The Grandest Challenge begins with a simple premise: that every person's life is of equal value, regardless of where in the world he or she lives. It also begins with an alarming fact: that in this age of spectacular scientific advances, it is still those who live in the developed world--mainly the west--who overwhelmingly benefit from our enormous new power to combat disease and enhance food, while those in the developing world are far more likely to die for lack of basic health care and inexpensive nutrition. As personalized medicine, designer drugs, and high-quality nutrients become more readily available than ever in the richest parts of the world, distinguished doctors Abdallah Daar and Peter Singer urge us to pause and ask these vital questions: Who will have access to the life-enhancing advances of biotechnology? And who are these advances ultimately meant to help? In this challenging, controversial, thought-provoking, and humane book, Daar and Singer inspire us to look more deeply at our new science, and at the revolution that is already changing all of our lives.
At STIAS, the ‘Health in Transition’ theme includes a programme to address the epidemic rise in the incidence of non-communicable diseases (NCDs) such as Type 2 diabetes, hypertension, obesity, coronary heart disease and stroke in Africa. The aim is to advance awareness, research capacity and knowledge translation of science related to the Developmental Origins of Health and Disease (DOHaD) as a means of preventing NCDs in future generations. Application of DOHaD science is a promising avenue for prevention, as this field is identifying how health and nutrition from conception through the first 1 000 days of life can dramatically impact a developing individual’s future life course, and specifically predicate whether or not they are programmed in infancy to develop NCDs in later life. Prevention of NCDs is an essential strategy as, if unchecked, the burden of caring for a growing and ageing population with these diseases threatens to consume entire health budgets, as well as negatively impact the quality of life of millions. Africa in particular needs specific, focussed endeavors to realize the maximal preventive potential of DOHaD science, and a means of generating governmental and public awareness about the links between health in infancy and disease in adult life. This volume summarizes the expertise and experience of a leading group of international scientists led by Abdallah Daar brought together at STIAS as part of the ‘Health in Transition’ programme.
The Grandest Challenge begins with a simple premise: that every person's life is of equal value, regardless of where in the world he or she lives. It also begins with an alarming fact: that in this age of spectacular scientific advances, it is still those who live in the developed world--mainly the west--who overwhelmingly benefit from our enormous new power to combat disease and enhance food, while those in the developing world are far more likely to die for lack of basic health care and inexpensive nutrition. As personalized medicine, designer drugs, and high-quality nutrients become more readily available than ever in the richest parts of the world, distinguished doctors Abdallah Daar and Peter Singer urge us to pause and ask these vital questions: Who will have access to the life-enhancing advances of biotechnology? And who are these advances ultimately meant to help? In this challenging, controversial, thought-provoking, and humane book, Daar and Singer inspire us to look more deeply at our new science, and at the revolution that is already changing all of our lives.
This book is the first systematic, detailed treatment of the approaches to ethical issues taken by biotech and pharmaceutical companies. The application of genetic/genomic technologies raises a whole spectrum of ethical questions affecting global health that must be addressed. Topics covered in this comprehensive survey include considerations for bioprospecting in transgenics, genomics, drug discovery, and nutrigenomics, as well as how to improve stakeholder relations, design ethical clinical trials, avoid conflicts of interest, and establish ethics advisory boards. The expert authors represent multiple disciplines including law, medicine, bioinformatics, pharmaceutics, business, and ethics.
The new science of nutrigenomics and its ethical and societal challenges Gene-diet interactions--which underlie relatively benign lactose intolerance to life-threatening conditions such as cardiovascular disease--have long been known. But until now, scientists lacked the tools to fully understand the underlying mechanisms that cause these conditions. In recent years, however, strides in human genomics and the nutritional sciences have allowed for the advancement of a new science--dubbed nutrigenomics. Although this science may lead to personalized nutrition and dietary recommendations that can mitigate, prevent, or cure sickness, current oversight mechanisms and regulations for emerging direct-to-public nutrigenomic tests are still in their infancy. Science, Society, and the Supermarket: The Opportunities and Challenges of Nutrigenomics discusses the many ethical, legal, and social challenges presented by nutrigenomics. Concerning itself with the basic uses of nutrigenomic research as well as its clinical and commercial aspects, this text sheds light on such issues as: * Opportunities and challenges for nutrigenomics * The science of nutrigenomics * The ethics of nutrigenomic tests and information both in a clinical setting and by private third parties * Alternatives for nutrigenomics service delivery * Nutrigenomics and the regulation of health claims for foods and drugs * Equity and access to nutrigenomics in industrialized and developing countries * Intellectual property issues By taking a proactive bioethical stance on the subject, Science, Society, and the Supermarket offers a thorough and timely analysis on both the benefits and risks of nutrigenomics. Along with a thought-provoking examination of the issues, this book provides ethical guidelines and recommendations for further study in policy and regulatory development.
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