Models offer benefits even before they are put on line. Based on years of experience, the authors reveal in New Directions in Bioprocess Modeling and Control that significant improvements can result from the process knowledge and insight that are gained when building experimental and first-principle models for process monitoring and control. Doing modeling in the process development and early commercialization phases is advantageous because it increases process efficiency and provides ongoing opportunities for improving process control. This technology is important for maximizing benefits from analyzers and control tool investments. If you are a process design, quality control, information systems, or automation engineer in the biopharmaceutical, brewing, or bio-fuel industry, this handy resource will help you define, develop, and apply a virtual plant, model predictive control, first-principle models, neural networks, and multivariate statistical process control. The synergistic knowledge discovery on bench top or pilot plant scale can be ported to industrial scale processes. This learning process is consistent with the intent in the Process Analyzer and Process Control Tools sections of the FDA_s Guidance for Industry PAT _ A Framework for Innovative Pharmaceutical Development, Manufacturing and Quality Assurance. It states in the Process Analyzer section of the FDA_s guidance: _For certain applications, sensor-based measurements can provide a useful process signature that may be related to the underlying process steps or transformations. Based on the level of process understanding these signatures may also be useful for the process monitoring, control, and end point determination when these patterns or signatures relate to product and process quality._
This book talks about a novel way of arranging the atomic structure of a substance so that it can be made thousands of times stronger than in its native state. It is often used to make duranium a further ten thousand times stronger. Thus, a lump of duranium can be made over ten million times stronger than the equivalent block of titanium. A one dimensional fullerene (a convex cage of atoms with only hexagonal and/ or pentagonal faces) with a cylindrical shape. Carbon nanotubes discovered in 1991 by Sumio Iijima resemble rolled up graphite, although they can not really be made that way. Depending on the direction that the tubes appear to have been rolled (quantified by the 'chiral vector'), they are known to act as conductors or semiconductors. Nanotubes are proving to be useful as molecular components for nanotechnology. This book assembles and presents new and important research in the field.
How far will an ounce of prevention really go? While the answer to that question may never be truly known, Process Plants: A Handbook for Inherently Safer Design, Second Edition takes us several steps closer. The book demonstrates not just the importance of prevention, but the importance of designing with prevention in mind. It emphasizes the role
Ludwig's Applied Process Design for Chemical and Petrochemical Plants Incorporating Process Safety Incidents is ever evolving starting with the first edition some 60 years ago. The volumes in this fifth edition provide improved techniques and fundamental design methodologies to guide the practicing engineer in designing process equipment and applying chemical processes to the properly detailed hardware. As indicative of the new title, process safety incidents are incorporated in many of the chapters, reviewing the root causes, and how these could be mitigated in future. Like its predecessor, this new edition continues to present updated information for achieving optimum operational and process conditions and to avoid problems caused by inadequate sizing and lack of internally detailed hardware. The volumes provide both fundamental theories where applicable and direct application of these theories to applied equations essential in the design effort. This approach in presenting design information is essential for troubleshooting process equipment and in executing system performance analysis. Volume 1B continues to cover mixing of liquids, process safety and pressure[1]relieving devices, metallurgy and corrosion, and process optimization. It builds upon Ernest E. Ludwig's classic text to further enhance its use as a chemical engineering process design manual of methods and proven fundamentals. This new edition includes new content on three-phase separation, mixing of liquids, ejectors, and mechanical vacuum systems, process safety and pressure-relieving devices, metallurgy and corrosion, and optimization of chemical process/blending. Some chapters review pressure-relieving devices and provide case studies for process safety incidents, which are well illustrated from US Chemical Safety Hazard Investigation Board (www.csb.gov). Finally, this book contains a glossary of Petroleum and Petrochemical Terminologies and Physical and Chemical Characteristics of Major Hydrocarbons.? Provides improved design manual for methods and proven fundamentals of process design with related data and charts? Covers complete range of basic day-to-day petrochemical operation topics? Extensively revised with new material added on three-phase separation, metallurgy, and corrosion? Process safety management/HAZOP and hazard analyses, and optimization of chemical process/blending? Presents many examples using Honeywell UniSim Design software, developed and executable computer programs, and Excel spreadsheet programs? Includes case studies of process safety incidents, guidance for troubleshooting, and checklists? Includes Software of Conversion Table and 30+ process data sheets in excel format
This book closes the gap between Chemical Reaction Engineering and Fluid Mechanics. It provides the basic theory for momentum, heat and mass transfer in reactive systems. Numerical methods for solving the resulting equations as well as the interplay between physical and numerical modes are discussed. The book is written using the standard terminology of this community. It is intended for researchers and engineers who want to develop their own codes, or who are interested in a deeper insight into commercial CFD codes in order to derive consistent extensions and to overcome "black box" practice. It can also serve as a textbook and reference book.
Between A.D. 700 and 1100 Native Americans built more effigy mounds in Wisconsin than anywhere else in North America, with an estimated 1,300 mounds—including the world’s largest known bird effigy—at the center of effigy-building culture in and around Madison, Wisconsin. These huge earthworks, sculpted in the shape of birds, mammals, and other figures, have aroused curiosity for generations and together comprise a vast effigy mound ceremonial landscape. Farming and industrialization destroyed most of these mounds, leaving the mysteries of who built them and why they were made. The remaining mounds are protected today and many can be visited. explores the cultural, historical, and ceremonial meanings of the mounds in an informative, abundantly illustrated book and guide. Finalist, Social Science, Midwest Book Awards
Through a unique interdisciplinary perspective on quality management in health care, this text covers the subjects of operations management, organizational behavior, and health services research. With a particular focus on Total Quality Management (TQM) and Continuous Quality Improvement (CQI), the challenges of implementation and institutionalization are addressed using examples from a variety of health care organizations, including primary care clinics, hospital laboratories, public health departments, and academic health centers. Significantly revised throughout, the Fifth Edition offers a greater focus on application techniques, and features 14 chapters in lieu of the prior edition's 20 chapters, making it an even more effective teaching tool. New chapters have been incorporated on Implementation Science (3), Lean Six Sigma (6), and Classification and the Reduction of Medical Errors (10).
Confectionery and chocolate manufacture has been dominated by large-scale industrial processing for several decades. It is often the case though, that a trial and error approach is applied to the development of new products and processes, rather than verified scientific principles. Confectionery and Chocolate Engineering: Principles and Applications, Second edition, adds to information presented in the first edition on essential topics such as food safety, quality assurance, sweets for special nutritional purposes, artizan chocolate, and confectioneries. In addition, information is provided on the fading memory of viscoelastic fluids, which are briefly discussed in terms of fractional calculus, and gelation as a second order phase transition. Chemical operations such as inversion, caramelization, and the Maillard reaction, as well as the complex operations including conching, drying, frying, baking, and roasting used in confectionery manufacture are also described. This book provides food engineers, scientists, technologists and students in research, industry, and food and chemical engineering-related courses with a scientific, theoretical description and analysis of confectionery manufacturing, opening up new possibilities for process and product improvement, relating to increased efficiency of operations, the use of new materials, and new applications for traditional raw materials.
Creating a Person-Centered Library provides a comprehensive overview of various services, programs, and collaborations to help libraries serve high-needs patrons as well as strategies for supporting staff working with these individuals. While public libraries are struggling to address growing numbers of high-needs patrons experiencing homelessness, food insecurity, mental health problems, substance abuse, and poverty-related needs, this book will help librarians build or contribute to library services that will best address patrons' psychosocial needs. The authors, experienced in both library and social work, begin by providing an overview of patrons' psychosocial needs, structural and societal reasons for the shift in these needs, and how these changes impact libraries and library staff. Chapters focus on best practices for libraries providing person-centered services and share lessons learned, including information about special considerations for certain patron populations that might be served by individual libraries. The book concludes with information about how library organizations can support public library staff. Librarians and library students who are concerned about both patrons and library staff will find the practical advice in this book invaluable.
Reframing Community Partnerships in Education provides both the theoretical framework as well as a practical guide to engage educators in interdisciplinary, inter-organizational, multicultural, and multi-generational work to improve the social fabric of communities. Using case examples of best practice, this book explores transformational practices for community development, community building, and civic engagement. Featuring "Community Learning Exchange" pedagogies adaptable to a wide range of contexts, this book encourages educators—through use of participatory practices and a collective leadership model—to build stronger communities and advance learning for all.
Impinging streams is a unique and multipurpose configuration of a two-phase suspension for intensifying transfer processes in heterogeneous systems, viz. gas-solid, gas-liquid, solid-liquid and liquid-liquid. The essence of the method lies in the collision which results from bringing two streams of a suspension flowing on the same axis in opposite directions. Following the impact of the streams, a relatively narrow zone is created, which offers excellent conditions for enhancing the heat and mass transfer between the phases in the suspension.The following processes are considered in the light of the method of impinging streams: drying of particles, solid-solid and gas-gas mixing, absorption and desorption of gases from liquids, combustion of gas and coal, calcination of phosphate, creation of emulsions, liquid-liquid extraction, dissolution of solids, ion exchange, dust collection and granulation as well as evaporative cooling of air. Additional aspects considered in the book are: power input in performing the above processes, heat and mass transfer coefficient and its correlation, mixing properties of impinging stream reactors, residence time of the particles in the reactors, scale-up of impinging-stream reactors with respect to pressure, drop, hold-up and mean residence time of the particles as well as the heat transfer.The aim of the book is to review the state-of-the-art in the field of impinging streams, to present results of theoretical and experimental research, and to stimulate research and industrial application of the method so that reactors employing impinging streams will become a common tool in chemical engineering and other disciplines of engineering. The major conclusion of this work is that almost any process in chemical engineering can be conducted by impinging streams, resulting in higher efficiency and less power input in comparison with conventional methods.
Describes the state-of-the-art techniques and methods involved in the design, operation, preparation and containment of bioreactor systems, taking into account the interrelated effects of variables associated with both upstream and downstream stages of the design process. The importance of the initial steps in the development of a bioprocess, such as strain and media selection, that have an overwhelming influence on all further operations, is emphasized.;This work is intended for biochemical, chemical and bioprocess engineers; biotechnologists; industrial biochemists; micro- and molecular biologists; food scientists; and upper-level undergraduate and graduate students in these disciplines.
The sector of fine chemicals, including pharmaceuticals, agrochemicals, dyes and pigments, fragrances and flavours, intermediates, and performance chemicals is growing fast. For obvious reasons chemistry is a key to the success in developing new processes for fine chemicals. However, as a rule, chemists formulate results of their work as recipes, which usually lack important information for process development. Fine Chemicals Manufacture, Technology and Engineering is intended to show what is needed to make the recipe more useful for process development purposes and to transform the recipe into an industrial process that will be safe, environmentally friendly, and profitable.The goal of this book is to form a bridge between chemists and specialists of all other branches involved in the scale-up of new processes or modification of existing processes with both a minimum effort and risk and maximum profit when commercializing the process. New techniques for scale-up and optimization of existing processes and improvements in the utilization of process equipment that have been developed in recent years are presented in the book.
Static mixers are an attractive alternative for the mixing of chemicals in water treatment plants. The attraction comes from the fact that static mixers do not require an external input of energy and do not have moving parts. Static mixers consist of mixing elements fixed on the inside of a pipe of channel. The elements do not move. Chemicals, added just upstream of the mixers, mix with the bulk fluid because of the complex, three-dimensional fluid motion generated by the elements. The goal of this project is to explore the use of static mixers in two of the key processes in drinking water treatment: for the mixing of coagulants for destabilization and the mixing of disinfectants for the inactivation of Cryptosporidium parvum oocysts in disinfection. The role of mixing in both of these processes is not well understood. But for each process experimental and theoretical evidence suggests that, at least in some circumstances, the mixing environment provided when chemicals are introduced into the flow will affect the resulting destabilization or inactivation.
This reference conveys a basic understanding of chemical reactor design methodologies that incorporate both control and hazard analysis. It demonstrates how to select the best reactor for any particular chemical reaction, and how to estimate its size to determine the best operating conditions.
Nanosilicon: Properties, Synthesis, Applications, Methods of Analysis and Control examines the latest developments on the physics and chemistry of nanosilicon. The book focuses on methods for producing nanosilicon, its electronic and optical properties, research methods to characterize its spectral and structural properties, and its possible applications. The first part of the book covers the basic properties of semiconductors, including causes of the size dependence of the properties, structural and electronic properties, and physical characteristics of the various forms of silicon. It presents theoretical and experimental research results as well as examples of porous silicon and quantum dots. The second part discusses the synthesis of nanosilicon, modification of the surface of nanoparticles, and properties of the resulting particles. The authors give special attention to the photoluminescence of silicon nanoparticles. The third part describes methods used for studying and controlling the structure and properties of nanocrystalline silicon. These methods include standard ones, such as electron microscopy, spectroscopy, and diffraction, as well as novel techniques, such as femtosecond spectroscopy, ultrafast electron nanocrystallography, and dynamic transmission electron microscopy. The fourth part details some of the practical applications of nanocrystalline silicon, including the use of nanoparticles as additives–absorbers of UV radiation in sunscreens. Incorporating much of the authors’ own extensive research results, this book provides a systematic account of the scientific problems of nanosilicon and its potential practical applications. It will help readers understand current and emerging applications and research methods of this unique material.
Crystallization of Organic Compounds Practical resource covering applications of crystallization principles with methodologies, case studies, and numerous industrial examples for emphasis Based on the authors’ hands-on experiences as process engineers, through the use of case studies and examples of crystallization processes, ranging from laboratory development through manufacturing scale-up, Crystallization of Organic Compounds guides readers through the practical applications of crystallization and emphasizes strategies that have proven to be successful, enabling readers to avoid common pitfalls that can render standard procedures unsuccessful. Most chapters feature multiple examples that guide readers, step by step, through the crystallization of active pharmaceutical ingredients (APIs), including an analysis of the major methods of carrying out crystallization operations, their strengths and potential issues, as well as numerous examples of crystallization processes from development through manufacturing scale. Advancements in the field of crystallization have been integrated throughout the book in the newly revised Second Edition to ensure the content adequately reflects current state-of-the-art industrial know-hows and practice. The new edition also adds chapters addressing downstream operations after the crystallization, including filtration/washing and drying, together with industrial use cases. Crystallization of Organic Compounds includes detailed information on: Solubility and solid behavior, covering phase rule, polymorph, salt/co-crystal, chiral resolution and in-silico solubility prediction; and kinetics, covering seed, supersaturation, nucleation, crystal growth and model-based experimental design Critical issues in the crystallization practice, covering oiling out, seeding/wet-milling, agglomeration/aggregation, mixing scale-up and quality-by-design principles Cooling, anti-solvent, evaporation and reactive crystallization process design, covering batch and continuous operations with industrial examples Special applications, covering crystallization with ultrasound, reaction selectivity enhancement, and computation fluid dynamics, and solid dispersion With highly practical coverage of the subject, Crystallization of Organic Compounds is an essential resource for engineers and chemists involved with the development, scaling, or operation of crystallization process in the pharmaceutical and fine chemical industries, particularly those with degrees in chemical engineering and chemistry.
This book deals with inventory systems in supply chains that face risks that could render products unsalable. These risks include possible cooling system failures, transportation risks, packaging errors, handling errors, or natural quality deterioration over time like spoilage of food or blood products. Classical supply chain inventory models do not regard these risks. This thesis introduces novel cost models that consider these risks. It also analyzes how real-time tracking with RFID sensors and smart containers can contribute to decision making. To solve these cost models, this work presents new solution methods based on dynamic programming. In extensive computational studies both with experimental as well as real-life data from large players in the retailer industry, the solution methods prove to lead to substantially lower costs than existing solution methods and heuristics.
Clear evidence of increasing demands in the processing industry prompted the editors and authors to publish a new book about High Pressure Process Technology: Fundamentals and Applications.This book presents the latest knowledge regarding the high pressure processing aspects combined with that about the modeling, the design and the operation of safe and reliable high pressure plants and equipment. This treatment and selection of the subjects is stimulating and unique. Consisting of nine chapters, each subdivided into several sections, the book addresses the high pressure aspects, providing well selected correlated information connected with a comprehensive overview together with a large number of references. The main body of the first eight chapters refers to subjects like high pressure in general, the thermodynamics and kinetics of the fluids involved, the design of high pressure equipment, the modeling and design of reactors, separation and fractionation units, the safety aspects, the control and economics.In the extended last chapter, examples of promising high pressure applications are explained, such as chemical and enzymatic reactions in supercritical solvents, hydrogenation under supercritical conditions, supercritical water oxidation, polymerization with metallocene catalysts, supercritical extraction, fractionation and precipitation, supercritical pharma processing, ultra-high pressure sterilization and supercritical dry-cleaning.
From Aaron T. Beck and colleagues, this is the definitive work on the cognitive model of schizophrenia and its treatment. The volume integrates cognitive-behavioral and biological knowledge into a comprehensive conceptual framework. It examines the origins, development, and maintenance of key symptom areas: delusions, hallucinations, negative symptoms, and formal thought disorder. Treatment chapters then offer concrete guidance for addressing each type of symptom, complete with case examples and session outlines. Anyone who treats or studies serious mental illness will find a new level of understanding together with theoretically and empirically grounded clinical techniques.
Enables readers to apply transport phenomena principles to solve advanced problems in all areas of engineering and science This book helps readers elevate their understanding of, and their ability to apply, transport phenomena by introducing a broad range of advanced topics as well as analytical and numerical solution techniques. Readers gain the ability to solve complex problems generally not addressed in undergraduate-level courses, including nonlinear, multidimensional transport, and transient molecular and convective transport scenarios. Avoiding rote memorization, the author emphasizes a dual approach to learning in which physical understanding and problem-solving capability are developed simultaneously. Moreover, the author builds both readers' interest and knowledge by: Demonstrating that transport phenomena are pervasive, affecting every aspect of life Offering historical perspectives to enhance readers' understanding of current theory and methods Providing numerous examples drawn from a broad range of fields in the physical and life sciences and engineering Contextualizing problems in scenarios so that their rationale and significance are clear This text generally avoids the use of commercial software for problem solutions, helping readers cultivate a deeper understanding of how solutions are developed. References throughout the text promote further study and encourage the student to contemplate additional topics in transport phenomena. Transport Phenomena is written for advanced undergraduates and graduate students in chemical and mechanical engineering. Upon mastering the principles and techniques presented in this text, all readers will be better able to critically evaluate a broad range of physical phenomena, processes, and systems across many disciplines.
This landmark publication distills the body of knowledge that characterizes mineral processing and extractive metallurgy as disciplinary fields. It will inspire and inform current and future generations of minerals and metallurgy professionals. Mineral processing and extractive metallurgy are atypical disciplines, requiring a combination of knowledge, experience, and art. Investing in this trove of valuable information is a must for all those involved in the industry—students, engineers, mill managers, and operators. More than 192 internationally recognized experts have contributed to the handbook’s 128 thought-provoking chapters that examine nearly every aspect of mineral processing and extractive metallurgy. This inclusive reference addresses the magnitude of traditional industry topics and also addresses the new technologies and important cultural and social issues that are important today. Contents Mineral Characterization and AnalysisManagement and ReportingComminutionClassification and WashingTransport and StoragePhysical SeparationsFlotationSolid and Liquid SeparationDisposalHydrometallurgyPyrometallurgyProcessing of Selected Metals, Minerals, and Materials
This book brings together a winning team of international operations experts to set the framework for building a world-class manufacturing organization. Pharmaceutical Operations Management focuses on key concepts such as: Policy Execution, Risk Management, Supply chain modeling, Advance process control and Six Sigma for the pharmaceutical industry: critical techniques which will offset cost, increase efficiency and turn any manufacture into financial winner.
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