The structural simplicity of nematode nervous systems has provided a useful resource for studies on basic neurobiology. Two species have underpinned basic neuroscience research in phylum Nematoda, the free-living nematode Caenorhabditis elegans and the pig parasitic nematode Ascaris suum due to their genetic tractability and large size, respectively. The fact that most of the chemotherapeutic targets for the treatment of roundworm parasite infections of animals and man associate with neuromuscular function means that nematode neurobiology research resonates beyond discovery biology and informs parasite control. These diverse drivers for the interrogation of nematode neurobiology have exposed a unique approach to the regulation of complex behavioral traits, encompassing structural simplicity with profound chemical complexity. The latter embraces extreme diversity in both the ligand-gated ion channel subunit complements for classical neurotransmitters and in the neuropeptide ligands that signal mostly via G-protein coupled receptors, offering compelling opportunities for parasite control-target discovery and validation.
The need to continually discover new agents for the control or treatment of invertebrate pests and pathogens is undeniable. Agriculture, both animal and plant, succeeds only to the extent that arthropod and helminth consumers, vectors and pathogens can be kept at bay. Humans and their companion animals are also plagued by invertebrate parasites. The deployment of chemical agents for these purposes inevitably elicits the selection of resistant populations of the targets of control, necessitating a regular introduction of new kinds of molecules. Experience in other areas of chemotherapy has shown that a thorough understanding of the biology of disease is an essential platform upon which to build a discovery program. Unfortunately, investment of research resources into understanding the basic physiology of invertebrates as a strategy to illuminate new molecular targets for pesticide and parasiticide discovery has been scarce, and the pace of introduction of new molecules for these indications has been slowed as a result. An exciting and so far unexploited area to explore in this regard is invertebrate neuropeptide physiology. This book was assembled to focus attention on this promising field by compiling a comprehensive review of recent research on neuropeptides in arthropods and helminths, with contributions from many of the leading laboratories working on these systems.
Provides a look into the rags-to-riches life of the famed Hollywood television producer who has been one of the most successful in the field for more than thirty-five years, creating such popular shows as Dynasty, The Love Boat and.
The structural simplicity of nematode nervous systems has provided a useful resource for studies on basic neurobiology. Two species have underpinned basic neuroscience research in phylum Nematoda, the free-living nematode Caenorhabditis elegans and the pig parasitic nematode Ascaris suum due to their genetic tractability and large size, respectively. The fact that most of the chemotherapeutic targets for the treatment of roundworm parasite infections of animals and man associate with neuromuscular function means that nematode neurobiology research resonates beyond discovery biology and informs parasite control. These diverse drivers for the interrogation of nematode neurobiology have exposed a unique approach to the regulation of complex behavioral traits, encompassing structural simplicity with profound chemical complexity. The latter embraces extreme diversity in both the ligand-gated ion channel subunit complements for classical neurotransmitters and in the neuropeptide ligands that signal mostly via G-protein coupled receptors, offering compelling opportunities for parasite control-target discovery and validation.
In The Unwritten War, Daniel Aaron examines the literary output of American writers—major and minor—who treated the Civil War in their works. He seeks to understand why this devastating and defining military conflict has failed to produce more literature of a notably high and lasting order, why there is still no "masterpiece" of Civil War fiction. In his portraits and analyses of 19th- and some 20th-century writers, Aaron distinguishes between those who dealt with the war only marginally—Henry Adams, Henry James, William Dean Howells, Mark Twain-and those few who sounded the war's tragic import—Herman Melville, Walt Whitman, and William Faulkner. He explores the extent to which the war changed the direction of American literature and how deeply it entered the consciousness of American writers. Aaron also considers how writers, especially those from the South, discerned the war's moral and historical implications. The Unwritten War was originally published by Alfred A. Knopf in 1973. The New Republic declared, [This book's] major contribution will no doubt be to American literary history. In this respect it resembles Edmund Wilson's Patriotic Gore and is certain to become an indispensable guide for anyone who wants to explore the letters, diaries, journals, essays, novels, short stories, poems-but apparently no plays-which constitute Civil War literature. The mass of material is presented in a systematic, luminous, and useful way.
Modern Global Seismology, Second Edition, is a complete, self-contained primer on seismology, featuring extensive coverage of all related aspects—from observational data through prediction—and emphasizing the fundamental theories and physics governing seismic waves, both natural and anthropogenic. Based on thoroughly class-tested material, the text provides a unique perspective on Earth’s large-scale internal structure and dynamic processes, particularly earthquake sources, and the application of theory to the dynamic processes of the earth’s upper layer. This insightful new edition is designed for accessibility and comprehension for graduate students entering the field. Exploration seismologists will also find it an invaluable resource on topics such as elastic-wave propagation, seismic instrumentation, and seismogram analysis. Includes more than 400 illustrations, from both recent and traditional research articles, to help readers visualize mathematical relationships, as well as boxed features to explain advanced topics Offers incisive treatments of seismic waves, waveform evaluation and modeling, and seismotectonics, as well as quantitative treatments of earthquake source mechanics and numerous examples of modern broadband seismic recordings Covers current seismic instruments and networks and demonstrates modern waveform inversion methods Includes extensive, updated references for further reading new to this edition Features reorganized chapters split into two sections, beginning with introductory content such as tectonics and seismogram analysis, and moving on to more advanced topics, including seismic wave excitation and propagation, multivariable and vector calculus, and tensor approaches Completely updated references and figures to bring the text up to date Includes all-new sections on recent advancements and to enhance examples and understanding Split into shorter chapters to allow more flexibility for instructors and easier access for researchers, and includes exercises
A masterly and beautifully written account of the impact of Alexander von Humboldt on nineteenth-century American history and culture The naturalist and explorer Alexander von Humboldt (1769-1859) achieved unparalleled fame in his own time. Today, however, he and his enormous legacy to American thought are virtually unknown. In The Humboldt Current, Aaron Sachs traces Humboldt's pervasive influence on American history through examining the work of four explorers—J. N. Reynolds, Clarence King, George Wallace, and John Muir—who embraced Humboldt's idea of a "chain of connection" uniting all peoples and all environments. A skillful blend of narrative and interpretation that also discusses Humboldt's influence on Emerson, Whitman, Thoreau, Melville, and Poe, The Humboldt Current offers a colorful, passionate, and superbly written reinterpretation of nineteenth-century American history.
The most comprehensive and definitive guide to the world of natural wine that every wine lover needs. * Named one of the year’s best books on wine by The New York Times and Bloomberg Natural wine has nothing to hide. Made from grapes alone—organically farmed, then harvested, fermented, aged, and bottled without additives—it’s wine that seeks to express, in every sip, its traditional and crucial link to nature. The World of Natural Wine is the book wine lovers need to navigate this movement—because it’s about so much more than labels and vintages. Meet the obsessive, often outspoken, winemakers; learn about the regions of France where natural wine culture first appeared and continues to flourish today; and explore natural wine in Spain, Italy, Georgia, and beyond. And just as important: find out what must be “unlearned” to discover the eye-opening pleasures of drinking naturally.
This book presents the concepts underlying the measurement of parasympathetic and sympathetic (P&S) activity in the autonomic nervous system and the application of these measurements in the development of therapeutic guidelines for treating dysfunctions in these processes. It provides an overview of the anatomy, physiology, and biochemistry of the autonomic nervous system; details general clinical applications of P&S monitoring that are independent of specialty or disease; presents the pathophysiology of P&S dysfunction in specific disorders, expected test results, therapeutic options, and expected outcomes; and includes case studies and longitudinal studies that demonstrate the major concepts for the common diseases for which P&S monitoring is recommended. Clinical Autonomic Dysfunction enables clinicians to improve patient outcomes by identifying and treating clinical problems related to autonomic nervous system disorders.
Rodman (government, Colby College) examines the use of sanctions from the early Cold War era through the 1990s, including the Helms-Burton Law and the Iran-Libya Sanctions Act. He argues that sanctions are weak and costly measures that damage diplomatic relations, particularly when used to prevent key multinational corporations from undertaking economically significant transactions with proscribed nations. Annotation copyrighted by Book News, Inc., Portland, OR.
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