INTRODUCTION TO ELECTROMAGNETIC COMPATIBILITY The revised new edition of the classic textbook is an essential resource for anyone working with today’s advancements in both digital and analog devices, communications systems, as well as power/energy generation and distribution. Introduction to Electromagnetic Compatibility provides thorough coverage of the techniques and methodologies used to design and analyze electronic systems that function acceptably in their electromagnetic environment. Assuming no prior familiarity with electromagnetic compatibility, this user-friendly textbook first explains fundamental EMC concepts and technologies before moving on to more advanced topics in EMC system design. This third edition reflects the results of an extensive detailed review of the entire second edition, embracing and maintaining the content that has “stood the test of time”, such as from the theory of electromagnetic phenomena and associated mathematics, to the practical background information on U.S. and international regulatory requirements. In addition to converting Dr. Paul’s original SPICE exercises to contemporary utilization of LTSPICE, there is new chapter material on antenna modeling and simulation. This edition will continue to provide invaluable information on computer modeling for EMC, circuit board and system-level EMC design, EMC test practices, EMC measurement procedures and equipment, and more such as: Features fully-worked examples, topic reviews, self-assessment questions, end-of-chapter exercises, and numerous high-quality images and illustrations Contains useful appendices of phasor analysis methods, electromagnetic field equations and waves. The ideal textbook for university courses on EMC, Introduction to Electromagnetic Compatibility, Third Edition is also an invaluable reference for practicing electrical engineers dealing with interference issues or those wanting to learn more about electromagnetic compatibility to become better product designers.
A black hole is a point of extreme mass in space-time with a radius, or event horizon, inside of which all electromagnetic radiation (including light) is trapped by gravity. A black hole is an extremely compact object, collapsed by gravity which has overcome electric and nuclear forces. It is believed that stars appreciably larger than the Sun, once they have exhausted all their nuclear fuel, collapse to form black holes: they are "black" because no light escapes their intense gravity. Material attracted to a black hole, though, gains enormous energy and can radiate part of it before being swallowed up. Some astronomers believe that enormously massive black holes exist in the centre of our galaxy and of other galaxies. This book brings together leading research from throughout the world.
Organometallic chemistry is based on the reactions and use of a class of compounds (R-M) that contain a covalent bond between carbon and metal. They are prepared either by direct reaction of the metal with an organic compound or by replacement of a metal from another organometallic substance. Research in organometallic chemistry is also conducted in the areas of cluster synthesis, main-group derivatives in unusual oxidation states, organometallic polymers, unstable organometallic compounds and intermediates in matrices, structure determination of organometallic compounds in the solid state [X-ray diffraction] and gaseous states [electron diffraction], and mechanisms of reactions of transient silylenes and related species. In addition to the traditional metals and semimetals, elements such as selenium, lithium and magnesium are considered to form organometallic compounds, e.g. organomagnesium compounds MeMgI, iodo(methyl)magnesium and diethylmagnesium which are Grignard reagents an organo-lithium compound BuLi butyllithium. Organometallic compounds often find practical use as catalysts, the processing of petroleum products and the production of organic polymers.
Simian Virology is the first text to comprehensively cover all currently known simian viruses. Chapters provide an overview of nonhuman primate models of medically important viral diseases as well as natural infections of nonhuman primates with human and animal viruses. The text covers a variety of topics including primate models of medically important viral diseases such as AIDS, hypotheses on the origins of epidemic forms of HIV, and viral diseases caused by non-simian viruses in both wild and captive primates.
DNA Replication, second edition, a classic of modernscience, is now back in print in a paperback edition. Kornberg and Baker'sinsightful coverage of DNA replication and related cellular processes have madethis the standard reference in the field.
Small group research is of particularly wide interest to people working in a fairly broad variety of areas concerned with understanding conflict, especially for practitioners and researchers concerned with conflict resolution, peace, and related areas. The editors will focus on six main topical areas of small group research, which include: - Cooperation, competition, and conflict resolution - Coalitions, bargaining, and games - Group dynamics and social cognition - The group and organization - Team performance - Intergroup relations
Rehabilitation of Musculoskeletal Injuries, Fifth Edition With HKPropel Online Video, presents foundational concepts that support a thorough understanding of therapeutic interventions and rehabilitative techniques. Updated with the latest research in evidence-based practice, this text prepares students for careers in health care while serving as a valuable reference for experienced clinicians. Readers will learn what to expect when treating clients, how to apply evidence-based knowledge, and how to customize individual rehab programs. Related online video demonstrates 47 of the most challenging or novel techniques and can be used in the classroom or in everyday practice. Titled Therapeutic Exercise for Musculoskeletal Injuries in previous editions, the revised title supports the advancement of the field and better reflects the concepts and understanding of total rehabilitation of the patient. The content featured in Rehabilitation of Musculoskeletal Injuries aligns with the accreditation standards of the Board of Certification (BOC) and prepares students for the BOC athletic trainers’ exam. Respected clinician Peggy A. Houglum, who has more than 50 years of experience in the field, leads the expert author team to provide evidence-based perspectives, updated theories, and real-world applications. The latest edition is enhanced with contributions from new authors Daniel E. Houglum and Kristine L. Boyle-Walker, who have over 54 combined years of experience as athletic trainers, physical therapists, and instructors. The fifth edition of Rehabilitation of Musculoskeletal Injuries places a greater emphasis on higher-order skills. Although it continues to present therapeutic exercise interventions, added content includes the other aspects of rehabilitation that would be applied to patients in clinical situations, including therapeutic interventions of modalities. Specific aspects of examination that are necessary to designing a rehabilitation program are also included. This edition also includes a new section on joint manipulation and a new chapter on functional adaptations in rehabilitation that focuses on providing emotional support as well as physical support in helping patients return to activities of daily living. Video content is expanded with 11 new clips that highlight therapeutic techniques, and more than 450 color photos and 750 illustrations help to enhance comprehension and clarify complicated concepts. Rehabilitation of Musculoskeletal Injuries, Fifth Edition, provides thorough coverage of healing concepts, examination, and assessment techniques, ensuring students move from a solid understanding of the foundational skills and knowledge required of clinicians to comprehension of advanced problem-solving skills to make reliable rehabilitation decisions. The text demonstrates how to create rehabilitation programs using various modalities, manual therapy, and therapeutic exercise, and it highlights special considerations and applications for specific body regions. Learning aids include case studies that emphasize practical application, Evidence in Rehabilitation sidebars that focus on peer-reviewed research and its practical application, and Clinical Tips that illustrate key points in each chapter. Additional learning aids include chapter objectives, lab activities, key terms, critical thinking questions, and references. For maximum flexibility to match course needs, instructors wanting to teach specific topics can adopt particular chapters or sections of the book through the Human Kinetics custom ebook program. Note: A code for accessing online videos is not included with this ebook but may be purchased separately.
- Content adapted for the current South Asian nursing setup - Current data and statistics pertaining to the South Asian region assimilated - Newest concepts and literature added to reflect the regional perspective - Regional pictures added to provide regional look and feel
The most up-to-date, comprehensives single-volume guide to adult, congenital, and general cardiothoracic surgery -- from many of the foremost experts in the field Developed by authorities from leading-edge cardiothoracic surgical training programs, this much-needed reference succinctly reviews a wide-range of important topics in cardiothoracic surgery. The Johns Hopkins Manual of Cardiothoracic Surgery is especially timely given the recent development of many new scientific findings and emerging technologies. You'll find it filled with precise information on surgical techniques and pre-and postoperative strategies for managing cardiothoracic disease. In this time-saving sourcebook, you'll get an in-depth look at the full spectrum of disorders and their surgical (and medical) management options, including congenital, acquired, and neoplastic diseases. Supporting this detailed coverage is an easy-to-navigate format featuring focused tables and outline-formatted bullets, along with step-by-step explanations of the most complex operations. Features: Thorough coverage of all major areas of cardiothoracic surgery-perfect for cardiothoracic surgery fellows getting ready for Board review exams (oral and written), and cardiothoracic surgeons preparing for Board certification or recertification Skill-building perspectives on open, minimally invasive, and endovascular surgical procedures-complete with relevant surgical anatomy Indications and techniques for heart and lung transplantation Balanced, detailed presentation of both pediatric and adult patient care issues Innovative chapters on surgical ventricular remodeling, endovascular repair of thoracic aortic pathologies, correction of complex congenital defects, and thoracic oncology that reflect the most promising new surgical technologies “Key Concepts” boxes throughout focus on important “take-home” messages of chapter topics Expert authorship, with most chapters written by current or past faculty and trainees from The John Hopkins Hospital
Psychology for Sustainability applies psychological science to so-called environmental problems that manifest when human behavior disrupts and degrades natural systems. Drawing on environmental psychology, ecopsychology, conservation psychology, and related disciplines, the authors provide an extensive review of relevant theory and research in a lively and easy-to-read style. This edition represents a substantial revision and expansion spurred by a burgeoning body of research and by global ecological, political, and social developments. Particular attention is paid to environmental justice and collective action for systems change. More than one-third of the content is entirely new, and there are more than nine hundred new references. This edition also features a new full-color design and over two hundred full-color figures, tables, and photos. Timely topics include climate change, biodiversity loss, environmental racism, Indigenous perspectives, social media, and COVID-19 and other pandemics. Content retained from the previous edition has been updated throughout. The twelve chapters are organized into four parts: What on Earth Are We Doing includes a prologue on psychology as a sustainability science, followed by three chapters that provide an overview of the ecological crisis and its historical origins, and a vision for a sustainable future. Psychology for a Sustainable Future encompasses five chapters on research methods, theory, and findings pertinent to understanding and shifting unsustainable behavior. What’s Good for the Planet is Good for Us includes two chapters that address the reciprocal relationship between planetary and human health. Being the Change We Want to See introduces two new chapters to inspire readers to take what they have learned and apply it as changemakers in the world. The first is about collective action for systemic change. The second presents a positive psychology perspective on how to tackle the ecological crisis in a way that promotes wellbeing and resilience and is personally meaningful and fulfilling. Carefully tailored to the length of a standard college semester, Psychology for Sustainability is essential reading for courses on sustainability across disciplines. It will be invaluable to people outside academia as well, including policymakers, legislators, and those working on sustainable communities. The text is also supplemented with online resources for instructors.
Thermophysical Properties of Individual Hydrocarbons of Petroleum and Natural Gases: Properties, Methods, and Low-Carbon Technologies is a go-to data source for engineers who need derive property data on everyday components. Providing more precise data improves existing oil and gas processing systems and creates opportunities for more sustainable operations and equipment, such as hydrogen and carbon capture. Covering modern equations of state, this source discusses detailed descriptions of experimental apparatus, methods of measurement, corrections and error estimates as well as results of previous experiments. Generalized predictive methods for calculating viscosity and thermal conductivity are also covered. Rounding out with property databases and lower-carbon technology advances, the book gives today's engineers a detailed study of methods for more sustainable experimental research of thermophysical properties. - Teaches approaches for the measurement and modeling of thermophysical properties for future sustainability growth, including hydrogen and carbon capture - Provides exact property data of natural gas and their main components, including saturated properties - Gives readers new knowledge in experimental measurement procedures and guidelines for calculating thermophysical properties, along with updates on applications
Anchored in the CACREP accredication standards, this third book in the Counseling and Professional Identity series provides counselors and human service professionals with a solid foundation to understand lifespan/developmental theory and apply these constructs to clients in counselling at various stages. Each chapter in the book is dividided into a 3-step method, starting with a description of the theoretical content, followed by clinical illustrations and finishing with a complex case study with the distinctive "counselor thinking" feature accompanied by guided practice exercises. The book will also emphasize self reflection to help students learn experientially as they move through the text.
Textbook of Pediatric Infectious Diseases is a comprehensive guide to the diagnosis and management of infectious diseases in children and adolescents. Beginning with a general introduction and diagnosis, the following sections discuss different types of infections – systemic, bacterial, viral, protozoal, parasitic and fungal, and newly emerging diseases. A separate chapter is dedicated to vaccines and immunisation. Written by a recognised author and editor team, which includes contributors from the USA and Switzerland, this practical textbook includes numerous clinical photographs, detailed illustrations and tables. Key points Comprehensive guide to diagnosis and management of infectious diseases in children and adolescents Covers all types of infections Separate chapter on vaccines and immunisation Includes contributions from experts in the USA and Switzerland Features nearly 200 clinical photographs, illustrations and tables
Psychology is of interest to academics from many fields, as well as to the thousands of academic and clinical psychologists and general public who can't help but be interested in learning more about why humans think and behave as they do. This award-winning twelve-volume reference covers every aspect of the ever-fascinating discipline of psychology and represents the most current knowledge in the field. This ten-year revision now covers discoveries based in neuroscience, clinical psychology's new interest in evidence-based practice and mindfulness, and new findings in social, developmental, and forensic psychology.
Nanotubes (both of carbon and inorganic materials) can be made in a variety of ways, demonstrating a wide range of fascinating properties. Many of these, such as high mechanical strength and interesting electronic properties relate directly to potential applications. Nanowires have been made from a vast array of inorganic materials and provide great scope for further research into their properties and possible applications. Chapters in this book systematically describe the fundamentals and applications of nanotubes and nanowires, providing a comprehensive and up-to-date survey of the research area, including synthesis, characterisation, properties and applications. This new edition of Nanotubes and Nanowires includes an extensive list of references and is ideal both for graduates needing an introduction to the field of nanomaterials as well as for professionals and researchers in academia and industry. Review of Nanotubes and Nanowires 1st Edition: “This book does a truly admirable job of summarizing the literature in this rapidly changing field.” Journal of the American Chemical Society, 2006, 128, 4163-4164 Review of Nanotubes and Nanowires 2nd Edition: “Rao and Govindaraj do a superb job of distilling the huge literature on inorganic nanotubes and nanowires.” Chemistry & Industry, 2011, 24, 27
This second edition presents the core fundamentals of the subject in 11 manageable chapters while maintaining the book's scientific integrity. The research methods students need to understand, interpret, and analyze social psychological research are emphasized throughout. The streamlined approach provides an economical textbook for students and a flexible format that allows instructors to cover the entire book in a single semester. A book specific Web site contains a free online study guide and a variety of teaching tools. An Instructor's Manual/Test Bank and a Computerized Test Bank are also available.
Database marketing is at the crossroads of technology, business strategy, and customer relationship management. Enabled by sophisticated information and communication systems, today’s organizations have the capacity to analyze customer data to inform and enhance every facet of the enterprise—from branding and promotion campaigns to supply chain management to employee training to new product development. Based on decades of collective research, teaching, and application in the field, the authors present the most comprehensive treatment to date of database marketing, integrating theory and practice. Presenting rigorous models, methodologies, and techniques (including data collection, field testing, and predictive modeling), and illustrating them through dozens of examples, the authors cover the full spectrum of principles and topics related to database marketing. "This is an excellent in-depth overview of both well-known and very recent topics in customer management models. It is an absolute must for marketers who want to enrich their knowledge on customer analytics." (Peter C. Verhoef, Professor of Marketing, Faculty of Economics and Business, University of Groningen) "A marvelous combination of relevance and sophisticated yet understandable analytical material. It should be a standard reference in the area for many years." (Don Lehmann, George E. Warren Professor of Business, Columbia Business School) "The title tells a lot about the book's approach—though the cover reads, "database," the content is mostly about customers and that's where the real-world action is. Most enjoyable is the comprehensive story – in case after case – which clearly explains what the analysis and concepts really mean. This is an essential read for those interested in database marketing, customer relationship management and customer optimization." (Richard Hochhauser, President and CEO, Harte-Hanks, Inc.) "In this tour de force of careful scholarship, the authors canvass the ever expanding literature on database marketing. This book will become an invaluable reference or text for anyone practicing, researching, teaching or studying the subject." (Edward C. Malthouse, Theodore R. and Annie Laurie Sills Associate Professor of Integrated Marketing Communications, Northwestern University)
Unless new discoveries are made in the prevention or treatment of stroke, Alzheimer's Disease and depression, the number of patients with these diseases is sure to increase dramatically by the year 2050. Thus, developing strategies to retard or delay the onset of stroke, AD and depression these neurological disorders is of critical important. The present monograph will provide current and comprehensive information on the relationship between neuroinflammation and oxidative stress in age-related neurological disorders at the molecular level. The information described in this monograph on lifestyle (diet and exercise), genes and age is intended to facilitate and promote new discoveries for the treatment of age-related neurological disorders.
Neurochemical Aspects of Alzheimer's Disease provides a comprehensive overview of molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies. The book focuses on molecular mechanisms and signal transduction processes associated with the pathogenesis, biomarkers, and therapeutic strategies of AD. The comprehensive and cutting edge information in this monograph may not only help in early detection of AD, but also promote discovery of new drugs to treat this chronic disease. Chapters discuss involvement of neural membrane phospholipids, sphingolipids, and cholesterol-derived lipid mediators, abnormal APP processing, and nucleic acid damage, risk factors, biomarker, and therapeutic strategies of Alzheimer's disease. This book is written for neurologists, neuroscientists, neurochemists, neuropharmacologists, and clinicianswho are interested in molecular mechanisms associated with the pathogenesis of age-related neurological disorders. - Provides a comprehensive overview of molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies for Alzheimer's disease - Written for researchers, clinicians, and advanced graduate students in neurology, neuroscience, neurochemistry, and neuropharmacology - Acts as the first book to provide a comprehensive description of the signal transduction processes associated with pathogenesis of Alzheimer's disease
Active killer attacks frequently dominate the headlines with stories of seemingly random mass killings in school, campus, and workplace settings. Nearly all of the attacks are over before the police can respond, leaving unanswered questions as to why these attacks happen and what can be done to prevent them. Fatal Grievances: Forecasting and Preventing Active Killer Threats in School, Campus, and Workplace Settings takes a proactive view of active killer threat management and resolution to prevent the attack before it occurs. Drawing from established threat assessment, behavioral analysis, and law enforcement negotiation theory and practice, the book presents models and methods designed to forecast and prevent an active killer attack through the process of identification, assessment, and engagement. This approach begins with definitions and orientations to violence, the importance of the primacy of focusing on direct behaviors of planned lethal violence over other more indirect behaviors, understanding how to identify a fatal grievance and that only fatal grievances result in planned lethal violence, the importance of understanding the process of crisis intervention as the key to eliminating the fatal grievance and the motivation to kill, and the use of time-series predictive behavioral threat forecasting methods to prevent an active killer attack. Case studies from within the United States (US) and abroad support this unique approach to threat assessment and make the concepts and principles accessible to professionals working in the fields of education, human resources, and security.
Modern production methods and environmental constraints demand chemical solutions. And as oilfields age, the need for chemicals to ensure steady production increases. Production Chemicals for the Oil and Gas Industry describes classes of production chemicals for use topside and downhole in the upstream oil and gas industry. It includes coverage of
1,2,3-Thiadiazoles are a group of heterocycles whose derivatives are important in industry, medicine, and agriculture. This volume provides a complete treatment of this group of heterocycles with an emphasis on syntheses, structural data, properties, reactions, and applications.
Market: Cardiologists, Vascular Specialists, Vascular Surgeons, Hematologists, Internists, Family Physicians, Rheumatologists More than 500 color charts and tables Includesw an entire section on diagnostic imaging modalities
The standard-setting text in oncology for 40 years, DeVita, Hellman and Rosenberg’s Cancer: Principles and Practice of Oncology, 12th Edition, provides authoritative guidance and strategies for managing every type of cancer by stage and presentation. Drs. Vincent T. DeVita, Jr., Theodore S. Lawrence, and Steven A. Rosenberg oversee an outstanding team of expert contributing authors who keep you up to date and fully informed in this fast-changing field. This award-winning reference is also continually updated on Health Library and VitalSource platforms for the life of the edition.
Molecular Aspects of Neurodegeneration, Neuroprotection, and Regeneration in Neurological Disorders presents readers with comprehensive and cutting-edge information on the neurochemical mechanisms of various types of neurological disorders. The book covers information on signal transduction processes associated with neurochemistry of neurological disorders, including neurodegenerative, neurotraumatic, and neuropsychiatric disorders. The book also discusses risk factors, symptoms, pathogenesis, biomarkers, and the potential treatments of neurological disorders. The comprehensive information in this monograph may not only help in early detection of various neurological disorders, but will also promote the discovery of new drugs. - Provides a comprehensive overview of the molecular aspects of neurodegeneration, neuroprotection, and neuro-regeneration, along with therapeutic strategies for various types of neurological disorders - Provides cutting-edge research information on the signal transduction processes associated with the neurochemistry of neurological disorders - Discusses risk factors, symptoms, pathogenesis, biomarkers, and the potential for treatments of neurological disorders
Research and literature on nanomaterials has exploded in volume in recent years. Nanotubes (both of carbon and inorganic materials) can be made in a variety of ways, and they demonstrate a wide range of interesting properties. Many of these properties, such as high mechanical strength and interesting electronic properties relate directly to potential applications. Nanowires have been made from a vast array of inorganic materials and provide great scope for further research into their properties and possible applications. This book provides a comprehensive and up-to-date survey of the research areas of carbon nanotubes, inorganic nanotubes and nanowires including: synthesis; characterisation; properties; applications Nanotubes and Nanowires includes an extensive list of references and is ideal both for graduates needing an introduction to the field of nanomaterials as well as for professionals and researchers in academia and industry.
DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology, 10th edition has garnered universal acclaim as the world’s definitive, standard-setting oncology reference. More than 400 respected luminaries explore today’s most effective strategies for managing every type of cancer by stage of presentation - discussing the role of all appropriate therapeutic modalities as well as combined-modality treatments. This multidisciplinary approach will help your cancer team collaboratively face the toughest clinical challenges and provide the best possible care for every cancer patient. Access the complete contents online or on your mobile device, with quarterly updates reflecting late-breaking developments in cancer care, free for the first year on LWW Health Library. Take full advantage of the latest advances with brand-new chapters on Hallmarks of Cancer, Molecular Methods in Cancer, Oncogenic Viruses, Cancer Screening, and new sections on Genetic testing and counseling for cancer, plus comprehensive updates throughout – including coverage of the newest biologic therapies. Make optimal, well-coordinated use of all appropriate therapies with balanced, multidisciplinary advice from a surgeon, a medical oncologist, and a radiation oncologist in each major treatment chapter. Review the latest molecular biology knowledge for each type of cancer and its implications for improved management. Make the best decisions on cancer screening and prevention, palliative care, supportive oncology, and quality-of-life issues
Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Now updated online for the life of the edition, DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology, 11th Edition keeps you up to date in this fast-changing field. Every quarter, your eBook will be updated with late-breaking developments in oncology, including new drugs, clinical trials, and more.
This book contains a selection of fully peer-reviewed papers which were presented at the 2nd ESIS TC4 Conference, held in Les Diablerets, Switzerland 13 - 15 September 1999. The meeting was designed to reflect the activities of the Committee over the last 15 years, and to plan future activities. The papers have been divided into four chapters under the headings of Composites, Elastic-Plastic Fracture, Adhesion, and Impact and General Fracture. These are convenient groupings, but there are many interactions between the areas, with the common theme of Fracture Mechanics underlying it all.
Theoretical chemistry has been an area of tremendous expansion and development over the past decade; from an approach where we were able to treat only a few atoms quantum mechanically or make fairly crude molecular dynamics simulations, into a discipline with an accuracy and predictive power that has rendered it an essential complementary tool to experiment in basically all areas of science. This volume gives a flavour of the types of problems in biochemistry that theoretical calculations can solve at present, and illustrates the tremendous predictive power these approaches possess.A wide range of computational approaches, from classical MD and Monte Carlo methods, via semi-empirical and DFT approaches on isolated model systems, to Car-Parinello QM-MD and novel hybrid QM/MM studies are covered. The systems investigated also cover a broad range; from membrane-bound proteins to various types of enzymatic reactions as well as inhibitor studies, cofactor properties, solvent effects, transcription and radiation damage to DNA.
Diagnostic Pathology of Pleuropulmonary Neoplasia highlights the morphologic basis, immunohistochemistry, electron microscopy, and molecular biology of tumoral and pseudotumoral conditions of the lung and pleura. The volume also highlights the nuances in the diagnosis of lung and pleural conditions and the applications of today’s most recent studies in molecular biology, and the way it is applied to diagnosis and treatment. In providing an expert guide for the histopathologic diagnosis of lung and pleural tumors, this volume be of great interest to general surgical pathologists, surgeons, oncologists, and those involved in the management of patients with lung tumors.
By detailing experimental and basic research, from premalignancy to fully invasive tumors, this book has wide applicability to all human carcinomas. No other group of human cancers is better positioned for the application of recently developed novel and targeted therapies, and this book uniquely presents the unusual opportunities tumors of the head and neck provide for clinical, translational, and basic science research. Cutting-edge and experimental treatment approaches are presented, along with future strategies and an evaluation of emerging technologies. - Presents a multi-disciplinary perspective from authorities in diverse fields - Addresses state-of-the art approaches in cancer research as well as other scientific opportunities in this field - Provides comprehensive yet easily comprehendible source of information
New Strategies Targeting Cancer Metabolism: Anticancer Drugs, Synthetic Analogues and Antitumor Agents presents up-to-date synthetic strategies for three categories of antimetabolites: antifolates, purines and pyrimidines, the main classes of antimetabolites which are integrated into various pharmaceutical agents. Many of these antimetabolites are considered potent chemotherapeutic agents which have great potential impact on medical research. These main classes of antimetabolites are used in the treatment of critical diseases including cancer, malignancies, autoimmune diseases, and many other non-malignant diseases. Antineoplastic drugs such as alkylating agents which have significant effects are described. Novel synthetic strategies for many anticancer alkylating agents including nitrogen mustards, chlorambucil, melphalan, ifosamide, oxaliplatin and temozolomide are explored. Natural products have offered some of the most significant drugs for treating cancer, as many drugs currently in clinical use are derived from natural products as camptothecins, vinca alkaloids, and derivatives of podophyllotoxin. They provide a contribution that is essential for modern drug discovery and development. In this book, insights into a broad array of novel compounds are reviewed, well-recognized synthetic approaches are emphasized for further anticancer drug development and discovery, and the biological evaluation of novel synthesized compounds are included. This comprehensive reference is a valuable resource for medical chemists working in drug discovery and development, as well as pharmacologists and biochemists working in related fields. - Provides the only resource dedicated to synthetic strategies of antimetabolites - Features synthetic strategies for nucleosides and their analogues - Includes coverage of purine-, pyrimidine- and antifolate-based anticancer drugs - The most significant anticancer alkylating agents and natural products are demonstrated
Covering every problem encountered in today’s intensive care unit, this leading critical care textbook presents the knowledge and expertise of more than 350 global experts in this fast-changing field. Beginning with the social aspects of medicine, it then discusses monitoring and organ system pathobiology followed by specific diseases states/syndromes. Each chapter begins with immediate concerns and proceeds to broader-based discussions of relevant pathophysiologic and clinical issues.
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