Enterohemorrhagic E. coli (EHEC), enteropathogenic E. coli (EPEC), and Shigella use a type 3 secretion system (T3SS) to inject dozens of effector proteins into the host cell. The effectors manipulate host cell processes including the host cytoskeleton, immune response, cell survival, and gut integrity. EPEC and EHEC share a large number of common effectors and some homologous effectors can be found in Shigella, however there is also considerable variability within and between pathotypes. For many effectors detailed molecular mechanisms of action have been described by identifying host interacting partners, homologous proteins, or enzymatic activities. However, understanding effector biology within the context of infection with multiple effectors, various cell populations, and host genetic differences remains a challenge.
The Doctor Is In . . . As a single mom and pediatrician, Sabrina Bankhead doesn't have time for romance. All that changes when she reluctantly agrees to take part in a dating show fundraiser for a children's hospital. But once she sets eyes on the journalist hired to cover the show, none of the four contestants stand a chance. If she doesn't choose one of the eligible bachelors, the hospital doesn't raise a cent. What's a lovestruck doc to do? Investigative journalist Quinn Donnelly is on the mend after an assignment in Afghanistan left him both physically and emotionally scarred. Though he's itching to return overseas and finish his story, he'll have to be content with this fluff piece assignment to cover a local dating show. One-night stands are Quinn's forte-but after he meets Sabrina, he's ready to say yes for the long haul. After years of chasing the next big story, Quinn is starting to wonder if maybe home really can be where the heart is . . .
This latest Revised Edition, builds on the previous editions by updating essential information relating to the law and practice surrounding caring for a disabled child. The book is used extensively by advice workers and also parents of disabled children and has proved an invaluable and indispensable guide.
Dr. Aaron Lewis is captivated by the new paediatric surgeon Dr. Annabel Swain—especially since she’s saved his daughter’s life! Aaron senses that Annabel, like him, has lost a loved one and is longing for a family. He’s determined to help her overcome her past—but first he has to convince Annabel to share her secrets with him…
Vittoria Colonna was one of the best known and most highly celebrated female poets of the Italian Renaissance. Her work went through many editions during her lifetime, and she was widely considered by her contemporaries to be highly skilled in the art of constructing tightly controlled and beautifully modulated Petrarchan sonnets. In addition to her literary contacts, Colonna was also deeply involved with groups of reformers in Italy before the Council of Trent, an involvement which was to have a profound effect on her literary production. In this study, Abigail Brundin examines the manner in which Colonna's poetry came to fulfil, in a groundbreaking and unprecedented way, a reformed spiritual imperative, disseminating an evangelical message to a wide audience reading vernacular literature, and providing a model of spiritual verse which was to be adopted by later poets across the peninsula. She shows how, through careful management of an appropriate literary persona, Colonna's poetry was able to harness the power of print culture to extend its appeal to a much broader audience. In so doing this book manages to provide the vital link between the two central facets of Vittoria Colonna's production: her poetic evangelism, and her careful construction of a gendered identity within the literary culture of her age. The first full length study of Vittoria Colonna in English for a century, this book will be essential reading for scholars interested in issues of gender, literature, religious reform or the dynamics of cultural transmission in sixteenth-century Italy. It also provides an excellent background and contextualisation to anyone wishing to read Colonna's writings or to know more about her role as a mediator between the worlds of courtly Petrachism and religious reform.
This book aims to provide fundamental knowledge and information for research in molecular systematics on parasitic helminths (nematode, trematode, cestode). The shreds of evidence of molecular systematics studies will be compiled and discussed in terms of the utilities and pitfalls of the genetic marker used for various purposes, which have been implemented for molecular systematics of parasitic nematodes, cestodes, and trematodes. Moreover, this book will also provide the procedure for research on molecular systematics and DNA taxonomy as the guideline to explore parasitic helminths. Finally, the further perspectives of utilizing genetic markers for molecular studies on parasitic helminths will be addressed in the context of applications from the laboratory to fieldwork such as DNA barcoding and environmental DNA metabarcoding of parasitic helminths. The book will benefit postgraduate students and researchers requiring the detailed knowledge of molecular systematics, as well as researchers desiring a guideline to select genetic markers and analyze DNA sequences to make phylogenetic inferences
Abigail Bray offers a lucid and accessible introduction to Hélène Cixous and her theorisation of writing and sexual difference. This book explores the context of feminist debates surrounding Cixous's work and provides a concise explanation of her major philosophical and literary concepts, including the 'other bisexuality', the 'third body', and l'écriture feminine. Bray demonstrates, through original and provocative readings of texts by James Joyce, Virginia Woolf, Clarice Lispector and Angela Carter, the creative potential of Cixous's thought on literature and philosophy. Reading Cixous alongside Nietzsche, Heidegger, Deleuze and Derrida, Bray argues for a recognition of Cixous as one of the important thinkers of our times.
Invaluable in providing vivid illustrations of the strengths and needs of young parents who have been 'looked after' and, therefore of their children at the start of their lives. It illuminates policy and practice implications and points the way forward to what needs to be done to ameliorate their lives. Throughout, it presents its research in an accessible style and measured tone that make it difficult to put down.' - Extract from the Foreword by Ann Phoenix, Co-Director of the Thomas Coram Research Unit, Institute of Education, University of London Supporting Young Parents explores early pregnancy and parenthood from the perspectives of young men and women in and leaving care. Most discussion about teenage pregnancy and parenthood focuses on the negative consequences for teenagers and their children. Yet, for some young people, particularly those who have been disadvantaged in life, early parenthood may offer the security of a family life, a sense of stability and an opportunity to build emotional attachments. This book draws on authoritative research into the reasons for and experiences of pregnancy and parenthood among young people from local authority care. It questions the assumptions that early parenthood always limits young people's choices and opportunities and examines the types of support most likely to enable successful parenting. This book will be essential reading for community nurses, health visitors, social workers, academics and students working in the fields of health, education and social care.
This textbook examines prisons and imprisonment. Historically, prisons and prisoners have been a source of interest to the general public. However, despite near universal acceptance of imprisonment as a feature of society, we know relatively little about the reality of prison life, or the effects it has on individuals and communities. Using academic scholarship, empirical research, government papers, policy reports, and accounts from lived experiences of the institution, this book analyses the complexities and contradictions of prison life, the place of the prison in twenty-first century society, and its prospects for the future. This book will introduce readers to key debates surrounding the use of imprisonment, and challenge readers to interrogate conventional perspectives on an institution that reflects the society in which it is situated.
An examination of how nonprofessional archivists, especially media fans, practice cultural preservation on the Internet and how “digital cultural memory” differs radically from print-era archiving. The task of archiving was once entrusted only to museums, libraries, and other institutions that acted as repositories of culture in material form. But with the rise of digital networked media, a multitude of self-designated archivists—fans, pirates, hackers—have become practitioners of cultural preservation on the Internet. These nonprofessional archivists have democratized cultural memory, building freely accessible online archives of whatever content they consider suitable for digital preservation. In Rogue Archives, Abigail De Kosnik examines the practice of archiving in the transition from print to digital media, looking in particular at Internet fan fiction archives. De Kosnik explains that media users today regard all of mass culture as an archive, from which they can redeploy content for their own creations. Hence, “remix culture” and fan fiction are core genres of digital cultural production. De Kosnik explores, among other things, the anticanonical archiving styles of Internet preservationists; the volunteer labor of online archiving; how fan archives serve women and queer users as cultural resources; archivists' efforts to attract racially and sexually diverse content; and how digital archives adhere to the logics of performance more than the logics of print. She also considers the similarities and differences among free culture, free software, and fan communities, and uses digital humanities tools to quantify and visualize the size, user base, and rate of growth of several online fan archives.
Presenting two decades of work by Abigail Solomon-Godeau, Photography after Photography is an inquiry into the circuits of power that shape photographic practice, criticism, and historiography. As the boundaries that separate photography from other forms of artistic production are increasingly fluid, Solomon-Godeau, a pioneering feminist and politically engaged critic, argues that the relationships between photography, culture, gender, and power demand renewed attention. In her analyses of the photographic production of Cindy Sherman, Robert Mapplethorpe, Susan Meiselas, Francesca Woodman, and others, Solomon-Godeau refigures the disciplinary object of photography by considering these practices through an examination of the determinations of genre and gender as these shape the relations between photographers, their images, and their viewers. Among her subjects are the 2006 Abu Ghraib prison photographs and the Cold War-era exhibition The Family of Man, insofar as these illustrate photography's embeddedness in social relations, viewing relations, and ideological formations.
Enterohemorrhagic E. coli (EHEC), enteropathogenic E. coli (EPEC), and Shigella use a type 3 secretion system (T3SS) to inject dozens of effector proteins into the host cell. The effectors manipulate host cell processes including the host cytoskeleton, immune response, cell survival, and gut integrity. EPEC and EHEC share a large number of common effectors and some homologous effectors can be found in Shigella, however there is also considerable variability within and between pathotypes. For many effectors detailed molecular mechanisms of action have been described by identifying host interacting partners, homologous proteins, or enzymatic activities. However, understanding effector biology within the context of infection with multiple effectors, various cell populations, and host genetic differences remains a challenge.
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