Grand Staircase-Escalante National Monument contains abundant fossil material in most formations within its borders. These formations range in age from Permian to Cretaceous. More than 800 individual fossil localities are known so far, and almost all areas of the monument that were examined contain at least some fossil material. Important new findings of this survey include: several partial dinosaur skeletons in the Kaiparowits Formation; a ceratopsian skull in the Wahweap Formation; the previously unreported presence of many ammonoid and bivalve genera in the monument in the Dakota, Tropic, and Straight Cliffs Formations; the first fossils of any kind from the Entrada Sandstone within the monument, including a dinosaur tracksite containing more than 250 tracks of at least 30 individuals; previously unrecognized sites and abundances of vertebrate ichnogenera in the Navajo, Kayenta, Moenave, and Chinle Formations; the first ichnofossil material from the Wingate Sandstone in the monument; and a previously unreported sponge genus from the Kaibab Limestone. The Cretaceous rocks exposed within the monument contain one of the best and most continuous records of Late Cretaceous terrestrial life in the world. Research on these strata is still in its earliest stages.
In the early 1970s a start was made on a broad review of what was known or could be surmised about sedimentation by strong tidal currents on modern continental shelves. This task was initiated because of the need to define the next phase of research in this field by the Marine Geology Group of the Institute of Oceano graphic Sciences. Related indications of the longer term evolution of the deposits were sought by close reference to the nature of modern tidal currents and the supposedly offshore tidal deposits of ancient seas. As the review grew in completeness it became of increasing relevance to a wider audience so it was amalgamated with the new results and shaped as a book. The fruits of the long-continued discussions within and outside the Geology Group have served to improve understanding of the processes and products of offshore tidal current sedimentation. On the other hand, the discussions have blurred the parts played by the people concerned. This applies to all chapters in varying degrees, but is especially true for Chapters 3, 4 and 5. The authorship attributed to each chapter therefore seeks to reflect those who were most con cerned with it.
Over the past 30 years many significant advances have been made in the management of a number of disseminated malignant diseases. The prognosis for diseases such as childhood leukaemia, choriocarcinoma and Hodgkin's disease has gradually been transformed as better anti tumour agents have become available and their clinical use has been refined. During the past 10 years the advent of new agents, particularly cisplatin, bleomycin and the podophyllotoxins, has allowed the cure of disseminated testicular tumours. This degree of success has not, however, been achieved in the case of a number of other common cancers. Ovarian carcinoma is tantalisingly chemo-sensitive and although there are long term survivors from disseminated disease, these are only a small proportion of the total. Breast cancer, although "sensitive" to a multitude of drugs appears to have yielded neither survival benefit, nor cure to the efforts of therapists, while tumours such as those of the colon remain stubbornly unresponsive. Against this backcloth it is apparent that additional more selective treatments are needed if further impact is to be made on the problem of cancer. The development of such agents requires the integration of a multidisciplinary effort encompassing the fields of chemistry, biology and medicine. This symposium provided a forum for clinical and preclinical sCientists, where current aspects of cancer treatment were reviewed and approaches to the development of a new generation of more selective anticancer drugs discussed.
The past five years have witnessed a remarkable development of interest in cell death 'from inside out'. After 30 years of relative obscurity, its quantitative importance in the building and maintenance of normal tissues, the subtle strategies involved in its regulation, and its significance in the pathogenesis of diseases of major social importance are becoming clear. Moreover, because a distinct set of biological events is involved in this death, these events themselves become reason able targets for new pharmacological agents in the treatment of cancer. The articles in this volume summarize the contents of a discussion meeting held at the Royal Society on 23 and 24 February 1994. The authors are a distinguished international group from a variety of disciplines in biology and medicine and hopefully their articles will convey something of the excitement of this fast-moving field. The three organizers are enormously indebted to all the contributors for the enthusiasm with which they delivered their talks, shared in discussion, and finally committed their contributions to these printed pages. We would also like to acknowledge the gracious way in which the Royal Society hosted the meeting, and in particular Mary Manning for making it the trouble-free and enjoyable experience that it was, and Janet Clifford and Simon Gribbin for skillfully managing the editorial processing of this volume. Michael Dexter June 1994 Martin Raff Andrew Wyllie x 1 Death from inside out: an overVIew ANDREW H.
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