The authors investigate the dynamics of weakly-modulated nonlinear wave trains. For reaction-diffusion systems and for the complex Ginzburg-Landau equation, they establish rigorously that slowly varying modulations of wave trains are well approximated by solutions to the Burgers equation over the natural time scale. In addition to the validity of the Burgers equation, they show that the viscous shock profiles in the Burgers equation for the wave number can be found as genuine modulated waves in the underlying reaction-diffusion system. In other words, they establish the existence and stability of waves that are time-periodic in appropriately moving coordinate frames which separate regions in physical space that are occupied by wave trains of different, but almost identical, wave number. The speed of these shocks is determined by the Rankine-Hugoniot condition where the flux is given by the nonlinear dispersion relation of the wave trains. The group velocities of the wave trains in a frame moving with the interface are directed toward the interface. Using pulse-interaction theory, the authors also consider similar shock profiles for wave trains with large wave number, that is, for an infinite sequence of widely separated pulses. The results presented here are applied to the FitzHugh-Nagumo equation and to hydrodynamic stability problems.
This volume will try to put current therapy - achievements, shortcomings, remaining medical needs - and emerging new targets into the context of increasing knowledge regarding the genetic and neurodevelopmental contributions to the pathophysiology of schizophrenia. Some of the chapters will also deal with respective experimental and clinical methodology, biomarkers, and translational aspects of drug development. The volume will concentrate on reviewing the ongoing research attempting to identify novel treatments for the cognitive deficits and negative symptoms of schizophrenia, which are not treated adequately by current antipsychotic medications.
Experts from the Massachusetts General Hospital-widely respected as one of the world's premier psychiatric institutions-provide practical advice on the diagnosis and treatment of psychiatric issues experienced by in-hospital, medically ill adults and children. This compact resource reads like a handbook, but delivers all the details you'd expect from a textbook. Find information quickly thanks to an improved chapter organization, and get just the answers you need with concise yet complete coverage appropriate for psychiatrists and generalists alike.
As the title suggests, A Revolution in the International Rule of Law: Essays in Honor of Don Wallace, Jr. is a European style Festschrift or Liber Amicorum, and compiles short essays by eminent scholars and practitioners who have known Prof. Wallace during his long and distinguished career as a Professor of law at Georgetown University Law Center and, among others, as the Chairman of the International Law Institute, the U.S. Delegate to UNCITRAL, the Legal Adviser to the USAID, President of the ABA Section on International Law, presiding officer of the UNIDROIT Foundation, and Of Counsel to a number of prominent international law firms including Winston & Strawn LLP, Morgan Lewis LLP, Arnold & Porter LLP, and Shearman & Sterling LLP. The primary topics covered in the book are: Foreign Investment and Political RiskInternational Investment Law and ArbitrationUnification of Private LawCommercial Law ReformPublic ProcurementRule of Law and Transitional JusticeInternational Business Law and Human RightsLegal Aspects of the United States' Foreign Affairs: Public International Law, Separation of Powers and Terrorism. Professor Wallace's friends, including the co-editors, have submitted 45 essays including a biographical piece prepared by the editors to this volume.
This Research Note collects reports of the invited plenary addresses given during the conference Elliptic and Parabolic Partial Differential Equations and Applications held in Capri, Italy, 19-23 September 1994. The conference was devoted to new developments in partial differential equations of elliptic and parabolic type and to their applications in various fields.
In the midst of an addiction epidemic, this newly updated edition of The American Society of Addiction Medicine Principles of Addiction Medicine, 5th edition is the sought-after text every addiction researcher and care provider needs. This comprehensive reference text dedicates itself to both the science and treatment of addiction. You’ll receive a thorough grounding in both the scientific principles behind the causes of addiction and the practical aspects of clinical care. Chapters are written by recognized experts, covering areas such as the basic science of addiction medicine; diagnosis, assessment and early intervention; pharmacologic and behavioral interventions; mutual help and twelve-step; and co-occurring addiction, medical and psychiatric disorders—backed by the latest research data and successful treatment methods. Features: Numerous figures, tables and diagrams elucidate the text Chapters include case examples List of data research reports provided at end of each chapter NEW material on Prescription Drug Abuse, Club Drugs, Nursing Roles in Addressing Addiction, Conceptual and Treatment Issues in Behavioral Addictions, Rehabilitation Approaches to Pain Management, Comorbid Pain and Addiction, Pharmacotherapy for Adolescents with Substance Use Disorders, Preventing and Treating Substance Use Disorders in Military Personnel, and more.
This book completely solves the problem of representing rings (and modules over them), which are locally noetherian over subsets of their prime spectrum by structure sheaves over this subset. In order to realise this, one has to develop the necessary localization theory as well as to study local equivalents of familiar concepts like the Artin-Rees property, Ore sets and the second layer condition. The first part of the book is introductory and self-contained, and might serve as a starting course (at graduate level) on localization theory within Grothendieck categories. The second part is more specialised and provides the basic machinery needed to effectively these structure sheaves, as well as to study their functorial behaviour. In this way, the book should be viewed as a first introduction to what should be called relative noncommutative algebraic geometry.
Presenting best practices for assessment and intervention with older adults experiencing cognitive decline, this book draws on cutting-edge research and extensive clinical experience. The authors' integrative approach skillfully interweaves neuropsychological and developmental knowledge. The volume provides guidelines for evaluating and differentiating among normal aging, subjective cognitive decline, mild cognitive impairment, and different types of dementia. It identifies risk and protective factors that may influence an individual's trajectory and describes how to create a sound case conceptualization. Evidence-based strategies for pharmacological, cognitive, behavioral, and psychological intervention with patients and their caregivers are illustrated with vivid case examples.ÿ ÿ
On July 4, 2009, the region celebrated thirty-six years as a formal Caribbean Community (CARICOM). The analyses contained in this publication in the The Integrationist Series all tend to suggest that CARICOM now, more than ever, needs to transform its experiences over these years into a more structured foundation for maximising the multiplier effects of collective representation, and for leveraging CARICOMs diplomatic efforts and resources in a more coordinated and integrated manner. This imperative is necessitated by the rapidly changing international environment which has far too often impacted negatively on small developing countries, leaving them increasingly vulnerable and marginalized.
Multivariable complex analysis and harmonic analysis provide efficient techniques to study many applied mathematical problems. The main objective of a conference held in Bordeaux in June 1995, in honour of Professor Roger Gay, was to connect these mathematical fields with some of their applications. This was also the guideline for the fourteen contributions collected in this volume. Besides presenting new results, each speaker made a substantial effort in order to present an up to date survey of his field of research. All the subjects presented here are very active domains of research: integral geometry (with its relation to X-ray tomography), classical harmonic analysis and orthogonal polynomials, pluricomplex potential theory (with its deep connection with polynomial approximation), complex analytic methods in the theory of partial differentiable operators with constant coefficients (in the spirit of those initiated by Leon Ehrenpreis), Calderon-Zygmund operators and nonlinear operators, oscillatory integrals and resonance, and finally multivariable residue theory in its most recent developments. It is hoped that the reader will find enough insight in the different survey papers presented here to become involved with one of these subjects or to pursue further applications.
This book addresses the interactions between the domestic courts and the international investment arbitral tribunals, one of the most pressing issues confronting both domestic legal systems and the international legal system. It deals with the core issues inherent in the above interactions, especially with regard to countries outside the ICSID system. It contrasts this narrative with the position under classical international investment law, where national courts are assigned a very specific and minimalistic role in the process of investment disputes settlement. For this purpose, the book chooses India, which follows the non-ICSID model, as the major point of focus and considers both domestic judicial decisions and investment arbitral decisions for critical analysis. The ICSID Convention grants limited powers to domestic courts to issue provisional measures and to enforce ICSID awards. As the central theme of the book lies at the intersection of domestic law and international law, the work is indispensable for any scholar working in the areas of general international law, international investment law, international economic law, law and economics, international dispute settlement, or international law in domestic courts, as well as domestic judges and international arbitrators. Further, as the subject matter has great implications for both domestic and global governance, it will benefit civil servants, opinion leaders, policy planners and subject experts in economics, the political economy and regional studies, to name a few. Excerpt from the Foreword: “One of the great merits of this book is that... It looks at bilateral investment treaties themselves to probe more deeply into the role of national courts in investment arbitration... This masterful book fills a major void as a resource in Indian international arbitration law. But is also the prototype of what any serious inquiry into the judicial role in investor-State arbitration in any jurisdiction should look like...” - George A. Bermann, Walter Gellhorn Professor of Law and Jean Monnet Professor of European Union Law, Columbia Law School, USA
Jennifer Thomson separates fact from fiction and explains why and how GM crops can help us combat poverty, starvation and disease in the developing world, in a safe and responsible way. She explains the technology and looks at the differences and similarities between genetic modification, conventional plant breeding, and natural processes such as cross pollination and mutations. There are chapters devoted to controversial issues such as food safety (for GM crops and organically grown food), patents labelling, regulations and controls, and a section dealing with frequently-asked questions. It ends with a focus on Africa and possible future developments in GM technology. Technical terms are explained and appendices provide additional information on testing for allergens, horizontal gene transfer, and international food safety assessment documents. For those who wish to explore the subject further, it also provides a list of more than 60 web sites dealing with issues related to the GM debate.
Parasitic wasps of the genus Scelio (Hymenoptera: Platygastri-dae) attack and destroy the eggs of short-horned grasshoppers (Acrididae). Included among these hosts are some of the most destructive of all insects, the plague locusts. As a result, species of Scelio are potential allies in the biological control of these pests. This paper is the first comprehensive examination of the species of Scelio of the Afrotropical region in over 50 years. A total of 62 species were found, 77% of which are new to science. Descriptions and keys for identification are provided, and each species is extensively illustrated. This work is a product of the Platygastroidea Planetary Biodiversity Program and was conducted using biodiversity informatics tools and applications developed as part of that project.
This book presents a collection of selected contributions on recent results in nonlinear partial differential equations from participants to an international conference held in Fes, Morocco in 1994. The emphasis is on nonlinear elliptic boundary value problems, but there are also papers deveoted to related areas such as monotone operator theory, calculus of variations, Hamiltonian systems and periodic solutions. Some of the papers are exhaustive surveys, while others contain new results,published here for the first time. This book will be of particular interest to graduate or postgraduate students as well as to specialists in these areas.
Synopsis of Psychiatry: Behavorial Sciences/Clinical Psychiatry, 11th Edition is the only authoritative textbook for clinicians, residents, and students covering all psychiatric conditions. It is a complete, concise overview of the entire field of psychiatry, for psychiatrists in training and practice and all others who study and provide mental health care. Its multidisciplinary approach encompasses the biological, psychological and sociological factors at work in health and disease. The latest information about specific diseases, psychopharmacotherapeutic and behavioral treatments and scientific research is incorporated into this revision. ICD (International Classification of Disease, World Health Organization) diagnostic criteria and numerical codes, used for reimbursement purposes, are included. Case studies throughout reinforce the clinical relevance of specific topics. The 11th edition is set apart from any other reference you have: • Contains DSM5 tables on every major psychiatric disorder • Use it to supplement the DSM5, offering current diagnostic and treatment protocols • Over 50 years of compounded knowledge in psychiatric medicine, offered by world-renowned experts
Mohamoud's work considers the underlying causes for the breakdown of the state across both time and space. Time is considered across the triple history - the pre-colonial, colonial and post-colonial processes. Space is used in the sense of taking the whole of Somalia as a unit of analysis. This approach enables the discovery of different structural crises over a period of time and examines these cumulative effects on the current upheavals in Somalia. Among the approaches, State Collapse and Post-Conflict Development in Africa covers the constraints in the harsh material environment; the subsistence pastoral mode of existence; the colonial intervention and the subsequent division of the land into five parts; Cold War geopolitics; decades of armed struggles; and the post-colonial crisis of governance. Dr. Abdulla (Awil) Mohamoud runs SAHAN, an academic research and consultancy agency, which conducts policy oriented research and fact finding missions abroad, mainly in Africa, undertakes evaluation and monitoring activities, provides training and offers advisory services on integration and multi-cultural issues. He holds an MA degree from Jawaharlal Nehru University, New Delhi, and earned his PhD at the University of Amsterdam. Mohamoud has served regularly as an election observer in UN, EU, Council of Europe and OSCE missions to conflict and war-torn societies (to East-Timor, Kosovo, Nigeria, Serbia, and Zimbabwe).
For more than 60 years, Merritt’s Neurology has remained a trusted landmark text in clinical neurology, providing unparalleled guidance on neurologic protocols, treatment guidelines, clinical pathways, therapeutic recommendations, and imaging. The fourteenth edition reflects the state of today’s practice, with fully updated content and timely new sections and chapters. With this edition, Dr. James Noble joins Drs. Elan Louis and Stephan A. Mayer as co-editor, all of whom trained at Columbia University where Dr. H. Houston Merritt wrote the initial editions of this book. Lauded for its comprehensive coverage, colorful and dynamic visual style, readability, and ease of use, this up-to-date reference is ideal for neurologists, primary care physicians, and residents alike.
This guide draws together the latest developments in eating disorders. Together with its companion volume "Annual Review of Eating Disorders Part 1-2007", this resource covers the twenty key topics.It is a compilation of reviews from leading scientists and clinicians, and is the essential update for busy professionals and health researchers, with a clear emphasis on clinical implications. It also provides invaluable information for psychologists, psychiatrists, dieticians, family doctors, pediatricians, counsellors and educators.'An impressive collection of comprehensive reviews covering the state-of-the-science in the eating disorders field. These reviews evaluate clinical and empirical data published in 2004-2006 examining issues as diverse as neurobiological influences, body image, and treatment of eating disorders. The depth and scope of the reviews are a testament to the hard work of the editors and the authors who volunteered their time for this important project.' - Kelly L Klump, in the Foreword.
Massachusetts General Hospital Handbook of General Hospital Psychiatry, by Theodore A. Stern, Gregory L. Fricchione, Ned H. Cassem, Michael Jellinek, and Jerrold F. Rosenbaum, is your ideal source of guidance on consultation-liaison psychiatry! Experts from the Massachusetts General Hospital—widely respected as one of the world's premier psychiatric institutions—provide practical advice on the diagnosis and treatment of psychiatric issues experienced by in-hospital, medically ill adults and children. This compact resource reads like a handbook, but delivers all the details you’d expect from a textbook. Understand and manage the psychological impact of chronic medical problems, life-threatening diseases, disfigurement, and more. Effectively manage difficult patients, including those with hypochondriacal and conversion disorders. Find information quickly thanks to an improved chapter organization, and get just the answers you need with concise yet complete coverage appropriate for psychiatrists and generalists alike. Implement the most current, effective pharmaceutical therapies as well as cognitive-behavioral approaches.
It has been 15 years since the original publication of Neuropsychology of Attention. At the time of its publication, attention was a construct that had long been of theoretical interest in the field of psychology and was receiving increased research by cognitive scientists. Yet, attention was typically viewed as a nuisance variable; a factor that needed to be accounted for when assessing brain function, but of limited importance in its own right. There is a need for a new edition of this book within Neuropsychology to present an updated and integrated review of what is know about attention, the disorders that affect it, and approaches to its clinical assessment and treatment. Such a book will provide perspectives for experimental neuropsychological study of attention and also provide clinicians with insights on how to approach this neuropsychological domain.
This Research Note aims to provide an insight into recent developments in the theory of pattern formation. In the last decade there has been considerable progress in this field, both from a theoretical and a practical point of view. Recent mathematical developments concern the study of the nonlinear stability of systems at near-critical conditions by an appropriate system of modulation equations. The complexity of the original problem can be reduced drastically by this approximation. Moreover, it provides unifying point of view for a wide range of problems. New applications of the theory arise in a multitude of scientific areas such as hydrodynamics, reaction-diffusion problems, oceanography, meteorology, combustion, geophysical and biological morphodynamics and semi-conductors.This book is intended to show the interactions between the mathematical theory of nonlinear dynamics and the study of pattern generating phenomena in the natural environment. There is an intimate relationship between new insights in the mathematical aspects of nonlinear pattern formation and the comprehension of such phenomena. Therefore there are two partly overlapping main themes: one in which the emphasis is on generally applicable mathematical theories and techniques and one in which the phenomenology of pattern evolution in various areas is discussed.The book comprises 19 contributions by experts in the field. Although the emphasis changes considerably from paper to paper, in each contribution the same two themes are present; all the authors have aimed to achieve a suitable balance between the mathematical theory and the physical phenomena.
Plant Tissue Culture and Its Agricultural Applications presents the proceedings of the 41st University of Nottingham Easter School in Agricultural Science held in England. The sessions covered in this volume reflect the revolution of tissue culture and its role in the propagation of elite plant material and the development of improved genotypes. This book is organized into four main sections. The first section chronicles the revolution of the plant tissue culture. This includes papers on clonal propagation, morphogenesis, germplasm storage, plant health, and genetic improvement. The core of this volume is covered by the introductory and the final chapters which interrelate the different subjects areas covered by the proceedings and provide a realistic assessment of future research required for the plant tissue culture revolution to come to fruition. This book will be useful to readers interested in understanding the history, evolution, and future of plant tissue culture and its applications in the agricultural sector.
With expert contributions from experienced educators, research scientists and clinicians, Foye’s Principles of Medicinal Chemistry, Eighth Edition is an invaluable resource for professional students, graduate students and pharmacy faculty alike. This ‘gold standard’ text explains the chemical basis of drug action, emphasizing the structure-activity relationships, physicochemical-pharmacokinetic properties, and metabolic profiles of the most commonly used drugs.
Oil palm is the top oil crop and the only major crop and only oil crop not to have been improved by plant mutation breeding. This manual is hands-on, providing step-by-step illustrated methods in a range of key activities in mutation induction, mutation detection and mutant line development in oil palm.
Practical and highly organized, The 5-Minute Clinical Consult 2021 is a reliable, go-to resource for primary care physicians, nurse practitioners, and physician assistants. This bestselling title provides rapid access to guidance on diagnosis, treatment, medications, follow-up, and associated factors for more than 540 diseases and conditions. The 5-Minute Clinical Consult 2021 delivers clinical confidence efficiently, allowing you to focus your valuable time on giving your patients the best possible care. Written by esteemed internal medicine and family medicine practitioners and published by the leading publisher in medical content, The 5-Minute Clinical Consult 2021, 29th Edition is your best resource for patient care.
Technology is changing how we practice medicine. Sensors and wearables are getting smaller and cheaper, and algorithms are becoming powerful enough to predict medical outcomes. Yet despite rapid advances, healthcare lags behind other industries in truly putting these technologies to use. A major barrier is the cross-disciplinary approach required to create digital tools, a process that requires knowledge from many people across a range of fields. 'Fast Facts: Digital Medicine – Measurement' aims to overcome that barrier, introducing the reader to core concepts and terms and facilitating dialogue. Contrasting 'clinical research' with routine 'clinical care', this short colorful book describes types of digital measurement and how to use and validate digital measures in different settings. And with the burgeoning development of digital medicine tools, the authors provide a timely overview of the security, ethical, regulatory and legal issues to be considered before a product can enter the market. Contents: • What is digital medicine? • Where does digital medicine fit? • Regulatory considerations • Ethical principles and our responsibilities • Ethics in practice • Security, data rights and governance • Digital biomarkers and clinical outcomes • Measurement in clinical trials • Verification and validation • The future of digital medicine
The book is devoted to an important aspect of pharmacology and pharmaceutical chemistry, i.e. the significance of stereoisomerism of drugs for their biological effect from the point of view of their pharmacokinetics, pharmacodynamics and toxicology. The authors review the landmarks in the development of stereochemistry and stereopharmacology. Present-day IUPAC terminology is discussed; general issues of stereoisomerism are considered including separation of racemic mixtures and asymmetric synthesis of isomers, methods of quantifying the isomers of a drug in biological material. The authors put special emphasis on general problems of the influence of stereoisomerism on pharmacological and adverse effects of drugs. A classification of drugs based on stereochemical properties of their isomers is proposed. Possibilities of interaction of stereoisomers in racemic mixtures are discussed. A considerable portion of the book is devoted to pharmacological action of the main groups of drugs whose structure includes asymmetric atoms (that is, drugs with several isomers). Detailed attention is paid to advisability of developing single isomer drugs and to the specifics of their study at the stage of preclinical and clinical trials.
Neurochemical Aspects of Alzheimer's Disease provides a comprehensive overview of molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies. The book focuses on molecular mechanisms and signal transduction processes associated with the pathogenesis, biomarkers, and therapeutic strategies of AD. The comprehensive and cutting edge information in this monograph may not only help in early detection of AD, but also promote discovery of new drugs to treat this chronic disease. Chapters discuss involvement of neural membrane phospholipids, sphingolipids, and cholesterol-derived lipid mediators, abnormal APP processing, and nucleic acid damage, risk factors, biomarker, and therapeutic strategies of Alzheimer's disease. This book is written for neurologists, neuroscientists, neurochemists, neuropharmacologists, and clinicianswho are interested in molecular mechanisms associated with the pathogenesis of age-related neurological disorders. - Provides a comprehensive overview of molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies for Alzheimer's disease - Written for researchers, clinicians, and advanced graduate students in neurology, neuroscience, neurochemistry, and neuropharmacology - Acts as the first book to provide a comprehensive description of the signal transduction processes associated with pathogenesis of Alzheimer's disease
Covers research achievements in the fields of developmental biology, physiology, and pathology. Chapters discuss sericulture techniques, cocoons, dormancy and hormones, clones, the apple biting silkworm, the sable mutation, separation of male and female eggs, and genetic engineering. An appendix explains the technical terminology. Numerous illustra
This book gathers contributions by twenty-five world-class practitioners, leading academics, adjudicators, and civil servants in the field of WTO litigation, investment arbitration, and commercial arbitration. It provides a practical cross-cutting analysis of the different dispute settlement mechanisms that exist in international trade and investment and offers valuable insights into how to use best practices among the three systems. The book addresses the critical areas of overlap that exist in the three disciplines, including: management of parallel proceedings and role of politics and ‘pressure points’ within host governments; selection and appointment of arbitrators, panels and Appellate Body members; use of experts and economics; search of the applicable law; interpretation of the national treatment principle and other substantive standards and legal tests; methods of redressing ‘moral damage’; regimes of review, appeals and annulment; enforcement systems of awards, implementation of WTO law and other legal remedies; and allocation of costs. In addition to being the first in-depth exploration of the interaction among WTO litigation, investment arbitration and international commercial arbitration, this book brings a singularly practical perspective to bear on the three dispute settlement mechanisms and how each can be used to best advantage.
The 5-Minute Clinical Consult Standard 2016, 24th Edition, provides rapid-access in a quick-reference print format. It delivers diagnosis, treatment, medications, follow-up, and associated factors for a broad range of diseases and conditions. Organized alphabetically by diagnosis, this best-selling clinical reference continues to present brief, bulleted information on disease topics in a consistent and reader-friendly three-column format. The 5-Minute Clinical Consult Standard 2016, 24th Edition provides: 650+ commonly encountered diseases and disorders 150+ Treatment and diagnostic algorithms ICD10 Codes Current evidence-based designations highlighted in each topic A revised and updated Health Maintenance section The Health Maintenance 1-page summaries, based on the US Preventive Services Task Force recommendations
Practical and highly organized, The 5-Minute Clinical Consult 2022 provides rapid access to the diagnosis, treatment, medications, follow-up, and associated conditions for more than 540 disease and condition topics to help you make accurate decisions at the point of care. Organized alphabetically by diagnosis, it presents brief, bulleted points in a templated format, and contains more than 100 diagnostic and therapeutic algorithms. This up-to-date, bestselling reference delivers maximum clinical confidence as efficiently as possible, allowing you to focus your valuable time on providing high-quality care to your patients.
Covering both surgical and anesthetic considerations, Anesthesiologist’s Manual of Surgical Procedures, Sixth Edition, is an essential resource for formulation of an anesthetic plan and perioperative management of patients. All chapters are written by both surgeons and anesthesiologists, giving you a detailed, real-world perspective on the many variables that accompany today’s surgical procedures.
The 5-Minute Clinical Consult provides rapid-access information on the diagnosis, treatment, medications, follow-up, and associated conditions of more than 700 medical conditions. Organized alphabetically by diagnosis, this best-selling clinical reference continues to present brief, bulleted points on disease topics in a consistent templated format.
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