for patient care decisions based on real-life scenarios. This is an essential new resource for both trainees and recently appointed consultants who will work with patients who have lung cancer, specialist nurses, and lung cancer MDT co-ordinators.
Used by generations of physicians who encounter patients with dermatological diseases, Lever’s Dermatopathology: Histopathology of the Skin comprehensively covers skin disease in which histopathology plays an important role in diagnosis. The updated 12th Edition, edited by Drs. David E. Elder, Rosalie Elenitsas, George F. Murphy, Misha Rosenbach, Adam I. Rubin, John T. Seykora, and Xiaowei Xu, maintains the proven, clinicopathologic classification of cutaneous disease while incorporating a “primer” on pattern-algorithm diagnosis. It features larger images throughout, as well as thoroughly revised content with new diseases and new information on pathophysiology and molecular pathogenesis—all in an easy-to-navigate, highly readable format.
They outline a comprehensive plan to reform medical education, research funding and protocols, and the process for approving new drugs that will ensure that more of what gets done in doctors' offices and hospitals is truly effective.
Biostatistics for Oncologists is the first practical guide providing the essential biostatistical concepts, oncology-specific examples, and applicable problem sets for medical oncologists, radiation oncologists, and surgical oncologists. The book also serves as a review for medical oncology and radiation oncology residents or fellows preparing for in-service and board exams. All examples are relevant to oncology and demonstrate how to apply core conceptual knowledge and applicable methods related to hypothesis testing, correlation and regression, categorical data analysis and survival analysis to the field of oncology. The book also provides guidance on the fundamentals of study design and analysis. Written for oncologists by oncologists, this practical text demystifies challenging statistical concepts and provides concise direction on how to interpret, analyze, and critique data in oncology publications, as well as how to apply statistical knowledge to understanding, designing, and analyzing clinical trials. With practical problem sets and twenty-five multiple choice practice questions with answers, the book is an indispensable review for anyone preparing for in-service exams, boards, MOC, or looking to hone a lifelong skill. Key Features: Practically explains biostatistics concepts important for passing the hematology, medical oncology, and radiation oncology boards and MOC exams. Provides guidance on how to read, understand, and critique data in oncology publications. Gives relevant examples that are important for analyzing data in oncology, including the design and analysis of clinical trials. Tests your comprehension of key biostatistical concepts with problem sets at the end of each section and a final section devoted to board-style multiple choice questions and answers Includes digital access to the eBook
Like many gentlemen of his time, Charles Darwin married his first cousin. In fact, marriages between close relatives were commonplace in nineteenth-century England, and Adam Kuper argues that they played a crucial role in the rise of the bourgeoisie. Incest and Influence shows us just how the political networks of the eighteenth-century aristocracy were succeeded by hundreds of in-married bourgeois clans—in finance and industry, in local and national politics, in the church, and in intellectual life. In a richly detailed narrative, Kuper deploys his expertise as an anthropologist to analyze kin marriages among the Darwins and Wedgwoods, in Quaker and Jewish banking families, and in the Clapham Sect and their descendants over four generations, ending with a revealing account of the Bloomsbury Group, the most eccentric product of English bourgeois endogamy. These marriage strategies were the staple of novels, and contemporaries were obsessed with them. But there were concerns. Ideas about incest were in flux as theological doctrines were challenged. For forty years Victorian parliaments debated whether a man could marry his deceased wife’s sister. Cousin marriage troubled scientists, including Charles Darwin and his cousin Francis Galton, provoking revolutionary ideas about breeding and heredity. This groundbreaking study brings out the connection between private lives, public fortunes, and the history of imperial Britain.
A long forgotten tale gets a new life as this book reveals the true story of the 18th-century shipwreck cannibalism scandalDuring the fierce winter of 1710, 14 Englishmen had taken refuge on Boon Island, a sparse 100-yard long stretch of rock, without food or adequate shelter, uncertain of when or if they would be rescued. They endured for 24 days. An attempt to escape failed and four men died. Facing starvation, their captain, John Dean, gave the order to butcher and eat a member of the crew. Dean's decision fended off starvation and sustained his crew until rescue. John Dean first emerged an unlikely hero, but soon thereafter an alternative version of events began to circulate. The First Mate painted Dean as a murderous fraudster, tyrant, and an enthusiastic consumer of human flesh. Centering on the scandal that defined him, this book tells the forgotten story of John Dean; criminal, mercenary, gentleman, diplomat, and cannibal.
MATLAB for Neuroscientists serves as the only complete study manual and teaching resource for MATLAB, the globally accepted standard for scientific computing, in the neurosciences and psychology. This unique introduction can be used to learn the entire empirical and experimental process (including stimulus generation, experimental control, data collection, data analysis, modeling, and more), and the 2nd Edition continues to ensure that a wide variety of computational problems can be addressed in a single programming environment. This updated edition features additional material on the creation of visual stimuli, advanced psychophysics, analysis of LFP data, choice probabilities, synchrony, and advanced spectral analysis. Users at a variety of levels—advanced undergraduates, beginning graduate students, and researchers looking to modernize their skills—will learn to design and implement their own analytical tools, and gain the fluency required to meet the computational needs of neuroscience practitioners. - The first complete volume on MATLAB focusing on neuroscience and psychology applications - Problem-based approach with many examples from neuroscience and cognitive psychology using real data - Illustrated in full color throughout - Careful tutorial approach, by authors who are award-winning educators with strong teaching experience
The structure of the book allows new students to understand the physiology underlying the patient's condition before concentrating on the priorities of interventions and nursing care. Critical Care Nursing will not only act as an excellent base for nurses new to the critical care area, but will also provide an updated review of evidence-based practice for nurses already familiar with the discipline."--BOOK JACKET.
Philosophical tweets -- What Twitter really is -- "Following" makes Twitter's social structure -- "Almost everything you see today in Twitter was invented by our users"--Referential complications -- Twitter's content and Twitter's context -- Twitter's constitution and Twitter's shape -- Digital institutions -- Digital language -- A natural history of digital institutions -- Since we make these digital institutions
Grasp key concepts quickly with the visual, concise, and clinical approach to physiology found in this second edition of Netter's Essential Physiology. Lucid prose combines with classic Netter art, clinical correlations, "light bulb" side notes, end-of-chapter questions, and brand-new videos to ensure a complete understanding of these complex concepts. Logically written and highly readable, it's ideal for a basic understanding of physiology, as an overview of the subject, or as a supplement to lectures. You may also be interested in: Netter's Physiology Flash Cards: ISBN 978-0-323-35954-2, the companion flash cards to this book. - Beautifully clear drawings and diagrams from the Netter collection illustrate key concepts and further your visual understanding of the subject. - Self-assessment review questions at the end of each chapter serve to expedite study. - Student Consult eBook version included with purchase. This enhanced eBook experience includes access -- on a variety of devices -- to the complete text, 8 animations, and new video tutorials. You'll also be able to test your knowledge with additional multiple-choice questions. - A brand-new chapter on blood provides increased coverage of immunology. - Additional "light bulb" boxes highlight interesting memorable details or examples providing enhanced context. - A greater number of clinical correlations integrate pathophysiology into the content. - New video tutorials explain difficult concepts and help to reinforce comprehension of the material.
Easy to read, superbly illustrated, and clinically relevant, Gray's Anatomy for Students, 4th Edition, is medical students' go-to text for essential information in human anatomy. This fully revised volume focuses on the core information students need to know, in an easy-access format and with additional multimedia tools that facilitate effective study and mastery of the material. A team of expert authors and global advisors share their extensive teaching and clinical experience, highlighted by more than 1,000 innovative, original illustrations throughout the text. - Helps students understand the practical applications of anatomical concepts through unique coverage of surface anatomy, correlative diagnostic images, and clinical case studies. - Presents anatomy logically by body region, and now offers bonus eBook chapters for each major body system to facilitate learning from a different perspective – covering the Cardiovascular System, Respiratory System, Gastrointestinal System, Urogenital System, Lymphatic System, and Nervous System. - Features an all-new eBook chapter covering the essentials of neuroanatomy, so readers can learn key aspects of this challenging topic in the context of general anatomy. - Offers new schematic drawings for key structures and topics in every chapter, providing an additional, simplified approach to introduce each topic—ideal for quick initial understanding and as a guide for students' own anatomy drawings. - Includes new and improved online materials such as self-assessment questions, clinical cases, an Interactive Surface Anatomy tool, an online anatomy and embryology self-study course, and more. - Provides fully revised and updated clinical content including numerous new In the Clinic boxes, plus new clinical cases, images, and correlates throughout. - Enables readers to quickly review the basic concepts from each chapter with Conceptual Overviews. - Evolve Instructor site with a downloadable image bank is available to instructors through their Elsevier sales rep or via request at: https://evolve.elsevier.com
Trusted by both radiologists and orthopaedic surgeons for authoritative, comprehensive guidance on the interpretation of musculoskeletal images, Orthopedic Imaging: A Practical Approach is an ideal resource at every stage of training and practice. The fully revised seventh edition retains the large images, easy-to-read writing style, and careful blend of illustrations and text that clearly depict all relevant imaging modalities and all pathological entities.
A comprehensive pocket guide for clinicians and residents, the Oxford American Handbook of Gastroenterology and Hepatology provides authoritative guidance and up-to-date information on the field. The Handbook gives thorough coverage of both diagnosis and therapy, includes an easy-to-reference emergency section, and maintains a focus on practical disease management. The book's anatomically organized sections are supplemented by special sections on management of GI emergencies and the "Top 10 GI Problems," including pertinent algorithms and practice guidelines. Useful appendices provide images of common GI problems and links to websites.
This first-of-its-kind book describes the roles of conventional medicine, complementary therapies, and natural alternative therapies in the treatment of gynecological disorders. The book gives practitioners much-needed information on how complementary and alternative therapies work and how they interact with conventional medicines. The chapters are organized by disease and each includes information on etiology, diagnosis, differential diagnosis, the conventional therapy (drug, procedure, etc.), complementary therapy (acupuncture, chiropractic and manipulative therapy, biofeedback, etc.), and alternative therapy (nutrition, herbal, homeopathy). The sections on complementary and alternative therapies explain what the therapies are and describe the postulated mechanisms of action.
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