The twelfth edition of this classic reference work includes: - More than 2,000 new entries - A total of more than 9,000 entries - New features and enhancement of the familiar old features - Mapping information on more than 4,000 genes of known function - Information on specific point mutations responsible for more than 700 genetic disorders or neoplasms Mendelian Inheritance in Man (MIM) is a genetic knowledgebase that serves clinical medicine and biomedical research, including the Human Genome Project. It aims to be comprehensive (not only complete, but also collated, integrated, and interpreted), authoritative (not only accurate but also sound in its interpretations and judgements), and timely (not only up-to-date but also historically dimensioned). From a review of the eleventh edition, Reproductive Toxicology: "Even the convenience of computer-based forms of MIM cannot eliminate the need for MIM in book form. The preface provides a wonderful synopsis of human genetics. The information contained in this text serves as a concise review for those with a genetics background." From a review of the tenth edition, New England Journal of Medicine: " Victor McKusick] has been for all these years the shepherd of the development of the field of clinical genetics]. Perhaps his most important pragmatic achievement has been the 10 editions of Mendelian Inheritance in Man, which rapidly became and has remained the principal source of information on inherited diseases for all clinical geneticists. "In addition to the erudite entries in the books, the references given with each description represent a magnificent bibliography of clinical genetics. With McKusick's leadership and continued interest in gene mapping, the book also rep-resents an important compen-dium of the location of genes on specific chromosomes. "The book is a magnificent security blanket for the clinical geneticist and should be in the libraries not only of these specialists, but also of all others who see patients with diseases that have genetic components.
From fundamental principles to advanced subspecialty procedures, Miller’s Anesthesia covers the full scope of contemporary anesthesia practice. This go-to medical reference book offers masterful guidance on the technical, scientific, and clinical challenges you face each day, in addition to providing the most up-to-date information available for effective board preparation. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Address the unique needs of pediatric patients with guidance from an entire section on pediatric anesthesia. View more than 1,500 full-color illustrations for enhanced visual clarity. Access step-by-step instructions for patient management, as well as an in-depth analysis of ancillary responsibilities and problems. Quickly reference important concepts with ‘Key Points’ boxes integrated into every chapter. Stay current on today's most recent anesthetic drugs and guidelines/protocols for anesthetic practice and patient safety, and access expanded coverage on new techniques such as TEE and other monitoring procedures. Take advantage of the unique, international perspectives of prominent anesthesiologists from all over the world, including the UK, Australia, India, Brazil, and Germany. Remain at the forefront of new developments in anesthesia with coverage of hot topics including Non-OR Anesthesia; Role of the Anesthesiologist in Disasters; Sleep Medicine in Anesthesia; Perioperative and Anesthesia-related Neurotoxicity; Anesthetic Implications of Complementary and Alternative Medicine; and Robotics. Study brand-new chapters on Perioperative Fluid Management; Extracorporeal Support Therapies; Anesthesia for Organ Donation/Procurement; and Malignant Hyperthermia and other Genetic Disorders.
I am unaware of any textbook which provides such comprehensive coverage of the field and doubt that this work will be surpassed in the foreseeable future, if ever!' From the foreword by Robert C. Moellering, Jr., M.D, Shields Warren-Mallinckrodt Professor of Medical Research, Harvard Medical School, USA Kucers' The Use of Antibiotics is the leading major reference work in this vast and rapidly developing field. More than doubled in length compared to the fifth edition, the sixth edition comprises 3000 pages over 2-volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into 4 sections: antibiotics, anti-fungal drugs, anti-parasitic drugs and anti-viral drugs, and is highly structured for ease of reference.Within each section, each chapter is structured to cover susceptibility, formulations and dosing (adult and paediatric), pharmacokinetics and pharmacodynamics, toxicity and drug distribution, detailed discussion regarding clinical uses, a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with a vast number of contributors spanning Europe, Africa, Asia, Australia, South America, the US and Canada, the sixth edition adopts a truly global approach. It will remain invaluable for anyone using antimicrobial agents in their clinical practice and provides in a systematic and concise manner all the information required when treating infections requiring antimicrobial therapy. Kucers' The Use of Antibiotics is available free to purchasers of the books as an electronic version on line or on your desktop: It provides access to the entire 2-volume print material It is fully searchable, so you can find the relevant information you need quickly Live references are linked to PubMed referring you to the latest journal material Customise the contents - you can highlight sections and make notes Comments can be shared with colleagues/tutors for discussion, teaching and learning The text can also be reflowed for ease of reading Text and illustrations copied will be automatically referenced to Kucers' The Use of Antibiotics
Obstetric Imaging will help you detect fetal abnormalities with greater confidence and accuracy. Covering MRI as well as ultrasound and interventional procedures, it equips you with expert tips for recognizing and addressing problems that you might otherwise miss. Obstetric Imaging provides the advanced guidance you need to recognize fetal health challenges early and respond effectively! Get advanced clinical guidance from a preeminent team of international maternal-fetal medicine specialists and obstetrician/gynecologists. See perfect examples of normal and variant anatomy, as well as the full range of fetal syndromes, with 1,318 images, 361 in full color. Know how to get optimal diagnostic accuracy from ultrasound and when to use MRI instead. Effectively perform image-guided interventions including amniocentesis, fetal transfusion, selective laser photocoagulation, radiofrequency ablation, fetal shunt placement, and more. Master important nuances of sonography by watching 69 videos online. Access Obstetric Imaging online at www.expertconsult.com, view all the videos, and download all the images.
Overcome the toughest clinical challenges in nephrology with Brenner & Rector’s The Kidney -- the most well-known nephrology resource in the world. A diverse team of more than 200 international contributors brings you the latest knowledge and best practices on every front in nephrology worldwide. From basic science and pathophysiology to clinical best practices, Brenner & Rector’s The Kidney is your go-to resource for any stage of your career. Review of the basic science that underpins clinical nephrology, comprehensive selection of the most important bibliographical sources in nephrology, and Board Review-style questions help you prepare for certification or recertification. Coverage of kidney health and disease from pre-conception through fetal and infant health, childhood, adulthood, and into old age. Expanded sections and chapter on global perspective and ethical considerations. Uniform terminology and nomenclature in line with emerging consensus in world kidney community. More than 700 full-color high-quality photographs as well as carefully chosen figures, algorithms, and tables to illustrate essential concepts, nuances of clinical presentation and technique, and decision making provide a visual grasp and better understanding of critical information. Internationally diverse, trusted guidance and perspectives from a team of well-respected global contributors . An editorial team headed by Dr. Skorecki and handpicked by Dr. Brenner ensures the ongoing adherence to previous standards of excellence. All chapters have been extensively updated or entirely rewritten by authorities in their respective fields. The latest clinical information including recent clinical trials, genetic causes of kidney disease, cardiovascular and renal risk prediction in chronic kidney disease, new paradigms in fluid and electrolyte management, and pediatric kidney disease, keep you current with the rapid development of care and research worldwide.
This paperback, full-color book is ideally suited for anesthesiologists, residents, and nurse anesthetists who need a concise, practical, easily accessible reference on anesthesia equipment. Written by the authors of the definitive text Understanding Anesthesia Equipment, A Practical Approach to Anesthesia Equipment covers the most commonly used machines and devices and addresses common problems and pitfalls that affect clinical situations. The book is written in outline format and thoroughly illustrated with full-color photographs and line drawings.
In this book the author presents the Opial, Poincaré, Sobolev, Hilbert, and Ostrowski fractional differentiation inequalities. Results for the above are derived using three different types of fractional derivatives, namely by Canavati, Riemann-Liouville and Caputo. The univariate and multivariate cases are both examined. Each chapter is self-contained. The theory is presented systematically along with the applications. The application to information theory is also examined. This monograph is suitable for researchers and graduate students in pure mathematics. Applied mathematicians, engineers, and other applied scientists will also find this book useful.
Multiple Equilibria in Proteins covers the multiple interactions between small ions and molecules and a protein molecule. The book also deals with the physicochemical mechanisms of this interaction and the information about protein structure and the forces stabilizing that structure. The text discusses the mathematical description of complex formation, the thermodynamic analysis of binding data, and various theoretical models which can be used to describe the phenomena of small molecule-macromolecule interactions. The measurement of complex formation; the binding of neutral molecules; and hydrogen-ion equilibria are also considered. The book further tackles metal-ion binding; the binding of organic ions by proteins; as well as protein-protein interaction. Chemists and biochemists will find the book useful.
Edited to avoid duplication and favor comprehensiveness, 20 contributors detail the recovery, separation, and purification operations of bioprocess technology. Individual chapters in this classic yet still highly relevant work emphasize concepts that are becoming more and more important when applied to the large scale versions of techniques that are considered well established. Aside from fully discussing processes, Separation Processes in Biotechnology includes sections on concentration separation and operation, purification operations, and product release and recovery. It also discusses plant operation and equipment and delves into economic considerations
From basic science to clinical care, to epidemiological disease patters, The Neurology of AIDS is the only complete textbook available on AIDS neurology and the only one comprehensive enough to stand alone in each segment of study in brain disorders affected by the human immunodeficiency virus. It is an indispensable resource for students, resident physicians, practicing physicians, and for researchers and experts in the HIV/AIDS field. Oxford Clinical Neuroscience is a comprehensive, cross-searchable collection of resources offering quick and easy access to eleven of Oxford University Press's prestigious neuroscience texts. Joining Oxford Medicine Online these resources offer students, specialists and clinical researchers the best quality content in an easy-to-access format.
The most authoritative guide to sonography in obstetrics and gynecology—now in full color Companion website includes images, case studies, and more Written by radiologists and ob/gyns to provide a balanced perspective, this standard-setting guide is both a clinically relevant reference text and atlas—presented in full color for the first time. It expertly examines the full spectrum of disorders and conditions you’re likely to encounter in gynecologic and maternal-fetal care, supported throughout by more than 2,000 detailed sonographic illustrations. You’ll also find the latest procedures and diagnostic guidelines for the use of sonography in ob/gyn, including 3D and 4D image processing, transvaginal sonography, and color Dopler sonography. The book opens with general obstetric sonography, covering such pivotal topics as normal pelvic anatomy and fetal echocardiography, before moving into fetal anomalies and disorders. Risk assessment and therapy, including first trimester screening and amniocentesis, are explored in the next section, while the remaining parts of the book focus on maternal disorders, gynecological sonography, and the newest complementary imaging modalities. Features The most trusted, accessible compendium of sonography in obstetrics and gynecology for residents and practitioners, filled with precise illustrations that add clarity to the text’s content All-inclusive coverage of everything from sonographic operating instruments and screening the fetal patient for syndromes and anomalies, to diagnosing the female patient for cysts, infertility, and incontinence NEW! Full-color format to aid readability and ease of use NEW! Up-to-date information on the significant advances made in three dimensional and even four-dimensional Doppler technology NEW! Learning aids: a “key points” section in each chapter; skill-building clinical scenarios; a stronger focus on differential diagnosis; multiple visuals (figure, illustration, or table) on each page; and helpful chapter-opening summaries NEW! Companion website filled with concept-clarifying images, video loops, case studies supplemented by Q&As, plus cutting-edge insights on a range of integral sonography topics NEW! SI Units incorporated throughout
An extraordinary compendium of information on herbal medicine, Medicinal Plants of the World, Volume 3 comprehensively documents the medicinal value of 16 major plant species widely used around the world in medical formulations. The book's exhaustive summary of available scientific data for the plants provides detailed information on how each plant is used in different countries, describing both traditional therapeutic applications and what is known from its use in clinical trials. A comprehensive bibliography of over 3000 references cites the literature available from a wide range of disciplines. This book offers an unprecedented collection of vital scientific information for pharmacologists, herbal medicine practitioners, drug developers, medicinal chemists, phytochemists, toxicologists, and researchers who want to explore the use of plant materials for medicinal and related purposes.
Covering every problem encountered in today’s intensive care unit, this leading critical care textbook presents the knowledge and expertise of more than 350 global experts in this fast-changing field. Beginning with the social aspects of medicine, it then discusses monitoring and organ system pathobiology followed by specific diseases states/syndromes. Each chapter begins with immediate concerns and proceeds to broader-based discussions of relevant pathophysiologic and clinical issues.
This book is a wealth of spanking insight for directing interdisciplinary exchange of information especially in the fields of abiotic stresses and climate change for planning meaningful research as well as advancing education programmes in such indispensable areas. Apart from satisfying the acute need of this kind of exclusive edition for research teams and scientists engaged in various facets of research in plant physiology in traditional and agricultural universities, institutes and research laboratories throughout the world, it would be extremely a constructive book and a voluminus reference material for imbibing thought provoking knowledge by post-graduate and Ph.D. scholars in response to the innovative course in plant Physiology, Plant Biochemistry, PlantMolecular Biology, Plant Biotechnology, Environmental Science, Plant Pathology, Microbiology, soil Science Agricultural Chemistry, Agronomy, Horticulture, and Botany.
Recognized as the definitive reference in laboratory medicine since 1908, Henry's Clinical Diagnosis continues to offer state-of-the-art guidance on the scientific foundation and clinical application of today's complete range of laboratory tests. Employing a multidisciplinary approach, it presents the newest information available in the field, including new developments in technologies and the automation platforms on which measurements are performed. Provides guidance on error detection, correction, and prevention, as well as cost-effective test selection. Features a full-color layout, illustrations and visual aids, and an organization based on organ system. Features the latest knowledge on cutting-edge technologies of molecular diagnostics and proteomics. Includes a wealth of information on the exciting subject of omics; these extraordinarily complex measurements reflect important changes in the body and have the potential to predict the onset of diseases such as diabetes mellitus. Coverage of today's hottest topics includes advances in transfusion medicine and organ transplantation; molecular diagnostics in microbiology and infectious diseases; point-of-care testing; pharmacogenomics; and the microbiome. Toxicology and Therapeutic Drug Monitoring chapter discusses the necessity of testing for therapeutic drugs that are more frequently being abused by users.
Models that include a notion of time are ubiquitous in disciplines such as the natural sciences, engineering, philosophy, and linguistics, but in computing the abstractions provided by the traditional models are problematic and the discipline has spawned many novel models. This book is a systematic thorough presentation of the results of several decades of research on developing, analyzing, and applying time models to computing and engineering. After an opening motivation introducing the topics, structure and goals, the authors introduce the notions of formalism and model in general terms along with some of their fundamental classification criteria. In doing so they present the fundamentals of propositional and predicate logic, and essential issues that arise when modeling time across all types of system. Part I is a summary of the models that are traditional in engineering and the natural sciences, including fundamental computer science: dynamical systems and control theory; hardware design; and software algorithmic and complexity analysis. Part II covers advanced and specialized formalisms dealing with time modeling in heterogeneous software-intensive systems: formalisms that share finite state machines as common “ancestors”; Petri nets in many variants; notations based on mathematical logic, such as temporal logic; process algebras; and “dual-language approaches” combining two notations with different characteristics to model and verify complex systems, e.g., model-checking frameworks. Finally, the book concludes with summarizing remarks and hints towards future developments and open challenges. The presentation uses a rigorous, yet not overly technical, style, appropriate for readers with heterogeneous backgrounds, and each chapter is supplemented with detailed bibliographic remarks and carefully chosen exercises of varying difficulty and scope. The book is aimed at graduate students and researchers in computer science, while researchers and practitioners in other scientific and engineering disciplines interested in time modeling with a computational flavor will also find the book of value, and the comparative and conceptual approach makes this a valuable introduction for non-experts. The authors assume a basic knowledge of calculus, probability theory, algorithms, and programming, while a more advanced knowledge of automata, formal languages, and mathematical logic is useful.
To interpret the laboratory results. To distinguish the normal from the abnormal and to understand the merits and demerits of the assays under study. The book attempts to train a laboratory medicine student to achievesound knowledge of analytical methods and quality control practices, tointerpret the laboratory results, to distinguish the normal from the abnormaland to understand the merits and demerits of the assays under study.
The plant physiology and plant molecular biology research group has evidently endorsed the new directions taken by the treatise to attract the pre-eminent scientists in plant biology/plant sciences. Certainly, the preparation of Volume 13 of the International Treatise Series on Advances in Plant Physiology has been done entirely due to commendable contributions from Scientists of Eminence in unequivocal fields. Unquestionably, our objective is to publish innovative science of value across the broad disciplinary range of the treatise. I restate that this plan has been undertaken with a view to strengthen the indistinguishable efforts to recognize the outcome of meticulous research in some of the very sensible and stirring areas of Plant Physiology-Plant Molecular Physiology/ Biology-Plant Biochemistry for holistic development of the science of agriculture and crop production under changing climate. I am ardent to keep on the exceptionality and the prologue of excellent new ideas ensuring that the treatise calls to the best science done across the full extent of modern plant biology, in general, and plant physiology, in particular. In Volume 13, with inventive applied research, attempts have been made to bring together much needed eighteen review articles by forty-eight contributors especially from premier institutions of India for this volume. All the eighteen review articles have been grouped in five broad sections, which on the whole highlight the necessity to find out evidence from the fields of plant nutriophysiology (physiology of plant mineral nutrients) and abiotic stresses under changing climate along with their control.
Although heart failure typically begins with the left side of the heart, it is also important for cardiologists to understand right-sided heart failure, which is the inability of the right side of the heart to adequately pump venous blood into the pulmonary circulation. Right heart failure causes a back-up of fluid in the body, resulting in swelling and edema. This issue covers the normal right ventricle (RV), imaging of the RV, RV failure in a variety of settings, and tratmen tof RV failure, including interventions.
Flavonoids are secondary plant products that have previously been shown to be helpful in determining relationships among plant groups. This work presents comprehensively the occurrence, patterns of variation, and systematic and evolutionary importance of flavonoids in the sunflower family (Asteraceae), the largest family of flowering plants (23,000 species). It gathers together the more than 2500 reports of flavonoids in Asteraceae published between 1950 to the present and interprets these data in context of new taxonomic (especially generic) alignments. The authors discuss flavonoid patterns with reference to modern phylogenetic studies based on morphology and DNA data. This book provides, therefore, the most exhaustive synthesis and evaluation of the systematic and evolutionary import of flavonoids ever accomplished for any large family of angiosperms.
PROTA 11 deals with the medicinal plants of Tropical Africa. Because the group is very large, it has been subdivided into 4 volumes. This volume, PROTA 11(2), describes 409 medicinal plants in 146 review articles. All articles are illustrated with geographic distribution maps and many with botanical line drawings.
A left ventricular assist device (LVAD) is a surgically implanted pump that helps the left ventricle pump blood to the rest of the body. The purpose of this issue is to let cardiologists know about the latest devices, their complications, and the clinical situations in which they are most beneficial.
As many developing countries strive to expand their manufacturing and export activities and to improve the efficiency of government administration, the quality and applicability of university management education becomes critically important. This case study traces the development and growth of management education in one of the key nations of Latin America. Dr. Anderson provides a comprehensive account of management programs throughout Brazil— their history, their current situation, their professorial staff, and their student population. He pays particular attention to the problems of curriculum development and the inappropriateness of U.S. models and texts. The book provides insights useful for understanding the problems faced by developing nations as they attempt to build modern educational systems in tune with economic realities.
From the development of each vaccine to its use in reducing disease, Plotkin's Vaccines, 7th Edition, provides the expert information you need to provide optimal care to your patients. This award-winning text offers a complete understanding of each disease, as well as the latest knowledge of both existing vaccines and those currently in research and development. Described by Bill Gates as "an indispensable guide to the enhancement of the well-being of our world," Plotkin's Vaccines is a must-have reference for current, authoritative information in this fast-moving field. - Includes complete information for each disease, including clinical characteristics, microbiology, pathogenesis, diagnosis, and treatment, epidemiology, and public health and regulatory issues – plus complete information for each vaccine, including its stability, immunogenicity, efficacy, duration of immunity, adverse events, indications, contraindications, precautions, administration with other vaccines, and disease-control strategies. - Analyzes the cost-benefit and cost-effectiveness of different vaccine options. - Helps you clearly visualize concepts and objective data through an abundance of tables and figures. - Covers the new oral cholera and zoster vaccines, as well as newly licensed meningococcal group B vaccines and a newly licensed dengue vaccine. - Brings you up to date on successful human trials of Ebola vaccines, an enterovirus 71 vaccine licensed in China, and new recommendations and changes to polio vaccines. - Features a new chapter on maternal immunization. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
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