The most comprehensive, single-volume guide to conductingexperiments with mixtures "If one is involved, or heavily interested, in experiments onmixtures of ingredients, one must obtain this book. It is, as wasthe first edition, the definitive work." -Short Book Reviews (Publication of the International StatisticalInstitute) "The text contains many examples with worked solutions and with itsextensive coverage of the subject matter will prove invaluable tothose in the industrial and educational sectors whose work involvesthe design and analysis of mixture experiments." -Journal of the Royal Statistical Society "The author has done a great job in presenting the vitalinformation on experiments with mixtures in a lucid and readablestyle. . . . A very informative, interesting, and useful book on animportant statistical topic." -Zentralblatt fur Mathematik und Ihre Grenzgebiete Experiments with Mixtures shows researchers and students how todesign and set up mixture experiments, then analyze the data anddraw inferences from the results. Virtually every technique thathas appeared in the literature of mixtures can be found here, andcomputing formulas for each method are provided with completelyworked examples. Almost all of the numerical examples are takenfrom real experiments. Coverage begins with Scheffe latticedesigns, introducing the use of independent variables, and endswith the most current methods. New material includes: * Multiple response cases * Residuals and least-squares estimates * Categories of components: Mixtures of mixtures * Fixed as well as variable values for the major componentproportions * Leverage and the Hat Matrix * Fitting a slack-variable model * Estimating components of variances in a mixed model using ANOVAtable entries * Clarification of blocking mates and choice of mates * Optimizing several responses simultaneously * Biplots for multiple responses
The concise yet authoritative presentation of key techniques for basic mixtures experiments Inspired by the author's bestselling advanced book on the topic, A Primer on Experiments with Mixtures provides an introductory presentation of the key principles behind experimenting with mixtures. Outlining useful techniques through an applied approach with examples from real research situations, the book supplies a comprehensive discussion of how to design and set up basic mixture experiments, then analyze the data and draw inferences from results. Drawing from his extensive experience teaching the topic at various levels, the author presents the mixture experiments in an easy-to-follow manner that is void of unnecessary formulas and theory. Succinct presentations explore key methods and techniques for carrying out basic mixture experiments, including: Designs and models for exploring the entire simplex factor space, with coverage of simplex-lattice and simplex-centroid designs, canonical polynomials, the plotting of individual residuals, and axial designs Multiple constraints on the component proportions in the form of lower and/or upper bounds, introducing L-Pseudocomponents, multicomponent constraints, and multiple lattice designs for major and minor component classifications Techniques for analyzing mixture data such as model reduction and screening components, as well as additional topics such as measuring the leverage of certain design points Models containing ratios of the components, Cox's mixture polynomials, and the fitting of a slack variable model A review of least squares and the analysis of variance for fitting data Each chapter concludes with a summary and appendices with details on the technical aspects of the material. Throughout the book, exercise sets with selected answers allow readers to test their comprehension of the material, and References and Recommended Reading sections outline further resources for study of the presented topics. A Primer on Experiments with Mixtures is an excellent book for one-semester courses on mixture designs and can also serve as a supplement for design of experiments courses at the upper-undergraduate and graduate levels. It is also a suitable reference for practitioners and researchers who have an interest in experiments with mixtures and would like to learn more about the related mixture designs and models.
First comprehensive survey of a major genre of medieval English texts: its purpose, characteristics, and reception.The "bestseller list" of medieval England would have included many manuals for penitents: works that could teach the public about the process of confession, and explain the abstract concept of sin through familiar situations. Among these 'bestselling' works were the Manuel des péchés (commonly known through its English translation Handlyng Synne), The Speculum Vitae, and Chaucer's Parson's Tale. This book is the first full-length overview of this body of writing and its material and social contexts. It shows that while manuals for penitents developed under the Church's control, they also became a site of the Church's concern. Manuals such as the Compileison (which was addressed to a much broader audience than its English analogue, Ancrene Wisse) brought learning that had been controlled by the Church into the hands of layfolk and, in so doing, raised significant concerns over who should have access to knowledge. Clerics worried that these manuals might accidentally teach people new sins, remind them of old ones, or become sites of prurient interest. This finding, and others explored in this book, call for a new awareness of the complications and contradictions inherent in late medieval orthodoxy and reveal plainly that even writing that happened firmly within the Church's control could promote new and complex ways of thinking about religion and the self.cess to knowledge. Clerics worried that these manuals might accidentally teach people new sins, remind them of old ones, or become sites of prurient interest. This finding, and others explored in this book, call for a new awareness of the complications and contradictions inherent in late medieval orthodoxy and reveal plainly that even writing that happened firmly within the Church's control could promote new and complex ways of thinking about religion and the self.cess to knowledge. Clerics worried that these manuals might accidentally teach people new sins, remind them of old ones, or become sites of prurient interest. This finding, and others explored in this book, call for a new awareness of the complications and contradictions inherent in late medieval orthodoxy and reveal plainly that even writing that happened firmly within the Church's control could promote new and complex ways of thinking about religion and the self.cess to knowledge. Clerics worried that these manuals might accidentally teach people new sins, remind them of old ones, or become sites of prurient interest. This finding, and others explored in this book, call for a new awareness of the complications and contradictions inherent in late medieval orthodoxy and reveal plainly that even writing that happened firmly within the Church's control could promote new and complex ways of thinking about religion and the self.
The third Symposium of the Foundation for Life Sciences was held in February 1983 at the Newport Inn Conference Centre in Sydney. It was direced towards an understanding of the molecular neuropathology of muscle and nerve under a wide variety of conditions that may be induced by external agents or genetic lesions. The first session on experimental neurology explored the processes involved in maintenance of nerve and muscle function. This included many papers on myelination, studies on immune reactions affecting nerves, on synapses, and on neuronal development. This section was expanded to explore the control of muscle function in nerves, including a discussion on cross reinnervation. Toxic models of disease in the nervous system were then discussed, including pathological states induced by physical agents such as kainic acid, diphtheria toxin, and IDPN. A new dimension was added to the Symposium when for the first time psychologists participated and contributed to the session on external stressors and their effects on behavior. Heavy metals, herbicides, repetitive work, anxiety, and their effects on behavior and health were all represented. The discussion in this session attracted much interest from the participants, particularly the basic scientists.
Contents Include: An introduction to the grave, conservation, metallurgical and other analyses, a catalogue of organic and inorganic materials, and a discussion of dates and context.
This volume offers a fascinating, impressively detailed, account of the professional and personal life of a prominent historian of Latin America. It covers his youth, contacts with a young Leonard Bernstein, and his education at Boston Latin School and Harvard. He served in WWII, rising from private to master sergeant, ending up in a three-man military intelligence unit on Okinawa. There he held in his hands the first aerial photos of atomic-bombed Hiroshima, and was an eye witness to the surrender of Japanese holdouts. In rising from college instructor to department chair Potash recounts the conflicts and tensions that make up academic life. His two-year leave with the State Department was a career transforming experience, turning him eventually into a best selling author on the the military's role in Argentine politics. Potash describes his experiences working with Nazi files as part of an investigating commission created by the Argentine government. Known for his expertise, Potash is frequently consulted in times of crisis by the Argentine media and his name has become a household word in that country. Potash also recalls his courtship and marriage and relationships with his two daughters. Readers have dubbed the manuscript "hard to put down.
Domestic Animal Behavior for Veterinarians and Animal Scientists, Sixth Edition is a fully updated revision of this popular, classic text offering a thorough understanding of the normal behavior of domestic animals. Provides a complete understanding of the normal behavior of domestic animals Covers dogs, cats, horses, pigs, sheep, cattle, and goats Describes all key aspects of animal behavior, with images to support the concepts Revised and updated to cover the latest thinking, with enhanced coverage of behavioral genetics, animal cognition, and learning Includes access to a companion website with review questions and answers and the figures from the book in PowerPoint
The second edition of this book spans the broad range of modern therapeutic drugs, from small molecules to biologic recombinant proteins. It offers a comprehensive review of the classification and description of different drug-induced systemic and cutaneous hypersensitivities; an up-to-date coverage of individual culprit drugs in each group of therapeutics; the diagnosis and mechanisms of reactions; and important structure-activity relationships. New content expands to two areas of drug allergy that have recently experienced explosive growth: biological therapies and new targeted chemotherapies. Other new and expanded chapters address antimicrobials; drugs used in anesthesia and surgery; opioids; non-targeted anti-cancer drugs; vaccines; and newly understood reaction mechanisms. This new edition includes photographs of a wide variety of cutaneous manifestations that will be of use to other clinicians as well as allergists and dermatologists. In addition to its wide clinical emphasis, the book’s mechanistic and structure-activity detail will provide valuable background for researchers and investigators in universities, medical research institutes, drug companies, and regulatory agencies. The second edition of Drug Allergy is an essential reference for practitioners across the medical disciplines from specialist clinicians, surgeons, GPs, residents, and medical students to nurses, pharmacists, dentists, and those taking undergraduate and graduate courses in the biomedical sciences.
East Tennessee is gorgeous country, but the hills and hollers have a dark side. James Earl Ray, who had already assassinated Dr. Martin Luther King Jr., created mayhem at Brushy Mountain State Penitentiary when he led six other men in a short-lived escape. Several thousand Cherokee Indians from East Tennessee were forced on what would later be called the "Trail of Tears." In the "Hankins Murder" case and in the triple killings in Oliver Springs, chaos and confusion resulted from the wrongful arrest and public accusations of innocent people. Jake and C.H. Butcher brought about bedlam with their banking scandal that at the time was unsurpassed in scope in the nation's history. Author Dewaine A. Speaks details these stories and more.
Presents an alphabetical listing of information on the peoples of Asia and Oceania including origins, prehistory, history, culture, languages, and relationships to other cultures.
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