From the New York Times–bestselling “master of suspense”: A woman’s mysterious past is unearthed during the 1906 San Francisco earthquake (Mary Higgins Clark). Sara Bishop was raised in Chicago, but her heart belongs in San Francisco, where her childhood sweetheart, Ritchie Temple, has moved to pursue a career in architecture. Convinced he feels the same way for her, she hopes his fiancée, the manipulative Judith Renwick, is just a passing fancy. And now Sara has packed her bags to prove it. Sarah’s mother is not only concerned by her daughter’s pursuit of an elusive romance, she’s also scared of the city itself—and the secret she and Sara’s father buried there years ago. Once Sara arrives on the far side of the Golden Gate, she finds herself in the midst of a tantalizing puzzle involving Ritchie, Judith, and Judith’s mysterious brother. She soon discovers a monstrously wicked matriarch nursing a strange and unfathomable vengeance in her Nob Hill mansion. And one fateful morning, when the earth moves and the city is set afire, the pieces of Sara’s past will emerge from the ashes—but will it be too late to save her? A recipient of the Agatha Award for Lifetime Achievement, Phyllis A. Whitney is the acknowledged “Queen of the American gothics” (The New York Times). This ebook features an illustrated biography of Phyllis A. Whitney including rare images from the author’s estate.
SON OF TERROR: Frankenstein Continued" is a direct sequel to Mary Shelley's classic "Frankenstein." The story begins shortly after Victor's Frankenstein's death on board an icebound ship in the Arctic in the late 1790s. The book continues the story of 8-foot tall Sohn Schrenk, Victor's monstrous and intelligent creation. Where does he go after Victor's death? Will he continue his monstrous behavior and be shunned by mankind forever? The other major character is 21-year-old Mary Godwin (Mary Shelley's maiden name), an investigative journalist in New York City and coastal Maine. The book traverses the centuries of Sohn's long, sometimes horrific life.
Three romantic novels of suspense from the New York Times–bestselling “Queen of the American gothics” (The New York Times). The Turquoise Mask: Manhattan illustrator Amanda Austin is summoned to her grandfather’s Santa Fe hacienda to get to know distant relatives of her late mother, who died years ago under mysterious circumstances. But once there, everyone greets her like an unwelcome guest. After a little investigating, she begins to fear the real reason she was invited . . . The Trembling Hills: In 1906, Sara Bishop is off to San Francisco to win back her childhood sweetheart, Ritchie Temple. Her mother, however, is not only concerned with her daughter’s pursuit of an elusive romance, but also with the city itself—and the secret she and Sara’s father buried there years ago . . . The Quicksilver Pool: After the Civil War, Lora, a young Confederate bride moves north to live with Wade, her Union soldier husband, in his Staten Island mansion. Waiting for her there are a bitterly unwelcoming family and the shadows of Wade’s past.
Uniquely designed for oncologists and general practitioners, this book offers clinicians comprehensive guidelines when dealing with women at high risk for breast cancer. Written by experts in the field on the cutting edge of this research, the following questions will be answered for the reader by the end of the book: · Who is at elevated risk for breast cancer? · Who should be genetically screened? · When and how often should we obtain imaging? · What type of imaging is adequate? · What medications are available for prevention? · When is surgical intervention appropriate? · What lifestyle changes should be implemented to prevent this disaster? With one in eight women likely to contract breast cancer in her lifetime, the significance of identifying and managing the high-risk patient is evident. Breakthroughs in the identification of genes associated with breast carcinoma, particularly BRCA1 and 2, as well as other risk factors, influence not only how patients are screened, but also how they are treated. Breast Cancer Prevention and Treatment provides a guided approach to prevention of breast cancer in women at elevated risk for this malignancy.
Charmaine A. Nelson analyzes not only how, where, why and by whom black female subjects have been represented in Western art, but also what the social and cultural impacts of the colonial legacy of racialized western representation have been. She poses critical questions about the contexts of production, the problems of representation, the pathways of circulation and the consequences of consumption.
Comprehensive and practical, Mills and Sternberg’s Diagnostic Surgical Pathology, 7th Edition, presents advanced diagnostic techniques for differential diagnosis of the surgical specimen and the latest information on all currently known diseases. Led by Drs. Teri A. Longacre, Joel K. Greenson, Jason, L. Hornick, and Victor E. Reuter, a virtual “who’s who” of experts in the field provide authoritative guidance on the diagnostic evaluation of every type of specimen from every anatomic site. Visually stunning and thoroughly up to date, this classic two-volume reference is a must-have resource no matter what your level of training or expertise.
The chapters of this text present theoretical foundations for and explanations of what important adults in young children's lives can do to encourage the development of social-emotional abilities, including promoting secure attachment relationships and providing positive behavior guidance.
2015 BMA Medical Book Awards Highly Commended in Oncology Category!The Molecular Basis of Cancer arms you with the latest knowledge and cutting-edge advances in the battle against cancer. This thoroughly revised, comprehensive oncology reference explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of this disease. A team of leading experts thoroughly explains the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Detailed descriptions of topics from molecular abnormalities in common cancers to new approaches for cancer therapy equip you to understand and apply the complexities of ongoing research in everyday clinical application. - Effectively determine the course of malignancy and design appropriate treatment protocols by understanding the scientific underpinnings of cancer. - Visually grasp and retain difficult concepts easily thanks to a user-friendly format with abundant full-color figures. - Find critical information quickly with chapters following a logical sequence that moves from pathogenesis to therapy. - Stay current with the latest discoveries in molecular and genomic research. Sweeping revisions throughout include eight brand-new chapters on: Tumor Suppressor Genes; Inflammation and Cancer; Cancer Systems Biology: The Future; Biomarkers Assessing Risk of Cancer; Understanding and Using Information About Cancer Genomes; The Technology of Analyzing Nucleic Acids in Cancer; Molecular Abnormalities in Kidney Cancer; and Molecular Pathology. - Access the entire text and illustrations online, fully searchable, at Expert Consult.
The twelfth edition of this classic reference work includes: - More than 2,000 new entries - A total of more than 9,000 entries - New features and enhancement of the familiar old features - Mapping information on more than 4,000 genes of known function - Information on specific point mutations responsible for more than 700 genetic disorders or neoplasms Mendelian Inheritance in Man (MIM) is a genetic knowledgebase that serves clinical medicine and biomedical research, including the Human Genome Project. It aims to be comprehensive (not only complete, but also collated, integrated, and interpreted), authoritative (not only accurate but also sound in its interpretations and judgements), and timely (not only up-to-date but also historically dimensioned). From a review of the eleventh edition, Reproductive Toxicology: "Even the convenience of computer-based forms of MIM cannot eliminate the need for MIM in book form. The preface provides a wonderful synopsis of human genetics. The information contained in this text serves as a concise review for those with a genetics background." From a review of the tenth edition, New England Journal of Medicine: " Victor McKusick] has been for all these years the shepherd of the development of the field of clinical genetics]. Perhaps his most important pragmatic achievement has been the 10 editions of Mendelian Inheritance in Man, which rapidly became and has remained the principal source of information on inherited diseases for all clinical geneticists. "In addition to the erudite entries in the books, the references given with each description represent a magnificent bibliography of clinical genetics. With McKusick's leadership and continued interest in gene mapping, the book also rep-resents an important compen-dium of the location of genes on specific chromosomes. "The book is a magnificent security blanket for the clinical geneticist and should be in the libraries not only of these specialists, but also of all others who see patients with diseases that have genetic components.
Love is a mystery-one revered yet feared-with questions always under the surface, the source of which is never quite known. Why do we love? How do we love? How will we know when we've found our own true love? Poet Edward Theodore Hayes explores the path of love through the story of one man and one woman destined to be together in The Love Scrolls: Love Passages, his first major work. The Love Scrolls is an epic rhyming poem of grand proportion, filled with the magic of love and the secrets of such revealed. It is sweeping and grand and plays on the heart and mind of readers as the love scrolls themselves play on the lives of the inhabitants of this work. The Love Scrolls is a beautiful, heartfelt, and creative work in which lovers of love and thoughtful readers will delight. Visit thelovescrolls.com for more.
As a planned community, Indianapolis boasted finished frame and brick buildings from its beginning. Architects and builders drew on Federal, Greek Revival, Italianate, French Second Empire, Gothic, Romanesque, and Italian Renaissance styles for commercial, industrial, public, and religious buildings and for residences. In Architecture in Indianapolis: 1820–1900, preservationist and architectural historian Dr. James Glass explores the rich variety of architecture that appeared during the city's first 80 years, to 1900. Glass explains how economic forces shaped building cycles, such as the Canal Era, the advent of railroads, the natural gas boom, and repeated recessions and recoveries. He describes 243 buildings that illustrate the styles that architects and builders incorporated into the designs that they devised in each era between 1820 and 1900. This book also documents the loss of distinctive 19th century architecture that has occurred in Indianapolis. It includes 373 photographs and drawings that depict the buildings described and locator maps that show where concentrations of buildings were constructed. Architecture in Indianapolis: 1820–1900 provides the first history of 19th-century architecture in the city and will serve as an indispensable reference for decades to come.
This engaging, authoritative text synthesizes a vast body of research on how young children develop the ability to understand, express, and manage their emotions, as well as the impact of these capacities on relationships, school readiness, and overall well-being. Illustrated with vivid vignettes, the book explains specific ways that parents, teachers, and education systems can foster or hinder emotional competence, and reviews relevant assessments and interventions. Compelling topics include emotion regulation as both product and process, cultural variations in emotion socialization, the expression of empathy and self-conscious emotions, risk factors for delays in emotional development, and connections between emotional competence and social–emotional learning (SEL). Almost entirely new, this book replaces Susanne A. Denham's influential earlier work, Emotional Development in Young Children.
Originally published in 1974. Here is a detailed discussion of educational change in New Zealand with implications which should provoke a fresh approach both to the educational tradition in Britain and to the problems of other educational systems which are subject to democratic control. It is primarily concerned with developments in the quarter-century between 1945 and 1970. With frequent reference to events preceding and following this period, the author stresses throughout the professed educational ideal of all post-war New Zealand governments: to provide equality of opportunity in education. He deals with principles of policy and administrative control, including the universities and estimates the influence on official policy of interest groups inside and outside the educational system. He examines social issues which include the extent to which governments have failed to promote equality of opportunity in the schooling of minority groups in the country, and treats, in an historical perspective, the perennial vexed question of state aid to private schools. The concluding chapters describe and analyse the characteristics, difficulties and prospects of primary, secondary and tertiary education.
Joanna Baillie and the Art of Moral Influence explores the project of moral reform that Baillie sets out for herself in the Introductory Discourse to her first volume of Plays on the Passions (1798). It begins by revealing the foundation that Baillie creates for her project as she combines her own unique theology with eighteenth-century moral philosophy and seventeenth- and eighteenth-century discourses on the theatre's potential to reform audiences. This book argues that Baillie uses this eclectic mix to craft a potentially radical social critique in the midst of a seemingly conservative moral project. Using examples from fifteen of her plays as well as from her prefaces and her religious tract, the book traces Baillie's moral project from its direct representations in De Monfort and Henriquez through its dangerous complexities in plays such as Orra and The Trial to its conflict with domestic ideology as an alternative means of reform in plays such as The Dream, Ethwald, The Phantom, and Witchcraft. This analysis of Baillie's project reveals how she ultimately overcomes the difficulties inherent in her project by asking her audiences to take responsibility for their moral reform rather than relying upon the domestic woman to change society and by asking her audiences to ground their interpretations in the basic truths of Christianity. Understanding Baillie's moral project and the discourses that influenced it and then seeing how it is enacted throughout her plays will allow teachers and scholars to appreciate even more fully the complexities of this British Romantic playwright.
A comprehensive reference on state-of-the-art risk assessment methodologies for drinking water Risk Assessment for Chemicals in Drinking Water discusses the major steps and goals in risk assessments and suggests ways to improve the methodologies and accuracy, while consolidating up-to-date information on the current principles and practices in one authoritative reference. After an enlightening overview of risk assessment practices and regulatory guidelines, it: Includes descriptions of the use of variability analysis, exposure analysis, physiologically based pharmacokinetics, and modeling for both cancer and non-cancer endpoints Describes the practices of major organizations, including the U.S. EPA, Health Canada, World Health Organization, and California Office of Environmental Health Hazard Assessment Includes complete chapters on risk assessment for essential nutrients, arsenic, chloroform, and perchlorate Explains how to address susceptible sub-populations, including the elderly and infants and children, in risk assessments Covers the potential of using genomic and proteomic screens Addresses recent advances, emerging issues, and future challenges With contributions and perspectives from leading scientists, this is the definitive resource for health and environmental scientists, toxicologists, risk assessors and managers, regulators, consultants, and other professionals responsible for the safety of drinking water.
Updated to reflect recent changes in the field, the 2nd Edition of Forensic Psychology presents a comprehensive overview of forensic psychology and its applications in the civil and criminal justice systems of the UK. Builds on the first edition to convey material in an engaging manner to postgraduate students in psychology Includes a significant expansion of pedagogical features, including text boxes highlighting key seminar issues and key debates in the field to further group discussion Provides an up-to-date summary of emerging evidence in the field, and its implications for evidence based practice Points to additional online learning resources at the conclusion of each chapter
Consolidates the many different chemistries being employed to provide environmentally acceptable products through the upstream oil and gas industry This book discusses the development and application of green chemistry in the oil and gas exploration and production industry over the last 25 years — bringing together the various chemistries that are utilised for creating suitable environmental products. Written by a highly respected consultant to the oil and gas industry — it introduces readers to the principles and development of green chemistry in general, and the regulatory framework specific to the oil and gas sector in the North Sea area and elsewhere in the world. It also explores economic drivers pertaining to the application of green chemistry in the sector. Topics covered in Oilfield Chemistry and its Environmental Impact include polymer chemistry, surfactants and amphiphiles, phosphorus chemistry, inorganic salts, low molecular weight organics, silicon chemistry and green solvents. It also looks at sustainability in an extractive industry, examining the approaches used and the other methodologies that could be applied in the development of better chemistries, along with discussions about where the application of green chemistry is leading in this industry sector. Provides the reader with a ready source of reference when considering what chemistries are appropriate for application to oilfield problems and looking for green chemistry solutions Brings together the pertinent regulations which workers in the field will find useful, alongside the chemistries which meet the regulatory requirements Written by a well-known specialist with a combined knowledge of chemistry, manufacturing procedures and environmental issues Oilfield Chemistry and its Environmental Impact is an excellent book for oil and gas industry professionals as well as scientists, academic researchers, students and policy makers.
In a field where even experts may find that years have elapsed since they last encountered a child with a given disorder, it is essential for the clinician to have a comprehensive source of practical and highly illustrated information covering the whole spectrum of metabolic disease to refer to. The second edition of this highly regarded book, authored by three of the foremost authorities in pediatric metabolic medicine, fulfils this need by providing an invaluable insight into the problems associated with metabolic diseases. For ease of reference, Atlas of Metabolic Disease is divided into sections of related disorders, such as disorders of amino acid metabolism, lipid storage disorders and mitochondrial diseases, with an introductory outline where appropriate summarizing the biochemical features and general management issues. Within sections each chapter deals with an individual disease, starting with a useful summary of major phenotypic expression and including clear and helpful biochemical pathways, identifying for the reader exactly where the defect is occurring. Throughout the book, plentiful photographs, often showing extremely rare disorders, are an invaluable aid to diagnosis.
In preparing the new completely revised edition of this glossary, which in the meantime has been translated into Russian and Polish, we have attempt ed to include the most important new terms and to revise the text in those cases where new data demanded it*. As a result about fifty percent of the text is completely rewritten. Once more we have tried to provide material suitable and usable both for students and research workers. Accordingly, depending upon our evaluation, some terms have been simply defined, others have been described at some length even to the extent of providing experi mental data. Wherever possible, synonymy and redundancy have been pointed out, and in the interest of historical accuracy the individual respon sible for introducing a particular term or concept listed with the specific paper included in the literature citations. Cross references between related terms are designated by an arrow (---*) before each relevant term. To keep the book, as far as possible, to a reasonable size the terms carried over from the earlier edition have once more been critically selected and, where necessary, revised. In spite of these efforts a certain increase in volume was unavoidable. We hope that the new edition will once more prove useful to a wide audience and enjoy the same cordial reception as the earlier ones. Comments and suggestions from the reviewers and users of the earlier editions have contribut ed signifiClllltly to the revision.
In recent years there has been considerable interest in the diagnosis and understanding of ventricular repolarisation, particularly the QT interval prolongation and abnormal T and T/U wave morphology associated with torsades de pointes. Advances in ion channel cloning have greatly improved our understanding of the role of ionic channels in mediating cardiac repolarisation. Unfortunately, it is increasingly recognised that a number of drugs, both those associated with altering repolarisation, and others for non-cardiac conditions can increase the propensity for polymorphic ventricular tachycardia, syncope and even ventricular fibrillation and sudden death. In this volume, arrhythmia specialists from St. George’s Hospital Medical School, London discuss the mechanisms behind QT prolongation and torsades de pointes. They focus particularly on the risk of individual cardiac and non-cardiac drugs in provoking long QT syndrome, providing a comprehensive review which will be useful for all electrophysiologists treating polymorphic ventricular tachycardias, and will expose important regulatory issues for pharmaceutical authorities and for the wider medical community.
The new edition of this comprehensive classic continues the tradition of offering the latest developments in the mechanisms of injury, the biomechanics of fracture reduction, and an understanding of the potential for healing. It correlates anatomy, pathology and radiography of childrens skeletal injuries with a plethora of photographs and line drawings, establishing diagnosis, management, and treatment in a comprehensive and practical manner. Important additions to this edition are an expansive chapter on the management of multiple injuries, the management of complications, extensive discussion of soft tissue injuries following skeletal trauma, new diagnostic techniques, and the use of flaps in childrens injuries. Written by one of the most highly respected names in the orthopaedic community world-wide, this third edition will remain an invaluable resource to paediatric orthopaedic surgeons, general orthopaedic surgeons, emergency room physicians, orthopaedic trauma surgeons and residents and fellows in these specialities.
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