This book discusses the contribution of genetics and epigenetics alterations in the initiation, development, and recurrence of breast cancer. It also reviews the potential of translating the epigenetic alterations into diagnosis, prognosis, and breast cancer therapy. The initial chapters explore the epigenetics, etiology, and conventional treatment strategies for breast cancer. The subsequent chapters discuss the genetic landscape and cover three main epigenetic modulation mechanisms; histone modification, DNA methylation, and miRNA silencing. Further, the book explores the potential of epigenetic drugs in treating breast cancer. Lastly, it covers the phytochemicals targeting epigenetic modulators in breast cancer treatment. This book is an essential source for researchers and practitioners interested in exploring the potential of epigenetics modulators in breast cancer treatment.
The book discusses cancer and the potential use of phytochemicals as cancer therapeutics. It begins with the basics of cancer, including the definition, types, etiology and molecular mechanisms involved, before discussing the fundamentals of diagnosis, treatment and associated problems as well as remedial measures. Since cancer is not a single disease, and the mechanisms of carcinogenesis are different for different cancers, it examines the genes and proteins involved in carcinogenesis, and signal transduction pathways for each individual cancer type. Further, the book reviews the latest research on phytochemicals for cancer treatment, highlighting their anti-cancer properties, sources, structure, active biomolecules and probable mechanisms of action, and describing their biochemical properties in the context of cancer prevention and treatment.
First published in 2003.When Amitava Kumar left Patna, India, he envisioned himself as an up-and-coming citizen of the world, leaving behind the confines of Indian traditions. Yet like the wave of exiles that preceded him, he found that once we leave our past, we are defined by it: in the U.S. he is pigeonholed by his appearance and quizzed about saris and arranged marriages. "There is no beginning that is a blank page," writes Kumar. Circling the three capitals of the Indian diaspora, Bombay-London-New York captures the contours of the expatriate experience, touching on the themes of abandonment, nostalgia, and exile that have powered some of the most prominent Indian writers today -- Naipaul, Rushdie, Roy, Kureishi, as well as E.M. Forster and Gandhi. With resonant, poetic language and a storyteller's sensibility, Kumar explores the works of these writers through the lens of his own life as an immigrant and writer. As their fiction reveals, the past of the expatriate is mythical,shaped by memory and loss. With tales of life in India and London and meditations on the form Indian fiction gives to the lives of those who read about it, this is a sweeping, passionate search to find one's own story in the stories of others.
To be a writer, Amitava Kumar says, is to be an observer. The twenty-six essays in Lunch with a Bigot are Kumar's observations of the world put into words. A mix of memoir, reportage, and criticism, the essays include encounters with writers Salman Rushdie and Arundhati Roy, discussions on the craft of writing, and a portrait of the struggles of a Bollywood actor. The title essay is Kumar's account of his visit to a member of an ultra-right Hindu organization who put him on a hit-list. In these and other essays, Kumar tells a broader story of immigration, change, and a shift to a more globalized existence, all the while demonstrating how he practices being a writer in the world.
This book discusses systematic designs of stable adaptive fuzzy logic controllers employing hybridizations of Lyapunov strategy-based approaches/H∞ theory-based approaches and contemporary stochastic optimization techniques. The text demonstrates how candidate stochastic optimization techniques like Particle swarm optimization (PSO), harmony search (HS) algorithms, covariance matrix adaptation (CMA) etc. can be utilized in conjunction with the Lyapunov theory/H∞ theory to develop such hybrid control strategies. The goal of developing a series of such hybridization processes is to combine the strengths of both Lyapunov theory/H∞ theory-based local search methods and stochastic optimization-based global search methods, so as to attain superior control algorithms that can simultaneously achieve desired asymptotic performance and provide improved transient responses. The book also demonstrates how these intelligent adaptive control algorithms can be effectively utilized in real-life applications such as in temperature control for air heater systems with transportation delay, vision-based navigation of mobile robots, intelligent control of robot manipulators etc.
This book is an enthralling journey through time, exploring the Golden Age, the rise of Bollywood, the Parallel Cinema movement, global acclaim, and technological advancements that shaped one of the world's most prolific film industries.
Hunger is an issue which has been subject to much rigorous intellectual examination by economists, philosophers, sociologists, NGOs and governments. This volume provides a critical overview of current academic and political perspectives and then compares these views from thenon-hungry people with those of thehungry particularly from a broad range of poor communities in India. Their views are gathered using participatory rural appraisal techniques and the scale of the material presented is unprecedented. Not surprisingly, the comparisons show that the perceptions of the hungry are fundamentally different from those of the non-hungry. It makes compelling suggestions about how best policy makers can attempt to eliminate hunger based on what the hungry themselves suggest. The book also draws attention to the critical role of Common Property Resources and women in the fight against under-nutrition, which have so far been largely ignored.
Air Pollution, Livelihood and Food Secuity - Indepth Studies Through PRA Methods on Community Perspectives in Urban and Peri-urban Areas of Varanasi and Faridabad, India
Air Pollution, Livelihood and Food Secuity - Indepth Studies Through PRA Methods on Community Perspectives in Urban and Peri-urban Areas of Varanasi and Faridabad, India
This title was first published in 2001. This text is an exercise in learning from the voices of the communities living in Indian villages near urban areas. It is concerned, primarily, with learning what these communities have to say on their well-being and livelihoods and is, therefore, an attempt to record and register as much as possible of what these communities say. Agriculture in urban areas of Haryana and Uttar Pradesh plays an important role for livelihoods and in supplying foodstuffs to communities and markets. It constitutes a major source of income both for landowners and labourers. The study then looks at the relationship between agriculture and urban areas, and the phenomenon of industrialization/urbanization. In presenting these perspectives, the farmers gave insights into some related issues such as the role of agriculture in their livelihoods, the nature of agricultural constraints and the the impact of air pollution on quality of life.
A blistering novel about a writer’s creative response to the daily onslaught of fake news, memory, and the ways in which truth gives over to fiction “An absorbing portrait of an inspired artist in the midst of our maddening cultural moment” —Ayad Akhtar, author of Homeland Elegies When Satya, a professor and author, attends a prestigious artists' retreat to write, he finds the pressures of the outside world won’t let up: the president rages online; a dangerous virus envelops the globe; and the twenty-four-hour news cycle throws fuel on every fire. For most of the retreat fellows, such stories are unbearable distractions, but for Satya, who sees them play out in both America and his native India, these Orwellian interruptions begin to crystallize into an idea for his new novel, Enemies of the People, about the lies we tell ourselves and one another. Satya scours his life for instances in which truth bends toward the imagined and misinformation is mistaken as fact. Mixing Satya’s experiences—as a father, husband, and American immigrant—with newspaper clippings, the president’s tweets, and observations on famous works of art, A Time Outside This Time captures a feverish political moment with intelligence, beauty, and an eye for the uncanny. It is a brilliant interrogation on life in a post-truth era and an attempt to imagine a time outside this one.
Modern inertial sensors and systems cover more than five decades of continuous research and development involving various branches of science and engineering. Various technologies have emerged in an evolutionary manner surpassing the earlier ones in performance and reliability. The subject is still growing with proliferation in newer cost effec-tive applications, while its wider usage in aerospace systems continues. This book exposes the readers to the subject of inertial navigation, the inertial sensors and inertial systems in a unified manner while emphasizing the growth areas in emerging technologies such as micro-electromechanical inertial sensors, satellite navigation, satellite navigation integrated inertial navigation, hemispherical resonator gyro, vibrating beam accelerometer, interferometric fibre optic gyro, inertial sensor signal processing, redundant inertial systems and the quite recent emergence of cold atom interferometer based inertial sensors. The contents are imaginatively designed that will of interest to a wide spectrum of readers. The book has been written with utmost lucidity and clarity and explanations provided with a large number of illustrative figures. Besides being an ideal introduction to the principles of inertial sensors and systems for undergraduate and postgraduate students of aerospace engineering, the topics dealt with will also be of benefit to practising engineers and can assist the researchers to locate excellent references for research work. The authors have had three decades of design and application research experience in premier research institutions and have made use of their experience in giving a user-friendly shape to the book.
Annotation. The most common complaints of today's cell phone users are poor reception, a lost signal that cuts off a call, and the inability to put a call through. Today's wireless providers struggle to ensure these problems do not occur. This book is an in-depth examination of two of the hottest research areas relating to these challenges: location management and mobile wireless routing.
Antioxidants in Food, Vitamins and Supplements bridges the gap between books aimed at consumers and technical volumes written for investigators in antioxidant research. It explores the role of oxidative stress in the pathophysiology of various diseases as well as antioxidant foods, vitamins, and all antioxidant supplements, including herbal supplements. It offers healthcare professionals a rich resource of key clinical information and basic scientific explanations relevant to the development and prevention of specific diseases. The book is written at an intermediate level, and can be easily understood by readers with a college level chemistry and biology background. - Covers both oxidative stress-induced diseases as well as antioxidant-rich foods (not the chemistry of antioxidants) - Contains easy-to-read tables and figures for quick reference information on antioxidant foods and vitamins - Includes a glycemic index and a table of ORAC values of various fruits and vegetables for clinicians to easily make recommendations to patients
A NEW YORK TIMES NOTABLE BOOK ONE OF THE NEW YORKER’S BEST BOOKS OF THE YEAR Carrying a single suitcase, Kailash arrives in post-Reagan America from India to attend graduate school. As he begins to settle into American existence, Kailash comes under the indelible influence of a charismatic professor, and also finds his life reshaped by a series of very different women with whom he recklessly falls in and out of love. Looking back on the formative period of his youth, Kailash’s wry, vivid perception of the world he is in, but never quite of, unfurls in a brilliant melding of anecdote and annotation, picture and text. Building a case for himself, both as a good man in spite of his flaws and as an American in defiance of his place of birth, Kailash weaves a story that is at its core an incandescent investigation of love—despite, beyond, and across dividing lines.
Networking Infrastructure for Pervasive Computing: Enabling Technologies & Systems is a comprehensive guide to tomorrow's world of ubiquitous computing where users can access and manipulate information from everywhere at all times. The emphasis is on networking, systems and standards rather than detailed physical implementation. Addressed are many technical obstacles, such as, connectivity, levels of service, performance, and reliability and fairness. The authors also describe the existing enabling off-the-shelf technologies and its underlying infrastructure known as pervasive networking (PervNet). PervNet ties different sets of smart nodes together enabling them to communicate with each other to provide pervasive computing services to users. Throughout the book, important issues related to scalability, transparency, security, energy management, QoS provisioning, fault tolerance, and disconnected operations are discussed. This work provides a research and development perspective to the field of PervNet and will serve as an essential reference for network designers, operators and developers.
UN declaration on sustainable goals on 2015, 17 by count, to be achieved by 2030, certainly focuses on ensuring well-being of people, especially of rural populace reeling under faster marginalization process. That is why and how the issues of ensuring happiness has earned that much of importance. The happiness for deprived class is attainable by ensuring a dedicated income, health and hygiene, minimal level of learning and social security. Happiness is the most adored goal for everyone on this planet and unquestionably every farmer in India. Farmers are wrongly portrayed as a human machine for producing food against some wages or income. Both wages and income are so uncertain for a small and marginal farmer, a happy return remains illusory and a faraway dream per se. The main problem of Indian farming is that they are under increasing stress for every consecutive month or year they have to survive with a market which is uncertain and income which fragile and wage which goes undulating. Globally on happiness-index India's position is just close to the lowest one. In this book, the conceptual heterodoxy of happiness has been well examined. Both the physical and mental well-being of the farmers are extremely important for augmenting and sustaining our food security and economic growth. The book creation has been extremely fascinating and voyaging to explore the cause and consequences of unhappiness of farmers, the most neglected humanity, who are supposed to save us from hunger and famine. Huge no of farmers' respondents, perhaps for the first time in agricultural extension in India, to examine how happy they are! The book has got a splendid combination of mind-mathematics-motivation as reflected through a plethora of hard evidences.
Amitava Kumar's Every Day I Write the Book is for academic writers what Annie Dillard's The Writing Life and Stephen King's On Writing are for creative writers. Alongside Kumar's interviews with an array of scholars whose distinct writing offers inspiring examples for students and academics alike, the book's pages are full of practical advice about everything from how to write criticism to making use of a kitchen timer. Communication, engagement, honesty: these are the aims and sources of good writing. Storytelling, attention to organization, solid work habits: these are its tools. Kumar's own voice is present in his essays about the writing process and in his perceptive and witty observations on the academic world. A writing manual as well as a manifesto, Every Day I Write the Book will interest and guide aspiring writers everywhere.
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