A.F. Casy's Books

Opioid Analgesics

Chemistry and Receptors

By: A.F. Casy,R.T. Parfitt

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Opioid Analgesics

Chemistry and Receptors

By: A.F. Casy,R.T. Parfitt

The rapidly burgeoning research of the past two decades on agonist-antagonist analgesics and opioid receptors makes this exhaustive review of opioid anal gesics particularly relevant and timely. After an introductory chapter the additional 12 chapters begin logically with morphine and congeners (4- epoxymorphinans) and end with opioid receptors. All principal chemical types of centrally acting analgesics (including endogenous opioid-like substances) and their antagonists as well as the mixed agonist-antagonists are treated thoroughly, although not always (and for good reason) in historical (chrono logical) order. A chapter on miscellaneous types (atypical structures for the most part) includes the benzimidazoles (etonitazene), aminotetralins (dezocine), tetrahydroisoquinolines (methopholine), and so on. Important aspects and correlations of chemistry, pharmacology, and biochemistry are discussed in depth. Literature citations are numerous. For educators, practicing laboratory scientists, and physicians, this scholarly review by two authors well of opioid analgesics versed in the chemistry, pharmacology, and biochemistry will be informative, stimulating, and thought-provoking. Everette L. May Medical College of Virginia Richmond, VA 23298 v Preface The history of opium predates the written word, although knowledge of its constituents dates back less than 200 years. Over the centuries its popularity for the relief of pain has waxed and waned, until today the opiates are widely recognized as excellent analgesics but with disadvantages that have impaired their use seriously. There is a clear need for a potent analgesic with minimal effects on the respiratory centers and gastrointestinal tract and preferably devoid of dependence liability.

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526

Publisher

Springer Science & Business Media

Published Date

ISBN 10

1489905855

ISBN 13

9781489905857

The Steric Factor in Medicinal Chemistry

Dissymmetric Probes of Pharmacological Receptors

By: A.F. Casy

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The Steric Factor in Medicinal Chemistry

Dissymmetric Probes of Pharmacological Receptors

By: A.F. Casy

It is indeed the merit of Dr. Alan F. Casy to bring in these pages a clear and comprehensive view of medicinal stereochemistry, a discipline in which he has been active and successful for many years both as a teacher and a researcher. Written for graduate students and research workers in medicinal chemistry and pharmacology, this book will contribute significantly towards a better education of scientists by removing the fear of stereochemistry caused by ignorance, moderating the overconfidence of possible zealots, and outlining a broader context.'-from the foreword by Bernard Testa

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580

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Springer Science & Business Media

Published Date

ISBN 10

1489923977

ISBN 13

9781489923974

Opioid Analgesics

Chemistry and Receptors

By: A.F. Casy,R.T. Parfitt

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Opioid Analgesics

Chemistry and Receptors

By: A.F. Casy,R.T. Parfitt

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526

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Springer Science & Business Media

Published Date

ISBN 10

1489905855

ISBN 13

9781489905857

The Steric Factor in Medicinal Chemistry

Dissymmetric Probes of Pharmacological Receptors

By: A.F. Casy

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The Steric Factor in Medicinal Chemistry

Dissymmetric Probes of Pharmacological Receptors

By: A.F. Casy

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580

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Springer Science & Business Media

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ISBN 10

1489923977

ISBN 13

9781489923974

Biological Threats and Terrorism

Assessing the Science and Response Capabilities: Workshop Summary

By: Institute of Medicine,Board on Global Health,Forum on Emerging Infections

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Biological Threats and Terrorism

Assessing the Science and Response Capabilities: Workshop Summary

By: Institute of Medicine,Board on Global Health,Forum on Emerging Infections

In the wake of September 11th and recent anthrax events, our nation's bioterrorism response capability has become an imminent priority for policymakers, researchers, public health officials, academia, and the private sector. In a three-day workshop, convened by the Institute of Medicine's Forum on Emerging Infections, experts from each of these communities came together to identify, clarify, and prioritize the next steps that need to be taken in order to prepare and strengthen bioterrorism response capabilities. From the discussions, it became clear that of utmost urgency is the need to cast the issue of a response in an appropriate framework in order to attract the attention of Congress and the public in order to garner sufficient and sustainable support for such initiatives. No matter how the issue is cast, numerous workshop participants agreed that there are many gaps in the public health infrastructure and countermeasure capabilities that must be prioritized and addressed in order to assure a rapid and effective response to another bioterrorist attack.

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335

Publisher

National Academies Press

Published Date

ISBN 10

030916995X

ISBN 13

9780309169950

Factors in American History

By: A. F. Pollard

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Factors in American History

By: A. F. Pollard

PREFACE. THE Author of this very practical treatise on Scotch Loch - Fishing desires clearly that it may be of use to all who had it. He does not pretend to have written anything new, but to have attempted to put what he has to say in as readable a form as possible. Everything in the way of the history and habits of fish has been studiously avoided, and technicalities have been used as sparingly as possible. The writing of this book has afforded him pleasure in his leisure moments, and that pleasure would be much increased if he knew that the perusal of it would create any bond of sympathy between himself and the angling community in general. This section is interleaved with blank shects for the readers notes. The Author need hardly say that any suggestions addressed to the case of the publishers, will meet with consideration in a future edition. We do not pretend to write or enlarge upon a new subject. Much has been said and written-and well said and written too on the art of fishing but loch-fishing has been rather looked upon as a second-rate performance, and to dispel this idea is one of the objects for which this present treatise has been written. Far be it from us to say anything against fishing, lawfully practised in any form but many pent up in our large towns will bear us out when me say that, on the whole, a days loch-fishing is the most convenient. One great matter is, that the loch-fisher is depend- ent on nothing but enough wind to curl the water, -and on a large loch it is very seldom that a dead calm prevails all day, -and can make his arrangements for a day, weeks beforehand whereas the stream- fisher is dependent for a good take on the state of the water and however pleasant and easy it may be for one living near the banks of a good trout stream or river, it is quite another matter to arrange for a days river-fishing, if one is looking forward to a holiday at a date some weeks ahead. Providence may favour the expectant angler with a good day, and the water in order but experience has taught most of us that the good days are in the minority, and that, as is the case with our rapid running streams, -such as many of our northern streams are, -the water is either too large or too small, unless, as previously remarked, you live near at hand, and can catch it at its best. A common belief in regard to loch-fishing is, that the tyro and the experienced angler have nearly the same chance in fishing, -the one from the stern and the other from the bow of the same boat. Of all the absurd beliefs as to loch-fishing, this is one of the most absurd. Try it. Give the tyro either end of the boat he likes give him a cast of ally flies he may fancy, or even a cast similar to those which a crack may be using and if he catches one for every three the other has, he may consider himself very lucky. Of course there are lochs where the fish are not abundant, and a beginner may come across as many as an older fisher but we speak of lochs where there are fish to be caught, and where each has a fair chance. Again, it is said that the boatman has as much to do with catching trout in a loch as the angler. Well, we dont deny that. In an untried loch it is necessary to have the guidance of a good boatman but the same argument holds good as to stream-fishing...

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Page Count

324

Publisher

Myers Press

Published Date

ISBN 10

1406704644

ISBN 13

9781406704648

Book's by A.F. Casy

Opioid Analgesics

Opioid Analgesics

The Steric Factor in Medicinal Chemistry

The Steric Factor in Medicinal Chemistry

Opioid Analgesics

Opioid Analgesics

The Steric Factor in Medicinal Chemistry

The Steric Factor in Medicinal Chemistry

Biological Threats and Terrorism

Biological Threats and Terrorism

Factors in American History

Factors in American History

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